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Property "Has-20abstract" (as page type) with input value "Hepatic-20mitochondrial-20dysfunction-20is-20thought-20to-20play-20a-20role-20in-20the-20development-20of-20liver-20steatosis-20and-20insulin-20resistance,-20which-20are-20both-20common-20characteristics-20of-20obesity-20and-20type-202-20diabetes-20mellitus-20(T2DM).-20It-20was-20hypothesized-20that-20the-20antioxidant-20properties-20of-20melatonin-20could-20potentially-20improve-20the-20impaired-20functions-20of-20hepatic-20mitochondria-20in-20diabetic-20obese-20animals.-20Male-20Zucker-20diabetic-20fatty-20(ZDF)-20rats-20and-20lean-20littermates-20(ZL)-20were-20given-20either-20melatonin-20(10-20mg-2Fkg-20BW-2Fday)-20orally-20for-206-20wk-20(M-2DZDF-20and-20M-2DZL)-20or-20vehicle-20as-20control-20groups-20(C-2DZDF-20and-20C-2DZL).-20Hepatic-20function-20was-20evaluated-20by-20measurement-20of-20serum-20alanine-20transaminase-20and-20aspartate-20transaminase-20levels,-20liver-20histopathology-20and-20electron-20microscopy,-20and-20hepatic-20mitochondrial-20functions.-20Several-20impaired-20functions-20of-20hepatic-20mitochondria-20were-20observed-20in-20C-2DZDF-20in-20comparison-20with-20C-2DZL-20rats.-20Melatonin-20treatment-20to-20ZDF-20rats-20decreases-20serum-20levels-20of-20ALT-20(-27-27P-27-27-20-3C-200.001),-20alleviates-20liver-20steatosis-20and-20vacuolation,-20and-20also-20mitigates-20diabetic-2Dinduced-20mitochondrial-20abnormalities,-20glycogen,-20and-20lipid-20accumulation.-20Melatonin-20improves-20mitochondrial-20dysfunction-20in-20M-2DZDF-20rats-20by-20increasing-20activities-20of-20mitochondrial-20citrate-20synthase-20(-27-27P-27-27-20-3C-200.001)-20and-20complex-20IV-20of-20electron-20transfer-20chain-20(-27-27P-27-27-20-3C-200.05)-20and-20enhances-20state-203-20respiration-20(-27-27P-27-27-20-3C-200.001),-20respiratory-20control-20index-20(RCR)-20(-27-27P-27-27-20-3C-200.01),-20and-20phosphorylation-20coefficient-20(ADP-2FO-20ratio)-20(-27-27P-27-27-20-3C-200.05).-20Also-20melatonin-20augments-20ATP-20production-20(-27-27P-27-27-20-3C-200.05)-20and-20diminishes-20uncoupling-20protein-202-20levels-20(-27-27P-27-27-20-3C-200.001).-20These-20results-20demonstrate-20that-20chronic-20oral-20melatonin-20reduces-20liver-20steatosis-20and-20mitochondria-20dysfunction-20in-20ZDF-20rats.-20Therefore,-20it-20may-20be-20beneficial-20in-20the-20treatment-20of-20diabesity." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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