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Property "Has-20abstract" (as page type) with input value "-27-27'Mitochondrial-20capacity-27-27':-20-5B-5BOXPHOS-5D-5D-20capacity-20is-20evaluated-20in-20isolated-20mitochondria-20(mt)-20and-20permeabilized-20cells-20with-20physiological-20substrate-20cocktails-20to-20reconstitute-20tricarboxylic-20acid-20cycle-20function.-20As-20a-20consequence,-20convergent-20electron-20flow-20from-20Complexes-20CI+II-20of-20the-20electron-20transfer-2Dpathway-20(-5B-5BET-2Dpathway-5D-5D)-20to-20the-20-5B-5BQ-2Djunction-5D-5D-20exerts-20an-20additive-20effect-20on-20flux-20-5B1-5D.-0A-0A-27-27'Oxygen-20kinetics-20of-20mt-2Drespiration-27-27':-20The-20apparent-20-27-27K-27-27-3Csub-3Em,O2-3C-2Fsub-3E-20or-20-27-27c-27-27-3Csub-3E50-3C-2Fsub-3E-20-5BµM-5D-20(-27-27p-27-27-3Csub-3E50-3C-2Fsub-3E-20-5BkPa-5D)-20of-20mt-2Drespiration-20increases-20linearly-20with-20respiratory-20capacity-20controlled-20by-20metabolic-20state,-20from-200.2-20to-201.6-20µM-20determined-20by-20-5B-5Bhigh-2Dresolution-20respirometry-5D-5D.-20O-3Csub-3E2-3C-2Fsub-3E-20gradients-20are-20significant-20only-20in-20large-20cells-20including-20cardiomyocytes.-20The-20apparent-20-27-27p-27-27-3Csub-3E50-3C-2Fsub-3E-20increases-20100-2Dfold-20in-20permeabilized-20muscle-20fibers-20due-20to-20diffusion-20gradients-20-5B2-5D.-0A-0A-27-27'mt-2Dfunction-20at-20-27-27V-27-27-3Csub-3EO2max-3C-2Fsub-3E-27-27':-20Aerobic-20capacity-20of-20the-20human-20leg-20muscle-20exceeds-20maximum-20O-3Csub-3E2-3C-2Fsub-3E-20uptake-20of-20isolated-20mitochondria-20-5B3-5D-20and-20v.-20lateralis-20during-20-27-27V-27-27-3Csub-3EO2max-3C-2Fsub-3E-20-5B4-5D.-20Therefore,-20oxygen-20supply-20limits-20aerobic-20performance,-20proportional-20to-20the-20apparent-20mt-2Dexcess-20capacity-20-5B5-5D.-20mt-2Drespiration-20is-20more-20sensitive-20to-20average-20-27-27p-27-27-3Csub-3EO2-3C-2Fsub-3E-20in-20heterogenous-20tissues-20than-20under-20homogenous-20conditions-20in-20vitro.-20Tissue-20heterogeneity-20increases-20the-20kinetic-20dependence-20of-20flux-20on-20average-20intracellular-20-27-27p-27-27-3Csub-3EO2-3C-2Fsub-3E.-20High-20mt-2Ddensity-20reinforces-20the-20steepness-20of-20oxygen-20gradients-20and-20oxygen-20heterogeneity-20in-20the-20tissue,-20contributing-20to-20the-20O-3Csub-3E2-3C-2Fsub-3E-20limitation-20in-20athletic-20vs-20sedentary-20inspaniduals-20at-20-27-27V-27-27-3Csub-3EO2max-3C-2Fsub-3E-20-5B6-5D.-20This-20provides-20a-20functional-20rationale-20for-20the-20observation-20that-20hypoxia-20does-20not-20specifically-20trigger-20mt-2Dbiogenesis-20-5B7-5D.-0A-0AContribution-20to-20K-2DRegio-20-27-27-5B-5BMitoCom_O2k-2DFluorometer-7CMitoCom-20Tyrol-5D-5D-27-27.-0A-0A-5B1-5D-20-5B-5BGnaiger-202009-20Int-20J-20Biochem-20Cell-20Biol-7CGnaiger-202009-5D-5D-3B-20-5B-5BLemieux_2011_Int-20J-20Biochem-20Cell-20Biol-7CLemieux-20et-20al-202011-20Int-20J-20Biochem-20Cell-20Biol-5D-5D-20-0A-0A-5B2-5D-20-5B-5BGnaiger_2003_Adv-20Exp-20Med-20Biol-7CGnaiger-202003-5D-5D-3B-20-5B-5BScandurra_2010_Adv-20Exp-20Med-20Biol-7CScandurra,-20Gnaiger-202010-20Adv-20Exp-20Med-20Biol-5D-5D.-20-0A-0A-5B3-5D-20Rasmussen-20et-20al-202001-20AJP.-0A-0A-5B4-5D-20-5B-5BBoushel_2011_Mitochondrion-7CBoushel-20et-20al-202011-20Mitochondrion-5D-5D.-0A-0A-5B5-5D-20-5B-5BGnaiger_1998_J_Exp_Biol-7CGnaiger-20et-20al-201998-20JEB-5D-5D.-0A-0A-5B6-5D-20Richardson-20et-20al-3B-20Haseler-20et-20al-20JAP.-0A-0A-5B7-5D-20-5B-5BPesta_2011_AJP-7CPesta-20et-20al-202011-20AJP-5D-5D-3B-20-5B-5BJacobs_2011_J_Appl_Physiol-7CJacobs-20et-20al-202011-20JAP-5D-5D." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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