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Sobotka 2014 Abstract IOC95 - Revision history
2024-03-29T11:05:23Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Sobotka_2014_Abstract_IOC95&diff=124501&oldid=prev
Beno Marija at 10:14, 8 November 2016
2016-11-08T10:14:18Z
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Beno Marija
https://wiki.oroboros.at/index.php?title=Sobotka_2014_Abstract_IOC95&diff=80495&oldid=prev
Bader Helga at 09:02, 13 February 2015
2015-02-13T09:02:28Z
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Bader Helga
https://wiki.oroboros.at/index.php?title=Sobotka_2014_Abstract_IOC95&diff=68159&oldid=prev
Gnaiger Erich at 16:55, 11 August 2014
2014-08-11T16:55:03Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sobotka O, Drahota Z, Cervinkova Z</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sobotka O, Drahota Z, Cervinkova Z</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4. Rauchova, H., M. Vokurkova, and Z. Drahota, Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate. Int J Biochem Cell Biol, 2014. 53: p. 409-13.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4. Rauchova, H., M. Vokurkova, and Z. Drahota, Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate. Int J Biochem Cell Biol, 2014. 53: p. 409-13.</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Sobotka_2014_Abstract_IOC95&diff=66894&oldid=prev
Krumschnabel Gerhard at 09:23, 6 August 2014
2014-08-06T09:23:02Z
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Krumschnabel Gerhard
https://wiki.oroboros.at/index.php?title=Sobotka_2014_Abstract_IOC95&diff=66893&oldid=prev
Krumschnabel Gerhard at 09:22, 6 August 2014
2014-08-06T09:22:04Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Sobotka O (2014) Effect of α-Tocopheryl succinate on complex II. Mitochondr Physiol Network</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Sobotka O (2014) Effect of α-Tocopheryl succinate on complex II. Mitochondr Physiol Network</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sobotka O, Drahota Z, Cervinkova Z </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sobotka O, Drahota Z, Cervinkova Z</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2014</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2014</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=IOC95</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=IOC95</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l9">Line 9:</td>
<td colspan="2" class="diff-lineno">Line 9:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Our study using HRR method showed a TOS inhibitory action on complex II activity. Strong inhibitory effect was detected on heart and liver mitochondria as well as on the homogenate. Lower sensitivity of liver homogenate compared to mitochondria may be the result of the presence of cytosolic esterases which split the molecule of TOS to α-tocopherol and succinate [3] or due to binding of TOS to cytosolic membrane structures.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Our study using HRR method showed a TOS inhibitory action on complex II activity. Strong inhibitory effect was detected on heart and liver mitochondria as well as on the homogenate. Lower sensitivity of liver homogenate compared to mitochondria may be the result of the presence of cytosolic esterases which split the molecule of TOS to α-tocopherol and succinate [3] or due to binding of TOS to cytosolic membrane structures.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>1. Angulo-Molina, A., et al., The Role of Alpha Tocopheryl Succinate (alpha-TOS) as a Potential Anticancer Agent. Nutr Cancer, 2013.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">References:</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>2. Zhao, Y., J. Neuzil, and K. Wu, Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside? Mol Nutr Food Res, 2009. 53(1): p. 129-39.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>3. Neuzil, J., et al., Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett, 2006. 580(22): p. 5125-9.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>1. Angulo-Molina, A., et al., The Role of Alpha Tocopheryl Succinate (alpha-TOS) as a Potential Anticancer Agent. Nutr Cancer, 2013.</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>2. Zhao, Y., J. Neuzil, and K. Wu, Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside? Mol Nutr Food Res, 2009. 53(1): p. 129-39.</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>3. Neuzil, J., et al., Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett, 2006. 580(22): p. 5125-9.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4. Rauchova, H., M. Vokurkova, and Z. Drahota, Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate. Int J Biochem Cell Biol, 2014. 53: p. 409-13.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4. Rauchova, H., M. Vokurkova, and Z. Drahota, Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate. Int J Biochem Cell Biol, 2014. 53: p. 409-13.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=CZ Hradec Kralove Cervinkova Z, CZ Prague Houstek J, </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=CZ Hradec Kralove Cervinkova Z, CZ Prague Houstek J,</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td></tr>
</table>
Krumschnabel Gerhard
https://wiki.oroboros.at/index.php?title=Sobotka_2014_Abstract_IOC95&diff=66892&oldid=prev
Krumschnabel Gerhard: Created page with "{{Abstract |title=Sobotka O (2014) Effect of α-Tocopheryl succinate on complex II. Mitochondr Physiol Network |authors=Sobotka O, Drahota Z, Cervinkova Z |year=2014 |event=IOC9..."
2014-08-06T09:20:31Z
<p>Created page with "{{Abstract |title=Sobotka O (2014) Effect of α-Tocopheryl succinate on complex II. Mitochondr Physiol Network |authors=Sobotka O, Drahota Z, Cervinkova Z |year=2014 |event=IOC9..."</p>
<p><b>New page</b></p><div>{{Abstract<br />
|title=Sobotka O (2014) Effect of α-Tocopheryl succinate on complex II. Mitochondr Physiol Network<br />
|authors=Sobotka O, Drahota Z, Cervinkova Z <br />
|year=2014<br />
|event=IOC95<br />
|abstract=α-Tocopheryl succinate (TOS) is a redox-silent analogue of vitamin E with specific anti-tumorous effects. According to some studies, TOS suppresses cell growth and induces apoptosis in cancer cells [1-3]. The inhibitory effect on transformed cells is related to an increase in reactive oxygen species (ROS) production possibly via inhibition of respiratory complex II - specifically mitochondrial flavoprotein-dependent enzymes succinate dehydrogenase (SDH) and glycerol-3-phosphate dehydrogenase (mGPDH) [1-4]. On the molecular level the effect of TOS is explained by interaction of TOS with the proximal and distal CoQ-binding sites of complex II [4]. However such effect was not found in non-cancer cells [1, 3].<br />
The aim of our study was to assess the inhibitory action of TOS on complex II in rat heart and liver homogenate and mitochondria. The maximum respiratory capacity of complex II induced by addition of succinate, cytochrome c and ADP was measured using the high resolution respirometry (HRR) Oroboros 2K. We evaluated the TOS inhibitory action on complex II respiration during concentration increase. <br />
The strong inhibitory effect of TOS on complex II respiration was found at the concentration range between 150-500 μM. Our results showed that both liver and heart mitochondria were more sensitive to TOS inhibitory action in comparison to homogenate.<br />
Our study using HRR method showed a TOS inhibitory action on complex II activity. Strong inhibitory effect was detected on heart and liver mitochondria as well as on the homogenate. Lower sensitivity of liver homogenate compared to mitochondria may be the result of the presence of cytosolic esterases which split the molecule of TOS to α-tocopherol and succinate [3] or due to binding of TOS to cytosolic membrane structures.<br />
<br />
1. Angulo-Molina, A., et al., The Role of Alpha Tocopheryl Succinate (alpha-TOS) as a Potential Anticancer Agent. Nutr Cancer, 2013.<br />
2. Zhao, Y., J. Neuzil, and K. Wu, Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside? Mol Nutr Food Res, 2009. 53(1): p. 129-39.<br />
3. Neuzil, J., et al., Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett, 2006. 580(22): p. 5125-9.<br />
4. Rauchova, H., M. Vokurkova, and Z. Drahota, Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate. Int J Biochem Cell Biol, 2014. 53: p. 409-13.<br />
|mipnetlab=CZ Hradec Kralove Cervinkova Z, CZ Prague Houstek J, <br />
}}<br />
{{Labeling<br />
|area=Respiration, Pharmacology;toxicology<br />
|organism=Rat<br />
|tissues=Heart, Liver<br />
|preparations=Homogenate, Isolated Mitochondria<br />
|enzymes=Complex II; Succinate Dehydrogenase<br />
|injuries=RONS; Oxidative Stress<br />
|couplingstates=OXPHOS<br />
|substratestates=CII<br />
|instruments=Oxygraph-2k<br />
}}</div>
Krumschnabel Gerhard