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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Short-2Dchain-20fatty-20acids-20(SCFAs)-20are-20the-20main-20products-20of-20dietary-20fiber-20fermentation-20and-20are-20believed-20to-20drive-20the-20fiber-2Drelated-20prevention-20of-20the-20metabolic-20syndrome.-20Here-20we-20show-20that-20dietary-20SCFAs-20induce-20a-20peroxisome-20proliferator-2Dactivated-20receptor-20(PPAR)-20γ-2Ddependent-20switch-20from-20lipid-20synthesis-20to-20utilization.-20Dietary-20SCFA-20supplementation-20prevented-20and-20reversed-20high-2Dfat-20diet-2Dinduced-20metabolic-20abnormalities-20in-20mice-20by-20decreasing-20PPARγ-20expression-20and-20activity.-20This-20increased-20the-20expression-20of-20mitochondrial-20uncoupling-20protein-202-20and-20raised-20the-20AMP-2FATP-20ratio,-20thereby-20stimulating-20oxidative-20metabolism-20in-20liver-20and-20adipose-20tissue-20via-20AMP-2Dactivated-20protein-20kinase.-20The-20SCFA-2Dinduced-20reduction-20in-20body-20weight-20and-20stimulation-20of-20insulin-20sensitivity-20were-20absent-20in-20mice-20with-20adipose-2Dspecific-20disruption-20of-20PPARγ.-20Similarly,-20SCFA-2Dinduced-20reduction-20of-20hepatic-20steatosis-20was-20absent-20in-20mice-20lacking-20hepatic-20PPARγ.-20These-20results-20demonstrate-20that-20adipose-20and-20hepatic-20PPARγ-20are-20critical-20mediators-20of-20the-20beneficial-20effects-20of-20SCFA-20on-20the-20metabolic-20syndrome,-20with-20clearly-20distinct-20and-20complementary-20roles.-20Our-20findings-20indicate-20that-20SCFAs-20may-20be-20used-20therapeutically-20as-20cheap-20and-20selective-20PPARγ-20modulators." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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