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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MITOEAGLE-5D-5D-0AAltered-20myocardial-20metabolism-20and-20cardiac-20inefficiency-20are-20hallmarks-20of-20the-20diabetic-20heart,-20and-20may-20play-20a-20central-20role-20in-20the-20pathogenesis-20of-20diabetes-20related-20cardiac-20dysfunction-20(diabetic-20cardiomyopathy).-20Although-20high-20levels-20of-20fatty-20acids-20has-20been-20demonstrated-20to-20have-20adverse-20effects-20in-20the-20normal-20heart,-20its-20effect-20in-20the-20obese-2Fdiabetic-20heart-20is-20less-20clear.-20In-20the-20present-20study-20we-20have-20examined-20how-20an-20acute-20fat-2Dload-20on-20the-20heart-20diet-2Dinduced-20obese-20(DIO)-20mice-20(20-20week-20on-20a-20high-2Dfat-20diet)-20and-20age-2Dmatched-20controls-20(CON)-20will-20influence-20mitochondrial-20respiration.-20-0AWe-20found-20reduced-20OXPHOS-20respiration-20in-20isolated-20mitochondrial-20from-20DIO-20as-20compared-20to-20CON-20hearts.-20By-20subjecting-20CON-20hearts-20to-20a-20high-20fat-2Dload-20(elevated-20levels-20of-20fatty-20acids-20prior-20to-20mitochondrial-20isolation),-20OXPHOS-20respiration-20and-20RCR-20(respiratory-20coupling-20ratio)-20were-20reduced.-20These-20changes-20were-20not-20observed-20in-20mitochondria-20from-20DIO-20hearts,-20which-20may-20suggest-20that-20in-20diabetes,-20the-20heart-20undergoes-20adaptation-20to-20chronic-20exposure-20of-20elevated-20circulating-20fatty-20acids,-20which-20protect-20these-20hearts-20from-20the-20adverse-20effects-20of-20an-20acute-20fat-2Dload." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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