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Property "Has-20abstract" (as page type) with input value "Development-20of-20hibernation-20strategies-20for-20cold-20preservation-20of-20human-20organs-20represents-20a-20far-2Dreaching-20goal-20in-20transplantation-20surgery.-20Short-20cold-20storage-20times-20of-20-3C6-20h-20tolerated-20by-20the-20human-20heart-20remain-20a-20major-20clinical-20problem.-20Mitochondrial-20cold-20storage-2Dreperfusion-20injury-20is-20becoming-20recognized-20as-20a-20limiting-20factor-20in-20preservation-20of-20organs-20from-20non-2Dhibernating-20mammals.-20Damaged-20mitochondria-20lead-20to-20cellular-20injury-20by-20reduction-20of-20ATP-20supply,-20oxidative-20stress,-20disturbance-20of-20ion-20balance,-20cytochrome-20c-20release-20and-20induction-20of-20apoptosis-20and-20necrosis.-20Profiles-20of-20mitochondrial-20injuries-20differed-20after-20(1)-20cold-20preservation-20of-20isolated-20rat-20heart-20mitochondria,-20(2)-20cold-20preservation-20of-20the-20rat-20heart,-20and-20(3)-20after-20transplantation-20and-20rewarming-2Freperfusion.-20Importantly,-20a-20specific-20defect-20of-20complex-20I-20of-20the-20electron-20transport-20chain,-20uncoupling-20of-20oxidative-20phosphorylation-20and-20the-20pronounced-20release-20of-20cytochrome-20c-20from-20mitochondria-20were-20absent-20after-20cold-20storage-20but-20developed-20during-20reperfusion,-20in-20proportion-20to-20the-20loss-20of-20heart-20function.-20Cold-20preservation-20of-20isolated-20heart-20mitochondria-20could-20be-20significantly-20prolonged-20by-20a-20mitochondrial-20preservation-20solution-20containing-20antioxidants,-20mitochondrial-20substrates,-20ATP,-20histidine,-20and-20oncotic-20agents.-20Successful-20cold-20storage-20of-20heart-20mitochondria-20demonstrates-20a-20large-20scope-20for-20improvement-20of-20heart-20preservation-20solutions.-20In-20this-20context,-20comparison-20of-20intracellular-20conditions-20and-20cold-20ischemia-2Dreperfusion-20injury-20in-20hibernating-20and-20non-2Dhibernating-20mammals-20may-20provide-20a-20rationale-20for-20improvement-20of-20clinical-20organ-20hibernation-20strategies." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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