Pena 2020 Int J Chronic Dis: Difference between revisions
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{{Publication | {{Publication | ||
|title=Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic | |title=Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501. | ||
|info=[https://www.hindawi.com/journals/ijcd/2020/5919501/ Open Access] | |info=[https://www.hindawi.com/journals/ijcd/2020/5919501/ Open Access] ยป[[File:O2k-brief.png|36px|link=https://wiki.oroboros.at/images/9/99/Pena_2020_Int_J_Chronic_Dis_O2k-brief.pdf|O2k-brief]] | ||
|authors=Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV | |authors=Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV | ||
|year=2020 | |year=2020 | ||
|journal=Int J Chronic | |journal=Int J Chronic Dis | ||
|abstract=Aerobic training (AT) can support brain health in Alzheimerโs disease (AD); however, the role of resistance training (RT) in AD is not well established. Aside from direct effects on the brain, exercise may also regulate brain function through secretion of muscle-derived myokines. Aims. This study examined the effects of AT and RT on hippocampal BDNF and IGF-1 signaling, ฮฒ-amyloid expression, and myokine cathepsin B in the triple transgenic (3xTg-AD) model of AD. 3xTg-AD mice were assigned to one of the following groups: sedentary (Tg), aerobic trained (Tg+AT, 9โwks treadmill running), or resistance trained (Tg+RT, 9โwks weighted ladder climbing) (''N''=10/group). Rotarod latency and strength were assessed pre- and posttraining. Hippocampus and skeletal muscle were collected after training and analyzed by high-resolution respirometry, ELISA, and immunoblotting. Tg+RT showed greater grip strength than Tg and Tg+AT at posttraining (''p''<0.01). Only Tg+AT improved rotarod peak latency (''p''<0.01). Hippocampal IGF-1 concentration was ~15 % greater in Tg+AT and Tg+RT compared to Tg (''p''<0.05); however, downstream signals of p-IGF-1R, p-Akt, p-MAPK, and p-GSK3ฮฒ were not altered. Cathepsin B, hippocampal p-CREB and BDNF, and hippocampal mitochondrial respiration were not affected by AT or RT. ฮฒ-Amyloid was ~30 % lower in Tg+RT compared to Tg (''p''<0.05). This data suggests that regular resistance training reduces ฮฒ-amyloid in the hippocampus concurrent with increased concentrations of IGF-1. Both types of training offered distinct benefits, either by improving physical function or by modifying signals in the hippocampus. Therefore, inclusion of both training modalities may address central defects, as well as peripheral comorbidities in AD. | |abstract=Aerobic training (AT) can support brain health in Alzheimerโs disease (AD); however, the role of resistance training (RT) in AD is not well established. Aside from direct effects on the brain, exercise may also regulate brain function through secretion of muscle-derived myokines. Aims. This study examined the effects of AT and RT on hippocampal BDNF and IGF-1 signaling, ฮฒ-amyloid expression, and myokine cathepsin B in the triple transgenic (3xTg-AD) model of AD. 3xTg-AD mice were assigned to one of the following groups: sedentary (Tg), aerobic trained (Tg+AT, 9โwks treadmill running), or resistance trained (Tg+RT, 9โwks weighted ladder climbing) (''N''=10/group). Rotarod latency and strength were assessed pre- and posttraining. Hippocampus and skeletal muscle were collected after training and analyzed by high-resolution respirometry, ELISA, and immunoblotting. Tg+RT showed greater grip strength than Tg and Tg+AT at posttraining (''p''<0.01). Only Tg+AT improved rotarod peak latency (''p''<0.01). Hippocampal IGF-1 concentration was ~15 % greater in Tg+AT and Tg+RT compared to Tg (''p''<0.05); however, downstream signals of p-IGF-1R, p-Akt, p-MAPK, and p-GSK3ฮฒ were not altered. Cathepsin B, hippocampal p-CREB and BDNF, and hippocampal mitochondrial respiration were not affected by AT or RT. ฮฒ-Amyloid was ~30 % lower in Tg+RT compared to Tg (''p''<0.05). This data suggests that regular resistance training reduces ฮฒ-amyloid in the hippocampus concurrent with increased concentrations of IGF-1. Both types of training offered distinct benefits, either by improving physical function or by modifying signals in the hippocampus. Therefore, inclusion of both training modalities may address central defects, as well as peripheral comorbidities in AD. | ||
|editor=[[Gnaiger E]], | |editor=[[Gnaiger E]], | ||
|mipnetlab=US FL Boca Raton Khamoui AV | |mipnetlab=US FL Boca Raton Khamoui AV | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration, Exercise physiology;nutrition;life style | |area=Respiration, Exercise physiology;nutrition;life style | ||
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|pathways=N, S, NS, ROX | |pathways=N, S, NS, ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional= | |additional=Alert2020, mitObesity2020, Comorbidity, O2k-brief | ||
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}} | }} | ||
::::::::ยป [[:Category:BME_and_mitObesity |BME and mitObesity news]] (2020-02-12) | |||
::::::::* '''Aerobic and strength training protect from peripheral comorbidities in Alzheimerโs disease''' | |||
Latest revision as of 11:32, 18 September 2020
| Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501. |
ยป Open Access ยป
Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Int J Chronic Dis
Abstract: Aerobic training (AT) can support brain health in Alzheimerโs disease (AD); however, the role of resistance training (RT) in AD is not well established. Aside from direct effects on the brain, exercise may also regulate brain function through secretion of muscle-derived myokines. Aims. This study examined the effects of AT and RT on hippocampal BDNF and IGF-1 signaling, ฮฒ-amyloid expression, and myokine cathepsin B in the triple transgenic (3xTg-AD) model of AD. 3xTg-AD mice were assigned to one of the following groups: sedentary (Tg), aerobic trained (Tg+AT, 9โwks treadmill running), or resistance trained (Tg+RT, 9โwks weighted ladder climbing) (N=10/group). Rotarod latency and strength were assessed pre- and posttraining. Hippocampus and skeletal muscle were collected after training and analyzed by high-resolution respirometry, ELISA, and immunoblotting. Tg+RT showed greater grip strength than Tg and Tg+AT at posttraining (p<0.01). Only Tg+AT improved rotarod peak latency (p<0.01). Hippocampal IGF-1 concentration was ~15 % greater in Tg+AT and Tg+RT compared to Tg (p<0.05); however, downstream signals of p-IGF-1R, p-Akt, p-MAPK, and p-GSK3ฮฒ were not altered. Cathepsin B, hippocampal p-CREB and BDNF, and hippocampal mitochondrial respiration were not affected by AT or RT. ฮฒ-Amyloid was ~30 % lower in Tg+RT compared to Tg (p<0.05). This data suggests that regular resistance training reduces ฮฒ-amyloid in the hippocampus concurrent with increased concentrations of IGF-1. Both types of training offered distinct benefits, either by improving physical function or by modifying signals in the hippocampus. Therefore, inclusion of both training modalities may address central defects, as well as peripheral comorbidities in AD.
โข Bioblast editor: Gnaiger E โข O2k-Network Lab: US FL Boca Raton Khamoui AV
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style
Pathology: Alzheimer's
Organism: Mouse Tissue;cell: Nervous system Preparation: Homogenate
Coupling state: LEAK, OXPHOS, ET
Pathway: N, S, NS, ROX
HRR: Oxygraph-2k
Alert2020, mitObesity2020, Comorbidity, O2k-brief
- ยป BME and mitObesity news (2020-02-12)
- Aerobic and strength training protect from peripheral comorbidities in Alzheimerโs disease
- ยป BME and mitObesity news (2020-02-12)
