OctPM pathway control state: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=PMOct | |abbr=PMOct | ||
|description=''' | |description='''OctPM''': [[Octanoylcarnitine]] & [[Pyruvate]] & [[Malate]]. | ||
'''MitoPathway control:''' | '''MitoPathway control:''' FAO<small>&</small>CI | ||
'''SUIT protocol:''' [[SUIT RP1]], [[SUIT RP1]] | '''SUIT protocol:''' [[SUIT RP1]], [[SUIT RP1]] | ||
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|mitopedia concept=Respiratory state, SUIT state | |mitopedia concept=Respiratory state, SUIT state | ||
}} | }} | ||
== OctPM(L) == | |||
== | |||
== | == OctPM(P) == | ||
# [[SUIT RP2]]_'''4P''': 1D 2Oct 3Mtit 3c (3NADH) '''<u>4P</u>''' 5G 6S 7U 8Gp 9Rot 10Ama 11Tm 12Azd''' | # [[SUIT RP2]]_'''4P''': 1D 2Oct 3Mtit 3c (3NADH) '''<u>4P</u>''' 5G 6S 7U 8Gp 9Rot 10Ama 11Tm 12Azd''' | ||
== | == OctPM(E) == | ||
# [[SUIT RP1]]_'''4Oct''': 1PM 2D 2c (2NADH) 3U '''<u>4Oct</u>''' 5G 6S 7Rot 8Gp 9Ama 10Tm 11Azd | # [[SUIT RP1]]_'''4Oct''': 1PM 2D 2c (2NADH) 3U '''<u>4Oct</u>''' 5G 6S 7Rot 8Gp 9Ama 10Tm 11Azd | ||
Revision as of 22:35, 21 August 2016
Description
OctPM: Octanoylcarnitine & Pyruvate & Malate.
MitoPathway control: FAO&CI
SUIT protocol: SUIT RP1, SUIT RP1
This substrate combination supports CI-linked flux which is typically higher than FAO capacity. In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare Malate alone, and pyruvate is added to compare FAO as the background state with CI&FAO as the reference state.
Abbreviation: PMOct
Reference: MiPNet21.06 SUIT reference protocol
MitoPedia concepts:
Respiratory state,
SUIT state
OctPM(L)
OctPM(P)
- SUIT RP2_4P: 1D 2Oct 3Mtit 3c (3NADH) 4P 5G 6S 7U 8Gp 9Rot 10Ama 11Tm 12Azd
OctPM(E)
- SUIT RP1_4Oct: 1PM 2D 2c (2NADH) 3U 4Oct 5G 6S 7Rot 8Gp 9Ama 10Tm 11Azd