Difference between revisions of "Shibata 2016 Abstract Mito Xmas Meeting Innsbruck"
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{{Abstract | {{Abstract | ||
|title=Linear | |title=Linear motor proteins induce mitochondrial shape change. | ||
|authors=Shibata K, Scorrano L | |authors=Shibata K, Scorrano L | ||
|year=2016 | |year=2016 | ||
|event=Mito Xmas Meeting 2016 Innsbruck AT | |event=Mito Xmas Meeting 2016 Innsbruck AT | ||
|abstract=Mitochondria are essential organelles that provide cellular ATP by oxidative phosphorylation, and regulate housekeeping processes. They undergo dynamic morphological changing and make a complex network in eukaryotic cells. The dynamics is linked to their functional versatility so deeply that it is important to elucidate the networks and mechanisms by which they change their shape. Motor proteins (kinesin, dynein and myosin) move along the cytoskeleton (microtubule and actin filament) with using the energy of ATP made by mitochondria and can be linked to mitochondria via adapter proteins on the mitochondrial membrane. Mitochondria use force from motor proteins for movement and transformation. However, it is not known how motor proteins regulate the complex morphology of mitochondria. Where are motor proteins during the dynamic shape changing of mitochondria? Are mitochondria pulled and extended by the motor proteins, or by other mechanisms? To answer these questions, we are visualizing the endogenous motor proteins and following them on mitochondria changing the shape in living cells, and try to demonstrate the allocation of roles among the motor proteins in mitochondrial shape change. | |abstract=Mitochondria are essential organelles that provide cellular ATP by oxidative phosphorylation, and regulate housekeeping processes. They undergo dynamic morphological changing and make a complex network in eukaryotic cells. The dynamics is linked to their functional versatility so deeply that it is important to elucidate the networks and mechanisms by which they change their shape. Motor proteins (kinesin, dynein and myosin) move along the cytoskeleton (microtubule and actin filament) with using the energy of ATP made by mitochondria and can be linked to mitochondria via adapter proteins on the mitochondrial membrane. Mitochondria use force from motor proteins for movement and transformation. However, it is not known how motor proteins regulate the complex morphology of mitochondria. Where are motor proteins during the dynamic shape changing of mitochondria? Are mitochondria pulled and extended by the motor proteins, or by other mechanisms? To answer these questions, we are visualizing the endogenous motor proteins and following them on mitochondria changing the shape in living cells, and try to demonstrate the allocation of roles among the motor proteins in mitochondrial shape change. | ||
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:::: Shibata K(1,2), Scorrano L(1,2) | :::: Shibata K(1,2), Scorrano L(1,2) | ||
::::# | ::::# Dept Biol, Univ Padua, Italy | ||
::::# Dulbecco-Telethon | ::::# Dulbecco-Telethon Inst, Venetian Inst Molecular Medicine, Padua, Italy | ||
Revision as of 16:00, 14 December 2016
| Linear motor proteins induce mitochondrial shape change. |
Link:
Shibata K, Scorrano L (2016)
Event: Mito Xmas Meeting 2016 Innsbruck AT
Mitochondria are essential organelles that provide cellular ATP by oxidative phosphorylation, and regulate housekeeping processes. They undergo dynamic morphological changing and make a complex network in eukaryotic cells. The dynamics is linked to their functional versatility so deeply that it is important to elucidate the networks and mechanisms by which they change their shape. Motor proteins (kinesin, dynein and myosin) move along the cytoskeleton (microtubule and actin filament) with using the energy of ATP made by mitochondria and can be linked to mitochondria via adapter proteins on the mitochondrial membrane. Mitochondria use force from motor proteins for movement and transformation. However, it is not known how motor proteins regulate the complex morphology of mitochondria. Where are motor proteins during the dynamic shape changing of mitochondria? Are mitochondria pulled and extended by the motor proteins, or by other mechanisms? To answer these questions, we are visualizing the endogenous motor proteins and following them on mitochondria changing the shape in living cells, and try to demonstrate the allocation of roles among the motor proteins in mitochondrial shape change.
Labels:
Event: Poster
Affiliations
- Shibata K(1,2), Scorrano L(1,2)
- Dept Biol, Univ Padua, Italy
- Dulbecco-Telethon Inst, Venetian Inst Molecular Medicine, Padua, Italy
