Garcia-Roves 2023 MiP2023

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MiPschool 2023

Garcia-Roves 2023 MiP2023

Garcia-Roves Pablo Miguel
Remission of obesity and insulin resistance. Is that enough?

Link: MiP2023 Obergurgl AT

Garcia-Roves Pablo Miguel (2023)

Event: MiP2023 Obergurgl AT

Effective preventive measures must be taken to address the obesity pandemic and reduce the risk of noncommunicable diseases. This includes health promotion initiatives such as promoting healthy lifestyles and increasing access to healthy foods and physical activity programs. Education is also key to ensuring that individuals understand the importance of staying fit and healthy.
Our β€œLiMa” (Lifestyle Matters) project uses a multidisciplinary approach aiming to examine the systemic and tissue-specific effects of obesity-related type 2 diabetes. This integrative approach has been in operation for more than a decade, providing novel insights about the underlying role played by each tissue in obesity-related pathophysiology and its progression. Significantly, we have found that obesity leaves a lasting β€˜metabolic fingerprint’ in adipose tissue even after a successful restoration of a healthy state through a diet and exercise intervention. This metabolic memory was observed particularly in visceral fat, where mitochondrial performance was compromised as suggested by permanent alterations in mitochondrial transcripts and proteins, a functional decay, and a significant loss of mtDNA (1). Interestingly, no major impact was evidenced on the subcutaneous depot, which implies a further step towards shedding light on the complex relationship between adipose tissue and metabolic disease.
We urge to validate the translational value of our preclinical model, since it could have an evident economic impact. It would enable earlier diagnosis and tailored interventions, reducing costs, improving patient outcomes, and providing new biomarkers to assess treatment success. This could be a game-changer for obesity and associated diseases.

  1. Gonzalez-Franquesa et al. (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi: 10.1016/j.redox.2022.102353

β€’ Keywords: obesity, nutritional and exercise intervention, multidisciplinary approach, adipose tissue depots, mitochondrial dysfunction

β€’ O2k-Network Lab: ES Barcelona Garcia-Roves PM


Garcia-Roves Pablo Miguel1,2,3
  1. Dept Physiological Sciences, Univ Barcelona
  2. Bellvitge Biomedical Research Institute
  3. CIBERobn (Centre of the national network for biomedical research in the pathophysiology of obesity and nutrition)
Correspondence: [email protected]

Labels: MiParea: Exercise physiology;nutrition;life style  Pathology: Obesity 

Organism: Human  Tissue;cell: Fat 

Event: Oral 

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