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Property "Has-20abstract" (as page type) with input value "Type-202-20diabetes-20is-20associated-20with-20impaired-20exercise-20capacity.-20Alterations-20in-20both-20muscle-20perfusion-20and-20mitochondrial-20function-20can-20contribute-20to-20exercise-20impairment.-20We-20hypothesized-20that-20impaired-20muscle-20mitochondrial-20function-20in-20type-202-20diabetes-20is-20mediated,-20in-20part,-20by-20decreased-20tissue-20oxygen-20delivery-20and-20would-20improve-20with-20oxygen-20supplementation.-20-27-27Ex-20vivo-27-27-20muscle-20mitochondrial-20content-20and-20respiration-20assessed-20from-20biopsy-20samples-20demonstrated-20expected-20differences-20in-20obese-20inspaniduals-20with-20(N=18)-20and-20without-20(N=17)-20diabetes.-20Similarly,-20-27-27in-20vivo-27-27-20mitochondrial-20oxidative-20phosphorylation-20capacity-20measured-20in-20the-20gastrocnemius-20muscle-20via-20-3Csup-3E31-2D-3C-2Fsup-3EPhosphorus-20magnetic-20resonance-20spectroscopy-20(-3Csup-3E31-3C-2Fsup-3EP-20MRS)-20indicated-20an-20impairment-20in-20the-20rate-20of-20ADP-20depletion-20with-20rest-20(27±6-20seconds-20diabetes,-2021±7-20controls-3B-20p=0.008)-20and-20oxidative-20phosphorylation-20(p=0.046)-20in-20type-202-20diabetes-20following-20isometric-2Dcalf-20exercise-20compared-20to-20controls.-20Importantly,-20the-20-27-27in-20vivo-27-27-20impairment-20in-20oxidative-20capacity-20resolved-20with-20oxygen-20supplementation-20in-20adults-20with-20diabetes-20(ADP-20depletion-20rate-205.0-20seconds-20faster-3B-20p=0.012,-20oxidative-20phosphorylation-200.046±0.079-20mmol-2FL-2Fsec-20faster,-20p=0.027).-20Multiple-20-27-27in-20vivo-27-27-20mitochondrial-20measures-20related-20to-20HbA1C.-20These-20data-20suggest-20that-20oxygen-20availability-20is-20rate-2Dlimiting-20for-20-27-27in-20vivo-27-27-20mitochondrial-20oxidative-20exercise-20recovery-20measured-20with-20-3Csup-3E31-2D-3C-2Fsup-3EP-20MRS-20in-20inspaniduals-20with-20uncomplicated-20diabetes.-20Targeting-20muscle-20oxygenation-20could-20improve-20exercise-20function-20in-20type-202-20diabetes." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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