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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0AOral-20and-20oesophageal-20cancers-20are-20aggressive-20tumours-20associated-20with-20high-20morbidity-20and-20mortality.-20Lack-20of-20early-20detection-20strategies-20is-20one-20of-20the-20reasons-20for-20late-20diagnosis,-20since-20these-20cancers-20often-20do-20not-20exhibit-20any-20symptoms-20until-20entering-20advanced-20stages.-20Their-20pathogenesis-20is-20still-20unclear,-20thus-20there-20are-20few-20satisfactory-20therapies.-20Difficulties-20in-20operating-20on-20oral-20cavity-20or-20oesophagus,-20as-20well-20as-20applying-20radiotherapy-20and-20often-20occurring-20chemotherapy-20resistance-20in-20these-20cancers-20is-20a-20major-20set-20back-20in-20increasing-20the-20survival-20rate-20of-20the-20patients.-20Due-20to-20the-20unfortunate-20placement-20of-20the-20tumours,-20patients-20experience-20difficulties-20with-20swallowing,-20chewing,-20breathing-20and-20talking,-20during-20the-20disease-20as-20well-20as-20during-20the-20therapy.-20Surgeries-20often-20greatly-20lower-20the-20comfort-20of-20living-20of-20patients,-20leave-20scars-20and-20the-20overall-20survival-20rate-20still-20remains-20low.-20Development-20of-20an-20effective-20adjuvant-20therapeutic-20agent-20that-20would-20gently-20ease-20the-20symptoms-20and-20quickly-20reduce-20the-20size-20of-20the-20tumour-20before-20applying-20more-20invasive-20therapies-20could-20greatly-20increase-20the-20comfort-20of-20patients-20and-20ideally-20increase-20the-20survival-20rate.-0A-0AHAMLET-20-2D-20-27-27'H-27-27'uman-20-27-27'A-27-27'lpha-2Dlactalbumin-20-27-27'M-27-27'ade-20-27-27'LE-27-27'thal-20to-20-27-27'T-27-27'umour-20cells-20–-20is-20a-20complex-20formed-20from-20partially-20unfolded-20α-2Dlactalbumin-20and-20oleic-20acid.-20Discovered-20by-20Catharina-20Svanborg-20and-20her-20group-20while-20studying-20the-20anti-2Dbacterial-20properties-20of-20human-20milk-20on-20human-20lung-20cancer-20cells,-20HAMLET-20has-20been-20since-20proven-20to-20selectively-20target-20tumour-20cells-20and-20causing-20their-20death-20while-20having-20no-20such-20effect-20on-20healthy-20differentiated-20cells.-20It-20is-20the-20first-20identified-20protein-20that-20has-20a-20defined-20function-20in-20its-20native-20site-20and-20acquires-20a-20new-20beneficial-20function-20after-20partial-20unfolding.-20Other-20similar-20protein-2Dfatty-20acid-20complexes-20that-20exhibit-20similar-20cytotoxic-20properties-20have-20been-20since-20identified.-0A-0AThe-20project-20aims-20to-20decipher-20the-20cellular-20mechanism-20that-20makes-20HAMLET-20selectively-20toxic-20to-20cancer-20cells.-20In-20particular,-20the-20research-20will-20focus-20on-20the-20process-20of-20metabolic-20transformation-20including-20aerobic-20glycolysis,-20extracellular-20acidification-20and-20membrane-20hyperpolarisation.-20It-20is-20hoped-20that-20by-20identifying-20the-20critical-20characteristics-20that-20selectively-20kill-20cancer-20cells,-20that-20it-20will-20be-20possible-20to-20further-20enhance-20HAMLET’s-20efficacy-20as-20an-20adjuvant-20therapy." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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