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Property "Has-20abstract" (as page type) with input value "-27-27'Objective-27-27':-20Impairments-20in-20mitochondrial-20physiology-20may-20play-20a-20role-20in-20diabetic-20sensory-20neuropathy.-20We-20tested-20the-20hypothesis-20that-20mitochondrial-20dysfunction-20in-20sensory-20neurons-20is-20due-20to-20abnormal-20mitochondrial-20respiratory-20function.-0A-0A-27-27'Research-20design-20and-20methods-27-27':-20Rates-20of-20oxygen-20consumption-20were-20measured-20in-20mitochondria-20from-20dorsal-20root-20ganglia-20(DRG)-20of-2012-2D-20to-2D-2022-2Dweek-20streptozotocin-20(STZ)-2Dinduced-20diabetic-20rats,-20diabetic-20rats-20treated-20with-20insulin,-20and-20age-2Dmatched-20controls.-20Activities-20and-20expression-20of-20components-20of-20mitochondrial-20complexes-20and-20reactive-20oxygen-20species-20(ROS)-20were-20analyzed.-0A-0A-27-27'Results-27-27':-20Rates-20of-20coupled-20respiration-20with-20pyruvate-20+-20malate-20(P-20+-20M)-20and-20with-20ascorbate-20+-20TMPD-20(Asc-20+-20TMPD)-20in-20DRG-20were-20unchanged-20after-2012-20weeks-20of-20diabetes.-20By-2022-20weeks-20of-20diabetes,-20respiration-20with-20P-20+-20M-20was-20significantly-20decreased-20by-2031-2D44-25-20and-20with-20Asc-20+-20TMPD-20by-2029-2D39-25-20compared-20with-20control.-20Attenuated-20mitochondrial-20respiratory-20activity-20of-20STZ-2Ddiabetic-20rats-20was-20significantly-20improved-20by-20insulin-20that-20did-20not-20correct-20other-20indices-20of-20diabetes.-20Activities-20of-20mitochondrial-20complexes-20I-20and-20IV-20and-20the-20Krebs-20cycle-20enzyme,-20citrate-20synthase,-20were-20decreased-20in-20mitochondria-20from-20DRG-20of-2022-2Dweek-20STZ-2Ddiabetic-20rats-20compared-20with-20control.-20ROS-20levels-20in-20perikarya-20of-20DRG-20neurons-20were-20not-20altered-20by-20diabetes,-20but-20ROS-20generation-20from-20mitochondria-20treated-20with-20antimycin-20A-20was-20diminished-20compared-20with-20control.-20Reduced-20mitochondrial-20respiratory-20function-20was-20associated-20with-20downregulation-20of-20expression-20of-20mitochondrial-20proteins.-0A-0A-27-27'Conclusions-27-27':-20Mitochondrial-20dysfunction-20in-20sensory-20neurons-20from-20type-201-20diabetic-20rats-20is-20associated-20with-20impaired-20rates-20of-20respiratory-20activity-20and-20occurs-20without-20a-20significant-20rise-20in-20perikaryal-20ROS." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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