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Gnaiger Erich

From Bioblast
Name Gnaiger Erich, A.Univ.-Prof. PhD
Institution
Address Daniel Swarovski Research Laboratory

Department of Visceral, Transplant and Thoracic Surgery

Medical University of Innsbruck

A-6020 Innsbruck, Austria

Email: [email protected]


and


Managing Director

OROBOROS INSTRUMENTS Corp.

high-resolution respirometry

Schöpfstrasse 18

A-6020 Innsbruck, Austria

T +43 512 566796; F +43 512 566796 20

http://www.oroboros.at,

City
State/Province
Country
Email [email protected]
Weblink
O2k-Network Lab AT Innsbruck Gnaiger E, AT Innsbruck MitoFit, AT Innsbruck Oroboros


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CURRICULUM VITAE

Erich Gnaiger


D. Swarovski Research Laboratory

Department of Visceral, Transplant and Thoracic Surgery

Medical University of Innsbruck

A-6020 Innsbruck, Austria

Tel: +43 512 5667960

E-mail: [email protected]


Erich Gnaiger has scientific and technical expertise in the fields of mitochondrial physiology and pathology, microcalorimetry and biological thermodynamics, contributing fundamentally to the understanding of mitochondrial respiratory control by oxygen, and development and application of high-resolution respirometry to cellular bioenergetics and the diagnosis of mitochondrial defects, particularly in relation to hypoxia, cold storage and ischemia-reperfusion injury. He is initiator (2003) and chairman of the International Mitochondrial Physiology Society (MiP; www.mitophysiology.org), and has organized numerous conferences (particularly MiP2003, MiP2005 and MiP2010 in Austria), workshops (more than 60 international workshops on high-resolution respirometry), and training courses on mitochondrial physiology, bioenergetics and biological thermodynamics, and is editor of several proceedings of international meetings. The international teaching activities range from non-equilibrium thermodynamics for chemical engineers (EU-level training; member of the IUPAC steering committee on biological thermodynamics) to mitochondrial physiology (Innsbruck Summer School 1991; initiator of the MiPsummer Schools 2007, 2008 in Austria; 2009 in Louisiana, US; 2010 in Lithuania). Erich Gnaiger is member of the editorial board of the journal ‘Mitochondrion’.


Erich Gnaiger is the founder of the company OROBOROS INSTRUMENTS (www.oroboros.at) with world-wide technological leadership in high-resolution respirometry and reference laboratories in more than 30 countries. The cooperation between academia (Medical University of Innsbruck) and industry (OROBOROS INSTRUMENTS) is formalized in a K-Regio Centre of Excellence with the project ‘Mitochondrial Competence Tyrol’ coordinated by Erich Gnaiger. Erich Gnaiger is initiator of ‘Gentle Science’ (www.bioblast.at). Academic training


1985:Habilitation: Stoichiometric and calorimetric principles of aerobic and anaerobic energy budgets and thermodynamic optimization in metabolic economy: Rate and power, versus efficiency. University of Innsbruck, Department of Zoology.

1974-80:University of Innsbruck, graduate, zoophysiology, limnology and biochemistry. Ph.D. thesis: Direct calorimetry and bioenergetics: aerobic and anoxic metabolism in aquatic oligochaetes. Dept. Zoology, University of Innsbruck.

1970-74:University of Vienna, undergraduate, zoology and biochemistry.


Positions held

1993 -Cooperation with Univ.-Prof. Dr. R. Margreiter, initiating and leading the research laboratory associated with the Department of Transplant Surgery, Medical School, University of Innsbruck; A.Univ.-Prof.; D. Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Austria.

1999 -Honorary Professor, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.

1992-99Honorary Fellow, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.

1989-92Research position, Austrian Science Foundation FWF and FFF.

1986-88FWF Erwin Schrödinger Fellowship (USA)

1985-92Research Assistant Professor, Dept. Zool., Univ. Innsbruck, Austria.

1984-85Research Assistant and Lecturer, Dept. Zool., Univ. Innsbruck

1982-83Postdoctoral position, Inst. Marine Environ. Research, Plymouth, UK.

1980-81Austrian Science Foundation FWF, postdoctoral associate, Dept. Zool., Univ. Innsbruck.

1980-81Lecturer, Dept. Zool., Univ. Innsbruck.

1974-80Austrian Science Foundation research assistant, Dept. Zool., Univ. Innsbruck.


Research support

K-Regio, MitoCom Tyrol.

COST Action TD0901 HypoxiaNet.

COST Action FA0602 Mitofood.

Marsden, Univ. Auckland, New Zealand.

FEBS Workshop Grant.

Austrian Science Foundation, FWF.

Austrian Science Foundation for Commerce FFF (now FFG).

Austrian Ministry of Science.

Austrian Ministry of the Environment.

Community Action Programme in Education and Training for Technology, COMETT.

ÖAD Acciones Integradas: Innsbruck-Barcelona; Innsbruck-Madrid.

Swedish National Science Foundation; co-PI with Dr. L. Gustafsson, Univ Gothenburg, Sweden.

Erwin-Schrödinger Fellowship, Austria (UK and USA).

British Council Postdoctoral Fellowship, UK.


Awards

2012 Houska Award 2011 (Vienna, AT, Apr 2012)

2003 Lavoisier award of the International Society of Biological Microcalorimetry (WĂŒrzburg, DE, Oct 2003)

1999 Honorary Professor, Dept. Biol. Sci., Univ. Wales, Aberystwyth, UK.

Selected publications

Selected conference proceedings / edited books

  1. Renner-Sattler K, Gnaiger E, eds (2010) Mitochondrial physiology. The many functions of the organism in our cells. Mitochondr. Physiol. Network 15.6: 1-128.
  2. Gnaiger E, ed (2007) Mitochondrial Pathways and Respiratory Control. OROBOROS MiPNet Publications, Innsbruck: 96 pp.
  3. Gnaiger E, Gellerich FN, Wyss M, eds (1994) What is Controlling Life? 50 Years after Erwin Schrödinger's What is Life? Modern Trends in BioThermoKinetics 3. Innsbruck Univ. Press, Innsbruck: 336 pp.
  4. Wieser W, Gnaiger E, eds (1989) Energy Transformations in Cells and Organisms. Thieme Publ., Stuttgart: 330 pp.
  5. Gnaiger E, Forstner H, eds (1983) Polarographic Oxygen Sensors. Aquatic and Physiological Applications. Springer, Berlin, Heidelberg, New York: 370 pp.


Selected publications 2010-

  1. Boushel R, Gnaiger E, Calbet JA, Gonzalez-Alonso J, Wright-Paradis C, Sondergaard H, Ara I, Helge JW, Saltin B (2011) Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. Mitochondrion 11: 303-307.
  2. Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? J Biol Chem in press.
  3. Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43: 1729–1738.
  4. Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301: R1078–R1087.
  5. Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopisies of human muscle. Methods Mol Biol 810: 25-58.
  6. Aguirre E, RodrĂ­guez-JuĂĄrez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797: 557-565.
  7. Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: Facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662: 7-25.

12 Selected Publications: 2000-2009

  1. Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41: 1837–1845.
  2. Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40: 170-180.
  3. Boushel R, Gnaiger E, Schjerling P, Skovbro M, KraunsĂže R, Dela F (2007) Patients with Type 2 Diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50: 790-796.
  4. Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxydative phosphorylation but decreased mitochondrial respiratory capacity in IL-1ÎČ treated human peritoneal mesothelial cells. Cell Biochem Biophys 44: 179-186.
  5. HĂŒtter E, Renner K, Pfister G, Stöckl P, Jansen-DĂŒrr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380: 919-928.
  6. Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Mark W, Steurer W, Saks V, Usson Y, Margreiter R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physiol 286: H1633–H1641.
  7. Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. Adv Exp Med Biol 543: 39-56.
  8. Renner K, Amberger A, Konwalinka G, Kofler R, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642: 115-123.
  9. Gnaiger E, Kuznetsov AV (2002) Mitochondrial respiration at low levels of oxygen and cytochrome c. Biochem Soc Trans 30: 252-258.
  10. Stadlmann S, Rieger G, Amberger A, Kuznetsov AV, Margreiter R, Gnaiger E (2002) H2O2-mediated oxidative stress versus cold ischemia-reperfusion: mitochondrial respiratory defects in cultured human endothelial cells. Transplantation 74: 1800-1803.
  11. Gnaiger E (2001) Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 128: 277-297.
  12. Gnaiger E, MĂ©ndez G, Hand SC (2000) High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc Natl Acad Sci U S A 97: 11080-11085.


12 selected publications: up to 1999

  1. Oexle H, Gnaiger E, Weiss G (1999) Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta 1413: 99-107.
  2. Gnaiger E, Lassnig B, Kuznetsov AV, Rieger G, Margreiter R (1998) Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase. J Exp Biol 201: 1129-1139.
  3. Gnaiger E, Lassnig B, Kuznetsov AV, Margreiter R (1998) Mitochondrial respiration in the low oxygen environment of the cell. Effect of ADP on oxygen kinetics. Biochim Biophys Acta 1365: 249-254.
  4. Steinlechner-Maran R, Eberl T, Kunc M, Schröcksnadel H, Margreiter R, Gnaiger E (1997) Respiratory defect as an early event in preservation/reoxygenation injury in endothelial cells. Transplantation 63: 136-142.
  5. Steinlechner-Maran R, Eberl T, Kunc M, Margreiter R, Gnaiger E (1996) Oxygen dependence of respiration in coupled and uncoupled endothelial cells. Am J Physiol Cell Physiol 271: C2053-C2061.
  6. Gnaiger E, Steinlechner-Maran R, MĂ©ndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. J Bioenerg Biomembr 27: 583-596.
  7. Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In Surviving Hypoxia: Mechanisms of Control and Adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo: 77-109.
  8. Von Stockar U, Gustafsson L, Larsson C, Marison I, Tissot P, Gnaiger E (1993) Thermodynamic considerations in constructing energy balances for cellular growth. Biochim Biophys Acta 1183: 221-240.
  9. Buck LT, Hochachka PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol 265: R1014-R1019.
  10. Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65: 1983-2002.
  11. Gnaiger E, Kemp RB (1990) Anaerobic metabolism in aerobic mammalian cells. Information from the ratio of calorimetric heat flux and respirometric oxygen flux. Biochim Biophys Acta 1016: 328-332.
  12. Hand SC, Gnaiger E (1988) Anaerobic dormancy quantified in Artemia embryos: A calorimetric test of the control mechanism. Science 239: 1425-1427.

Websites

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