Juhasz 2017 MiPschool Obergurgl

Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.

Link: MITOEAGLE

Juhasz L, Poles MZ, Tallosy SZP, Rutai A, Boros M, Vecsei L, Szabo A, Kaszaki J (2017)

Event: MiPschool Obergurgl 2017

At the request of the authors, this abstract is not made available online.

• Bioblast editor: Kandolf G • O2k-Network Lab: HU Szeged Boros M

Labels: MiParea: Respiration  Pathology: Other 

Organism: Rat  Tissue;cell: Liver  Preparation: Homogenate 

Regulation: Calcium  Coupling state: LEAK, OXPHOS  Pathway: N, S  HRR: Oxygraph-2k 

Affiliations

Juhász L(1), Poles MZ(1), Tallósy SZP(1), Rutai A(1), Boros M(1), Vécsei L(2), Szabó A(1), Kaszaki J(1)

1. Univ Szeged, Inst Surgical Research
2. Univ Szeged, Dept Neurol.- [email protected]

References and support

1. Singer M (2014) The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence 5:66-72.
2. Duan Y, Gross RA, Sheu SS (2007) Ca²⁺-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol 585:741-58.
3. Pinto BB, Dyson A, Umbrello M, Carré JE, Ritter C, Clatworthy I, Duchen MR, Singer M (2017) Improved Survival in a long term-model of sepsis is associated with reduced mitochondrial calcium uptake despite increased energetic demand. Crit Care Med [Epub ahead of print]

Financial support: NKFIH K116689, GINOP-2.3.2-15-2016-00034

Instructions

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