Uncoupler: Difference between revisions
From Bioblast
No edit summary |
No edit summary |
||
Line 2: | Line 2: | ||
|abbr=''u'' | |abbr=''u'' | ||
|description=An '''uncoupler''' is a protonophore ([[FCCP]], [[CCCP]], [[DNP]]) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. See also: [[Uncoupled respiration]]. | |description=An '''uncoupler''' is a protonophore ([[FCCP]], [[CCCP]], [[DNP]]) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. See also: [[Uncoupled respiration]]. | ||
|type=Chemicals | |type=Chemicals | ||
}} | }} | ||
Line 10: | Line 9: | ||
|kinetics=Inhibitor; Uncoupler | |kinetics=Inhibitor; Uncoupler | ||
}} | }} | ||
[http://www.bmb.leeds.ac.uk/illingworth/oxphos/poisons.htm Wikipedia] |
Revision as of 12:40, 16 September 2010
Description
An uncoupler is a protonophore (FCCP, CCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. See also: Uncoupled respiration.
Abbreviation: u
Labels:
HRR: Chemicals; Media"Chemicals; Media" is not in the list (Oxygraph-2k, TIP2k, O2k-Fluorometer, pH, NO, TPP, Ca, O2k-Spectrophotometer, O2k-Manual, O2k-Protocol, ...) of allowed values for the "Instrument and method" property.