O2k-Publications: Other cell lines

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BSC-40 cells were a continuous line of African green monkey cells derived from kidney BSC-1 cells (Hruby, et al., 1979). Cells were maintained as monolayer (adherent) cultures in Dulbecco's modified Eagle's medium.

HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney.

NCI-H295R cells were adapted from the NCI-H295 pluripotent adrenocortical carcinoma cell line established by A.F. Gazdar and associates (1990) from a carcinoma of the adrenal cortex. While the original cells grew in suspension, the adapted cells were selected to grow in a monolayer. This cell line retains the ability to produce adrenal androgens. It is responsive to angiotensin II and potassium ions.

Jurkat cells are an immortalized line of T lymphocyte cells that are used to study acute T cell leukemia, T cell signaling, and the expression of various chemokine receptors susceptible to viral entry, particularly HIV. Jurkat cells are also useful in science because of their ability to produce interleukin 2. Their primary use, however, is to determine the mechanism of differential susceptibility of cancers to drugs and radiation.