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- Avila-Rojas 2020 Food Chem Toxicol + (Curcumin has protective effects in several … Curcumin has protective effects in several acute kidney injury models, including that induced by potassium dichromate (K<sub>2</sub>Cr<sub>2</sub>O<sub>7</sub>). The protective effect of curcumin in this experimental model has been associated to the preservation of mitochondrial bioenergetics. This study is aimed at evaluating whether or not curcumin's protective effect in mitochondrial bioenergetics is related to the modulation of mitochondrial dynamics and biogenesis. Wistar rats were treated with a single subcutaneous dose of K<sub>2</sub>Cr<sub>2</sub>O<sub>7</sub> (12.5 mg/kg) or received curcumin (400 mg/kg/day) by oral gavage 10 days before and one day after the K<sub>2</sub>Cr<sub>2</sub>O<sub>7</sub> injection. K<sub>2</sub>Cr<sub>2</sub>O<sub>7</sub> induced kidney dysfunction and increased mitochondrial hydrogen peroxide production, while decreasing the respiration directly attributable to oxidative phosphorylation and mitochondrial membrane potential. In mitochondria, K<sub>2</sub>Cr<sub>2</sub>O<sub>7</sub> increased fission and reduced fusion. Structural analysis of mitochondria in the proximal tubular cells corroborated their fragmentation and loss of crests' integrity. Regarding mitochondrial biogenesis, K<sub>2</sub>Cr<sub>2</sub>O<sub>7</sub> decreased peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) levels. Conversely, curcumin treatment mitigated the aforementioned alterations and increased the expression of the mitochondrial transcription factor A (TFAM). Taken together, our results suggest that curcumin can protect against renal injury by modulating mitochondrial homeostasis, mitigating alterations in bioenergetics and dynamics, possibly by stimulating mitochondrial biogenesis.transcription factor A (TFAM). Taken together, our results suggest that curcumin can protect against renal injury by modulating mitochondrial homeostasis, mitigating alterations in bioenergetics and dynamics, possibly by stimulating mitochondrial biogenesis.)
