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Property "Has-20abstract" (as page type) with input value "The-20presence-20of-20brown-20adipose-20tissue-20(BAT)-20in-20human-20adults-20opens-20attractive-20perspectives-20to-20treat-20metabolic-20disorders.-20Indeed,-20BAT-20dissipates-20energy-20as-20heat-20via-20uncoupling-20protein-20(UCP)1.-20Brown-20adipocytes-20are-20located-20in-20specific-20deposits-20or-20can-20emerge-20among-20white-20fat-20through-20the-20so-2Dcalled-20browning-20process.-20Although-20numerous-20inducers-20have-20been-20shown-20to-20drive-20this-20process,-20no-20study-20has-20investigated-20whether-20it-20could-20be-20controlled-20by-20specific-20metabolites.-20Here,-20we-20show-20that-20lactate,-20an-20important-20metabolic-20intermediate,-20induces-20browning-20of-20murine-20white-20adipose-20cells-20with-20expression-20of-20functional-20UCP1.-20Lactate-2Dinduced-20browning-20also-20occurs-20in-20human-20cells-20and-20-27-27in-20vivo-27-27.-20Lactate-20controls-20Ucp1-20expression-20independently-20of-20hypoxia-2Dinducible-20factor-2D1α-20and-20PPARα-20pathways-20but-20requires-20active-20PPARγ-20signaling.-20We-20demonstrate-20that-20the-20lactate-20effect-20on-20Ucp1-20is-20mediated-20by-20intracellular-20redox-20modifications-20as-20a-20result-20of-20lactate-20transport-20through-20monocarboxylate-20transporters.-20Further,-20the-20ketone-20body-20β-2Dhydroxybutyrate,-20another-20metabolite-20that-20impacts-20redox-20state,-20is-20also-20a-20strong-20browning-20inducer.-20Because-20this-20redox-2Ddependent-20increase-20in-20Ucp1-20expression-20promotes-20an-20oxidative-20phenotype-20with-20mitochondria,-20browning-20appears-20as-20an-20adaptive-20mechanism-20to-20alleviate-20redox-20pressure.-20Our-20findings-20open-20new-20perspectives-20for-20the-20control-20of-20adipose-20tissue-20browning-20and-20its-20physiological-20relevance.-0A-0A©-202014-20by-20the-20American-20Diabetes-20Association.-20Readers-20may-20use-20this-20article-20as-20long-20as-20the-20work-20is-20properly-20cited,-20the-20use-20is-20educational-20and-20not-20for-20profit,-20and-20the-20work-20is-20not-20altered." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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