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Property "Has-20abstract" (as page type) with input value "The-20Tim23-20protein-20is-20the-20key-20component-20of-20the-20mitochondrial-20import-20machinery.-20It-20locates-20to-20the-20inner-20mitochondrial-20membrane-20and-20its-20own-20import-20is-20dependent-20on-20the-20DDP1-2FTIM13-20complex.-20Mutations-20in-20human-20DDP1-20cause-20the-20Mohr-2DTranebjaerg-20syndrome-20(MTS-2FDFN-2D1-3B-20OMIM-20-23304700),-20which-20is-20one-20of-20the-20two-20known-20human-20diseases-20of-20the-20mitochondrial-20protein-20import-20machinery.-20We-20created-20a-20-27-27Tim23-27-27-20knockout-20mouse-20from-20a-20gene-20trap-20embryonic-20stem-20cell-20clone.-20Homozygous-20Tim23-20mice-20were-20not-20viable.-20Heterozygous-20F1-20mutants-20showed-20a-2050-25-20reduction-20of-20Tim23-20protein-20in-20Western-20blot,-20a-20-27-27neurological-20phenotype-27-27-20and-20a-20markedly-20reduced-20life-20span.-20Haploinsufficiency-20of-20the-20-27-27Tim23-27-27-20mutation-20underlines-20the-20critical-20role-20of-20the-20mitochondrial-20import-20machinery-20for-20maintaining-20mitochondrial-20function." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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