SE Stockholm Larsson NG

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SE Stockholm Larsson NG

Oroboros O2k-Network

O2k-Network
O2k-Network Lab Karolinska Institutet, Karolinska University Hospital, SE
Address Solnavägen 9, 171 65
City Stockholm
State/Prov
Country Sweden
Weblink
Contact Larsson Nils-Goeran
Team
Team previous Milenkovic Dusanka, Schmitz Lysann, Franko Andras, Mourier Arnaud, Mussmann Marcel
Status 2 Power-O2k incl. 1 NextGen-O2k O2k 2009-
Oroboros Events MiP2014, IOC93, IOC68, IOC53, IOC47
Topics


O2k-Publications

 PublishedReference
Jiang 2024 Nat Metab2024Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3
Rossetti 2021 Sci Adv2021Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A (2021) A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv 7:eabi7514.
Jiang 2019 EMBO Rep2019Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG (2019) TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep 20:e48101.
Silva Ramos 2019 PLoS Genet2019Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085.
Kauppila 2018 Thesis2018Kauppila JHK (2018) Generating mammalian mitochondrial disease models with mitochondrial DNA mutations. PhD Thesis p120.
Kauppila 2018 Nucleic Acids Res2018Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69.
Perks 2018 Cell Rep2018Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42.
Franko 2016 Diabetes2016Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GK, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ, Hrabě de Angelis M (2016) Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice. Diabetes 65:2540-52.
Silva Ramos 2016 Biochim Biophys Acta2016Silva Ramos E, Larsson NG, Mourier A (2016) Bioenergetic roles of mitochondrial fusion. Biochim Biophys Acta 1857:1277-83.
Rackham 2016 Cell Rep2016Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90.
Richman 2016 Nat Commun2016Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A (2016) Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun 7:11884.
Bratic 2016 PLoS Genet2016Bratic A, Clemente P, Calvo-Garrido J, Maffezzini C, Felser A, Wibom R, Wedell A, Freyer C, Wredenberg A (2016) Mitochondrial polyadenylation is a one-step process required for mRNA integrity and tRNA maturation. PLoS Genet 12:e1006028.
Bratic 2015 Nat Commun2015Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG (2015) Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nat Commun 6:8808.
Kishita 2015 Am J Hum Genet2015Kishita Y, Pajak A, Bolar NA, Marobbio CM, Maffezzini C, Miniero DV, Monné M, Kohda M, Stranneheim H, Murayama K, Naess K, Lesko N, Bruhn H, Mourier A, Wibom R, Nennesmo I, Jespers A, Govaert P, Ohtake A, Van Laer L, Loeys BL, Freyer C, Palmieri F, Wredenberg A, Okazaki Y, Wedell A (2015) Intra-mitochondrial methylation deficiency due to mutations in SLC25A26. Am J Hum Genet 97:761-8.
Mourier 2015 J Cell Biol2015Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42.
Mourier 2014 Hum Mol Genet2014Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG (2014) Loss of LRPPRC causes ATP synthase deficiency. Hum Mol Genet 23:2580-92.
Baggio 2014 Nucleic Acids Res2014Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG5 (2014) Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. Nucleic Acids Res 42:13920-38.
Wredenberg 2013 PLoS Genet2013Wredenberg A, Lagouge M, Bratic A, Metodiev MD, Spåhr H, Mourier A, Freyer C, Ruzzenente B, Tain L, Grönke S, Baggio F, Kukat C, Kremmer E, Wibom R, Polosa PL, Habermann B, Partridge L, Park CB, Larsson NG (2013) MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PLoS Genet 9:e1003178.
Freyer 2012 Nat Genet2012Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF (2012) Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 44:1282-5.
Franko 2012 J Mol Med2012Franko A, von Kleist-Retzow JC, Böse M, Sanchez-Lasheras C, Brodesser S, Krut O, Kunz WS, Wiedermann D, Höhn M, Stöhr O, Moll L, Freude S, Krone W, Schubert M, Wiesner RJ (2012) Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle. J Mol Med 90:1145-60.
Hench 2011 PloS One2011Hench J, Bratic Hench I, Pujol C, Ipsen S, Brodesser S, Mourier A, Tolnay M, Frank S, Trifunovic A (2011) A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans. PloS One 6:e28417.
Bratic 2011 PLoS Genet2011Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG (2011) The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS Genet 7:e1002324.

O2k-Abstracts

 PublishedReference
Felser 2014 Abstract MiP20142014Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry.
Brandt 2013 Abstract MiP20132013Brandt T, Mourier A, Stewart JB, Larsson NG, Kühlbrandt W (2013) Structure and function of aged mouse mitochondria. Mitochondr Physiol Network 18.08.

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I already start to use this wonderfull instrument. It works really well now! - Arnaud Mourier (2009)

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