Search results

...VA (2000) Rapid spectrophotometric method for quantitation of cytochrome c release from isolated mitochondria or permeabilized cells revisited. Biochim Biophy |authors=Appaix F, Minatchy M-N, Riva-Lavieille C, Olivares J, Antonsson B, Saks VA

...ee WK, Bork U, Gholamrezaei F, Thévenod F (2005) Cd2+-induced cytochrome c release in apoptotic proximal tubule cells: role of mitochondrial permeability tran ...nhibitors (La3+, ruthenium red, Ru360) prevented swelling and cytochrome c release; and 2) ruthenium red attenuated Cd²⁺ inhibition of PO43–-indu

...ker E (1972) Ion transport and respiratory control in vesicles formed from cytochrome oxidase and phospholipids. J Biol Chem 247:1338-9. ...in with reduced 1,4-naphthoquinone-2-sulfonate as reductant for cytochrome c. With ascorbate as reductant 3- to 5-fold stimulation of respiration was ob

...(2002) Mitochondrial respiration at low levels of oxygen and cytochrome ''c''. Biochem Soc Trans 30:242-8. ...p''-phenylenediamine dihydrochloride (TMPD)­ascorbate] respectively at 30 °C and with maximum ADP stimulation ([[OXPHOS]]).

|title=Borrás C, Gambini J, López-Grueso R, Pallardó FV, Viña J (2010) Direct antioxidan |authors=Borras C, Gambini J, Lopez-Grueso R, Pallardo FV, Vina J

|authors=Quirin C, Cendron L, Cuzzolin A, Moro S, Scorrano L ...ical inhibition of the GTPase activity of Opa1 can facilitate cytochrome c release by inducing the opening of the cristae, and consequently sensitizing cells

...r R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physio ...he Complex I defect and uncoupling correlated with heterogeneous Cyt ''c'' release, the extent of which increased with loss of cardiac performance. These resu

...mitochondria was preserved, apart from the slight degree of cytochrome c release, either through a pore formed by the oligomerisation of BAK in coupled mito

...permeabilization of mitochondrial membranes and the release of cytochrome c remain unclear. To clarify these mechanisms, we examined the effects of bra |keywords=Cytochrome c, Lipid phase, Mitochondria, Permeability transition, Polyethyleneimine

...fication of the outer mitochondrial membrane and the release of cytochrome c during reoxygenation. This action of nitrite protects mitochondrial functio |keywords=Cytochrome c, Cytoprotection, Iron ions, Lipid peroxidation, Mitochondria, Nitrite, Rats

...aglivo Eleonora]]Baglivo E, Timon-Gomez A, Gnaiger E (2023) The cytochrome c test for respirometric quality control of the integrity of the mitochondria ...associated with apoptosis. Stimulation of respiration by added cytochrome c indicates damage of the mtOM. This respirometric test for mtOM integrity pr

...s associated with HK2 release [2]. However, it remains unclear whether HK2 release is the primary signal mediating ischaemia-induced mitochondrial damage. Her ...e perfusion protocol. Moreover, HK2 depletion alone does not promote cyt c release. Surprisingly, complete removal of HK2 neither enhanced mPTP opening nor al

...ilateral carotid artery occlusion and hypotension. No loss of cytochrome ''c'' from mitochondria was observed in any model of cerebral ischemia. This su ...iously for heart ischemia where it was found that the loss of cytochrome ''c'' from mitochondria is the earliest event in ischemic mitochondrial damage

|abbr=c ...o test the integrity of the [[mitochondrial outer membrane]] ([[cytochrome c control efficiency]]).

|title=Schnaitman C, Erwin VG, Greenawalt JW (1967) The submitochondrial localization of monoam |authors=Schnaitman C, Erwin VG, Greenawalt JW

|abbr=''j''_{cyt ''c''} ...ed flux; CHNO is the [[background state]] with CHNO substrates, upon which c is added:

...mitochondrial permeability transition pore and resultant cytochrome ''c'' release. J Biol Chem 287:29837-50. ...n to wild-type littermates. In support of these findings, cytochrome ''c'' release from iPLA_2γ(-/-) mitochondria was dramatically decreased in res

...t therefore appears that, at concentrations required to inhibit cytochrome c peroxidase activity, TPP-IOA perturbs oxidative phosphorylation. In light o |keywords=Apoptosis, Cytochrome c, Oxidative phosphorylation, Peroxidase, TPP-IOA, Triphenylphosphonium

...ates hair graying. The anti-apoptotic Bcl2 protein suppresses cytochrome c release from mitochondrial cristae [2,3]. These reports suggest that mitochondria p ...of Opa1, which keeps cristae structures tight and suppresses cytochrome c release, is less well established in melanocytes and melanoma. Remarkably, we found

...ecanati MA, Grossman LI, Lee I, Edwards BFP, Hüttemann M (2020) Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and ...t a new model proposing that the electron transfer from Cytc to cytochrome c oxidase is the rate-limiting step of the ETC, which is regulated via post-t

...n host cells by measuring Annexin V staining and the release of cytochrome c; also the enzymatic activity of acid sphingomyelinase and the formation of ...is reduced death, on the other hand, is associated with an increase in the release of interleukin-8 from pyocyanin- activated acid sphingomyelinase-deficient

|authors=Pereira Goncalo C, Lee Laura, Rawlings Nadia, Ouwendijk Joke, Parker Joanne E, Andrienko Taty ...ture would destabilize outer / inner membrane interactions, increase cyt-c release and enhance mPTP sensitivity to [Ca²⁺].

...nternalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris. J Autoimmun 47:45-57. ...rnalised, aPL increased inner mitochondrial membrane leak and Cytochrome c release while depressing oxidative flux through Complex IV of the electron transpor

...ed by the mitochondrial pyruvate carrier inhibitor UK5099 and cytochrome c release induced by the anti-apoptotic BCL-2 family protein inhibitor ABT-737.

|title=Hogeboom GH, Claude A, Hotchkiss RD (1946) The distribution of cytochrome oxidase and succinoxidase in the cytoplasm of the mammalian liver cell. J B |keywords=Cytochrome oxidase, Succinoxidase, Liver cell extract

...educing [[oxygen]] to [[water]], with reduced [[cytochrome c |cytochrome ''c'']] as a substrate. Concomitantly to that, CIV [[Proton pump|pumps protons] ::::Electron flow through [[Complex IV]] (CIV / cytochrome ''c'' oxidase, COX) is measured in intact mitochondria after inhibition of [[Co

...d III enzyme activity in EC. Mitochondria-associated intracellular ROS and release of ROS from EC were significantly increased after eoLDL treatment. These fi ...I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase

...d mitochondrial permeability transition pore-related release of cytochrome c and subsequent cell death [1]. In this study we sought to determine whether ...t cells died by necrosis. Pre-treatment of brain with NOC-18 abolished LDH release by 33% compared to ischemia. KT5823 applied together with NOC-18 restored n

...cytochrome c from the organelles. ItA by itself promotes the cytochrome c release from mitochondria. Possible mechanisms of the effect of ItA on mitochondria

|abstract='''Authors:''' [[Whitcomb Luke A]], [[Li Puma Lance C]], [[Zilhaver PT]], [[Izon CS]], [[Chicco Adam J]]<br><br> ...greater impacts on old, largely abolishing the effect of aging on both ROS release and mPTP opening. Similar attenuation of mPTP opening was seen following i

|title=Ma L, Dong JX, Wu C, Li XY, Chen J, Zhang H, Liu Y (2017) Spectroscopic, polarographic, and mic |authors=Ma L, Dong JX, Wu C, Li XY, Chen J, Zhang H, Liu Y

...ed to LDL or control. The abundance of mitochondria-associated ROS and the release of ROS from EC were significantly increased after glyLDL treatment. The fin

...RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N (2010) Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing. https://doi ...S, Derfuss T, Krug A, Gnaiger Erich, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N

...II dissociation during ischemia correlates with mitochondrial cytochrome c release, reactive oxygen species production, and infarct size on reperfusion. J Am ...b>O₂ production in the presence and absence of added cytochrome c in isolated mitochondria and permeabilized fibers. IP prevented OMM permeab

|title=Debska G, May R, Kicinska A, Swewczyk A, Elger C, Kunz WS (2001) Potassium channel openers depolarize hippocampal mitochondr |authors=Debska G, May R, Kicinska A, Swewczyk A, Elger C, Kunz WS

...ome ''c'' release. As a molecule that interacts directly with cytochrome ''c'', TPP-IOA may also affect mitochondrial respiration. We are evaluating the

...nirole failed to suppress respiratory chain-linked reactive oxygen species release. In conclusion, our data suggest that the neuroprotective activity of ropin '''Abbreviations''': CsA, cyclosporin A; Cyt c, cytochrome c; FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; IC50, inhibito

...''c'' oxidoreductase; cytochrome bc1 complex), are known to predominantly release superoxide and the derived hydrogen peroxide (H₂O₂) i

...potential, improvement of mitochondrial respiration, inhibition of cyto-c release, suppression of caspase-9. Furthermore, CoQ10 enhanced mitochondrial biogen

...rity is lost, depressing ATP synthesis capacity and promoting cytochrome c release, prior to THF. Mitochondria can mediate HF in heat stressed hearts in fish

...oproteins such as guanylate cyclase, haemoglobin, myoglobin and cytochrome c oxidase (CcOX). The NO-CcOX interaction is of particular interest, being r ...de reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356: 295-298.

|authors=Bean C, Varanita T, Favaretto F, Vettor R, Scorrano L ...1 (Opa1) protects multiple tissues from damage by regulating cytochrome c release and mitochondrial respiratory efficiency, but whether this is mirrored by s

|title=Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis i ...respiration [1-3]. There is no consensus as to the threshold of ''FCF_c'' applied as a quantitative exclusion criterion in permeabilized fibe

|title=Marshall C, Mamary AJ, Verhoeven AJ, Marshall BE (1996) Pulmonary artery NADPH-oxidase |authors=Marshall C, Mamary AJ, Verhoeven AJ, Marshall BE

...he redox state of cytochromes – principally cytochrome c and aa3, but also cytochrome b. The first approach to measuring cytochrome absorption spectra in the O2k respirometer used a specially designed stoppe

...ling of oxidative phosphorylation and the pronounced release of cytochrome c from mitochondria were absent after cold storage but developed during reper |topics=Cyt c, Ion;substrate transport, Substrate, Temperature

...ere partially preserved by CH₄ , and additionally, cytochrome c release and apoptosis of cardiomyocytes were reduced in the CH₄ -treated

|title=Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A (2018) Dea |authors=Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A

...energy status, oxidative stress, disturbance of ion balance, cytochrome c release, and induction of apoptosis.^1-3 Improved understanding of preser

...Palacios-Callender M, Springett RJ, Delpy DT, Moncada S (2003) Monitoring cytochrome redox changes in the mitochondria of intact cells using multi-wavelength vi ...which cells maintain their VO(2) at low [O(2)]. This, in turn, favors the release of O(2)(-), which initiates the transcriptional activation of NF-kappa B as

...reduction site. For complex III, we hypothesize that each CLP binds to the cytochrome b subunit and the Fe-S subunit to inhibit the required rotational movement

...ub>i</sub>-dependent swelling of mitochondria, suppression of cytochrome c release, and an increase in the Ca²⁺ capacity of the organelles. BDQ als ...I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase

|title=Rauchova H, Drahota Z, Bergamini C, Fato R, Lenaz G (2008) Modification of respiratory-chain enzyme activities |authors=Rauchova H, Drahota Z, Bergamini C, Fato R, Lenaz G

...d unfolded protein responses. Our data suggest that the lost of cytochrome c and disrupted ATP synthesis are the predominant mitochondrial response to h

...ant experimental considerations: malate concentration and the cytochrome ''c'' effect. |authors=Kane DA, Kane C, George M

...rifted away from bioenergetics since the discovery of cytochrome c (Cyt c) release as a signal for programmed cell death. Complex I has been shown to generate

...sing rapid swelling and rupture of mitochondria with release of cytochrome c. The inner membrane anion channel (IMAC) is altered by micafungin to transf

...rklund A, Balasuriya C, Scholz H, Grill V (2017) Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hypero |authors=Hals I, Ohki T, Singh R, Ma Z, Bjoerklund A, Balasuriya C, Scholz H, Grill V

...M, Romio M, Manago A, Becker K, Mattarei A, Zoratti M, Gulbins E, Paradisi C, Leanza L, Szabo I ...depolarization, production of mitochondrial ROS and release of cytochrome c. Downregulation by siRNA of Kv1.3 prevented all these effects, indicating s

...I activity compared to vehicle-treated mice. ''In vitro'', the rate of FMN release during oxidation of succinate was not affected by the oxygen level and amou ...ition defining respiratory chain failure in I/R. Strategies preventing FMN release during HI and reperfusion may limit the extent of energy failure and cerebr

|title=Menin L, Panchichkina M, Keriel C, Olivares J, Braun U, Seppet EK, Saks VA (2001) Macrocompartmentation of to |authors=Menin L, Panchichkina M, Keriel C, Olivares J, Braun U, Seppet EK, Saks VA

...h coupled and uncoupled states. Activities of citrate synthase, cytochrome c oxidase (COX), catalase and aconitase, and the excess capacity of COX at hi ...28 °C) whereas it is quite high at a lower temperature (12 °C), suggesting release of respiration control by COX at low temperature.

|title=Roy J, Fauconnier J, Oger C, Farah C, Angebault-Prouteau C, Thireau J, Bideaux P, Scheuermann V, Bultel-Poncé V, Demion M, Galano JM, |authors=Roy J, Fauconnier J, Oger C, Farah C, Angebault-Prouteau C, Thireau J, Bideaux P, Scheuermann V, Bultel-Poncé V, Demion M, Galano JM,

|title=Paech F, Mingard C, Grünig D, Abegg VF, Bouitbir J, Krähenbühl S (2018) Mechanisms of mitoc |authors=Paech F, Mingard C, Gruenig D, Abegg VF, Bouitbir J, Kraehenbuehl S

...miech M, Büchele B, Schäfer P, Arnim CA, Calzia, E, Feuring‐Buske M, Buske C, Vick B, Jeremias I, Syrovets T, Simmet T (2019) Gold nanoparticles with se ...iech M, Buechele B, Schaefer P, Arnim CA, Calzia E, Feuring‐Buske M, Buske C, Vick B, Jeremias I, Syrovets T, Simmet T

|title=Quoilin C (2014) Les effets délétères métaboliques et oxydants induits lors d'un |authors=Quoilin C

...e aggravated these changes in a concentration-dependent manner. Cytochrome c completely restored respiration with succinate but not with glutamate, sugg ...us, preventing damage to the outer mitochondrial membrane and cytochrome c release. The involvement of Complex I in the mechanisms of nitrite-mediated cytopro

...riati A, Hassoun SM, Mortier L, Vienne JC, Briand G, Formstecher P, Bailly C, Nevière R, Marchetti P (2010) Inhibition of mitochondrial respiration med ...riati A, Hassoun SM, Mortier L, Vienne JC, Briand G, Formstecher P, Bailly C, Neviere R, Marchetti P

|title=Bouillaud F, Andriamihaja M, Mimoun S, Ransy C, Chaumontet C, Blachier F (2013) Adaptation of mitochondria in colonocytes to hydrogen su |authors=Bouillaud F, Andriamihaja M, Mimoun S, Ransy C, Chaumontet C, Blachier F

|title=[[File:Cristiane Cecatto.jpg|left|100px|Cristiane Cecatto]]Cecatto C, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is low ...into the cytosolic space of several other substances such as cytochrome ''c''. We measured net calcium uptake and respiration simultaneously in mitocho

...y transfer efficiency was evidenced by a decreased release of cytochrome ''c'' and preserved half-saturation constant of respiration for ADP and adenine |enzymes=Complex IV;cytochrome c oxidase, Inner mt-membrane transporter

...e matrix calcium loads that are independent of infusion rate. Cytochrome c release precedes the permeability transition. Cyclosporin A enhances the loading ca |editor=[[Cecatto C]]

mitochondrial membranes leading to the release of cytochrome c protein kinases C and G which, in turn, may increase resistance of

...t stress causes oscillation of the mPTP prior to reperfusion. Cytochrome c release from mitochondria to the cytosol was not detected until after reperfusion,

...ospholipids, and this impairs membrane integrity and leads to cytochrome c release into cytosol and apoptosis. Group VIA phospholipase A₂ (iPLA₂β) appear

...ted elevation of cytosolic Ca²⁺ concentration ([Ca²⁺]c) suggests an additional effect on the endoplasmic reticulum (ER) leading to ...n, Oub, Oub-BODIPY, RLU/s, St, TMRE, Z-LEHD-FMK, ZLF, [Ca(2+)](c), [Na(+)](c), Arbitrary fluorescence units, Bromide (3-[4,5-dimethyltiazol-2-yl]-2,5-di

|title=Scrima R, Menga M, Pacelli C, Agriesti F, Cela O, Piccoli C, Cotoia A, De Gregorio A, Gefter JV, Cinnella G, Capitanio N (2017) Para-hy |authors=Scrima R, Menga M, Pacelli C, Agriesti F, Cela O, Piccoli C, Cotoia A, De Gregorio A, Gefter JV, Cinnella G, Capitanio N

...-density.jpg|right|400px]] Mitochondrial damage with release of cytochrome c is implicated in cell death signalling pathways. To examine mitochondrial f |topics=Coupling efficiency;uncoupling, Cyt c

...er CJ (2012) A radical approach to beating hypoxia: depressed free radical release from heart fibers of the hypoxia-tolerant epaulette shark (''Hemiscyllum oc ...tive shovelnose ray halved oxidative phosphorylation flux and cytochrome ''c'' oxidase flux was depressed by 34% following hypoxic stress. In contrast,

...ts as a receptor-like protein for BH3-only BID, important for cytochrome c release and for Fas-induced liver apoptosis in vivo. On the other hand, in the DNA

...P production at high concentrations. Only halothane increased cytochrome c release indicating damage of the mitochondrial membrane. In summary, volatile gener

|title=Lin Y, Nan J, Shen J, Lv X, Chen X, Lu X, Zhang C, Xiang P, Wang Z, Li Z (2020) Canagliflozin impairs blood reperfusion of is ...malfunction in BM-MSCs and the inhibition of ATP production, cytochrome c release and vessel endothelial growth factor A (VEGFA) secretion, which may contrib

...e activities in population-specific manners. Chronic hypoxia decreased the release of reactive oxygen species by isolated mitochondria in both populations. Th ...I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase

...ondria through a mechanism that does not involve the release of cytochrome c. We also demonstrate that these improved isolation and assay procedures are

..., cytochrome c, located on the outer face of inner membrane, complex IV or cytochrome oxidase. Finally 4 e− are transferred to 2 O atoms, which with 4 H+ form

...ankova H, Sticova E, Burian M, Drahota Z, Cervinkova Z, Kucera O, Gladkova C, Stopka P, Krizova J, Papackova Z, Oliyarnyk O, Kazdova L (2016) Metformin ...ankova H, Sticova E, Burian M, Drahota Z, Cervinkova Z, Kucera O, Gladkova C, Stopka P, Krizova J, Papackova Z, Oliyarnyk O, Kazdova L

...neration of mitochondria is paralleled by a decline of the NADH-cytochrome c reductase activity (reflecting combined enzymatic activity of Complex I plu

...rity is lost, depressing ATP synthesis capacity and promoting cytochrome c release, prior to THF. It was concluded that mitochondria can mediate HF in heat st ...lation efficiencies (depressed respiratory control ratio, RCR), cytochrome c oxidase (CCO) flux and ET-pathway flux. In situ assays conducted across a r

...ription factor Nrf-2, and the anti-inflammatory cytokines IL-10 and IL-1ra release, which would induce the inhibition of the inflammasome activation. Altogeth ...I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase

...could explain the cytosolic release of the proapoptotic protein cytochrome c in cryopreserved cells. Nevertheless, no caspase 9-3 activation and only fe

...ation, but ischemia- induced MPTP does not cause the release of cytochrome c. The inhibition of MPTP formation just partly protected against necrosis [1

|title=Doleželová E, Kunzová M, Dejung M, Levin M, Panicucci B, Regnault C, Janzen CJ, Barrett MP, Butter F, Zíková A (2020) Cell-based and multi-om ...the emerging concept that mitochondria act as signaling organelles through release of ROS to drive cellular differentiation.

...J, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via ex ...nferrari Giulia, Rogall Rebecca, Fernandez-Vizarra Erika, Williamson James C, Braga Alice, van den Bosch Aletta, Leonardi Tommaso, Krzak Grzegorz, Kitte

...ub>i</sub>-dependent swelling of mitochondria, suppression of cytochrome c release, and an increase in the Ca²⁺ capacity of the organelles. BDQ als

...n of the release of NO from a chemical source (DETA-NO) and the endogenous release from controlled intracellular NO production. We determined the inhibition o

...tosolic cytochrome C, coincident with strong annexin V binding, P selectin release from lysed platelets and in plasma MPs compared to controls (p<0.05). These

cytochrome c release. MC-dependent swelling was associated with mitochondrial

...oscopy fiber-optic system (Ocean Optics, USA). The release of cytochrome ''c'' from mitochondria was determined using western-blot analysis. ...les (cytochrome ''c'', AIF etc.). BDQ prevents the release of cytochrome ''c'' from mitochondria.

...ochondrial membrane protein that controls cristae remodeling, cytochrome c release and apoptosis. OPA1 cleavage was dependent upon both ROS and the OMA1 mitoc

...perhaps because the adipocyte isolation requires lengthy incubation at 37°C, potentially reversing any changes that occur in torpor. Such changes may i ...I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase

....0 mg) were permeabilized by saponin [1]. Using SUIT protocol (G, M, P, D, c, S, Rot, Ama, As+Tm, Azd) standard respiratory states (LEAK, OXPHOS, and RO ...Complex II (OXPHOS II), Complex I respiration was not affected. Cytochrome c oxidase (Complex IV) respiration was also decreased in sepsis.

...cells (PASMC), acute hypoxia-induced redox changes of NADH and cytochrome c, and superoxide production. In contrast, AOX did not affect the development

...on human aortic endothelial cells. MPs decreased ''in vitro'' nitric oxide release by human aortic endothelial cells, whereas ''in vivo'' MP injection into mi |enzymes=Complex IV;cytochrome c oxidase

...ers the release of calcium and several other substances such as cytochrome c. We measured calcium uptake and respiration in mitochondria isolated from m

...ochondrial permeability transition pores and subsequenced cytochrome ''c'' release. It is anticipated that NO through cGMP-dependent mechanisms can activate

...mitochondrial permeability transition pores and subsequenced cytochrome c release. It is anticipated that NO through cGMP-dependent mechanisms can activate

...roscopy fiber-optic system (Ocean Optics, USA). The amount of cytochrome ''c'' released from mitochondria was determined spectrophotometrically at 414 n ...rome ''c'', a proapoptotic protein. It can, therefore, be assumed that the release of this proapoptotic protein and the subsequent initiation of programmed ce

...iferation, in addition to inducing the release of mitochondrial cytochrome c and activating caspases-9 and -3. Transfection with FASN siRNA did not resu

|title=Gnaiger Erich, Wright-Paradis C, Sondergaard H, Lundby C, Calbet Jose AL, Saltin Bengt, Helge J, Boushel R (2005) High-resolution re |authors=Gnaiger Erich, Wright-Paradis C, Sondergaard H, Lundby C, Calbet Jose AL, Saltin Bengt, Helge J, Boushel R

...), ('''''b''''') the proton pumps ([[proton slip]]; decoupling), and ('''''c''''') is regulated by molecular uncouplers ([[uncoupling proteins]], UCP1). ...r R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physio

...ansition pore opening, membrane potential dissipation and cytochrome ''c'' release, which are key pathogenic events during stroke. This molecule also prevente

...on of ''N. celidotus'' at their winter low of 15 °C and summer high of 21 °C revealed that the RCR values of heart mitochondria from warm acclimated ani # Portner HO, Mark FC, Bock C (2004) Oxygen limited thermal tolerance in fish? Answers obtained by nuclea

...], indicating that AOX is also thermogenic in ''Drosophila'' and/or it can release developmental constraints imposed on the ETS. ...48% higher and the latter ~33% lower than in w¹¹¹⁸ flies. At 12°C, AOX inhibition led to a ~37% decrease in mGPDH-driven coupled respiration,

...changes in human skeletal muscle mitochondrial H₂O₂ release, respiration and cell signaling as endurance exercise even with less work. ...pen Access] »[[File:O2k-brief.png|36px|link=http://wiki.oroboros.at/images/c/c0/Trewin_2018_Ama_J_Physiol_Regul_Integr_Comp_Physiol_O2k-brief.pdf |O2k-b

...eabilized fibres using high-resolution respirometry ([[Oroboros O2k]]; 37 °C) for functional mitochondrial diagnosis. Replicate measurements (''n''=5 t ...the outer mitochondrial membrane was maintained for 16 h, but cytochrome ''c'' stimulation was significant after 140 h of preservation (2.7±0.9, 2.9±1

...N₂O₃); Life Technologies, R302, 25 mg, store at -20 °C, M = 380.83 g·mol^-1 ::::# Store at -20 °C.

...ectron transfer of the NADH- and succinate-linked pathways, and cytochrome c oxidase activity of the autism lymphoblastoid cell line were higher. Mitoch |keywords=autism spectrum disorders, oxidative phosphorylation, cytochrome ''c'' oxidase activity, mitochondrial membrane potential, mitochondrial disease

...Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, ::::* Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2017) Impairment of mitochondrial respirat

...rague Dawley rats. The ovariectomized rats were treated with either a 21 d release, 0.5 mg of 17 -estradiol pellet (OVX+E) or placebo (OVX). The OCR was me ...I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase

...-Boas Eloisa A, Amaral Andressa G, Ohya Georgia, Caldeira da Silva Camille C, Kowaltowski Alicia J ...hondrial membrane (OMM) integrity was assessed with exogenous cytochrome ''c''. Calcium transport was measured following concentrations in the extramito

...Sigma T5428, store at 2-8 °C or ThermoFischer T 668; 25 mg, store at -20 °C; M = 500.93 g·mol^-1 ::::# Store at -20 °C.

...mpairment in 120 hpf embryos. (A) Basal respiration. (B) ETS capacity. (C) Percentage of proton leak. (D) L/E (proton leak/ETS) ratio. Melatonin res ...ia in producing melatonin and driving GPCR signaling to block cytochrome c release. PNAS doi/10.1073/pnas.1705768114.

::::* Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2 ...ewer GJ (2009) Critical age-related loss of cofactors of neuron cytochrome c oxidase reversed by estrogen. Exp Neurology 215: 212-219]]

...ijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gn :::* Boushel R, Gnaiger E, Calbet JA, Gonzalez-Alonso J, Wright-Paradis C, Sondergaard H, Ara I, Helge JW, Saltin B (2011) Muscle mitochondrial capac

...the product of [[elementary charge]], ''e'' = 1.602176634∙10^-19 C/x, and the [[Avogadro constant]], ''N''_A = 6.02214076∙10<sup>2 - [[Elementary charge]] of O₂ in [C]

...ijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gn # Bianchi C, Genova ML, Parenti Castelli G, Lenaz G (2004) The mitochondrial respirator

# [[Garlid 1993 BTK | Garlid KD, Semrad C, Zinchenko V (1993) Does redox slip contribute significantly to mitochondri ...AV (2002) Mitochondrial respiration at low levels of oxygen and cytochrome c. Biochem Soc Trans 30:252-8.]]

:::* Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2 ...ine, pH 7.1 [MiPNet03.02]. BIOPS can be stored and shipped frozen at -20 °C.

...pfi below air-level oxygen pressures at a physiological temperature of 37 °C, therefore, it must be shown that the preparation is not oxygen limited due ...lized muscle fibers. In BioThermoKinetics in the Post Genomic Era (Larsson C, Påhlman I-L, Gustafsson L, eds) Chalmers Reproservice, Göteborg:273-6. -

...ch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B ( :::# Harrison DK, Fasching M, Fontana-Ayoub M, '''Gnaiger E''' (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria a

* 2015-10-28: * Burtscher J, Zangrandi L, Schwarzer C, Gnaiger E (2015) Differences in mitochondrial function in homogenated sa * 2015-08-16: Harrison DK, Fasching M, Fontana-Ayoub M, Gnaiger E (2015) Cytochrome redox states and respiratory control in mouse and beef heart mitochondria a

:::# Garlid KD, Semrad C, Zinchenko V (1993) Does redox slip contribute significantly to mitochondri ...(2002) Mitochondrial respiration at low levels of oxygen and cytochrome ''c''. Biochem Soc Trans 30:252-8. - [[Gnaiger 2002 Biochem Soc Trans |»Biobla

...logies (former Invitrogen): A36006; 5* 1 mg commercial vials, store at -20°C. ...ots and stored in the dark in a desiccator, protected from moisture at –20°C for future use. When stored properly, the 10 mM storage solution is stable

* Cecatto C, Cardoso LHD, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Gnaiger E, Makrecka-Kuka M, Liepinsh E (2023) Fatty acid β-ox ...Prat E, González L, Espino Guarch M, Vilches C, Muñoz L, Asensi MA, Serra C, Llebaria A, Casado M, Artuch R, Garrabou G, Garcia-Roves PM, Pallardó FV,

:::# Garlid KD, Semrad C, Zinchenko V (1993) Does redox slip contribute significantly to mitochondri ...(2002) Mitochondrial respiration at low levels of oxygen and cytochrome ''c''. - [[Gnaiger 2002 Biochem Soc Trans |»Bioblast link«]]

::::* 15:00-16:00 [[Dias C|Cândida Dias]]: Presentation of the results of the [[Short-Term Scientific M ::::* 16:00-17:00 [[Dias C|Cândida Dias]]: Presentation of the [[Short-Term Scientific Missions MitoEAG

...t SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BA * Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H,

...0. Ref 64''' Fahlbusch P, Nikolic A, Hartwig S, Jacob S, Kettel U, Köllmer C, Al-Hasani H, Lehr S, Müller-Wieland D, Knebel B, Kotzka J (2022) Adaptati :::: '''1.27. Ref 71''' Hinder LM, Sas KM, O'Brien PD, Backus C, Kayampilly P, Hayes JM, Lin CM, Zhang H, Shanmugam S, Rumora AE, Abcouwer

...t SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BA * Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H,