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Property "Has-20abstract" (as page type) with input value "OBJECTIVE—Heat-20treatment-20and-20overexpression-20of-20heat-20shock-20protein-2072-20(HSP72)-20have-20been-20shown-20to-20protect-20against-20high-2Dfat-20diet–induced-20insulin-20resistance,-20but-20little-20is-20known-20about-20the-20underlying-20mechanism-20or-20the-20target-20tissue-20of-20HSP-20action.-20The-20purpose-20of-20this-20study-20is-20to-20determine-20whether-20-27-27in-20vivo-27-27-20heat-20treatment-20can-20prevent-20skeletal-20muscle-20insulin-20resistance.-0ARESEARCH-20DESIGN-20AND-20METHODS—Male-20Wistar-20rats-20were-20fed-20a-20high-2Dfat-20diet-20(60-25-20calories-20from-20fat)-20for-2012-20weeks-20and-20received-20a-20lower-2Dbody-20heat-20treatment-20(41°C-20for-2020-20min)-20once-20per-20week.-0A-0ARESULTS—Our-20results-20show-20that-20heat-20treatment-20shifts-20the-20metabolic-20characteristics-20of-20rats-20on-20a-20high-2Dfat-20diet-20toward-20those-20on-20a-20standard-20diet.-20Heat-20treatment-20improved-20glucose-20tolerance,-20restored-20insulin-2Dstimulated-20glucose-20transport,-20and-20increased-20insulin-20signaling-20in-20soleus-20and-20extensor-20digitorum-20longus-20(EDL)-20muscles-20from-20rats-20fed-20a-20high-2Dfat-20diet.-20Heat-20treatment-20resulted-20in-20decreased-20activation-20of-20Jun-20NH2-2Dterminal-20kinase-20(JNK)-20and-20inhibitor-20of-20kB-20kinase-20(IKK-2Dβ),-20stress-20kinases-20implicated-20in-20insulin-20resistance,-20and-20upregulation-20of-20HSP72-20and-20HSP25,-20proteins-20previously-20shown-20to-20inhibit-20JNK-20and-20IKK-2Dβ-20activation,-20respectively.-20Mitochondrial-20citrate-20synthase-20and-20cytochrome-20oxidase-20activity-20decreased-20slightly-20with-20the-20high-2Dfat-20diet,-20but-20heat-20treatment-20restored-20these-20activities.-20Data-20from-20L6-20cells-20suggest-20that-20one-20bout-20of-20heat-20treatment-20increases-20mitochondrial-20oxygen-20consumption-20and-20fatty-20acid-20oxidation.-0A-0ACONCLUSIONS—Our-20results-20indicate-20that-20heat-20treatment-20protects-20skeletal-20muscle-20from-20high-2Dfat-20diet–induced-20insulin-20resistance-20and-20provide-20strong-20evidence-20that-20HSP-20induction-20in-20skeletal-20muscle-20could-20be-20a-20potential-20therapeutic-20treatment-20for-20obesity-20induced-20insulin-20resistance-20-5Bhttp:-2F-2Fhealthy-2Dojas.com-2Fdiabetes-2Fdiabetes-2Ddetails.html-20diabetes-5D." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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