Difference between revisions of "Creatine kinase"
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The mitochondrial creatine kinase (CK), which is bound to the outer surface of the inner mitochondrial membrane, hydrolyses ATP to ADP, which is directly transported to the adenine nucleotide translocase (ANT) for regulation of respiration and no release of ATP occurs. Instead, the mitochondrial CK phosphorylates Cr to PCr which is transported into myofibrils where PCr is dephosphorylated to Cr by the myofibrillar CK. The phosphoryl group from PCr is then used to rephosphorylate ADP into ATP while Cr diffuses back to the mitochondria to be rephosphorylated to PCr. | |||
The ADP produced in the intermembrane space by the mitochondrial CK | |||
stimulates respiration more effectively than ADP produced directly in the | |||
cytoplasm. This means that Cr, by activating the mitochondrial CK reaction | |||
can directly control the mitochondrial energy production. | |||
Revision as of 10:37, 21 May 2012
- high-resolution terminology - matching measurements at high-resolution
Creatine kinase
Description
The mitochondrial creatine kinase, also known as phosphocreatine kinase (CPK), facilitates energy transport with creatine and phosphocreatine as diffusible intermediates.
Abbreviation: CK
Reference: Saks 2000 Acta Physiol Scand
MitoPedia topics: Enzyme
Labels:
Enzyme: TCA Cycle and Matrix Dehydrogenases"TCA Cycle and Matrix Dehydrogenases" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.
The mitochondrial creatine kinase (CK), which is bound to the outer surface of the inner mitochondrial membrane, hydrolyses ATP to ADP, which is directly transported to the adenine nucleotide translocase (ANT) for regulation of respiration and no release of ATP occurs. Instead, the mitochondrial CK phosphorylates Cr to PCr which is transported into myofibrils where PCr is dephosphorylated to Cr by the myofibrillar CK. The phosphoryl group from PCr is then used to rephosphorylate ADP into ATP while Cr diffuses back to the mitochondria to be rephosphorylated to PCr.
The ADP produced in the intermembrane space by the mitochondrial CK
stimulates respiration more effectively than ADP produced directly in the
cytoplasm. This means that Cr, by activating the mitochondrial CK reaction
can directly control the mitochondrial energy production.
