Scott 2013 Abstract MiP2013: Difference between revisions
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|abstract= | |abstract=The hypoxic and cold environment at high altitudes requires endothermic animals to sustain high rates of O2 consumption for both locomotion and thermogenesis while facing a diminished O2 supply. We are examining the mitochondrial mechanisms of genotypic adaptation and phenotypic plasticity that help maintain ATP supply during hypoxia in high-altitude birds and mammals. Respiratory capacity, cytochrome oxidase activity, phosphorylation efficiency, oxygen kinetics, and several other variables were measured in mitochondria isolated from the flight muscle of bar-headed geese and the hindlimb muscle of highland deer mice, and each were compared to closely-related lowland taxa. Our results suggest that several mitochondrial adaptations, coupled with enhanced mitochondrial O2 supply, contribute to performance in hypoxia. | ||
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{{Labeling | |||
|area=Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style | |||
|organism=Other mammals | |||
|taxonomic group=Birds | |||
|tissues=Skeletal muscle | |||
|preparations=Isolated Mitochondria, Enzyme | |||
|injuries=Hypoxia | |||
|topics=O2 | |||
|couplingstates=LEAK, OXPHOS | |||
|instruments=Oxygraph-2k | |||
|additional=MiP2013 | |||
}} | }} | ||
__TOC__ | __TOC__ | ||
== Affiliations and author contributions == | == Affiliations and author contributions == | ||
Department of Biology, McMaster University, Hamilton, Ontario, Canada | |||
Email: [email protected] | Email: [email protected] | ||
Supported by NSERC of Canada. | |||
Revision as of 15:07, 21 August 2013
| Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08. |
Link:
Scott GR, Mahalingam S, McClelland GB (2013)
Event: MiP2013
The hypoxic and cold environment at high altitudes requires endothermic animals to sustain high rates of O2 consumption for both locomotion and thermogenesis while facing a diminished O2 supply. We are examining the mitochondrial mechanisms of genotypic adaptation and phenotypic plasticity that help maintain ATP supply during hypoxia in high-altitude birds and mammals. Respiratory capacity, cytochrome oxidase activity, phosphorylation efficiency, oxygen kinetics, and several other variables were measured in mitochondria isolated from the flight muscle of bar-headed geese and the hindlimb muscle of highland deer mice, and each were compared to closely-related lowland taxa. Our results suggest that several mitochondrial adaptations, coupled with enhanced mitochondrial O2 supply, contribute to performance in hypoxia.
Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style
Stress:Hypoxia Organism: Other mammals Tissue;cell: Skeletal muscle Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property., Enzyme
Regulation: O2"O2" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property. Coupling state: LEAK, OXPHOS
HRR: Oxygraph-2k
MiP2013
Affiliations and author contributions
Department of Biology, McMaster University, Hamilton, Ontario, Canada
Email: [email protected]
Supported by NSERC of Canada.
