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Property "Has-20abstract" (as page type) with input value "-5B-5BFile:Eva-20albertini.jpg-7Cright-7C150px-7CEva-20Albertini-5D-5D-0AAvailability-20of-20methionine-20is-20known-20to-20modulate-20the-20rate-20of-20aging-20in-20model-20organisms,-20best-20illustrated-20by-20the-20observation-20that-20dietary-20methionine-20restriction-20extends-20the-20lifespan-20of-20rodents.-20However,-20the-20underlying-20mechanisms-20are-20incompletely-20understood.-20In-20eukaryotic-20cells,-20methionine-20can-20be-20converted-20to-20cysteine-20through-20the-20reverse-20transsulfuration-20pathway-20thereby-20modulating-20intracellular-20methionine-20availability.-20Whereas-20previous-20results-20obtained-20in-20yeast-20and-20fruit-20flies-20suggest-20that-20alterations-20in-20the-20reverse-20transsulfuration-20pathway-20modulate-20the-20rate-20of-20aging,-20it-20is-20not-20known-20whether-20this-20function-20is-20conserved-20in-20evolution.-20Here-20we-20show-20that-20depletion-20of-20cystathionine-20beta-20synthase-20(CBS),-20a-20rate-20limiting-20enzyme-20in-20the-20reverse-20transsulfuration-20pathway,-20induces-20premature-20senescence-20in-20human-20endothelial-20cells.-20We-20found-20that-20CBS-20depletion-20induces-20mild-20mitochondrial-20dysfunction-20and-20increases-20the-20sensitivity-20of-20endothelial-20cells-20to-20homocysteine,-20a-20known-20inducer-20of-20endothelial-20cell-20senescence-20and-20an-20established-20risk-20factor-20for-20vascular-20disease.-20Our-20finding-20that-20CBS-20deficiency-20induces-20endothelial-20cell-20senescence-20in-20vitro,-20involving-20both-20mitochondrial-20dysfunction-20and-20increased-20susceptibility-20of-20the-20cells-20to-20homocysteine,-20suggests-20a-20new-20mechanism-20linking-20CBS-20deficiency-20to-20vascular-20aging-20and-20disease.-0A-23-20-5B-5BAlbertini-202012-20Aging-20(Albany-20NY)-7CAlbertini-20E,-20Kozieł-20R,-20Duerr-20A,-20Neuhaus-20M,-20Jansen-2DDuerr-20P-20(2012)-20Cystathionine-20beta-20synthase-20modulates-20senescence-20of-20human-20endothelial-20cells.-20Aging-20(Albany-20NY)-204:664-2D73.-5D-5D" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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