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...efsky EJ, Spiegel S (2011) Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate Complex IV assemb ...mitochondrial respiration through cytochrome-c oxidase. Our data point to a new action of S1P in mitochondria and suggest that interaction of S1P with

...(2016) Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. Redox Biol 11:176-91. |authors=Valek L, Haeussler A, Droese S, Eaton P, Schroeder K, Tegeder I

...CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidativ ...eletal muscle does not exacerbate obesity or insulin resistance in mice on a HFD, despite impaired mitochondrial content and function and elevated infla

..., Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell ...this new therapeutic strategy for NASH has the potential to translate into a beneficial anti-NASH therapy with fewer adverse events than is observed in

...compared to control. In GPA-fed rats, the specific activities of adenylate kinase (ADK) and succinate dehydrogenase were significantly higher in brain and so ...Guanidino propionic acid; Creatine; Mitochondrial inclusion body; Creatine kinase; Adenine nucleotide translocator; Metabolism; Oxidative phosphorylation; (R

...out Tiffany L, Mikhail Andrew I, Ng Sean Y, Raziee Rozhin, Edgett Brittany A, Vasam Goutham, Webb Erin K, Gilotra Kevin S, Markou Matthew, Pineda Hannah ...1 deletion also elicited PPARGC1A (PPARG coactivator 1 alpha) activity and a slower, more oxidative muscle phenotype. As such, these carm1 mKO-evoked ad

...cose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Diabetes 58:567-78. |abstract=OBJECTIVE—Heat treatment and overexpression of heat shock protein 72 (HSP72) have been shown to protect against high-fat diet–induced insul

...per MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN (2021) Myocardial Lipin 1 knocko |authors=Chambers Kari T, Cooper Michael A, Swearingen Alison R, Brookheart Rita T, Schweitzer George G, Weinheimer Ca

...ang S, Zhao L, Chen S, Mak TW, Wang X (2010) The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. ...ENTPD5 is therefore an integral part of the PI3K/PTEN regulatory loop and a potential target for anticancer therapy

...ctivation and Bcy1 phosphorylation converging in PKA inhibition. Slt2/Mpk1 kinase partially contributes to Bcy1 phosphorylation, although additional targets

...le=Elksnis A, Schiffer TA, Palm F, Wang Y, Cen J, Turpaev K, Ngamjariyawat A, Younis S, Huang S, Shen Y, Leng Y, Bergsten P, Karlsborn T, Welsh N, Wang |authors=Elksnis Andris, Schiffer Tomas A, Palm Fredrik, Wang Yun, Cen Jing, Turpaev Kyril, Ngamjariyawat Anongnad, Y

...l-CoA carboxylase, and the p70S6 kinase were assessed. Overexpression of a protein that maintains complex-I supported mitochondrial respiration (NDI1) was use ...ed protein kinase AMPK, AMPK, 5′-adenosine monophosphate-activated protein kinase, Breast cancer, Cancer metabolism, Colon cancer, ECAR, Extracellular acidif

...activity. Serum starvation clearly represents a major event that triggers a plethora of divergent responses and has therefore great potential to interf

..., Fernández-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rüb U, Chen A, Nussbaum RL, Auburger G (2009) Parkinson phenotype in aged PINK1-deficient ...Fernandez-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rueb U, Chen A, Nussbaum RL, Auburger G

...C-1α completely preserves muscle mass by preventing the fall in pro-fusion protein expression, AMPK and catabolic system activation, suggesting that compounds ...boxylase (ACC) phosphorylation was found, suggesting AMP-activated protein kinase (AMPK) pathway activation. To test the role of mitochondrial alterations we

...lopment. Although first focused on proline catabolism, recent studies from a number of laboratories have emphasized the regulatory effects of proline sy ...ynthetic side, two well-recognized oncogenes, c-MYC and phosphoinositide 3-kinase (PI3K), markedly upregulate enzymes of proline synthesis; mechanisms affect

...ltitude-associated ambient hypoxia affects insulin sensitivity in mice fed a high-fat diet (HFD). Mice were randomly divided into a control group (with normal diet feeding and low-altitude housing), LA/HFD g

|authors=Russell Jake S, Griffith Tia A, Naghipour Saba, Vider Jelena , Du Toit Eugene F, Patel Hemal H, Peart Jaso ...ction in T2D mice, unrelated to caveolins/cavins, mitochondrial, or stress kinase modulation. Although evidence suggests inflammatory involvement, the basis

...se C, microRNA, and exosome pathways. The aim of this review is to provide a contemporary view of these instigators of diabetic cardiomyopathy, as well

...stenbrink BD (2023) A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exerc ...ina C, Wolters Anouk HG, Giepmans Ben NG, Sillje Herman HW, de Boer Rudolf A, Bakker Barbara M, Westenbrink B Daan