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Truu 2017 Abstract IOC122 - Revision history
2024-03-29T08:36:44Z
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https://wiki.oroboros.at/index.php?title=Truu_2017_Abstract_IOC122&diff=135909&oldid=prev
Kandolf Georg at 13:57, 30 May 2017
2017-05-30T13:57:43Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Tallinn Univ <del style="font-weight: bold; text-decoration: none;">Technology</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::Truu L(1), Chekulayev V(1), Klepinin A(1), Ounpuu L(1), Tepp K(1), Puurand M(1), Koit A(1), Shevchuk I (1), Kaambre T(1,2)</ins></div></td></tr>
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Truu_2017_Abstract_IOC122&diff=135900&oldid=prev
Kandolf Georg at 12:42, 30 May 2017
2017-05-30T12:42:53Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|title=Bioenergetics of colorectal cancer.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=Mitochondr Physiol Network 22.01</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=Mitochondr Physiol Network 22.01</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|authors=Truu L, Chekulayev V, Klepinin A, Ounpuu L, Tepp K, Puurand M, Koit A, Shevchuk I, Kaambre T</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2017</div></td></tr>
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|abstract=Bioenergetics is a fast growing field in cancer research, where many promising outcomes could provide targeted cancer treatment. Energy metabolism specific literature is characterized by many contradictions, concluding that cancer cells metabolize their increased glucose uptake via glycolysis rather than more energy efficient oxidative phosphorylation (OXPHOS). Furthermore, the majority of these conclusions are the outcome of only ''in vitro'' studies on cell culture models, without taking into consideration the factors arising from the tumor microenvironment giving significant effects ''in vivo''. We have conducted quantitative cellular respiration analysis on normal colon tissue, colorectal cancer (HCC) clinical tissue samples and CaCo-2 cell cultures. Our results show that HCC is not a fully glycolytic tumor and OXPHOS system might be the main source of ATP. Comparing healthy colon, HCC tissue and CaCo-2 cells, we found elevated rates of maximal ADP-activated respiration and greater activity of respiratory complex (C) II over CI in both HCC and CaCo-2 cells, whereas the opposite result in healthy tissue was present. These results indicate that the bioenergetic profile of Caco-2 cells corresponds generally to HCC tissue. Further research is in progress to generate a full cancer development model consisting of cell cultures, clinical polyps and malignant versus healthy tissue samples.</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td></tr>
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Truu_2017_Abstract_IOC122&diff=135899&oldid=prev
Kandolf Georg: Created page with "{{Abstract |info=Mitochondr Physiol Network 22.01 |year=2017 |event=IOC122 }} {{Labeling}} == Affiliations =="
2017-05-30T12:22:24Z
<p>Created page with "{{Abstract |info=Mitochondr Physiol Network 22.01 |year=2017 |event=IOC122 }} {{Labeling}} == Affiliations =="</p>
<p><b>New page</b></p><div>{{Abstract<br />
|info=Mitochondr Physiol Network 22.01<br />
|year=2017<br />
|event=IOC122<br />
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{{Labeling}}<br />
== Affiliations ==</div>
Kandolf Georg