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Property "Has-20abstract" (as page type) with input value "The-20ability-20for-20the-20brain-20to-20sense-20peripheral-20fuel-20availability-20is-20mainly-20accomplished-20within-20the-20hypothalamus,-20which-20detects-20ongoing-20systemic-20nutrients-20and-20adjusts-20food-20intake-20and-20peripheral-20metabolism-20as-20needed.-20Here,-20we-20hypothesized-20that-20mitochondrial-20reactive-20oxygen-20species-20(ROS)-20could-20trigger-20sensing-20of-20nutrients-20within-20the-20hypothalamus.-20For-20this-20purpose,-20we-20induced-20acute-20hypertriglyceridemia-20in-20rats-20and-20examined-20the-20function-20of-20mitochondria-20in-20the-20hypothalamus.-20Hypertriglyceridemia-20led-20to-20a-20rapid-20increase-20in-20the-20mitochondrial-20respiration-20in-20the-20ventral-20hypothalamus-20together-20with-20a-20transient-20production-20of-20ROS.-20Cerebral-20inhibition-20of-20fatty-20acids-2DCoA-20mitochondrial-20uptake-20prevented-20the-20hypertriglyceridemia-2Dstimulated-20ROS-20production,-20indicating-20that-20ROS-20derived-20from-20mitochondrial-20metabolism.-20The-20hypertriglyceridemia-2Dstimulated-20ROS-20production-20was-20associated-20with-20change-20in-20the-20intracellular-20redox-20state-20without-20any-20noxious-20cytotoxic-20effects,-20suggesting-20that-20ROS-20function-20acutely-20as-20signaling-20molecules.-20Moreover,-20cerebral-20inhibition-20of-20hypertriglyceridemia-2Dstimulated-20ROS-20production-20fully-20abolished-20the-20satiety-20related-20to-20the-20hypertriglyceridemia,-20suggesting-20that-20hypothalamic-20ROS-20production-20was-20required-20to-20restrain-20food-20intake-20during-20hypertriglyceridemia.-20Finally,-20we-20found-20that-20fasting-20disrupted-20the-20hypertriglyceridemia-2Dstimulated-20ROS-20production,-20indicating-20that-20the-20redox-20mechanism-20of-20brain-20nutrient-20sensing-20could-20be-20modulated-20under-20physiological-20conditions.-20Altogether,-20these-20findings-20support-20the-20role-20of-20mitochondrial-20ROS-20as-20molecular-20actors-20implied-20in-20brain-20nutrient-20sensing." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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