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Property "Has-20abstract" (as page type) with input value "Iron-20replacement-20improves-20clinical-20status-20in-20iron-2Ddeficient-20patients-20with-20heart-20failure-20(HF),-20but-20the-20pathophysiology-20is-20poorly-20understood.-20Iron-20is-20essential-20not-20only-20for-20erythropoiesis,-20but-20also-20for-20cellular-20bioenergetics.-20The-20impact-20of-20myocardial-20iron-20deficiency-20(MID)-20on-20mitochondrial-20function,-20measured-20directly-20in-20the-20failing-20human-20heart,-20is-20unknown.-0A-0ALeft-20ventricular-20samples-20were-20obtained-20from-2091-20consecutive-20HF-20patients-20undergoing-20transplantation-20and-2038-20HF-2Dfree-20organ-20donors-20(controls).-20Total-20myocardial-20iron-20content,-20mitochondrial-20respiration,-20citric-20acid-20cycle-20and-20respiratory-20chain-20enzyme-20activities,-20respiratory-20chain-20components-20(complex-20I-2DV),-20and-20protein-20content-20of-20reactive-20oxygen-20species-20(ROS)-2Dprotective-20enzymes-20were-20measured-20in-20tissue-20homogenates-20to-20quantify-20mitochondrial-20function.-20Myocardial-20iron-20content-20was-20lower-20in-20HF-20compared-20with-20controls-20(156 ± 41-20vs.-20200 ± 38 µg·g-2D1-20dry-20weight,-20P-20-3C-200.001),-20independently-20of-20anaemia.-20MID-20(the-20lowest-20iron-20tercile-20in-20HF)-20was-20associated-20with-20more-20extensive-20coronary-20disease-20and-20less-20beta-2Dblocker-20usage-20compared-20with-20non-2DMID-20HF-20patients.-20Compared-20with-20controls,-20HF-20patients-20displayed-20reduced-20myocardial-20oxygen-3Csub-3E2-3C-2Fsub-3E-20respiration-20and-20reduced-20activity-20of-20all-20examined-20mitochondrial-20enzymes-20(all-20P-20-3C-200.001).-20MID-20in-20HF-20was-20associated-20with-20preserved-20activity-20of-20respiratory-20chain-20enzymes-20but-20reduced-20activity-20of-20aconitase-20and-20citrate-20synthase-20(by-20-2D26-25-20and-20-2D15-25,-20P-20-3C-200.05)-20and-20reduced-20expression-20of-20catalase,-20glutathione-20peroxidase,-20and-20superoxide-20dismutase-202.-0A-0AMyocardial-20iron-20content-20is-20decreased-20and-20mitochondrial-20functions-20are-20impaired-20in-20advanced-20HF.-20MID-20in-20HF-20is-20associated-20with-20diminished-20citric-20acid-20cycle-20enzyme-20activities-20and-20decreased-20ROS-2Dprotecting-20enzymes.-20MID-20may-20contribute-20to-20altered-20myocardial-20substrate-20use-20and-20to-20worsening-20of-20mitochondrial-20dysfunction-20that-20exists-20in-20HF.-0A-0A©-202016-20The-20Authors.-20European-20Journal-20of-20Heart-20Failure-20©-202016-20European-20Society-20of-20Cardiology." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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