Santanasto 2016 Exp Gerontol: Difference between revisions
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{{Publication | {{Publication | ||
|title=Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB (2016) The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function. Exp Gerontol 81:1-7. ย | |title=Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB (2016) The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function. Exp Gerontol 81:1-7. | ||
|info= | |info=[http://www.ncbi.nlm.nih.gov/pubmed/27084585 PMID: 27084585] | ||
|authors=Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB | |authors=Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB | ||
|year=2016 | |year=2016 | ||
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Mitochondrial function was associated with walking performance in higher functioning, active older adults, but not lower functioning, sedentary older adults. | Mitochondrial function was associated with walking performance in higher functioning, active older adults, but not lower functioning, sedentary older adults. | ||
|keywords=Mitochondrial Function, Mobility Aging, Muscle Physical Performance, Walking Performance | |||
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{{Labeling | {{Labeling | ||
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|tissues=Skeletal muscle | |tissues=Skeletal muscle | ||
|diseases=Aging;senescence | |diseases=Aging;senescence | ||
| | |topics=ATP production | ||
}} | }} |
Revision as of 11:55, 7 July 2016
Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB (2016) The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function. Exp Gerontol 81:1-7. |
Santanasto AJ, Coen PM, Glynn NW, Conley KE, Jubrias SA, Amati F, Strotmeyer ES, Boudreau RM, Goodpaster BH, Newman AB (2016) Exp Gerontol
Abstract: Age related declines in walking performance may be partly attributable to skeletal muscle mitochondrial dysfunction as mitochondria produce over 90% of ATP needed for movement and the capacity for oxidative phosphorylation decreases with age.
Participants were from two studies: an ancillary to the Lifestyle Interventions and Independence for Elders (LIFE) Study (n=33), which recruited lower functioning participants (Short Physical Performance Battery [SPPB], 7.8ยฑ1.2), and the Study of Energy and Aging-Pilot (SEA, n=29), which enrolled higher functioning (SPPB, 10.8ยฑ1.4). Physical activity was measured objectively using the Actigraph accelerometer (LIFE) and SenseWear Pro armband (SEA). Phosphocreatine recovery following muscle contraction of the quadriceps was measured using (31)P magnetic resonance spectroscopy and ATPmax (mM ATP/s) was calculated. Walking performance was defined as time (s) to walk 400m at a usual-pace. The cross-sectional association between mitochondrial function and walking performance was assessed using multivariable linear regression.
Participants were 77.6ยฑ5.3years, 64.2% female and 67.2% white. ATPmax was similar in LIFE vs. SEA (0.52ยฑ0.14 vs. 0.55ยฑ0.14, p=0.31), despite different function and activity levels (1.6ยฑ2.2 vs.77.4ยฑ73.3min of moderate activity/day, p<0.01). Higher ATPmax was related to faster walk-time in SEA (r(2)=0.19, p=0.02,); but not the LIFE (r(2)<0.01, p=0.74) cohort.
Mitochondrial function was associated with walking performance in higher functioning, active older adults, but not lower functioning, sedentary older adults. โข Keywords: Mitochondrial Function, Mobility Aging, Muscle Physical Performance, Walking Performance
Labels: MiParea: Exercise physiology;nutrition;life style
Pathology: Aging;senescence
Organism: Human Tissue;cell: Skeletal muscle
Regulation: ATP production