- high-resolution terminology - matching measurements at high-resolution
PGC-1α
Description
Peroxisome proliferator-activated receptorγ coactivator-1α (PGC-1α) is a transcriptional coactivator that interacts with cofactors containing intrinsic chromatin remodeling activities.
Abbreviation: PGC-1α
Reference: Scarpulla_2011_Biochim Biophys Acta; Lin_2005_Cell Metab
PGC-1α is a member of the PGC-1 family of coactivators, which includes PGC-1β and PGC-1–related coactivator(PRC). PGC-1α, however, seems to be a powerful regulator of energy metabolism under conditions of both health and disease and as such interacts with a broad range of transcription factors that are involved in a wide variety of biological responses including adaptive thermogenesis, mitochondrial biogenesis, glucose and fatty acid metabolism, fiber type switching in skeletal muscle, and heart ontogenesis. In general, PGC-1α is highly expressed in mitochondria-rich tissues with active oxidative metabolism such as brown adipose tissue (BAT), the heart, and skeletal muscle.
Mechanism By interacting with transcription factors, a transcription coactivator, increases the probability of a gene being transcribed without itself binding to DNA in a sequence-specific manner. Although members of the PGC-1 family lack histone acetyltransferase (HAT) activities, their amino-terminal region interacts with proteins containing HAT activity. The HAT activity of this complex remodels histones within chromatin, leading to enzymatic modification of chromatin, increased access of the RNA polymerase II machinery to RNA, thereby activating target gene transcription.
