Difference between revisions of "Vendelin 2018 MiPschool Tromso D2"

Revision as of 14:22, 2 October 2018

Modeling actomyosin contraction in the heart muscle.

Link: MitoEAGLE

Vendelin M (2018)

Event: MiPschool Tromso-Bergen 2018

In this talk, I will give an introduction to the models of cross-bridge cycle. With the simple examples, challenges in the modeling of this system will be explained. Theoretical background on how to link generation of mechanical force to ATP hydrolysis will be given.

• Bioblast editor: Beno M, Plangger M

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Affiliations

Lab Systems Biology, Inst Cybernetics, Tallinn, Estonia

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 {{Abstract
-|title=[[File:Vendelin Marko.jpg|left|90px|Marko Vendelin]] Restrictions to intracellular diffusion of ATP and ADP in cardiomyocytes.
+|title=[[File:Vendelin Marko.jpg|left|90px|Marko Vendelin]] Modeling actomyosin contraction in the heart muscle.
 |info=[[MitoEAGLE]]
 |authors=Vendelin M
@@ Line 6: / Line 6: @@
 |event=MiPschool Tromso-Bergen 2018
 |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MitoEAGLE]]
-In this talk, I will review the evidence of compartmentalization in the heart muscle cell. On the example of ATP and ADP diffusion, I will show how the system can be studied and which experimental approaches have been applied to analyze the movements of molecules in the cardiac cell. The creatine kinase system and its role in energy transfer between mitochondria, actomyosin and EC coupling system will be discussed.
+In this talk, I will give an introduction to the models of cross-bridge cycle. With the simple examples, challenges in the modeling of this system will be explained. Theoretical background on how to link generation of mechanical force to ATP hydrolysis will be given.
 |editor=[[Beno M]], [[Plangger M]],
 }}