Rivas 2018 Am J Physiol Endocrinol Metab
Rivas E, Herndon DN, Porter C, Meyer W, Suman OE. (2018) Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control, and mitochondrial function in children with burn injury.. Am J Physiol Endocrinol Metab. 314(3):E232-E240. |
Β» https://www.ncbi.nlm.nih.gov/pubmed/29138224
Rivas E, Herndon DN, Porter C, Meyer W, Suman OE. (2018) Am J Physiol Endocrinol Metab.
Abstract: Severely burned children experience a chronic state of sympathetic nervous system activation that is associated with hypermetabolic/cardiac stress and muscle wasting. Metformin, a diabetes medication, helps control hyperglycemia in obese diabetic populations, and exercise has been shown to improve exercise strength and aerobic exercise capacity after severe burns. However, whether exercise improves glycemic control in burned children and whether combining exercise and metformin improves outcomes to a greater degree than exercise alone are unknown. We tested the hypothesis that a 6-wk exercise program combined with short-term metformin administration (E + M) improves aerobic and strength exercise capacity to a greater degree than exercise and placebo (E), while improving glucose tolerance and muscle metabolic function. We found that, before exercise training, the metformin group compared with the placebo group had attenuated mitochondrial respiration (pmolΒ·s-1Β·mg-1) for each state: state 2 (-22.5βΒ±β3), state 3 (-42.4βΒ± 13), and oxphos (-58.9βΒ±β19) ( P β€ 0.02, M vs. E + M group for each state). However, in the E + M group, exercise increased mitochondrial respiration in each state ( P β€ 0.05), with respiration being comparable to that in the E group (each P > 0.05). In both groups, exercise induced comparable improvements in strength (change from preexercise, Ξ1.6βΒ±β0.6 N-MΒ·kgLBM) and VΜo2peak (Ξ9βΒ±β7 mlO2Β·kgLBM) as well as fasting glucose (Ξ19.3βΒ±β13 mgΒ·dl) and glucose AUC (Ξ3402βΒ±β3674 mgΒ·dl-1Β·min-1), as measured by a 75-g OGTT (all P β€ 0.03). Exercise reduced resting energy expenditure in E + M (Ξ539βΒ±β480 kcal/24 h, P < 0.01) but not E subjects ( P = 0.68). Both groups exhibited reduced resting heart rate (Ξ30βΒ±β23 beats/min, P β€ 0.02). These data indicate that short-term metformin combined with exercise provides no further improvement beyond that of exercise alone for strength, exercise capacity, and glycemic control β’ Keywords: Skeletal muscle, burns, trauma, exercise
β’ O2k-Network Lab: US TX Galveston Porter C
Labels: MiParea: Respiration
Pathology: Other
Organism: Human Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue
Coupling state: LEAK, OXPHOS
HRR: Oxygraph-2k
Metformin