https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&feed=atom&action=history
Sharma 2017 MiPschool Obergurgl - Revision history
2024-03-29T11:19:07Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=149849&oldid=prev
Nirschl Lisa at 14:15, 12 January 2018
2018-01-12T14:15:09Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:15, 12 January 2018</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:SharmaV.jpg|left|90px|Vipin Sharma]] Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta<sub>3</sub>-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:SharmaV.jpg|left|90px|Vipin Sharma]] Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta<sub>3</sub>-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|info=[[<del style="font-weight: bold; text-decoration: none;">MITOEAGLE</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|info=[[<ins style="font-weight: bold; text-decoration: none;">MitoEAGLE</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sharma V, Choudhury S, Nair SV, Jaitley P, Nakade UP, Sharma A, Yadav RK, Garg SK</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sharma V, Choudhury S, Nair SV, Jaitley P, Nakade UP, Sharma A, Yadav RK, Garg SK</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action <del style="font-weight: bold; text-decoration: none;">MITOEAGLE</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action <ins style="font-weight: bold; text-decoration: none;">MitoEAGLE</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Considerable progress in understanding the relationship between Ca<sup>2+</sup> signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Considerable progress in understanding the relationship between Ca<sup>2+</sup> signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In summary, although major advances in understanding the molecular physiology of myometrium have been achieved, there is a pressing need to understand human uterine contractile activity and the role of other channels and receptors such as chloride, sodium, ryanodine and the role of nucleotides such as adenosine, adenosine diphosphate (ADP), and ATP in human myometrium. The role of CICR is still unclear in myometrium and needs further elucidation. There is also a need to fully understand the role of mitochondria in calcium homeostasis. These investigations and the development with the action of agonists and antagonists on uterine smooth muscle will add more to our understanding of uterine physiology and lead to more successful approaches in diagnosing and managing the reproductive disorders such as preterm labor, dysmenorrhea, prolonged labor, and weak uterine contractions (dystocia). It is apparent that understanding the normal physiology of uterine contractions and relaxation at the molecular and cellular level would help clinicians and healthcare providers to modulate unnecessary uterine activity if problems arise throughout Calcium Signaling pregnancy and to plan a suitable therapeutic target according to each problem.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In summary, although major advances in understanding the molecular physiology of myometrium have been achieved, there is a pressing need to understand human uterine contractile activity and the role of other channels and receptors such as chloride, sodium, ryanodine and the role of nucleotides such as adenosine, adenosine diphosphate (ADP), and ATP in human myometrium. The role of CICR is still unclear in myometrium and needs further elucidation. There is also a need to fully understand the role of mitochondria in calcium homeostasis. These investigations and the development with the action of agonists and antagonists on uterine smooth muscle will add more to our understanding of uterine physiology and lead to more successful approaches in diagnosing and managing the reproductive disorders such as preterm labor, dysmenorrhea, prolonged labor, and weak uterine contractions (dystocia). It is apparent that understanding the normal physiology of uterine contractions and relaxation at the molecular and cellular level would help clinicians and healthcare providers to modulate unnecessary uterine activity if problems arise throughout Calcium Signaling pregnancy and to plan a suitable therapeutic target according to each problem.</div></td></tr>
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Nirschl Lisa
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=139525&oldid=prev
Gnaiger Erich at 15:27, 18 July 2017
2017-07-18T15:27:47Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=138332&oldid=prev
Gnaiger Erich at 09:13, 7 July 2017
2017-07-07T09:13:10Z
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=138099&oldid=prev
Kandolf Georg at 12:46, 5 July 2017
2017-07-05T12:46:38Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:46, 5 July 2017</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Hakak Y, Shrestha D, Goege MC, Behan DP, Chalmers DT (2003) Global analysis of G-protein-coupled receptor signaling in human tissues. FEBS Lett 550:11-17.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Hakak Y, Shrestha D, Goege MC, Behan DP, Chalmers DT (2003) Global analysis of G-protein-coupled receptor signaling in human tissues. FEBS Lett 550:11-17.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Lirussi F, O’Brien M, Wendremaire M, Goirand F, Sagot P, Dumas M, Morrison JJ, Bardou M (2010) SAR150640, a selective b3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis. Br J Pharmacol 159:1354–66.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Lirussi F, O’Brien M, Wendremaire M, Goirand F, Sagot P, Dumas M, Morrison JJ, Bardou M (2010) SAR150640, a selective b3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis. Br J Pharmacol 159:1354–66.</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=137549&oldid=prev
Kandolf Georg at 14:57, 21 June 2017
2017-06-21T14:57:54Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:SharmaV.jpg|left|90px|Vipin Sharma]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:SharmaV.jpg|left|90px|Vipin Sharma]] Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta<sub>3</sub>-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta<sub>3</sub>-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sharma V, Choudhury S, Nair SV, Jaitley P, Nakade UP, Sharma A, Yadav RK, Garg SK</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sharma V, Choudhury S, Nair SV, Jaitley P, Nakade UP, Sharma A, Yadav RK, Garg SK</div></td></tr>
</table>
Kandolf Georg
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=137517&oldid=prev
Kandolf Georg at 13:32, 21 June 2017
2017-06-21T13:32:52Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:32, 21 June 2017</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:<del style="font-weight: bold; text-decoration: none;">MITOEAGLE-representation</del>.jpg|left|<del style="font-weight: bold; text-decoration: none;">60px</del>|<del style="font-weight: bold; text-decoration: none;">link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE</del>]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:<ins style="font-weight: bold; text-decoration: none;">SharmaV</ins>.jpg|left|<ins style="font-weight: bold; text-decoration: none;">90px</ins>|<ins style="font-weight: bold; text-decoration: none;">Vipin Sharma</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta<sub>3</sub>-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta<sub>3</sub>-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td></tr>
</table>
Kandolf Georg
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=137354&oldid=prev
Kandolf Georg at 09:05, 19 June 2017
2017-06-19T09:05:24Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:05, 19 June 2017</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:MITOEAGLE-representation.jpg|left|60px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:MITOEAGLE-representation.jpg|left|60px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in <del style="font-weight: bold; text-decoration: none;">beta3</del>-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in <ins style="font-weight: bold; text-decoration: none;">beta<sub>3</sub></ins>-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sharma V, Choudhury S, Nair SV, Jaitley P, Nakade UP, Sharma A, Yadav RK, Garg SK</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sharma V, Choudhury S, Nair SV, Jaitley P, Nakade UP, Sharma A, Yadav RK, Garg SK</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In summary, although major advances in understanding the molecular physiology of myometrium have been achieved, there is a pressing need to understand human uterine contractile activity and the role of other channels and receptors such as chloride, sodium, ryanodine and the role of nucleotides such as adenosine, adenosine diphosphate (ADP), and ATP in human myometrium. The role of CICR is still unclear in myometrium and needs further elucidation. There is also a need to fully understand the role of mitochondria in calcium homeostasis. These investigations and the development with the action of agonists and antagonists on uterine smooth muscle will add more to our understanding of uterine physiology and lead to more successful approaches in diagnosing and managing the reproductive disorders such as preterm labor, dysmenorrhea, prolonged labor, and weak uterine contractions (dystocia). It is apparent that understanding the normal physiology of uterine contractions and relaxation at the molecular and cellular level would help clinicians and healthcare providers to modulate unnecessary uterine activity if problems arise throughout Calcium Signaling pregnancy and to plan a suitable therapeutic target according to each problem.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In summary, although major advances in understanding the molecular physiology of myometrium have been achieved, there is a pressing need to understand human uterine contractile activity and the role of other channels and receptors such as chloride, sodium, ryanodine and the role of nucleotides such as adenosine, adenosine diphosphate (ADP), and ATP in human myometrium. The role of CICR is still unclear in myometrium and needs further elucidation. There is also a need to fully understand the role of mitochondria in calcium homeostasis. These investigations and the development with the action of agonists and antagonists on uterine smooth muscle will add more to our understanding of uterine physiology and lead to more successful approaches in diagnosing and managing the reproductive disorders such as preterm labor, dysmenorrhea, prolonged labor, and weak uterine contractions (dystocia). It is apparent that understanding the normal physiology of uterine contractions and relaxation at the molecular and cellular level would help clinicians and healthcare providers to modulate unnecessary uterine activity if problems arise throughout Calcium Signaling pregnancy and to plan a suitable therapeutic target according to each problem.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>This study was undertaken to elucidate the cellular coupling mechanism of <del style="font-weight: bold; text-decoration: none;">beta3</del>-adrenergic receptors with potassium channels in myometrium of non-pregnant buffaloes. In materials and methods the uteri of diestrous stage buffaloes were collected from local abattoir and myometrial strips were prepared from the mid-cornual region of uterus for measurement of isometric tension.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>This study was undertaken to elucidate the cellular coupling mechanism of <ins style="font-weight: bold; text-decoration: none;">beta<sub>3</sub></ins>-adrenergic receptors with potassium channels in myometrium of non-pregnant buffaloes. In materials and methods the uteri of diestrous stage buffaloes were collected from local abattoir and myometrial strips were prepared from the mid-cornual region of uterus for measurement of isometric tension.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Result shows that Both BRL-37344 and SAR150640, two specific agonists of β3-adrenoceptors, produced dose-dependent inhibitory effect on myometrial spontaneity and this effect was blocked by SR 59230A, a selective β3 specific adrenoceptorantagonist. BRL-37344 was found to be more potent than SAR 150640 as the respective pD2 values were found to be 7.22 ± 0.09 (n = 7) and 3.27 ± 2.67 (n = 6). Further, potassium channel blockers, namely-glybenclamide (10 μM), tetraethyl ammonium (1 mM) and iberiotoxin (100 nM) significantly shifted the dose response curve of BRL-37344 towards right with reduction in efficacy (Rmax). However, 4-aminopyridine (1 mM) failed to alter the tocolytic effect of BRL-37344.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Result shows that Both BRL-37344 and SAR150640, two specific agonists of β3-adrenoceptors, produced dose-dependent inhibitory effect on myometrial spontaneity and this effect was blocked by SR 59230A, a selective β3 specific adrenoceptorantagonist. BRL-37344 was found to be more potent than SAR 150640 as the respective pD2 values were found to be 7.22 ± 0.09 (n = 7) and 3.27 ± 2.67 (n = 6). Further, potassium channel blockers, namely-glybenclamide (10 μM), tetraethyl ammonium (1 mM) and iberiotoxin (100 nM) significantly shifted the dose response curve of BRL-37344 towards right with reduction in efficacy (Rmax). However, 4-aminopyridine (1 mM) failed to alter the tocolytic effect of BRL-37344.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Our conclusion shows that results suggest by <del style="font-weight: bold; text-decoration: none;">beta3</del>-adrenergic receptors mediate an additional mechanism of myometrial relaxation in buffaloes and, besides direct involvement of β3-adrenoceptor, their tocolytic effect is also mediated through K<sub>ATP</sub> and BK<sub>Ca</sub> channels in buffalo myometrium. Therefore, <del style="font-weight: bold; text-decoration: none;">beta3</del>-adrenergic receptors seem to be a potential alternative target for management of pre-term labour; however, similar studies are warranted on uterus of pregnant animals.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Our conclusion shows that results suggest by <ins style="font-weight: bold; text-decoration: none;">beta<sub>3</sub></ins>-adrenergic receptors mediate an additional mechanism of myometrial relaxation in buffaloes and, besides direct involvement of β3-adrenoceptor, their tocolytic effect is also mediated through K<sub>ATP</sub> and BK<sub>Ca</sub> channels in buffalo myometrium. Therefore, <ins style="font-weight: bold; text-decoration: none;">beta<sub>3</sub></ins>-adrenergic receptors seem to be a potential alternative target for management of pre-term labour; however, similar studies are warranted on uterus of pregnant animals.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Kandolf G]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Kandolf G]]</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Bardou M, Dousset, B, Deneux-Tharaux, C (1998) ''In vitro'' inhibition of human colonic motility with SR 59119A and SR 59104A: evidence of a <del style="font-weight: bold; text-decoration: none;">beta3</del>-adrenoceptor-mediated effect. Eur J Pharmacol. 353:281-7.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::#Bardou M, Dousset, B, Deneux-Tharaux, C (1998) ''In vitro'' inhibition of human colonic motility with SR 59119A and SR 59104A: evidence of a <ins style="font-weight: bold; text-decoration: none;">beta<sub>3</sub></ins>-adrenoceptor-mediated effect. Eur J Pharmacol. 353:281-7.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Bardou M, Dousset B, Deneux-Tharaux C, Smadja C, Naline E, Chaput JC, Naveau S, Manara L, Croci T, Advenier C (2007) Is the <del style="font-weight: bold; text-decoration: none;">beta3</del>-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs? BMC Pregnancy Childbirth. 7:S14.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::#Bardou M, Dousset B, Deneux-Tharaux C, Smadja C, Naline E, Chaput JC, Naveau S, Manara L, Croci T, Advenier C (2007) Is the <ins style="font-weight: bold; text-decoration: none;">beta<sub>3</sub></ins>-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs? BMC Pregnancy Childbirth. 7:S14.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Hakak Y, Shrestha D, Goege MC, Behan DP, Chalmers DT (2003) Global analysis of G-protein-coupled receptor signaling in human tissues. FEBS Lett 550:11-17.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Hakak Y, Shrestha D, Goege MC, Behan DP, Chalmers DT (2003) Global analysis of G-protein-coupled receptor signaling in human tissues. FEBS Lett 550:11-17.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Lirussi F, O’Brien M, Wendremaire M, Goirand F, Sagot P, Dumas M, Morrison JJ, Bardou M (2010) SAR150640, a selective b3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis. Br J Pharmacol 159:1354–66.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::#Lirussi F, O’Brien M, Wendremaire M, Goirand F, Sagot P, Dumas M, Morrison JJ, Bardou M (2010) SAR150640, a selective b3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis. Br J Pharmacol 159:1354–66.</div></td></tr>
</table>
Kandolf Georg
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=136812&oldid=prev
Kandolf Georg at 13:27, 12 June 2017
2017-06-12T13:27:27Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:27, 12 June 2017</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l14">Line 14:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Result shows that Both BRL-37344 and SAR150640, two specific agonists of β3-adrenoceptors, produced dose-dependent inhibitory effect on myometrial spontaneity and this effect was blocked by SR 59230A, a selective β3 specific adrenoceptorantagonist. BRL-37344 was found to be more potent than SAR 150640 as the respective pD2 values were found to be 7.22 ± 0.09 (n = 7) and 3.27 ± 2.67 (n = 6). Further, potassium channel blockers, namely-glybenclamide (10 μM), tetraethyl ammonium (1 mM) and iberiotoxin (100 nM) significantly shifted the dose response curve of BRL-37344 towards right with reduction in efficacy (Rmax). However, 4-aminopyridine (1 mM) failed to alter the tocolytic effect of BRL-37344.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Result shows that Both BRL-37344 and SAR150640, two specific agonists of β3-adrenoceptors, produced dose-dependent inhibitory effect on myometrial spontaneity and this effect was blocked by SR 59230A, a selective β3 specific adrenoceptorantagonist. BRL-37344 was found to be more potent than SAR 150640 as the respective pD2 values were found to be 7.22 ± 0.09 (n = 7) and 3.27 ± 2.67 (n = 6). Further, potassium channel blockers, namely-glybenclamide (10 μM), tetraethyl ammonium (1 mM) and iberiotoxin (100 nM) significantly shifted the dose response curve of BRL-37344 towards right with reduction in efficacy (Rmax). However, 4-aminopyridine (1 mM) failed to alter the tocolytic effect of BRL-37344.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Our conclusion shows that results suggest by beta3-adrenergic receptors mediate an additional mechanism of myometrial relaxation in buffaloes and, besides direct involvement of β3-adrenoceptor, their tocolytic effect is also mediated through K<<del style="font-weight: bold; text-decoration: none;">sup</del>>ATP</<del style="font-weight: bold; text-decoration: none;">sup</del>> and BK<<del style="font-weight: bold; text-decoration: none;">sup</del>>Ca</<del style="font-weight: bold; text-decoration: none;">sup</del>> channels in buffalo myometrium. Therefore, beta3-adrenergic receptors seem to be a potential alternative target for management of pre-term labour; however, similar studies are warranted on uterus of pregnant animals.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Our conclusion shows that results suggest by beta3-adrenergic receptors mediate an additional mechanism of myometrial relaxation in buffaloes and, besides direct involvement of β3-adrenoceptor, their tocolytic effect is also mediated through K<<ins style="font-weight: bold; text-decoration: none;">sub</ins>>ATP</<ins style="font-weight: bold; text-decoration: none;">sub</ins>> and BK<<ins style="font-weight: bold; text-decoration: none;">sub</ins>>Ca</<ins style="font-weight: bold; text-decoration: none;">sub</ins>> channels in buffalo myometrium. Therefore, beta3-adrenergic receptors seem to be a potential alternative target for management of pre-term labour; however, similar studies are warranted on uterus of pregnant animals.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Kandolf G]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Kandolf G]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
</table>
Kandolf Georg
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=136807&oldid=prev
Kandolf Georg at 12:46, 12 June 2017
2017-06-12T12:46:01Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:46, 12 June 2017</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta3-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta3-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|authors=Sharma V, Choudhury S, Nair SV, Jaitley P, Nakade UP, Sharma A, Yadav RK, Garg SK</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td></tr>
</table>
Kandolf Georg
https://wiki.oroboros.at/index.php?title=Sharma_2017_MiPschool_Obergurgl&diff=136800&oldid=prev
Kandolf Georg at 12:16, 12 June 2017
2017-06-12T12:16:17Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:16, 12 June 2017</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:MITOEAGLE-representation.jpg|left|60px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:MITOEAGLE-representation.jpg|left|60px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Role of ATP-sensitive potassium (K<sub>ATP</sub>) and maxi potassium (BK<sub>Ca</sub>) channels in beta3-adrenoceptors mediated tocolytic effect and involvement of associated mitochondrial calcium dynamics pathways in buffaloes (''Bubalus bubalis'').</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MITOEAGLE]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiPschool Obergurgl 2017</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]]</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Considerable progress in understanding the relationship between Ca<sup>2+</sup> signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">In summary, although major advances in understanding the molecular physiology of myometrium have been achieved, there is a pressing need to understand human uterine contractile activity and the role of other channels and receptors such as chloride, sodium, ryanodine and the role of nucleotides such as adenosine, adenosine diphosphate (ADP), and ATP in human myometrium. The role of CICR is still unclear in myometrium and needs further elucidation. There is also a need to fully understand the role of mitochondria in calcium homeostasis. These investigations and the development with the action of agonists and antagonists on uterine smooth muscle will add more to our understanding of uterine physiology and lead to more successful approaches in diagnosing and managing the reproductive disorders such as preterm labor, dysmenorrhea, prolonged labor, and weak uterine contractions (dystocia). It is apparent that understanding the normal physiology of uterine contractions and relaxation at the molecular and cellular level would help clinicians and healthcare providers to modulate unnecessary uterine activity if problems arise throughout Calcium Signaling pregnancy and to plan a suitable therapeutic target according to each problem.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">This study was undertaken to elucidate the cellular coupling mechanism of beta3-adrenergic receptors with potassium channels in myometrium of non-pregnant buffaloes. In materials and methods the uteri of diestrous stage buffaloes were collected from local abattoir and myometrial strips were prepared from the mid-cornual region of uterus for measurement of isometric tension.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Result shows that Both BRL-37344 and SAR150640, two specific agonists of β3-adrenoceptors, produced dose-dependent inhibitory effect on myometrial spontaneity and this effect was blocked by SR 59230A, a selective β3 specific adrenoceptorantagonist. BRL-37344 was found to be more potent than SAR 150640 as the respective pD2 values were found to be 7.22 ± 0.09 (n = 7) and 3.27 ± 2.67 (n = 6). Further, potassium channel blockers, namely-glybenclamide (10 μM), tetraethyl ammonium (1 mM) and iberiotoxin (100 nM) significantly shifted the dose response curve of BRL-37344 towards right with reduction in efficacy (Rmax). However, 4-aminopyridine (1 mM) failed to alter the tocolytic effect of BRL-37344.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Our conclusion shows that results suggest by beta3-adrenergic receptors mediate an additional mechanism of myometrial relaxation in buffaloes and, besides direct involvement of β3-adrenoceptor, their tocolytic effect is also mediated through K<sup>ATP</sup> and BK<sup>Ca</sup> channels in buffalo myometrium. Therefore, beta3-adrenergic receptors seem to be a potential alternative target for management of pre-term labour; however, similar studies are warranted on uterus of pregnant animals.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|editor=[[Kandolf G]]</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">}}</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Labeling</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|organism=Bovines</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|tissues=Genital</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{Labeling}}</del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>:::: (<del style="font-weight: bold; text-decoration: none;">1</del>)</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>:::: <ins style="font-weight: bold; text-decoration: none;">Dept Pharmacol & Toxicol College Veterinary Science Animal Husbandry U.P. Pandit Deen Dayal Upadhyaya pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan, Mathura, India.- asvipinsharma10@gmail.com</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Figures ==</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Sharma_Figure1_MiPschool_Obergurgl_2017.jpg|left|400px]]</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''Figure 1.''' (a) Representative physiograph recordings showing the effect of BRL 37344, a β3-agonist, in the absence and presence of SR59230A, a specific β3-antagonist, on isolated myometrial strips of non-pregnant buffaloes. Comparative line diagrams showing the mean concentration response curves of BRL 37344 (b) or SAR 150640 </ins>(<ins style="font-weight: bold; text-decoration: none;">c</ins>) <ins style="font-weight: bold; text-decoration: none;">in the absence and presence of SR59230 A.Vertical bars represent SEM. *P <0.05 in comparison to BRL 37344 alone.</ins></div></td></tr>
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">::::# </del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== </del>Figure 1 <del style="font-weight: bold; text-decoration: none;">==</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[File:Sharma_Figure2_MiPschool_Obergurgl_2017.jpg|left|400px]]</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Figure <ins style="font-weight: bold; text-decoration: none;">2.''' Regulation of UCP1 abundance and activity in brown adipose tissue Noradrenergic stimulation of β3-adrenergic receptors triggers cAMP-responsive pathways that act in two ways: </ins>1<ins style="font-weight: bold; text-decoration: none;">) enhancing transcription of Ucp1 and 2) initiating PKA-dependent lipolysis to release fatty acids that acutely activate UCP1. </ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::#Bardou M, Dousset, B, Deneux-Tharaux, C (1998) ''In vitro'' inhibition of human colonic motility with SR 59119A and SR 59104A: evidence of a beta3-adrenoceptor-mediated effect. Eur J Pharmacol. 353:281-7.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::#Bardou M, Dousset B, Deneux-Tharaux C, Smadja C, Naline E, Chaput JC, Naveau S, Manara L, Croci T, Advenier C (2007) Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs? BMC Pregnancy Childbirth. 7:S14.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::#Hakak Y, Shrestha D, Goege MC, Behan DP, Chalmers DT (2003) Global analysis of G-protein-coupled receptor signaling in human tissues. FEBS Lett 550:11-17.</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::#Lirussi F, O’Brien M, Wendremaire M, Goirand F, Sagot P, Dumas M, Morrison JJ, Bardou M (2010) SAR150640, a selective b3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis. Br J Pharmacol 159:1354–66.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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</table>
Kandolf Georg