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Property "Has-20abstract" (as page type) with input value "Both-20acute-20and-20chronic-20apelin-20treatment-20have-20been-20shown-20to-20improve-20insulin-20sensitivity-20in-20mice.-20However,-20the-20effects-20of-20apelin-20on-20fatty-20acid-20oxidation-20(FAO)-20during-20obesity-2Drelated-20insulin-20resistance-20have-20not-20yet-20been-20addressed.-20Thus,-20the-20aim-20of-20the-20current-20study-20was-20to-20determine-20the-20impact-20of-20chronic-20treatment-20on-20lipid-20use,-20especially-20in-20skeletal-20muscles.-20High-2Dfat-20diet-20(HFD)-2Dinduced-20obese-20and-20insulin-2Dresistant-20mice-20treated-20by-20an-20apelin-20injection-20(0.1-20μmol-2Fkg-2Fday-20i.p.)-20during-204-20weeks-20had-20decreased-20fat-20mass,-20glycemia,-20and-20plasma-20levels-20of-20triglycerides-20and-20were-20protected-20from-20hyperinsulinemia-20compared-20with-20HFD-20PBS-2Dtreated-20mice.-20Indirect-20calorimetry-20experiments-20showed-20that-20apelin-2Dtreated-20mice-20had-20a-20better-20use-20of-20lipids.-20The-20complete-20FAO,-20the-20oxidative-20capacity,-20and-20mitochondrial-20biogenesis-20were-20increased-20in-20soleus-20of-20apelin-2Dtreated-20mice.-20The-20action-20of-20apelin-20was-20AMP-2Dactivated-20protein-20kinase-20(AMPK)-20dependent-20since-20all-20the-20effects-20studied-20were-20abrogated-20in-20HFD-20apelin-2Dtreated-20mice-20with-20muscle-2Dspecific-20inactive-20AMPK.-20Finally,-20the-20apelin-2Dstimulated-20improvement-20of-20oxidative-20capacity-20led-20to-20decreased-20levels-20of-20acylcarnitines-20and-20enhanced-20insulin-2Dstimulated-20glucose-20uptake-20in-20soleus.-20Thus,-20by-20promoting-20complete-20lipid-20use-20in-20muscle-20of-20insulin-2Dresistant-20mice-20through-20mitochondrial-20biogenesis-20and-20tighter-20matching-20between-20FAO-20and-20the-20tricarboxylic-20acid-20cycle,-20apelin-20treatment-20could-20contribute-20to-20insulin-20sensitivity-20improvement." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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