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Property "Has-20abstract" (as page type) with input value "Recruitment-20of-20brown-20adipose-20tissue-20(BAT)-20has-20emerged-20as-20a-20potential-20tool-20to-20combat-20obesity-20and-20associated-20metabolic-20complications.-20Short-2Dterm-20cold-20acclimation-20has-20been-20shown-20to-20not-20only-20enhance-20BAT-20presence-20and-20activity-20in-20lean-20humans,-20but-20also-20improve-20skeletal-20muscle-20metabolic-20profile-20to-20benefit-20glucose-20uptake-20in-20type-202-20diabetic-20patients.-20Here,-20we-20examined-20whether-20short-2Dterm-20cold-20acclimation-20also-20induced-20such-20adaptations-20in-20ten-20metabolically-20healthy-20obese-20male-20subjects.-20A-2010-2Dday-20cold-20acclimation-20period-20resulted-20in-20increased-20cold-2Dinduced-20glucose-20uptake-20in-20BAT,-20as-20assessed-20by-20-5B18F-5DFDG-2DPET-2FCT-20scanning.-20BAT-20activity-20was-20negatively-20related-20to-20age,-20with-20a-20similar-20trend-20for-20body-20fat-25.-20In-20addition,-20cold-2Dinduced-20glucose-20uptake-20in-20BAT-20was-20positively-20related-20to-20glucose-20uptake-20in-20visceral-20WAT,-20although-20glucose-20uptake-20in-20visceral-20and-20subcutaneous-20WAT-20depots-20was-20unchanged-20upon-20cold-20acclimation.-20Cold-2Dinduced-20skeletal-20muscle-20glucose-20uptake-20tended-20to-20increase-20upon-20cold-20acclimation,-20which-20was-20paralleled-20by-20increased-20basal-20GLUT4-20localization-20in-20the-20sarcolemma,-20as-20assessed-20in-20muscle-20biopsies.-20Proximal-20skin-20temperature-20was-20increased-20and-20subjective-20responses-20to-20cold-20were-20slightly-20improved-20at-20the-20end-20of-20the-20acclimation-20period.-20These-20metabolic-20adaptations-20to-20prolonged-20mild-20cold-20exposure-20may-20lead-20to-20improved-20glucose-20metabolism-20or-20prevent-20development-20of-20obesity-2Dassociated-20insulin-20resistance-20and-20hyperglycemia." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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