Uncoupled respiration

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Uncoupled respiration

Description

The uncoupled part of respiration in state P pumps protons to compensate for intrinsic uncoupling, which is a property of:

(a) the inner mt-membrane (proton leak),

(b) the proton pumps (proton slip; decoupling), and

(c) is regulated by molecular uncouplers (uncoupling protein, UCP1).

Uncoupled and dyscoupled respiration are summarized as LEAK respiration. In contrast, non-coupled respiration is induced experimentally for evaluation of ETS capacity.


Reference: MiPNet12.15, MiPNet10.04


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Enzyme: Uncoupler Protein"Uncoupler Protein" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.  Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property. 




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