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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0ANonhuman-20primates-20can-20serve-20as-20useful-20models-20for-20human-20disease.-20Specifically,-20cynomolgus-20macaques-20(-27-27Macaca-20fascicularis-27-27)-20are-20well-20suited-20to-20model-20long-2Dterm-20dietary-20changes-20-5B1-5D.-20Similar-20to-20humans,-20these-20animals-20exhibit-20similar-20risk-20factors-20for-20developing-20disease,-20such-20as:-20concentrations-20of-20circulating-20lipids,-20blood-20pressure,-20obesity,-20and-20inflammation.-20-5B2-5D-20A-20western-20diet-20has-20been-20associated-20with-20increased-20incidences-20of-20obesity,-20cardiovascular-20disease,-20hypertension,-20type-202-20diabetes,-20and-20hypercholesterolemia.-20-5B3-5D-20Conversely,-20a-20mediterranean-20diet-20has-20been-20associated-20with-20lower-20risk-20of-20cardiometabolic-20disease-20by-20improvement-20of-20insulin-20resistance,-20lipid-20levels,-20blood-20pressure,-20and-20inflammation.-20-5B4-5D-0A-0AIn-20this-20ongoing-20study,-2022-20middle-2Daged-20female-20cynomolgus-20macaques-20were-20randomly-20assigned-20to-20receive-20a-20western-20(n-20=-2010)-20or-20mediterranean-2Dlike-20diet-20(n-20=-2012)-20for-2030-20months.-20The-20monkeys-20are-20between-2011-2D13-20years-20of-20age-20at-20the-20time-20of-20tissue-20collection-3B-20this-20corresponds-20to-2040-20to-2050-2Dyear-2Dold-20human-20women.-20The-20length-20of-20diet-20is-20equivalent-20to-20about-208-20years-20of-20intervention-20in-20humans.-20The-20western-20diet-20was-20designed-20to-20mimic-20the-20typical-20American-20diet:-20protein-20and-20fats-20from-20mainly-20animal-20sources,-20high-20in-20saturated-20fat,-20and-20high-20in-20sodium.-20The-20mediterranean-20diet-20was-20designed-20to-20mirror-20a-20typical-20diet-20in-20the-20mediterranean-20region:-20protein-20and-20fats-20from-20mainly-20plant-20and-20fish-20sources,-20with-20some-20dairy-20proteins,-20and-20high-20in-20monounsaturated-20fatty-20acids.-20The-20composition-20of-20each-20diet-20can-20be-20found-20in-20Figure-201.-20-27-27Vastus-20lateralis-27-27-20skeletal-20muscle-20tissue-20is-20being-20obtained-20from-20each-20monkey.-20A-20small-20sample-20of-20muscle-20(~20-20mg)-20is-20placed-20in-20BIOPS-20on-20ice-20for-20fiber-20separation.-20Any-20connective-20tissue-20or-20fat-20is-20removed-20and-20the-20bundles-20are-20separated-20gently-20using-20needle-20tip-20forceps-20under-20a-20dissecting-20microscope.-20The-20separated-20fibers-20are-20transferred-20to-20a-20saponin-20solution-20(30-20ug-2FmL-20saponin-20in-20BIOPS)-20and-20incubated-20on-20ice-20for-2030-20minutes.-20The-20fibers-20are-20then-20transferred-20to-20a-20wash-20buffer-20for-2015-20minutes-20on-20ice.-20Samples-20of-20approximately-202.5-20mg-20(wet-20weight)-20are-20selected-20and-20analyzed-20in-20the-20Oroboros-20O2k-20using-20two-20protocols:-20SUIT-20Reference-20Protocol-202-20(RP2)-20and-20a-20protocol-20adapted-20from-20the-20Neufer-20Lab-20at-20East-20Carolina-20University.-20-5B5-5D-20The-20injection-20strategies-20and-20representative-20traces-20from-20preliminary-20experiments-20are-20shown-20in-20Figure-202.-20Analysis-20will-20focus-20on-20comparing-20results-20from-20both-20protocols.-20RP2-20is-20designed-20to-20reveal-20the-20differences-20in-20fatty-20acid-20oxidation-20between-20the-20two-20diet-20groups-20and-20the-20Neufer-20protocol-20will-20provide-20detailed-20information-20about-20state-202-20and-20state-203-20respiration-20and-20respiratory-20control-20ratios." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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