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Property "Has-20abstract" (as page type) with input value "Perilipin-205-20(PLIN5)-20is-20a-20lipid-20droplet-20protein-20and-20is-20highly-20expressed-20in-20oxidative-20tissue.-20Expression-20of-20the-20PLIN5-20gene-20is-20regulated-20by-20peroxisome-20proliferator-2Dactivated-20receptor-2Dα,-20fasting,-20and-20exercise.-20However,-20the-20effect-20of-20increased-20muscle-20PLIN5-20expression-20on-20whole-2Dbody-20energy-20homeostasis-20remains-20unclear.-20To-20examine-20this,-20we-20developed-20a-20mouse-20line-20with-20skeletal-20muscle-20PLIN5-20overexpression-20(MCK-2DPlin5).-20We-20show-20that-20MCK-2DPlin5-20mice-20have-20increased-20energy-20metabolism-20and-20accumulate-20more-20intramyocellular-20triacylglycerol-20but-20have-20normal-20glucose-20and-20insulin-20tolerance.-20MCK-2DPlin5-20mice-20fed-20high-2Dfat-20chow-20manifest-20lower-20expression-20of-20inflammatory-20markers-20in-20their-20liver-20and-20increased-20expression-20of-20"browning"-20factors-20in-20adipose-20tissue.-20This-20muscle-2Ddriven-20phenotype-20is,-20at-20least-20in-20part,-20mediated-20by-20myokines-3B-20the-20MCK-2DPlin5-20mice-20have-2080-2Dfold-20higher-20FGF21-20gene-20expression-20in-20muscle-20and-20increased-20serum-20FGF21-20concentration.-20The-20increase-20in-20FGF21-20occurs-20mainly-20in-20muscles-20with-20a-20predominance-20of-20fast-2Dtwitch-20fibers,-20suggesting-20that-20fiber-20type-2Dspecific-20lipid-20storage-20may-20be-20part-20of-20the-20mechanism-20conferring-20metabolic-20protection-20in-20MCK-2DPlin5-20mice.-20In-20conclusion,-20upregulating-20the-20PLIN5-20level-20in-20skeletal-20muscle-20drives-20expression-20of-20the-20FGF21-20gene-20in-20fast-2Dtwitch-20fibers-20and-20is-20metabolically-20protective.-20These-20findings-20provide-20insight-20into-20the-20physiology-20of-20PLIN5-20and-20the-20potential-20contribution-20of-20its-20upregulation-20during-20exercise." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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