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Oroboros Ecosystem Agenda 2020 Archive

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Oroboros Ecosystem Agenda 2020 Archive

Oroboros Ecosystem Agenda 2020
Mitochondria and Cell Research - the Oroboros Ecosystem
» Current Oroboros Ecosystem Agenda 2020

Mar 2020

 2020 Week 12  
  • Mar-16 Mo
Oroboros
Oroboros operates from now on in home office mode - we stay connected.


MitoPedia: SUIT
The standardized coupling control protocol to explore the bioenergetics of living cells
- DatLab 7.4 provides a step-by-step guide through the SUIT-003 protocol and its extensions. - »SUIT-003«



  • Mar-17 Tu
O2k-Publications in the MiPMap
Zika virus infection leads to mitochondrial dysfunction
- from the O2k-Network »BR Rio de Janeiro Galina A«
  • Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218. - »Bioblast link«

  • Mar-18 We
O2k-brief repository Exercise protects against the effects of aging on mitochondrial function
- from the O2k-Network »KR Busan Han J« »KR Incheon Kwak HB«
  • No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93. - »Bioblast link«



  • Mar-19 Th
DatLab
Home office mode is a world-wide protective strategy facing the COVID-19 pandemic. Supporting institutions and individual scientists in their home office strategy, during the time of crisis Oroboros Instruments provides free of charge copies of our newest software DatLab 7.4, for downloading at your personal or institutional PC at home.
- » For the download link and password, please email [email protected]



  • Mar-20 Fr
2020 Week 11
Gentle Science
Promising practices for addressing the underrepresentation of women in science, engineering, and medicine: opening doors. National Academies of Sciences, Engineering, and Medicine (2020) - »Bioblast link«



  • Mar-09 Mo
COST Action MitoEAGLE »MitoEAGLE WG2 Innsbruck AT« (Mar 09-13)


O2k-Publications in the MiPMap Protein-specific mitochondrial respiratory capacity is higher in women than men
- from the O2k-Network »SE Stockholm Cardinale DA«
  • Cardinale DA, Larsen FJ, Schiffer TA, Morales-Alamo D, Ekblom B, Calbet JAL, Holmberg HC, Boushel R (2018) Superior intrinsic mitochondrial respiration in women than in men. Front Physiol 9:1133. - »Bioblast link«



  • Mar-10 Tu
O2k-Publications in the MiPMap Muscular exercise for training adipose tissue mitochondria
- from the O2k-Network »DK Copenhagen Larsen S«
  • Mendham Amy E, Larsen Steen, George Cindy, Adams Kevin, Hauksson Jon, Olsson Tommy, Fortuin-de Smidt Melony C, Nono Nankam Pamela A, Hakim Olah, Goff Louise M, Pheiffer Carmen, Goedecke Julia H (2020) Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Sci Rep 10:3785. - »Bioblast link«

  • Mar-11 We
MitoPedia Does blebbistatin reduce oxygen dependence of respiration of permeabilized muscle fibers? This is one of the questions addressed in the COST Action CA15203 MitoEAGLE WG2. - »Blebbistatin«


Gentle Science
Let's talk COVID-19 - a new culture of communication in science. - Kay Kupferschmidt in Science


O2k-Open Support Info: improve Do you change the slope smoothing to 20 while operating the O2k with biological sample?
- It is advantageous to decrease 'slope smoothing' to visualize changes of respiration more rapidly in O2k-experiments after calibration - especially before uncoupler titrations. - »Slope smoothing«

  • Mar-12 Th
O2k-Publications in the MiPMap Multiple Sclerosis Month: Mitochondrial permeability transition pore protection as novel therapeutic approach in multiple sclerosis
- from the O2k-Network »UK London Duchen MR«
  • Warne J, Pryce G, Hill J, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker A, Duchen MR, Szabadkai G, Baker D, Selwood D (2015) Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis. J Biol Chem 291:4356-73. - »Bioblast link«

  • Mar-13 Fr
O2k-Publications in the MiPMap Men and women with Type 1 diabetes and skeletal muscle mitochondria
- from the O2k-Network »CA Toronto Perry CG«
  • Monaco CMF, Bellissimo CA, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ (2020) Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol Endocrinol Metab 318:E44-E51. - »Bioblast link«


2020 Week 10
  • Mar-02 Mo
O2k-Network
An amazing number of new O2k-Publications from China. - »O2k-Network Labs China«



O2k-Publications in the MiPMap Salty diet, cardiac hypertrophy, calcium overload, and mitochondrial dysfunction
- from the O2k-Network »CN Chongqing Zhu Z«
  • Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52. - »Bioblast link«



  • Mar-03 Tu
O2k-Publications in the MiPMap Rapamycin suppresses senescence in galactose versus glucose cell culture
- from the O2k-Network »US PA Philadelphia Orynbayeva Z«
  • Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience 40:243-56. - »Bioblast link«


MitoPedia Rapamycin - more differences or more in common with other mitObesity drugs? - »Rapamycin«


Gentle Science
Advancing Open Science practices: stakeholder perspectives on incentives and disincentives. National Academies of Sciences, Engineering, and Medicine (2020) - »Bioblast link« - The concept of Preprints needs full attention in Open Science.



  • Mar-04 We
Platelet.jpg
O2k-Publications in the MiPMap Systemic mitochondrial bioenergetics in older adults - skeletal muscle and platelets
- from the O2k-Network »US FL Orlando Goodpaster BH«
  • Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248. - »Bioblast link«
Softdrink.jpg
O2k-brief repository Sugar and fat - initial mitochondrial aging in the brain
- from the O2k-Network »IT Naples Iossa S«
  • Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63. - »Bioblast link«
OroboPOS-Holder002.jpg


O2k-Open Support Warning: loss of data A damaged OroboPOS-Holder may cause medium to leak from the O2k-Chamber.
See how you can check that the two blue OroboPOS-Holders are intact. - »O2k-OroboPOS-Holder«




  • Mar-05 Th


MitoFit
With a preprint you can communicate recent findings fast to the scientific community, secure a DOI, and receive input from other scientists even before submitting to a peer-reviewed journal. - »Preprint«



  • Mar-06 Fr
MitoPedia: SUIT Explore metabolic profiles and specific modultations of mitochondrial pathways in health and disease with SUIT reference protocols. - »RP1« and »RP2«


Feb 2020

2020 Week 9
  • Feb-23 Su
» 2020 PaduaMuscleDays Padova IT - postponed to fall/winter 2020 due to coronavirus outbreak in Northern Italy

  • Feb-24 Mo
MitoPedia
More research is needed on the impact of viral infection on mitochondrial function. - »Viruses and mitochondrial medicine«



  • Feb-25 Tu
O2k-Network
High quality mitochondrial research is increasing rapidly in South Korea. - »O2k-Network Labs Republic of Korea«



O2k-Publications in the MiPMap An active lifestyle protects cardiac mitochondria
- from the O2k-Network: KR Busan Han J, KR Incheon Kwak HB
  • No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93. - »Bioblast link«



MitoEAGLE WG4 retreat; left to right: Luiz, Erich, Eleonor, Slawomir
  • Feb-26 We
MitoPedia
It is essential to titrate uncouplers in multiple steps for respirometric measurement of electron transfer capacity. - »Noncoupled respiration«


COST Action MitoEAGLE MitoEAGLE WG4 Innsbruck AT (Feb 26-28)

  • Feb-27 Th
O2k-Publications in the MiPMap Regulation of mitochondrial oxygen kinetics by cytochrome c oxidase
- from the O2k-Network: CZ Prague Houstek J
  • Pajuelo-Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443. - »Bioblast link«

  • Feb-28 Fr
O2k-Open SupportTake care Calibration parameters are transferred to experimental DatLab files
Save calibration information from selected Marks while DatLab is connected to the O2k during an instrumental calibration run. Air calibration and zero oxygen calibration can be performed and saved in a single DatLab file or in separate DatLab files. - » Oxygen calibration - DatLab«


2020 Week 8
  • Feb-17 Mo
EBEClogo2020.jpg Registration is open: European Bioenergetics Conference 2020, Marseille, France, 2020

  • Feb-18 Tu
MitoPedia Why do we fight gas bubbles? » Dive deep into Oxygen solubility
O2k-Publications in the MiPMap Aging and hyperlipidemia impair aortic mitochondrial function and increase the risk of atherosclerosis
- from the O2k-Network »US MI Ann Arbor Beard DA«
  • Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314. - »Bioblast link«



  • Feb-19 We
MitoFit Preprints.png - »MitoFit Preprint Arch« was initiated one year ago. We invite submissions of mitochondrial preprints.
MitoPedia Spermidine and other calorie restriction mimetics control autophagy and mitochondrial function. - »Spermidine«



  • Feb-20 Th
Logo MitoFit s.jpg - MitoFit Open Seminar: Eduard Stefan: “Decoding and Perturbation of ONCO-Kinase functions” and Omar Torres Quesada: “MitoKIN - Systematic barcoding of kinase-controlled mitochondrial function”


2020 Week 7
  • Feb-10 Mo

  • Feb-12 We
MitoPedia What do metformin, melatonin and other bioactive mitObesity compounds have in common? - »MitObesity drugs«


O2k-Feedback
I had a very pleasant experience at the work shop. I thank you and all the team members for devoting their time for us and teaching each step in a systematic manner. - Gayathri Narayanappa participaing in MiPNet25.03 IOC144 Innsbruck AT



  • Feb-13 Th


2020 Week 6
  • Feb-03 Mo
FFG »Official start of the FFG funded project »MitoKIN«
O2k-Publications in the MiPMap Blood cell mitochondrial function does not provide a general substitute for muscle biopsies
- from the O2k-Network »US AR Little Rock Boersheim E«
  • Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Boersheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. - »Bioblast link«
  • Do you know that the Oroboros O2k can also be used to study the mitochondrial dark respiration of microalgae and its response to climate change impact in the ocean? One of our customers, Dr Nelly Tremblay is using for the first time the SUIT-022 protocol to study alternative oxidases in the marine model organism Phaeodactylum tricornutum.



  • Feb-04 Tu
O2k-Workshops MiPNet25.10 IOC and Distributor engagement Tokyo JP (Feb 4-7)
O2k-brief Cronin (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature - Lymphocytes, Cancer - O2k-brief repository



  • Feb-05 We
O2k-Publications in the MiPMap Aerobic and resistance training address central defects and peripheral comorbidities in Alzheimer’s disease
- from the O2k-Network »US FL Boca Raton Khamoui AV«
  • Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Diseases 2020:Article ID 5919501. - »Bioblast link«



  • Feb-06 Th
MitoFit Open Seminar
  • 16:00-16:30 Jorge Beleza: Exercise performed during pregnancy as a preventive tool against transgenerational development of diabetes mellitus and NAFLD in the offspring. The role of epigenetic-mediated mechanisms. »Abstract«
  • 16:30-17:00 Rita Pereira: The Handball4Health Project : A community-based intervention programme


Jan 2020

2020 Week 5
  • Jan-27 Mo
O2k-Workshops IOC145 Innsbruck AT - O2k-Coaching Days (Jan 27-29)
DSL-Seminar, 16:00
Gnaiger E: mitObesity: compromised mitochondrial fitness in degenerative comorbidities of early aging.
Univ.-Klinik für Visceral-, Transplantations- u. Thoraxchirurgie, Surgery building, 12th floor, north, seminar room



  • Jan-28 Tu
O2k-Publications in the MiPMap Mitochondrial respiration of blood cells and cardiovascular disease
- from the O2k-Network »FR Strasbourg Zoll J«
  • Alfatni A, Riou M, Charles AL, Meyer A, Barnig C, Andres E, Lejay A, Talha S, Geny B (2020) Peripheral blood mononuclear cells and platelets mitochondrial dysfunction, oxidative stress, and circulating mtDNA in cardiovascular diseases. J Clin Med 9 pii:E311. - »Bioblast link«



  • Jan-30 Th - MitoFit Open Seminar - Alexander Karabatsiakis: Targeting the reversibility of mitochondrial changes in bioenergetics and biogenesis in Major Depressive Disorder by clinical routine antidepressant treatment.
O2k-Open Support Take care Do you check the O2 flux at the end of the air calibration with the O2k-chamber closed?
In DatLab 7.4, instrumental DL-Protocols guide you automatically towards closing the O2k-chamber after air calibration, to monitor "O2 slope neg." (negative) as a test of any biological contamination which would increase oxygen consumption in the absence of a biological sample. - »Oxygen calibration - DatLab«
O2k-Open Support Info: improve Do you set mark ‘R1’ and complete the air calibration correctly?
Your air calibration is not effective until you set mark ‘R1’ andclick on Calibrate and copy to clipboard in the O2 calibration window. - »Oxygen calibration - DatLab«




  • Jan-31 Fr
O2k-Open SupportTake care Reproducibility committment in high-resolution respirometry: quality control in oxygen calibration
In the DatLab 7.4 software, new instrumental DL-Protocols guide the user automatically step-by-step, to calibrate the instrument accurately. Reproducibility is monitored and documented when following user-friendly standard operating procedures (SOP). - »Oxygen calibration - DatLab«
2020 Week 4
  • Jan-20 Mo
O2k-Workshops IOC144 Innsbruck AT - O2k-Coaching Days (Jan 20-22)



  • Jan-21 Tu
  • Mr Hai Wu (CEO of Huawei, Oroboros distributor in China) and Dr. Rupert Ecker (CEO of Vienna TissueGnostics) join the O2k-Coaching Days for extending collaborative projects.



  • Jan-23 Th - MitoFit Open Seminar - Erich Gnaiger: An improved index of obesity versus BMI - an issue of mitObesity and gender medicine in our modern world's obesogenic environment.



  • Jan-24 Fr
O2k-Open Support Info: improve Do you write the serial number of the polarographic oxygen sensor (POS) in the ‘O2k configuration’ window?
Including the POS serial number in the ´O2k configuration´ window is important to keep a track record of the sensors used according to the O2k. This will be especially helpful if troubleshooting is needed. - »O2k configuration«
O2k-Open Support Warning: loss of data Do you perform O2k-Chamber volume calibration?
The volume calibration is essential to ensure that the chamber volume is correctly calibrated to its standard volume of 2 mL (or 0.5 mL for the O2k-sV-Module). - »O2k-Chamber MitoPedia«
O2k-Open Support Take care Do you use the correct O2 solubility factor (FM) in the ‘O2 calibration’ window in DatLab?
The O2 solubility factor varies according to the medium used and influences the air calibration. - »Oxygen solubility factor«
2020 Week 3
  • Jan-14 Tu



  • Jan-15 We
O2k-Publications in the MiPMap Statistical evaluation on replica in HRR with permeabilized skeletal muscle fibers
- from the O2k-Network »AU Melbourne Stepto NK«
  • Jacques M, Kuang J, Bishop DJ, Yan X, Alvarez-Romero J, Munson F, Garnham A, Papadimitriou I, Voisin S, Eynon N (2019) Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study. FASEB J [Epub ahead of print]. - »Bioblast link«



  • Jan-16 Th
MitoPedia Oxygen flux - which SI units should be used?
MitoPedia Did you ever think that units for body mass could be an issue? - »Body mass«



  • Jan-17 Fr
About Oroboros HRR - high-resolution respirometry and oxygen kinetics 10 years ago: Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 2010. - »Bioblast link«
TRANSMIT TRANSMIT Symposium 2020 Brussels BE (Jan 17-18)


O2k-Publications in the MiPMap Mitochondrial respiration is oxygen-dependent in human cardiac homogenate preparations
- from the O2k-Network »CZ Prague Krajcova A«
  • Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. - »Bioblast link«
2020 Week 2
  • Jan-07 Tu The Oroboros Office opens in the New Year 2020
EBEClogo2022.jpg
  • From the Austrian Bioenergetics Group to Mitochondrial Physiology and Bioenergetics DACH (D: Germany; A: Austria; CH: Switzerland)
EBEC22 - the 22nd European Bioenergetics Conference will be held in Innsbruck (2022, Aug 22-27). We would like to invite several Austrian colleagues to join the EBEC22 National Scientific Committee. This provides an excellent opportunity to establish an Austrian Bioenergetics Group towards and beyond EBEC22. We hope that this topic will be discussed at the forthcoming 1st Myocardial Function Symposium 2020 Graz AT, and further at the MitoEAGLE Summit Obergurgl 2020. Please, contact the organizer of EBEC22 - [email protected]



  • Jan-08 We
MitoPedia Force and Energy: this we all need in the New Year - and MitoPedia may help to clarify the difference.
Quality



  • Jan-09 Th
COST Action MitoEAGLE
Members of the Management Committee MitoEAGLE and Working Group Leaders: please submit your suggestions for MitoEAGLE Summit Obergurgl 2020:
  1. Suggested type and title of your personal presentation, according to the MoU and final MitoEAGLE output
  2. Suggested scientists (titles) for presentations, according to the MoU



  • Jan-10 Fr
» 1st Myocardial Function Symposium 2020 Graz AT (Jan 10-11)
  • 14:45 Novel technologies for mitochondria and cell research (Gnaiger, Innsbruck, AUT)



  • Jan-12 So
  • One month ago
Oroboros
Cluster Awards 2019

Cluster Awards 2019

On December 12th, the Cluster Awards 2019 were presented for the best Tyrolean innovations of the year. We are thrilled to be the recipient in the Life Sciences Cluster for our EU Horizon 2020-funded NextGen-O2k project.

Life Sciences

Oroboros Instruments GmbH, Innsbruck: "NextGen-O2k"

Renewable Energies

Heliotherm Wärmepumpentechnik GmbH, Langkampfen: "Invisible Heatpump"

Forest and wood

Holzbau Unterrainer GmbH, Ainet: "Radius wood - production of curved cross laminated timber elements"

Information Technologies

Lo.La Peak Solutions GmbH, Trins: "LO.LA Safety - Digital Safety Management in Ski Resorts"

Mechatronics: ALPEX Technologies GmbH, Mils: "EVEREST 4.0"

Wellness: Organoid Technologies GmbH, Flow: "natural sauna surfaces made of hay"

» More details (in German): Standortagentur Tirol.

Photo © Standortagentur Tirol
2020 Week 1 The Oroboros team enjoys holidays from 2019 Dec 24 to 2020 Jan 06
Oroboros
Oroboros picture of the month

Oroboros of the month

Season's Greetings
Our office is closed until 2020-01-06.
We wish you a Happy New Year 2020!
Your Oroboros team



  • Jan-04 Sa
News The Oroboros Ecosystem Agenda 2020 is launched as a signature of the Oroboros Ecosystem.
Gentle Science 2020: a critical year for women, gender equity, and health - a Lancet Editorial
  • One month ago
Oroboros
NextGen-O2k SME2 coaching Orily Pratt part 2

MitoFit Guest Seminar
On December 03/04 the second part of the SME phase 2 Coaching for the NextGen-O2k project with Orily Pratt (Tel Aviv, IL) took place in Innsbruck.



» Wednesday, 4th of December; Oroboros Instruments, Schoepfstrasse 18, MiPArt, Innsbruck, Austria.


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