Search by property

This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

Search by property

Property "Has-20abstract" (as page type) with input value "Nitric-20oxide-20(NO)-20inhibits-20mitochondrial-20respiration-20by-20decreasing-20the-20apparent-20affinity-20of-20cytochrome-20c-20oxidase-20(CcO)-20for-20oxygen.-20Using-20iNOS-2Dtransfected-20HEK-20293-20cells-20to-20achieve-20regulated-20intracellular-20NO-20production,-20we-20determined-20NO-20and-20O-3Csub-3E2-3C-2Fsub-3E-20concentrations-20and-20mitochondrial-20O-3Csub-3E2-3C-2Fsub-3E-20consumption-20by-20high-2Dresolution-20respirometry-20over-20a-20range-20of-20O-3Csub-3E2-3C-2Fsub-3E-20concentrations-20down-20to-20nanomolar.-20Inhibition-20of-20respiration-20by-20NO-20was-20reversible,-20and-20complete-20NO-20removal-20recovered-20cell-20respiration-20above-20its-20routine-20reference-20values.-20Respiration-20was-20observed-20even-20at-20high-20NO-20concentrations,-20and-20the-20dependence-20of-20IC-3Csub-3E50-3C-2Fsub-3E-20on-20-5BO-3Csub-3E2-3C-2Fsub-3E-5D-20exhibits-20a-20characteristic-20but-20puzzling-20parabolic-20shape-3B-20both-20these-20features-20imply-20that-20CcO-20is-20protected-20from-20complete-20inactivation-20by-20NO-20and-20are-20likely-20to-20be-20physiologically-20relevant.-20We-20present-20a-20kinetic-20model-20of-20CcO-20inhibition-20by-20NO-20that-20efficiently-20predicts-20experimentally-20determined-20respiration-20at-20physiological-20O-3Csub-3E2-3C-2Fsub-3E-20and-20NO-20concentrations-20and-20under-20hypoxia,-20and-20accurately-20predicts-20the-20respiratory-20responses-20under-20hyperoxia.-20The-20model-20invokes-20competitive-20and-20uncompetitive-20inhibition-20by-20binding-20of-20NO-20to-20the-20reduced-20and-20oxidized-20forms-20of-20CcO,-20respectively,-20and-20suggests-20that-20dissociation-20of-20NO-20from-20reduced-20CcO-20may-20involve-20its-20O-3Csub-3E2-3C-2Fsub-3E-20dependent-20oxidation.-20It-20also-20explains-20the-20non-2Dlinear-20dependence-20of-20IC-3Csub-3E50-3C-2Fsub-3E-20on-20O-3Csub-3E2-3C-2Fsub-3E-20concentration,-20and-20the-20hyperbolic-20increase-20of-20c-3Csub-3E50-3C-2Fsub-3E-20as-20a-20function-20of-20NO-20concentration." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)

Property: Value:

List of results

No results.