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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "The-20soil-2Ddwelling-20nematode-20-27-27Caenorhabditis-20elegans-27-27-20is-20a-20bacteriovorous-20animal,-20excreting-20the-20vast-20majority-20of-20its-20nitrogenous-20waste-20as-20ammonia-20(25.3±1.2 µmol-20gFW-3Csup-3E-2D1-3C-2Fsup-3E-20day-3Csup-3E-2D1-3C-2Fsup-3E)-20and-20very-20little-20urea-20(0.21±0.004 µmol-20gFW-3Csup-3E-2D1-3C-2Fsup-3E-20day-3Csup-3E-2D1-3C-2Fsup-3E).-20Although-20these-20roundworms-20have-20been-20used-20for-20decades-20as-20genetic-20model-20systems,-20very-20little-20is-20known-20about-20their-20strategy-20to-20eliminate-20the-20toxic-20waste-20product-20ammonia-20from-20their-20bodies-20into-20the-20environment.-20The-20current-20study-20provides-20evidence-20that-20ammonia-20is-20at-20least-20partially-20excreted-20via-20the-20hypodermis.-20Starvation-20reduced-20the-20ammonia-20excretion-20rates-20by-20more-20than-20half,-20whereas-20mRNA-20expression-20levels-20of-20the-20Rhesus-20protein-20CeRhr-2D2,-20V-2Dtype-20H-3Csup-3E+-3C-2Fsup-3E-2DATPase-20(subunit-20A)-20and-20Na-3Csup-3E+-3C-2Fsup-3E-2FK-3Csup-3E+-3C-2Fsup-3E-2DATPase-20(α-2Dsubunit)-20decreased-20correspondingly.-20Moreover,-20ammonia-20excretion-20rates-20were-20enhanced-20in-20media-20buffered-20to-20pH-205-20and-20decreased-20at-20pH-209.5.-20Inhibitor-20experiments,-20combined-20with-20enzyme-20activity-20measurements-20and-20mRNA-20expression-20analyses,-20further-20suggested-20that-20the-20excretion-20mechanism-20involves-20the-20participation-20of-20the-20V-2Dtype-20H-3Csup-3E+-3C-2Fsup-3E-2DATPase,-20carbonic-20anhydrase,-20Na-3Csup-3E+-3C-2Fsup-3E-2FK-3Csup-3E+-3C-2Fsup-3E-2DATPase,-20and-20a-20functional-20microtubule-20network.-20These-20findings-20indicate-20that-20ammonia-20is-20excreted,-20not-20only-20by-20apical-20ammonia-20trapping,-20but-20also-20via-20vesicular-20transport-20and-20exocytosis.-20Exposure-20to-201 mmol-20l-3Csup-3E-2D1-3C-2Fsup-3E-20NH4Cl-20caused-20a-2010-2Dfold-20increase-20in-20body-20ammonia-20and-20a-20tripling-20of-20ammonia-20excretion-20rates.-20Gene-20expression-20levels-20of-20CeRhr-2D1-20and-20CeRhr-2D2,-20V-2DATPase-20and-20Na-3Csup-3E+-3C-2Fsup-3E-2FK-3Csup-3E+-3C-2Fsup-3E-2DATPase-20also-20increased-20significantly-20in-20response-20to-201 mmol-20l-3Csup-3E-2D1-3C-2Fsup-3E-20NH4Cl.-20Importantly,-20a-20functional-20expression-20analysis-20showed,-20for-20the-20first-20time,-20ammonia-20transport-20capabilities-20for-20CeRhr-2D1-20in-20a-20phylogenetically-20ancient-20invertebrate-20system,-20identifying-20these-20proteins-20as-20potential-20functional-20precursors-20to-20the-20vertebrate-20ammonia-2Dtransporting-20Rh-2Dglycoproteins." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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