NS e-input: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=CI&II | |abbr=CI<small>&</small>II | ||
|description='''CI&II e-input''' is electron input though Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction]] corresponding to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[ETS]]. In [[Mitochondrial preparations|mt-preparations]], CI&II e-input requires addition not only of CI-linked substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of CII-linked respiration. For more details, see: [[Additive effect of convergent CI&II electron flow]]. | |description='''CI<small>&</small>II e-input''' is electron input though Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction]] corresponding to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[ETS]]. In [[Mitochondrial preparations|mt-preparations]], CI&II e-input requires addition not only of CI-linked substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of CII-linked respiration. For more details, see: [[Additive effect of convergent CI&II electron flow]]. | ||
|info=[ | |info=[[Gnaiger 2014 MitoPathways]], [[Gnaiger 2009 Int J Biochem Cell Biol]] | ||
|type=Transport | |type=Transport | ||
}} | }} | ||
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|mitopedia topic=Substrate and metabolite | |mitopedia topic=Substrate and metabolite | ||
|type=Transport | |type=Transport | ||
}} | }} | ||
Revision as of 06:11, 28 January 2016
- high-resolution terminology - matching measurements at high-resolution
NS e-input
Description
CI&II e-input is electron input though Complexes CI and CII simultaneously into the Q-junction corresponding to TCA cycle function in vivo, with convergent electron flow through the ETS. In mt-preparations, CI&II e-input requires addition not only of CI-linked substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since metabolite depletion in the absence of succinate prevents a significant stimulation of CII-linked respiration. For more details, see: Additive effect of convergent CI&II electron flow.
Abbreviation: CI&II
Reference: Gnaiger 2014 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
MitoPedia methods: Respirometry
MitoPedia topics: Substrate and metabolite
