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Property "Has-20abstract" (as page type) with input value "Mitochondrial-20dysfunction-20contributing-20to-20the-20etiology-20of-20preventable-20metabolic-20diseases-20is-20subject-20of-20intensive-20research-20with-20world-2Dwide-20health-20implications.-20These-20investigations-20gained-20depth-20and-20scope-20by-20technological-20advances-20for-20diagnosis-20by-20comprehensive-20OXPHOS-20analysis-20using-20high-2Dresolution-20respirometry.-20Fundamental-20questions-20of-20a-20causal-20relationship,-20however,-20between-20compromised-20mitochondrial-20function-20and-20disease-20remain-20to-20be-20resolved-20to-20optimize-20prevention-20and-20treatment.-0A-0APost-2Dindustrial-20societies-20are-20characterized-20by-20a-20high-2Denergy-20input-20lifestyle-20with-20diminished-20physical-20activity-20and-20high-20incidence-20of-20non-2Dtransmittable-20diseases,-20in-20comparison-20to-20human-20populations-20where-20physical-20work-20is-20essentially-20important-20for-20sustaining-20life-20and-20in-20which-20degenerative-20diseases-20(T2-20diabetes,-20various-20cancers,-20Alzheimer's)-20are-20essentially-20absent.-20Oxidative-20phosphorylation-20capacity-20(OXPHOS)-20is-20maintained-20high-20by-20a-20life-20style-20involving-20endurance-20and-20strength-20exercise.-20Depending-20on-20group-20selection-20in-20cross-2Dsectional-20studies,-20OXPHOS-20declines-20from-2020-2D30-20years,-20or-20is-20independent-20of-20age-20up-20to-2080-20years.-20Independent-20of-20age-20at-20a-20BMI-20-3E30,-20a-20threshold-20of-20declining-20OXPHOS-20capacity-20is-20reached-20in-20human-20-27-27V.-20lateralis-27-27-20characteristic-20of-20a-20low-2Dgrade-20inflammatory-20state-20(‘mitochondrial-20fever’).-20Onset-20of-20degenerative-20diseases-20(T2-20diabetes,-20neuromuscular-20degeneration,-20various-20cancers)-20and-20mitochondrial-20fever-20interact-20in-20an-20amplification-20loop-20progressing-20slowly-20with-20age,-20such-20that-20cause-20and-20effect-20of-20mitochondrial-20dysfunction-20cannot-20be-20distinguished.-20Diminished-20antioxidant-20capacity-20at-20low-20mitochondrial-20density-20is-20an-20important-20biomarker.-0A-0AFor-20implementing-20a-20life-20style-20supporting-20mitochondrial-20competence-20and-20preventing-20degenerative-20diseases-20in-20modern-20societies,-20we-20need-20(1)-20extended-20research-20programmes-20focused-20on-20the-20causative-20link-20between-20mitochondrial-20competence-20and-20effective-20prevention-20of-20degenerative-20diseases,-20(2)-20educational-20programmes-20on-20mitochondrial-20physiology-20targeted-20at-20general-20practitioners,-20teachers-20and-20the-20society-20at-20large,-20(3)-20cooperation-20of-20health-20care-20and-20insurance-20organizations-20to-20support-20preventive-20life-20style-20activities,-20and-20(4)-20do-20not-20miss-20any-20opportunity-20in-20taking-20the-20lead-20in-20living-20the-20mtLife-20Style-20Drug:-20mtLSD.-0A-0AContribution-20to-20K-2DRegio-20project-20MitoFit." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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