Difference between revisions of "NS e-input"
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== From CI<small>&</small>II e-input to NS e-input == | == From CI<small>&</small>II e-input to NS e-input == | ||
::::» [[Pathway_control_state#Terminology:_from_CI-_and_CII-linked_to_N_and_S |Terminology]] | ::::» [[Pathway_control_state#Terminology:_from_CI-_and_CII-linked_to_N_and_S |Terminology]] | ||
Revision as of 12:37, 8 November 2016
- high-resolution terminology - matching measurements at high-resolution
NS e-input
Description
NS e-input or the NS-pathway control state is electron input from a combination of substrates for the N-pathway control state and S-pathway control state through Complexes CI and CII simultaneously into the Q-junction. NS e-input corresponds to TCA cycle function in vivo, with convergent electron flow through the ETS. In mt-preparations, NS e-input requires addition not only of NADH- (N-) linked substrates (pyruvate&malate or glutamate&malate), but of succinate (S) simultaneously, since metabolite depletion in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: Additive effect of convergent electron flow.
Abbreviation: NS, CI&II
Reference: Gnaiger 2014 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
MitoPedia concepts:
MiP concept,
SUIT concept
