P/E control ratio: Difference between revisions

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{{MitoPedia
{{MitoPedia
|abbr=P/E
|abbr=P/E
|description=The '''OXPHOS control ratio''', P/E, increases from a minimum of L/E if the capacity of the phosphorylation system is zero, to the maximum of 1.0 if the capacity of the phosphorylation system fully matches the ETS capacity (or in fully dyscoupled mitochondria), when there is no limitation of P by the phosphorylation system or the proton backpressure. It is important to separate the effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration ([[Pesta_2010_Protocols]]).
|description=The OXPHOS control ratio or OXPHOS/ETS capacity decreases with limitation by the phosphorylation system.  P/E increases from the lower boundary set by L/E (zero capacity of the phosphorylation system), to the upper limit of 1.0, when there is no limitation of P by the phosphorylation system or the proton backpressure (capacity of the phosphorylation system fully matches the ETS capacity; or if the system is fully uncoupled). It is important to separate the effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration.
|info=[[MiPNet12.15]], [[Gnaiger_2009_IJCBC]]
|info=[[MiPNet12.15]], [[Gnaiger_2009_IJCBC]], Pesta_2010_Protocols
|type=Respiration
|type=Respiration
}}
}}

Revision as of 13:40, 15 September 2010


high-resolution terminology - matching measurements at high-resolution


P/E control ratio

Description

The OXPHOS control ratio or OXPHOS/ETS capacity decreases with limitation by the phosphorylation system. P/E increases from the lower boundary set by L/E (zero capacity of the phosphorylation system), to the upper limit of 1.0, when there is no limitation of P by the phosphorylation system or the proton backpressure (capacity of the phosphorylation system fully matches the ETS capacity; or if the system is fully uncoupled). It is important to separate the effect of ADP limitation from limitation by enzymatic capacity at saturating ADP concentration.

Abbreviation: P/E

Reference: MiPNet12.15, Gnaiger_2009_IJCBC, Pesta_2010_Protocols


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Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property. 




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