Sobotka 2023 MiP2023

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Sobotka 2023 MiP2023

Sobotka Lubos
Macronutrients energy metabolism and obesity.

Link: MiP2023 Obergurgl AT

Sobotka Lubos (2023)

Event: MiP2023 Obergurgl AT

Authors: Sobotka Lubos, Sobotka Ondrej

Obesity is associated with insulin resistance, which is the cause of subsequent metabolic complications, including increased morbidity. Despite several decades of efforts to prevent the growth of obesity, its incidence continues to increase. We do not even know what ratio of nutrients is optimal for preventing obesity and insulin resistance, and the optimal ratio of carbohydrates to lipids has not been proven.
Some studies, including calorimetric measurements performed at our workplace, have shown that the oxidation of individual substrates does not correspond to their ratio in the given diet. However, this apparent paradox makes sense because food intake in humans is intermittent and usually does not occur during increased or even maximal physical activity. Energy and metabolic substrates are stored in the body during intake and are subsequently mobilized during periods of starvation and physical activity. As a result, the human body is never in true energy balance; storage and subsequent mobilization of energy is necessary for a functioning organism.
In addition, carbohydrates, fats and proteins are not only a source of energy, but also important substances with many functions [1]. After ingestion of a mixed meal, carbohydrates (especially glucose) are used for both oxidation and non-oxidative pathways (antioxidant, anaplerotic, cataplerotic processes). Only a relatively small fraction of glucose is a source for new lipid synthesis. Ingested fats are preferentially stored in adipose tissue and does not influence carbohydrate oxidation. The lack of glucose can explain more insulin resistance in whole organism than Randle cycle measured in vitro conditions [2].

  1. Sobotka L, Sobotka O. The predominant role of glucose as a building block and precursor of reducing equivalents. https://doi.org/10.1097/mco.0000000000000786
  2. Sobotka O, et al. Should Carbohydrate Intake Be More Liberal during Oral and Enteral Nutrition in Type 2 Diabetic Patients? https://doi.org/10.3390/nu15020439

β€’ Keywords: Obesity, insulin resistance, glucose intake


Affiliation

Sobotka Lubos and Sobotka Ondrej
3rd Department of Medicine Metabolic Care & Gerontology, Faculty Hospital, Medical Faculty, Charles University, 50005 Hradec Kralove - Czech Republic


Labels: Pathology: Obesity 

Organism: Human 




Event: Oral 


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