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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Among-20the-20wide-20range-20of-20mitochondrial-20disorders,-20defects-20in-20the-20oxidative-20phosphorylation-20(OxPhos)-20are-20the-20most-20prevalent.-20OxPhos-20deficiencies-20often-20lead-20to-20early-20death-20and-20are-20associated-20with-20severe-20and-20highly-20variable-20clinical-20symptoms.-20Despite-20intense-20efforts-20in-20the-20comprehension-20of-20the-20mechanisms-20underlying-20mitochondrial-20disorders,-20patients-20are-20still-20without-20effective-20treatment.-20The-20need-20of-20predictive-20-27-27in-20vivo-27-27-20models-20of-20the-20pathology-20is-20an-20important-20issue-20in-20the-20development-20of-20new-20therapeutics-20in-20order-20to-20study-20their-20therapeutic-20potential,-20toxicity-20and-20pharmacokinetics.-20Due-20to-20the-20extreme-20genetic-20and-20phenotypic-20heterogeneity-20of-20OxPhos-20disorders-20one-20cannot-20rely-20on-20a-20single-20in-20-27-27vivo-20model-27-27.-0A-20-0AHere-20we-20present-20the-20method-20and-20strategy-20we-20use-20to-20create,-20characterize-20and-20validate-20a-20set-20of-20-27-27Drosophila-20melanogaster-27-27-20models-20of-20nuclear-20DNA-2Dencoded-20OxPhos-20subunits-20and-20preliminary-20results-20of-20systematic-20evaluation-20of-20Khondrion´s-20lead-20compound.-20We-20primarily-20focus-20on-20complex-20I-20by-20knocking-20down-20the-20core-20and-20accessory-20subunits-20the-20most-20prone-20to-20mutation-20in-20patients-20and-20selecting-20phenotypes-2Dreadouts-20suitable-20for-20drug-20screening-20(death-20at-20critical-20stages-20of-20development,-20survival-20curves,-20ROS-20level).-0A-0AThese-20models-20will-20represent-20a-20valuable-20tool-20with-20predictive-20power-20to-20evaluate-20new-20potential-20therapeutics-20as-20an-20initial-20step-20in-20the-20drug-20development-20process." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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