high-resolution terminology - matching measurements at high-resolution

LEAK respiration

Description

EAK respiration or LEAK oxygen flux L compensating for proton leak, proton slip, cation cycling and electron leak, is a dissipative component of respiration which is not available for performing biochemical work and thus related to heat production. LEAK respiration is measured in the LEAK state, in the presence of reducing substrate(s), but absence of ADP - abbreviated as L(n) (theoretically, absence of inorganic phosphate presents an alternative), or after enzymatic inhibition of the phosphorylation system, which can be reached with the use of oligomycin - abbreviated as L(Omy). The LEAK state is the non-phosphorylating resting state of intrinsic uncoupled or dyscoupled respiration when oxygen flux is maintained mainly to compensate for the proton leak at a high chemiosmotic potential, when ATP synthase is not active. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined mainly by the proton leak and the H⁺/O₂ ratio. In this state of maximum protonmotive force, LEAK respiration, L, is higher than the LEAK component of OXPHOS capacity, P. The conditions for measurement and expression of respiration vary (oxygen flux in the LEAK state, J_O₂L, or oxygen flow, I_O₂L). If these conditions are defined and remain consistent within a given context, then the simple symbol L for respiratory rate can be used as a substitute for the more explicit expression for respiratory activity. » MiPNet article

Abbreviation: L

Reference: BEC 2020.1, Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

LEAK respiration: concept-linked terminology of respiratory states

LEAK respiration corresponds to resting, non-phosphorylating electron transfer with a shortcircuit of the proton cycle across the inner mt-membrane due to intrinsic uncoupling or dyscoupling. 2[H] indicates the reduced hydrogen equivalents of CHO substrates and electron transfer to oxygen. H⁺_out are protons pumped out of the matrix phase. Proton leaks (a property of the inner mt-membrane) dissipate energy of translocated protons, and proton slip prevents full translocation of protons across the inner mt-membrane (a property of the proton pumps). Measurement of LEAK respiration is possible in living cells by inhibition of the phosphorylation system and in mt-preparations supported by an ET-pathway competent substrate state, exemplifed as the NS-pathway (CI&II-linked substrate supply) (Gnaiger 2020 BEC MitoPathways).

Gnaiger E (2019) LEAK respiration: concept-linked terminology of respiratory states. Mitochondr Physiol Network 2019-01-24.

» Gnaiger 2020 BEC MitoPathways

Oroboros (2019) MiPNet

Abstract: Mitochondrial respiratory states have been defined originally by Chance and Williams (1955) as a sequence (from 1 to 5) of titrations and transitions in a respiratory protocol, including State 4 as a LEAK state of respiration obtained after exhaustion of the added ADP. The second state (State 2) is induced by addition of 'high ADP'. Confusion persists in the current literature as to the meaning of State 2, which can be resolved by a transition from a specific protocol-linked to a generalized concept-linked terminology.

• O2k-Network Lab: AT Innsbruck Gnaiger E

The LEAK state

LEAK states of respiration are frequently called State 4, State 4o, basal state, or inactive state. Importantly, State 2 is not a LEAK state according to the classical definition.

Respiration compensating for the proton leak is the main component of LEAK respiration. If proton leak were the only component involved, it would make sense to simply write leak respiration for the compensatory oxygen flux. Proton slip and cation cycling, however, are also involved to a larger or smaller extent to stimulate LEAK respiration. The upper case 'LEAK', therefore, should make us aware that this is more accurately considered as an acronym, and cannot be taken as a definitive delineation of the stimulatory mechanism in the LEAK state of respiration.

Note: The distinction between LEAK- and ET capacity helps to clarify the important difference between physiologically uncoupled or pathologically dyscoupled respiration (LEAK) in contrast to noncoupled respiration (ET capacity).

States and rates are distinguished: The LEAK state is a respiratory state, LEAK; whereas LEAK respiration L is a rate (Gnaiger 2019 MitoFit Preprint Arch).

Protocols for measurement of LEAK respiration

The LEAK state can be induced experimentally in various ways, which may yield idential estimates of LEAK respiration, or may show deviations that help to critically assess the proper protocol to be applied in specific cases:

a) LEAK state with ATP

LEAK respiration in the presence of ATP, L(T), and absence of ATPase activity.

LEAK state with ATP: classical State 4 in isolated mitochondria), LEAK respiration L(T) after phosphorylation of ADP to ATP is completed, or when a high concentration of ATP is added in the absence of ADP (Gnaiger 2000 Proc Natl Acad Sci U S A).

In contradiction to the original definition of State 2 (ROX), yet with reference to Chance and Williams (1956), 'State 2' has later been used for describing this functionally different LEAK state:

‘State 2: substrate added, respiration low due to lack of ADP. .. the controlled respiration prior to addition of ADP, which is strictly termed “state 2”, is functionally the same as state 4, and the latter term is usually used for both states’ (Nicholls & Ferguson 1992).

Thus State 2 was re-defined as functionally the same as State 4. State 2 (Chance and Williams 1955, 1956), however, is substrate-limited residual oxygen consumption at high ADP (ROX_D), whereas L(n) and L(T) (State 4) are LEAK respiration in the absence of adenylates, L(n) (no ADP, no ATP) or presence of ATP, L(T).

To overcome the termonological confusion persisting in the scientific literature, the respiratory coupling states of LEAK respiration, OXPHOS capacity and ET capacity are distinguished from residual oxygen consumption (ROX; Gnaiger 2009).

b) LEAK state with oligomycin

LEAK respiration induced by inhibition of ATP synthase by oligomycin, L(Omy).

LEAK state with oligomycin: rate L(Omy) (in isolated mitochondria or other mitochondrial preparations, and non-permeabilized cells).

c) LEAK state without adenylates

LEAK respiration without adenylates, L(n).

LEAK state without adenylates: rate L(n) (in isolated mitochondria or other mitochondrial preparations, using a protocol different from the classical State 2-3-4 sequence).

Sequential addition of (1) mitochondria, (2) ADP, and (3) reduced substrates is the basis of the original State 1-2-3 definitions of respiratory states (Chance and Williams 1955 part III, 1956), where State 2 is zero respiration or residual oxygen consumption in the absence of substrate. An alternative protocol is well established, as shown, e.g., by the classical Fig. 5A (Chance and Williams 1955 part I): 600 µM ADP is added after a state described as ‘Aerobic mitochondria plus succinate’. That state was never defined as ‘State 2’ by Brit Chance. Later Estabrook (1967) made this protocol more popular, with addition of substrate before any ADP or ATP was added.

In this alternative protocol, a respiratory LEAK state is induced in isolated mitochondria, permeabilized tissues, or permeabilized cells, adding the mitochondrial preparation to respiration medium containing inorganic phosphate (State 1), then adding reduced substrate (no external adenylates). This second state (Estabrook 1967) is a non-phosphorylating LEAK state, with respiration L(n) (n for no adenylates; Gnaiger 2009), when substrate-saturated respiration compensates for the proton leak (mainly) in the absence of ADP.

State 4 versus State 2

State 4 is a LEAK state - in contrast: State 2 is a ROX state.

Static head

LEAK state - Static head

State 4 is frequently referred to as 'static head' of isolated mitochondria. Equivalence requires testing, if at State 4 (in a protocol defined by Chance and Williams 1955) ATPase activity is actually zero, such that respiration at State 4 is not partially stimulated by partial recycling of ATP to ADP. In the latter case, State 4 respiration would be higher than LEAK respiration and thus higher than respiration at static head.

Keywords

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The Blue Book 2020
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OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
(P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.

Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

1. Mitochondrial and cellular respiratory rates in coupling-control states

» Baseline state

Respiratory rate	Defining relations
OXPHOS capacity	P = P´-Rox	mt-preparations
ROUTINE respiration	R = R´-Rox	living cells
ET capacity	E = E´-Rox	» Level flow
		» Noncoupled respiration - Uncoupler
LEAK respiration	L = L´-Rox	» Static head
		» LEAK state with ATP
		» LEAK state with oligomycin
		» LEAK state without adenylates
Residual oxygen consumption Rox	L = L´-Rox

Chance and Williams nomenclature: respiratory states

» State 1 —» State 2 —» State 3 —» State 4 —» State 5

2. Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio

» Coupling-control ratio

» Coupling-control protocol

FCR	Definition
L/P coupling-control ratio	L/P	» Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio	L/R
L/E coupling-control ratio	L/E	» Uncoupling-control ratio, UCR = E/L (ambiguous)
P/E control ratio	P/E
R/E control ratio	R/E	» Uncoupling-control ratio, UCR = E/L
net P/E control ratio	(P-L)/E
net R/E control ratio	(R-L)/E

3. Net, excess, and reserve capacities of respiration

Respiratory net rate	Definition	Icon
P-L net OXPHOS capacity	P-L
R-L net ROUTINE capacity	R-L
E-L net ET capacity	E-L
E-P excess capacity	E-P
E-R reserve capacity	E-R

4. Flux control efficiencies related to coupling-control ratios

» Flux control efficiency j_Z-Y

» Background state

» Reference state

» Metabolic control variable

Coupling-control efficiency		Definition		Canonical term
P-L control efficiency	j_P-L	= (P-L)/P	= 1-L/P	P-L OXPHOS-flux control efficiency
R-L control efficiency	j_R-L	= (R-L)/R	= 1-L/R	R-L ROUTINE-flux control efficiency
E-L coupling efficiency	j_E-L	= (E-L)/E	= 1-L/E	E-L ET-coupling efficiency » Biochemical coupling efficiency
E-P control efficiency	j_E-P	= (E-P)/E	= 1-P/E	E-P ET-excess flux control efficiency
E-R control efficiency	j_E-R	= (E-R)/E	= 1-R/E	E-R ET-reserve flux control efficiency

5. General

» Basal respiration

» Cell ergometry

» Dyscoupled respiration

» Dyscoupling

» Electron leak

» Electron-transfer-pathway state

» Hyphenation

» Oxidative phosphorylation

» Oxygen flow

» Oxygen flux

» Permeabilized cells

» Phosphorylation system

» Proton leak

» Proton slip

» Respiratory state

» Uncoupling

Bioblast links: Uncoupling - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

Specific

» Artefacts by single dose uncoupling

» ATP synthase

» CCCP

» Coupling-control protocol

» DNP

» Dyscoupled respiration

» FCCP

» Is respiration uncoupled - noncoupled - dyscoupled?

» Noncoupled respiration: Discussion

» Uncoupler

» Uncoupled respiration - see » Noncoupled respiration

» Uncoupling proteins

» Uncoupling protein 1

» Uncoupler titrations - Optimum uncoupler concentration

Respiratory states and control ratios

» Biochemical coupling efficiency

» Coupling-control state

» Electron-transfer-pathway state

» Electron-transfer pathway

ET capacity

» E-L coupling efficiency

» Flux control efficiency

» Flux control ratio

» LEAK-control ratio

» LEAK respiration

» Noncoupled respiration

» OXPHOS

» OXPHOS capacity; » State 3

» OXPHOS-control ratio, P/E ratio

» Respiratory acceptor control ratio

» ROUTINE-control ratio

» ROUTINE respiration

» ROUTINE state

» State 3u

» State 4

» Uncoupling-control ratio UCR

Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002

General (alphabetical order)

» Adenine nucleotide translocase

» Adenylates

» Electron transfer pathway

» Mitochondrial preparations

» mt-membrane potential

» Oxygen flux

» Phosphorylation system

» Proton leak

» Proton slip

» TIP2k

Other keyword lists

» Template:Keywords: Force and membrane potential

Bioblast links: pH and protons - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

pH and protons

» pH

» hydrogen ion

» proton

» pH buffering capacity

» proton flux

» proton pump versus hydrogen ion pump

» proton leak

» proton slip

» protonmotive force

O2k-pH

» O2k-Catalogue: O2k-pH ISE-Module

» O2k-Manual pH electrode: MiPNet23.15 O2k-pH ISE-Module

» O2k-SOP: MiPNet08.16 pH calibration

» File:PH-Calibration-List.xls

» NextGen-O2k, ratiometric: Carboxy SNARF 1

» NextGen-O2k, ratiometric: HPTS

» pH calibration buffers

O2k-Publications

» O2k-Publications: O2k-pH ISE-Module

HRFR - general

» O2k-Manual: MiPNet22.11 O2k-FluoRespirometer manual

» O2k signals and output

» O2k-SOP: MiPNet14.06 Instrumental O2 background

» MiPNet19.18A O2k-Series G: Start

» ESD

» O2k configuration

» O2k control

» O2k-FluoRespirometer

» O2k-Main Unit#O2k-Series

» Titration-Injection microPump

» Compare: O2k-TPP+_ISE-Module

DatLab

» DatLab 7

» MiPNet26.06 DatLab 7: Guide

» DatLab 6

» MiPNet19.18C DatLab 6: Guide

» MiPNet19.18D O2k-Series G and DatLab 6: Calibration

» Reference layouts for DatLab graphs

References

Bioblast link	Reference	Year
Chance 1955 J Biol Chem-III	Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation: III. The steady state. J Biol Chem 217:409-27.	1955
Chance 1955 J Biol Chem-I	Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem 217:383-93.	1955
Chance 1956 Adv Enzymol Relat Subj Biochem	Chance B, Williams GR (1956) The respiratory chain and oxidative phosphorylation. Adv Enzymol Relat Subj Biochem 17:65-134.	1956
Estabrook 1967 Methods Enzymol	Estabrook RW (1967) Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios. Methods Enzymol 10:41-7.	1967
Gnaiger 1993 Hypoxia	Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving hypoxia: Mechanisms of control and adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109.	1993
Gnaiger 1993 Pure Appl Chem	Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. http://dx.doi.org/10.1351/pac199365091983	1993
Gnaiger 2009 Int J Biochem Cell Biol	Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. https://doi.org/10.1016/j.biocel.2009.03.013	2009
BEC 2020.1 doi10.26124bec2020-0001.v1	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. https://doi.org/10.26124/bec:2020-0001.v1	2020

Caplan SR, Essig A (1983) Bioenergetics and linear nonequilibrium thermodynamics. The steady state. Harvard Univ. Press, Cambridge:435 pp.
Nicholls DG, Ferguson SJ (2002) Bioenergetics 3. Academic Press, London:287 pp.
Bioblast alert 2014(04)

» List of publications: LEAK

Sort in ascending/descending order by a click on one of the small symbols in squares below.
Default sorting: chronological. Empty fields appear first in ascending order.

	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Nord 2023 FASEB J	2023	Nord A, Chamkha I, Elmér E (2023) A whole blood approach improves speed and accuracy when measuring mitochondrial respiration in intact avian blood cells. https://doi.org/10.1096/fj.202201749r	LEAK ROUTINE ET	ROX	Intact cells	Birds	Blood cells
Pacheco-Fuentes 2023 Oecologia	2023	Pacheco-Fuentes H, Ton R, Griffith SC (2023) Short- and long-term consequences of heat exposure on mitochondrial metabolism in zebra finches (Taeniopygia castanotis). https://doi.org/10.1007/s00442-023-05344-7	LEAK ROUTINE OXPHOS ET	N ROX	Intact cells	Birds	Blood cells
Martell 2023 Nat Commun	2023	Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. https://doi.org/10.1038/s41467-023-38049-9	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Permeabilized cells Intact cells	Human	Nervous system
Marin 2023 Exp Gerontol	2023	Marin CT, de Souza Lino AD, Avelar IDS, Barbosa MR, Scarlato GCG, Cavalini DF, Tamanini F, Alexandrino AV, Vercesi AE, Shiguemoto GE (2023) Resistance training prevents dynamics and mitochondrial respiratory dysfunction in vastus lateralis muscle of ovariectomized rats. https://doi.org/10.1016/j.exger.2023.112081	LEAK OXPHOS ET	N	Permeabilized tissue	Rat	Skeletal muscle
Kankuri 2023 Exp Mol Med	2023	Kankuri E, Finckenberg P, Leinonen J, Tarkia M, Björk S, Purhonen J, Kallijärvi J, Kankainen M, Soliymani R, Lalowski M, Mervaala E (2023) Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity. https://doi.org/10.1038/s12276-023-00967-5	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Mouse	Heart
Kyriazis 2023 Res Sq	2023	Kyriazis G, Serrano J, Boyd J, Mason C, Smith K, Karolyi K, Kondo S, Brown I, Maurya S, Meshram N, Serna V, Gilger J, Branch D, Gardell S, Baskin K, Ayala J, Pratley R, Goodpaster B, Coen P (2023) The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness. https://doi.org/10.21203/rs.3.rs-2475555/v1	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Calabria 2023 Biomedicines	2023	Calabria E, Muollo V, Cavedon V, Capovin T, Saccenti L, Passarotti F, Ghiotto L, Milanese C, Gelati M, Rudi D, Salvagno GL, Lippi G, Tam E, Schena F, Pogliaghi S (2023) Type 2 diabetes related mitochondrial defects in peripheral mononucleated blood cells from overweight postmenopausal women. https://doi.org/10.3390/biomedicines11010121	LEAK ROUTINE OXPHOS ET	N NS ROX S	Permeabilized cells Intact cells	Human	Blood cells
Oliveira 2023 J Biol Chem	2023	Oliveira AG, Oliveira LD, Cruz MV, Guimarães DSPSF, Lima TI, BC Santos-Fávero, Luchessi AD, BA Pauletti, Leme AP, Bajgelman MC, Afonso J, Regitano LCA, Carvalho HF, Carneiro EM, Kobarg J, Perissi V, Auwerx J, Silveira LR (2023) Interaction between poly-A binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. https://doi.org/10.1016/j.jbc.2023.104702	LEAK ROUTINE ET	ROX	Intact cells
Vilas-Boas 2023 J Biol Chem	2023	Vilas-Boas EA, Cabral-Costa JV, Ramos VM, Caldeira da Silva CC, Kowaltowski AJ (2023) Goldilocks calcium concentrations and the regulation of oxidative phosphorylation: too much, too little, or just right. https://doi.org/10.1016/j.jbc.2023.102904	LEAK OXPHOS ET	N S	Isolated mitochondria	Mouse	Liver
Bellissimo 2023 BEC	2023	Bellissimo CA, Soendergaard S, Hughes MC, Ramos SV, Larsen S, Perry CGR (2022) The influence of adenylate cycling on mitochondrial calcium-induced permeability transition in permeabilized skeletal muscle fibers. Bioenerg Commun 2023.1. https://doi.org/10.26124/bec:2023-0001	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Temelie 2023 Int J Mol Sci	2023	Temelie M, Talpur R, Dominguez-Prieto M, Dantas Silva A, Cenusa C, Craciun L, Savu DI, Moisoi N (2023) Impaired integrated stress response and mitochondrial integrity modulate genotoxic stress impact and lower the threshold for immune signalling. https://doi.org/10.3390/ijms24065891	LEAK OXPHOS ET	N NS	Intact cells	Mouse	Fibroblast
Hoogstraten 2023 Arch Toxicol	2023	Hoogstraten CA, Jacobs MME, de Boer G, van de Wal MAE, Koopman WJH, Smeitink JAM, Russel FGM, Schirris TJJ (2023) Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells. https://doi.org/10.1007/s00204-023-03510-7	LEAK OXPHOS	N	Isolated mitochondria	Human	Kidney
Kim 2023 bioRxiv	2023	Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka TA, Sivapackiam J, Fang Y, Kidd K, Park SJ, Johnson BG, Kmoch S, Duffield JS, Bleyer AJ, Jackrel ME, Urano F, Sharma V, Lindahl M, Chen YM (2023) MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy. https://doi.org/10.1101/2023.01.10.523171	LEAK OXPHOS ET	N NS	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Pharaoh 2023 bioRxiv	2023	Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martin-Perez M, Qian WJ, MacCoss MJ, Villen J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ (2023) Elamipretide improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). https://doi.org/10.1101/2023.02.01.525989	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Mioc 2023 Molecules	2023	Mioc M, Mioc A, Racoviceanu R, Ghiulai R, Prodea A, Milan A, Barbu Tudoran L, Oprean C, Ivan V, Șoica C (2023) The antimelanoma biological assessment of triterpenic acid functionalized gold nanoparticles. https://doi.org/10.3390/molecules28010421	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Dominguez-Lopez 2023 Neuropharmacology	2023	Dominguez-Lopez S, Ahn B, Sataranatarajan K, Ranjit R, Premkumar P, Van Remmen H, Beckstead MJ (2023) Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione. https://doi.org/10.1016/j.neuropharm.2023.109436	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Nervous system
Robertson 2023 J Cell Sci	2023	Robertson GL, Riffle S, Patel M, Bodnya C, Marshall A, Beasley HK, Garza-Lopez E, Shao J, Vue Z, Hinton A, Stoll MS, de Wet S, Theart RP, Chakrabarty RP, Loos B, Chandel NS, Mears JA, Gama V (2023) DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs. https://doi.org/10.1242/jcs.260370	LEAK ROUTINE OXPHOS ET	F N S DQ CIV NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Mills 2023 Nature	2023	Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA (2023) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. https://doi.org/10.1038/nature25986	LEAK ET	S	Isolated mitochondria	Rat	Liver
Pavluch 2023 Sci Rep	2023	Pavluch V, Engstová H, Špačková J, Ježek P (2023) Deficiency of transcription factor Nkx6.1 does not prevent insulin secretion in INS-1E cells. https://doi.org/10.1038/s41598-023-27985-7	LEAK ROUTINE ET		Intact cells	Rat	Islet cell;pancreas;thymus
Gong 2023 Biomed Pharmacother	2023	Gong DF, Sun SC, Wang RR, Dawuti A, Kong DW, Liu RQ, Du LD, Wang SB, Lu Y, Yuan TY, Du GH, Fang LH (2023) Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy. https://doi.org/10.1016/j.biopha.2023.114382	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Heart
Shirakawa 2023 Sci Rep	2023	Shirakawa R, Nakajima T, Yoshimura A, Kawahara Y, Orito C, Yamane M, Handa H, Takada S, Furihata T, Fukushima A, Ishimori N, Nakagawa M, Yokota I, Sabe H, Hashino S, Kinugawa S, Yokota T (2023) Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults. https://doi.org/10.1038/s41598-023-32549-w	LEAK OXPHOS ET		Permeabilized cells	Human	Blood cells
Horvath 2023 Antioxidants (Basel)	2023	Horváth T, Sándor L, Baráth B, Donka T, Baráth B, Mohácsi Á, Jász KD, Hartmann P, Boros M (2023) Methane admixture protects liver mitochondria and improves graft function after static cold storage and reperfusion. Antioxidants (Basel) 12:271. https://doi.org/10.3390/antiox12020271	LEAK OXPHOS	N NS ROX	Homogenate	Rat	Liver
Moellering 2023 Arthritis Res Ther	2023	Moellering DR, Smith-Johnston K, Kelley C, Sammy MJ, Benedict J, Brock G, Johnson J, Baskin KK, Jarjour WN, Belury MA, Reiser PJ, Nagareddy PR, Hanaoka BY (2023) Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case-control study. https://doi.org/10.1186/s13075-023-03065-z	LEAK OXPHOS ET	F N CIV ROX	Permeabilized tissue	Human	Skeletal muscle
Vamesu 2023 JCI Insight	2023	Vamesu BM, Nicola T, Li R, Hazra S, Matalon S, Kaminski N, Ambalavanan N, Kandasamy J (2023) Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function. https://doi.org/10.1172/jci.insight.160697	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Lung;gill
Devaux 2023 J Comp Physiol B	2023	Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2023) Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae). https://doi.org/10.1007/s00360-023-01495-4	LEAK OXPHOS ET	N S NS CIV	Permeabilized cells	Fishes	Nervous system
Duran-Gueell 2023 FASEB J	2023	Duran-Güell M, Garrabou G, Flores-Costa R, Casulleras M, López-Vicario C, Zhang IW, Cantó-Santos J, Contreras BJ, Sánchez-Rodríguez MB, Romero-Grimaldo B, Horrillo R, Costa M, Arroyo V, Clària J (2023) Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury. https://doi.org/10.1096/fj.202201526r	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Liver
Airik 2023 Antioxidants (Basel)	2023	Airik M, Arbore H, Childs E, Huynh AB, Phua YL, Chen CW, Aird K, Bharathi S, Zhang B, Conlon P, Kmoch S, Kidd K, Bleyer AJ, Vockley J, Goetzman E, Wipf P, Airik R (2023) Mitochondrial ROS triggers KIN pathogenesis in FAN1-deficient kidneys. https://doi.org/10.3390/antiox12040900	OXPHOS ET LEAK	N S NS	Isolated mitochondria	Human	Kidney
Wu 2023 Int Immunopharmacol	2023	Wu F, Zhang YT, Teng F, Li HH, Guo SB (2023) S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fission and respiratory dysfunction. https://doi.org/10.1016/j.intimp.2023.109716	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Heart
Sathiaseelan 2023 J Gerontol A Biol Sci Med Sci	2023	Sathiaseelan R, Ahn B, Stout MB, Logan S, Wanagat J, Van M Nguyen H, Hord NG, Vandiver AR, Selvarani R, Ranjit R, Yarbrough H, Masingale A, Miller BF, Wolf RF, Austad SN, Richardson A (2023) A genetically heterogeneous rat model with divergent mitochondrial genomes. https://doi.org/10.1093/gerona/glad056	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Szulik 2023 Basic Res Cardiol	2023	Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S (2023) SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation. https://doi.org/10.1007/s00395-023-00991-6	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Heart
Thoral 2023 J Exp Biol	2023	Thoral E, Roussel D, Gasset E, Dutto G, Queiros Q, McKenzie DJ, Bourdeix JH, Metral L, Saraux C, Teulier L (2023) Temperature-dependent metabolic consequences of food deprivation in the European sardine. https://doi.org/10.1242/jeb.244984	LEAK OXPHOS	N NS ROX	Intact cells	Fishes	Skeletal muscle
Gautam 2023 Neurobiol Dis	2023	Gautam M, Genç B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, Günay A, Koçak N, Aguilar-Wickings IR, Keefe D, Zheng G, Swaminathan S, Redmon M, Zariwala HA, Özdinler PH (2023) SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function. https://doi.org/10.1016/j.nbd.2023.106022	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue Homogenate	Rat	Heart Nervous system
Cruz-Gregorio 2023 Phytother Res	2023	Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2023) α-Mangostin induces oxidative damage, mitochondrialdysfunction, and apoptosis in a triple-negative breastcancer model. https://doi.org/10.1002/ptr.7812	LEAK ROUTINE ET	ROX CIV	Intact cells	Mouse	Endothelial;epithelial;mesothelial cell
Koizumi 2023 Front Cardiovasc Med	2023	Koizumi T, Watanabe M, Yokota T, Tsuda M, Handa H, Koya J, Nishino K, Tatsuta D, Natsui H, Kadosaka T, Koya T, Nakao M, Hagiwara H, Kamada R, Temma T, Tanaka S, Anzai T (2023) Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats. Front Cardiovasc Med 10: 1005408.	LEAK OXPHOS		Permeabilized tissue	Rat	Heart
Scandalis 2023 JAMA Cardiol	2023	Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA (2023) Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction. https://doi.org/10.1001/jamacardio.2023.0957	OXPHOS ET LEAK	N NS ROX S	Permeabilized tissue	Human	Skeletal muscle
Horcas-Nieto 2023 Biochim Biophys Acta Mol Basis Dis	2023	Horcas-Nieto JM, Versloot CJ, Langelaar-Makkinje M, Gerding A, Blokzijl T, Koster MH, Baanstra M, Martini IA, Coppes RP, Bourdon C, van Ijzendoorn SCD, Kim P, Bandsma RHJ, Bakker BM (2023) Organoids as a model to study intestinal and liver dysfunction in severe malnutrition. https://doi.org/10.1016/j.bbadis.2022.166635	LEAK ET OXPHOS	F		Mouse	Liver Other cell lines
Mahmoud 2023 Pharmacol Res	2023	Mahmoud AM, Kostrzewa M, Marolda V, Cerasuolo M, Maccarinelli F, Coltrini D, Rezzola S, Giacomini A, Mollica MP, Motta A, Paris D, Zorzano A, Marzo VD, Ronca R, Ligresti A (2023) Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer. https://doi.org/10.1016/j.phrs.2023.106683	LEAK	N S NS ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Leduc-Gaudet 2023 Nat Commun	2023	Leduc-Gaudet JP, Franco-Romero A, Cefis M, Moamer A, Broering FE, Milan G, Sartori R, Chaffer TJ, Dulac M, Marcangeli V, Mayaki D, Huck L, Shams A, Morais JA, Duchesne E, Lochmuller H, Sandri M, Hussain SNA, Gouspillou G (2023) MYTHO is a novel regulator of skeletal muscle autophagy and integrity. https://doi.org/10.1038/s41467-023-36817-1	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Luther 2023 Am J Physiol Renal Physiol	2023	Luther T, Bülow Anderberg S, Persson P, Franzén S, Skorup P, Wernerson A, Hultenby K, Palm F, Schiffer TA, Frithiof R (2023) Renal mitochondrial dysfunction in ovine experimental sepsis associated acute kidney injury. https://doi.org/10.1152/ajprenal.00294.2022	LEAK OXPHOS	N S NS	Isolated mitochondria	Other mammals	Kidney
Giovarelli 2023 Mol Med	2023	Giovarelli M, Serati A, Zecchini S, Guelfi F, Clementi E, Mandò C (2023) Cryopreserved placental biopsies maintain mitochondrial activity for high-resolution respirometry. https://doi.org/10.1186/s10020-023-00645-2	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Genital
Salmon 2023 Geroscience	2023	Salmón P, Millet C, Selman C, Monaghan P, Dawson NJ (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. https://doi.org/10.1007/s11357-022-00624-1	LEAK OXPHOS	N CIV NS ROX	Homogenate	Birds	Skeletal muscle Liver
Gemmink 2023 Mol Metab	2023	Gemmink A, Daemen S, Wefers J, Hansen J, van Moorsel D, Astuti P, Jorgensen JA, Kornips E, Schaart G, Hoeks J, Schrauwen P, Hesselink MKC (2023) Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity. https://doi.org/10.1016/j.molmet.2023.101727	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Shi 2023 Redox Biol	2023	Shi L, Tao Z, Zheng L, Yang J, Hu X, Scott K, de Kloet A, Krause E, Collins JF, Cheng Z (2023) FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway. https://doi.org/10.1016/j.redox.2023.102727	LEAK ET ROUTINE	F	Intact cells	Mouse	Fat
Zhu 2022 Metabolism	2022	Zhu JY, Chen M, Mu WJ, Luo HY, Guo L (2022) Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. https://doi.org/10.1016/j.metabol.2022.155241	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Liver
Bina 2022 Mol Cell Biochem	2022	Bînă AM, Aburel OM, Avram VF, Lelcu T, Lința AV, Chiriac DV, Mocanu AG, Bernad E, Borza C, Craina ML, Popa ZL, Muntean DM, Crețu OM (2022) Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies. https://doi.org/10.1007/s11010-022-04415-2	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human	Genital Platelet
Lai 2022 PLoS One	2022	Lai RE, Holman ME, Chen Q, Rivers J, Lesnefsky EJ, Gorgey AS (2022) Assessment of mitochondrial respiratory capacity using minimally invasive and noninvasive techniques in persons with spinal cord injury. PLoS One 17:e0265141.	LEAK OXPHOS	N S	Permeabilized tissue		Skeletal muscle
Donnarumma 2022 Nat Commun	2022	Donnarumma E, Kohlhaas M, Vimont E, Kornobis E, Chaze T, Gianetto QG, Matondo M, Moya-Nilges M, Maack C, Wai T (2022) Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure. https://doi.org/10.1038/s41467-022-34316-3	LEAK OXPHOS ET	F N S CIV	Isolated mitochondria	Mouse	Heart
Crislip 2022 Biomolecules	2022	Crislip GR, Wohlgemuth SE, Wolff CA, Gutierrez-Monreal MA, Douglas CM, Ebrahimi E, Cheng KY, Masten SH, Barral D, Bryant AJ, Esser KA, Gumz ML (2022) Apparent absence of BMAL1-dependent skeletal muscle-kidney cross talk in mice. https://doi.org/10.3390/biom12020261	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Kidney
Guo 2022 Sci Adv	2022	Guo Q, Xu Z, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z (2022) Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. https://doi.org/10.1126/sciadv.abo0340	LEAK OXPHOS	N S ROX	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle Fat
Risiglione 2022 Life (Basel)	2022	Risiglione P, Cubisino SAM, Lipari CLR, De Pinto V, Messina A, Magrì A (2022) α-Synuclein A53T promotes mitochondrial proton gradient dissipation and depletion of the organelle respiratory reserve in a neuroblastoma cell line. https://doi.org/10.3390/life12060894	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Qvit 2022 Pharmaceuticals (Basel)	2022	Qvit N, Lin AJ, Elezaby A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022) A selective inhibitor of cardiac troponin I phosphorylation by delta protein kinase C (δPKC) as a treatment for ischemia-reperfusion injury. https://doi.org/10.3390/ph15030271	LEAK OXPHOS	NS	Isolated mitochondria	Rat	Heart
Smith 2022 J Pineal Res	2022	Smith KLM, Swiderska A, Lock MC, Graham L, Iswari W, Choudhary T, Thomas D, Kowash HM, Desforges M, Cottrell EC, Trafford AW, Giussani DA, Galli GLJ (2022) Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex-dependent manner. https://doi.org/10.1111/jpi.12821	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Rat	Heart
Melin 2022 JHEP Rep	2022	Melin N, Yarahmadov T, Sanchez-Taltavull D, Birrer FE, Brodie TM, Petit B, Felser A, Nuoffer JM, Montani M, Vozenin MC, Herrmann E, Candinas D, Aebersold DM, Stroka D (2022) A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus. https://doi.org/10.1016/j.jhepr.2022.100508	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Mouse	Liver
Soares 2022 Geroscience	2022	Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C (2022) SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice. https://doi.org/10.1007/s11357-022-00563-x	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Cruz-Gregorio 2022 Antioxidants (Basel)	2022	Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired autophagy flux in a mouse model of breast cancer. https://doi.org/10.3390/antiox12010056	LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Endothelial;epithelial;mesothelial cell
Zdrazilova 2022 PLOS ONE	2022	Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. https://doi.org/10.1371/journal.pone.0264496	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Brown 2022 Redox Biol	2022	Brown JL, Peelor FF 3rd, Georgescu C, Wren JD, Kinter M, Tyrrell VJ, O'Donnell VB, Miller BF, Van Remmen H (2022) Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. https://doi.org/10.1016/j.redox.2022.102518	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Pruuchova 2022 Antioxidants (Basel)	2022	Průchová P, Gotvaldová K, Smolková K, Alán L, Holendová B, Tauber J, Galkin A, Ježek P, Jabůrek M (2022) Antioxidant role and cardiolipin remodeling by redox-activated mitochondrial Ca²⁺-independent phospholipase A_2γ in the brain.	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Nervous system
Sleda 2022 mBio	2022	Sleda MA, Li ZH, Behera R, Baierna B, Li C, Jumpathong J, Malwal SR, Kawamukai M, Oldfield E, Moreno SNJ (2022) The heptaprenyl diphosphate synthase (Coq1) is the target of a lipophilic bisphosphonate that protects mice against toxoplasma gondii infection. https://doi.org/10.1128/mbio.01966-22	LEAK OXPHOS	S	Permeabilized cells Intact cells	Protists
Antona 2022 Cancers (Basel)	2022	Antona A, Varalda M, Roy K, Favero F, Mazzucco E, Zuccalà M, Leo G, Soggia G, Bettio V, Tosi M, Gaggianesi M, Riva B, Reano S, Genazzani A, Manfredi M, Stassi G, Corà D, D'Alfonso S, Capello D (2022) Dissecting the mechanism of action of spiperone-a candidate for drug repurposing for colorectal cancer. https://doi.org/10.3390/cancers14030776	LEAK OXPHOS ET	N ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Hadjihambi 2022 J Hepatol	2022	Hadjihambi A, Konstantinou C, Klohs J, Monsorno K, Le Guennec A, Donnelly C, Cox J, Kusumbe A, Hosford PS, Soffientini U, Lecca S, Mameli M, Jalan R, Paolicelli RC, Pellerin L (2022) Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. https://doi.org/10.1016/j.jhep.2022.08.008	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Munro 2022 Mitochondrion	2022	Munro D, Rodríguez E, Blier PU (2022) The longest-lived metazoan, Arctica islandica, exhibits high mitochondrial H₂O₂ removal capacities. https://doi.org/10.1016/j.mito.2022.11.005	LEAK OXPHOS	N CIV	Isolated mitochondria	Molluscs	Lung;gill Endothelial;epithelial;mesothelial cell
Galambo 2022 Curr Res Physiol	2022	Galambo D, Bergdahl A (2022) Physiological levels of cardiolipin acutely affect mitochondrial respiration in vascular smooth muscle cells. https://doi.org/10.1016/j.crphys.2022.100097	LEAK OXPHOS	F N NS ROX	Permeabilized cells	Mouse	Other cell lines
Schober 2022 Hum Mol Genet	2022	Schober FA, Tang JX, Sergeant K, Moedas MF, Zierz CM, Moore D, Smith C, Lewis D, Guha N, Hopton S, Falkous G, Lam A, Pyle A, Poulton J, Gorman GS, Taylor RW, Freyer C, Wredenberg A (2022) Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease. https://doi.org/10.1093/hmg/ddac002	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse Drosophila	Fibroblast
Takada 2022 Proc Natl Acad Sci U S A	2022	Takada S, Maekawa S, Furihata T, Kakutani N, Setoyama D, Ueda K, Nambu H, Hagiwara H, Handa H, Fumoto Y, Hata S, Masunaga T, Fukushima A, Yokota T, Kang D, Kinugawa S, Sabe H (2022) Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure. Proc Natl Acad Sci U S A 119: e2203628119.	LEAK OXPHOS		Isolated mitochondria	Mouse	Heart
Salazar-Petres 2022 Biol Reprod	2022	Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN (2022) Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†. https://doi.org/10.1093/biolre/ioac056	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Genital
Serna 2022 MitoFit	2022	Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca²⁺ efflux in isolated mitochondria and permeabilized cells. https://doi.org/10.26124/mitofit:2022-0021 — 2022-07-28 published in Bioenerg Commun 2022.7.	LEAK OXPHOS	S ROX	Permeabilized cells Isolated mitochondria	Human Mouse	Liver Other cell lines
Ceja-Galicia 2022 Antioxidants (Basel)	2022	Ceja-Galicia ZA, García-Arroyo FE, Aparicio-Trejo OE, El-Hafidi M, Gonzaga-Sánchez G, León-Contreras JC, Hernández-Pando R, Guevara-Cruz M, Tovar AR, Rojas-Morales P, Aranda-Rivera AK, Sánchez-Lozada LG, Tapia E, Pedraza-Chaverri J (2022) Therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia: association with the improvement of renal mitochondrial β-oxidation and lipid metabolism in kidney and liver. https://doi.org/10.3390/antiox11112195	LEAK OXPHOS	F N ROX	Isolated mitochondria	Rat	Kidney
Hegazy 2022 Biomedicines	2022	Hegazy L, Gill LE, Pyles KD, Kaiho C, Kchouk S, Finck BN, McCommis KS, Elgendy B (2022) Identification of novel mitochondrial pyruvate carrier inhibitors by homology modeling and pharmacophore-based virtual screening. https://doi.org/10.3390/biomedicines10020365	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Heart
Wang 2022 Transl Cancer Res	2022	Wang B, Liu B, Luo Q, Sun D, Li H, Zhang J, Jin X, Cheng X, Niu J, Yuan Q, Chen Y (2022) PANK1 associates with cancer metabolism and immune infiltration in clear cell renal cell carcinoma: a retrospective prognostic study based on the TCGA database. https://doi.org/10.21037/tcr-22-1488	LEAK OXPHOS ET	N NS S		Human	Kidney Endothelial;epithelial;mesothelial cell
Davies 2022 Biomolecules	2022	Davies KL, Smith DJ, El-Bacha T, Wooding PFP, Forhead AJ, Murray AJ, Fowden AL, Camm EJ (2022) Cortisol regulates cerebral mitochondrial oxidative phosphorylation and morphology of the brain in a region-specific manner in the ovine fetus. https://doi.org/10.3390/biom12060768	LEAK OXPHOS	N S NS	Homogenate	Other mammals	Nervous system
Hansen 2022 Free Radic Biol Med	2022	Hansen C, Møller S, Ehlers T, Wickham KA, Bangsbo J, Gliemann L, Hellsten Y (2022) Redox balance in human skeletal muscle-derived endothelial cells - Effect of exercise training. https://doi.org/10.1016/j.freeradbiomed.2021.12.265	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Meza-Buendia 2022 PLoS One	2022	Meza-Buendia AK, Aparicio-Trejo OE, Díaz F, Caamal-Monsreal C, Pedraza-Chaverri J, Álvarez-Delgado C, Paschke K, Rosas C (2022) High resolution respirometry of isolated mitochondria from adult Octopus maya (Class: Cephalopoda) systemic heart. https://doi.org/10.1371/journal.pone.0273554	LEAK OXPHOS	ROX	Isolated mitochondria	Molluscs	Heart
Alexander 2022 Cardiovasc Drugs Ther	2022	Alexander ED, Aldridge JL, Burleson TS, Frasier CR (2022) Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts. https://doi.org/10.1007/s10557-022-07341-z	ET LEAK OXPHOS	N NS	Isolated mitochondria	Rat	Heart
Gvozdjakova 2022 Environ Sci Pollut Res Int	2022	Gvozdjáková A, Sumbalová Z, Kucharská J, Rausová Z, Kovalčíková E, Takácsová T, Navas P, López-Lluch G, Mojto V, Palacka P (2022) Mountain spa rehabilitation improved health of patients with post-COVID-19 syndrome: pilot study. https://doi.org/10.1007/s11356-022-22949-2	LEAK ROUTINE OXPHOS ET	N NS	Permeabilized cells Intact cells	Human	Platelet
Vacurova 2022 Nat Commun	2022	Vacurova E, Trnovska J, Svoboda P, Skop V, Novosadova V, Reguera DP, Petrezselyová S, Piavaux B, Endaya B, Spoutil F, Zudova D, Stursa J, Melcova M, Bielcikova Z, Werner L, Prochazka J, Sedlacek R, Huttl M, Hubackova SS, Haluzik M, Neuzil J (2022) Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice. https://doi.org/10.1038/s41467-022-29486-z	LEAK ROUTINE		Intact cells	Mouse	Fat
Crowder 2022 Islets	2022	Crowder JJ, Zeng Z, Novak AN, Alves NJ, Linnemann AK (2022) Stabilization protects islet integrity during respirometry in the Oroboros Oxygraph-2K analyzer. Islets 14:128-38.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Islet cell;pancreas;thymus
Karavyraki 2022 BEC	2022	Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. https://doi.org/10.26124/bec:2022-0011	LEAK ROUTINE ET	S ROX	Permeabilized cells	Human
Yoval-Sanchez 2022 Redox Biol	2022	Yoval-Sánchez B, Ansari F, James J, Niatsetskaya Z, Sosunov S, Filipenko P, Tikhonova IG, Ten V, Wittig I, Rafikov R, Galkin A (2022) Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart. https://doi.org/10.1016/j.redox.2022.102258	LEAK OXPHOS	NS	Isolated mitochondria	Mouse	Heart Nervous system
Deng 2022 Cell Mol Life Sci	2022	Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, Urzi C, Ge H, Geest GA, Bruggmann R, Djonov V, Nuoffer JM, Vermathen P, Zamboni N, Riether C, Ochsenbein A, Peng RW, Kocher GJ, Schmid RA, Dorn P, Marti TM (2022) Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. https://doi.org/10.1007/s00018-022-04453-5	LEAK	ROX N S CIV	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Roy 2022 Am J Pathol	2022	Roy N, Alencastro F, Roseman BA, Wilson SR, Delgado ER, May MC, Bhushan B, Bello FM, Jurczak MJ, Shiva S, Locker J, Gingras S, Duncan AW (2022) Dysregulation of lipid and glucose homeostasis in hepatocyte-specific SLC25A34 knockout mice. https://doi.org/10.1016/j.ajpath.2022.06.002	LEAK OXPHOS ET	N NS ROX	Homogenate	Mouse	Liver
Ryan 2022 Clin Transl Med	2022	Ryan TE, Kim K, Scali ST, Berceli SA, Thome T, Salyers ZR, O'Malley KA, Green TD, Karnekar R, Fisher-Wellman KH, Yamaguchi DJ, McClung JM (2022) Interventional- and amputation-stage muscle proteomes in the chronically threatened ischemic limb. https://doi.org/10.1002/ctm2.658	LEAK	F N	Permeabilized tissue	Human	Skeletal muscle
VanLieshout 2022 Mol Metab	2022	vanLieshout TL, Stouth DW, Hartel NG, Vasam G, Ng SY, Webb EK, Rebalka IA, Mikhail AI, Graham NA, Menzies KJ, Hawke TJ, Ljubicic V (2022) The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology. https://doi.org/10.1016/j.molmet.2022.101555	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Kluckova 2022 Hemasphere	2022	Kluckova K, Clear AJ, D'Avola A, Rassenti LZ, Kipps TJ, Gribben JG, Riches JC (2022) B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities. https://doi.org/10.1097/hs9.0000000000000722	LEAK ET	ROX	Intact cells		Blood cells
Nadeu 2022 Nat Med	2022	Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, Giró A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, González M, Climent F, Abrisqueta P, Castellví J, Bosch F, Aymerich M, Enjuanes A, Ruiz-Gaspà S, López-Guillermo A, Jares P, Beà S, Capella-Gutierrez S, Gelpí JL, López-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, Martín-Subero JI, Campo E (2022) Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. https://doi.org/10.1038/s41591-022-01927-8	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte Blood cells
Petry 2022 Antioxidants (Basel)	2022	Petry SF, Römer A, Rawat D, Brunner L, Lerch N, Zhou M, Grewal R, Sharifpanah F, Sauer H, Eckert GP, Linn T (2022) Loss and recovery of glutaredoxin 5 is inducible by diet in a murine model of diabesity and mediated by free fatty acids in vitro. https://doi.org/10.3390/antiox11040788	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Mouse	Islet cell;pancreas;thymus
Molinie 2022 Biochim Biophys Acta Bioenerg	2022	Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. Biochim Biophys Acta Bioenerg 1863:148532.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart Liver
Felix 2022 Chemosphere	2022	Félix L, Carreira P, Peixoto F (2022) Effects of chronic exposure of naturally weathered microplastics on oxidative stress level, behaviour, and mitochondrial function of adult zebrafish (Danio rerio). https://doi.org/10.1016/j.chemosphere.2022.136895	LEAK OXPHOS	N S CIV ROX	Homogenate	Zebrafish	Nervous system Liver
Xu 2022 Nat Commun	2022	Xu Z, Fu T, Guo Q, Zhou D, Sun W, Zhou Z, Chen X, Zhang J, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu MS, Fei W, Lu B, Gan Z (2022) Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. https://doi.org/10.1038/s41467-022-28557-5	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Mouse	Skeletal muscle
Saraiva 2022 Pathogens	2022	Saraiva FMS, Cosentino-Gomes D, Inacio JDF, Almeida-Amaral EE, Louzada-Neto O, Rossini A, Nogueira NP, Meyer-Fernandes JR, Paes MC (2022) Hypoxia effects on Trypanosoma cruzi epimastigotes proliferation, differentiation, and energy metabolism. https://doi.org/10.3390/pathogens11080897	LEAK OXPHOS	S ROX	Permeabilized cells	Protists
Muccini 2022 Oxid Med Cell Longev	2022	Muccini AM, Tran NT, Hale N, McKenzie M, Snow RJ, Walker DW, Ellery SJ (2022) The effects of in utero fetal hypoxia and creatine treatment on mitochondrial function in the late gestation fetal sheep brain. https://doi.org/10.1155/2022/3255296	LEAK OXPHOS	S	Isolated mitochondria	Other mammals	Nervous system
Daradics 2022 PLoS One	2022	Daradics N, Horvath G, Tretter L, Paal A, Fulop A, Budai A, Szijarto A (2022) The effect of Cyclophilin D depletion on liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy. https://doi.org/10.1371/journal.pone.0271606	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Liver
Kataura 2022 Dev Cell	2022	Kataura T, Sedlackova L, Otten EG, Kumari R, Shapira D, Scialo F, Stefanatos R, Ishikawa KI, Kelly G, Seranova E, Sun C, Maetzel D, Kenneth N, Trushin S, Zhang T, Trushina E, Bascom CC, Tasseff R, Isfort RJ, Oblong JE, Miwa S, Lazarou M, Jaenisch R, Imoto M, Saiki S, Papamichos-Chronakis M, Manjithaya R, Maddocks ODK, Sanz A, Sarkar S, Korolchuk VI (2022) Autophagy promotes cell survival by maintaining NAD levels. https://doi.org/10.1016/j.devcel.2022.10.008	LEAK OXPHOS	N NS	Permeabilized cells	Mouse	Fibroblast
Gschwind 2022 Ann Clin Transl Neurol	2022	Gschwind M, Garcia Segarra N, Schaller A, Bolognini R, Nuoffer JM, Hourez R, Deprez M, Lhermitte B, Maeder P, Tran C, Kuntzer T (2022) Early-onset leukoencephalomyelopathy due to a biallelic NDUFV1 variant in a mid-forties patient. https://doi.org/10.1002/acn3.51556	LEAK OXPHOS	N S CIV	Homogenate	Human	Skeletal muscle Fibroblast
De Goede 2022 FASEB J	2022	de Goede P, Wüst RCI, Schomakers BV, Denis S, Vaz FM, Pras-Raves ML, van Weeghel M, Yi CX, Kalsbeek A, Houtkooper RH (2022) Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle. FASEB J 36:e22133.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Cherix 2022 Mol Psychiatry	2022	Cherix A, Poitry-Yamate C, Lanz B, Zanoletti O, Grosse J, Sandi C, Gruetter R, Cardinaux JR (2022) Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior. https://doi.org/10.1038/s41380-022-01791-5	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Starr 2022 Curr Res Physiol	2022	Starr VJ, Dzialowski EM (2022) Developing chicken cardiac muscle mitochondria are resistant to variations in incubation oxygen levels. https://doi.org/10.1016/j.crphys.2022.03.001	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Chicken	Heart
Pallag 2022 Int J Mol Sci	2022	Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111	LEAK OXPHOS ET	N S Gp CIV NS Other combinations ROX	Isolated mitochondria	Mouse	Liver Kidney
Zhang 2022 Nat Metab	2022	Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC (2022) The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. https://doi.org/10.1038/s42255-022-00640-7	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Skeletal muscle
Zhao 2022 J Cell Sci	2022	Zhao Q, Yan S, Lu J, Parker DJ, Wu H, Sun Q, Crossman DK, Liu S, Wang Q, Sesaki H, Mitra K, Liu K, Jiao K (2022) Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. https://doi.org/10.1242/jcs.258956	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Heart
Ilha 2022 Cell Biol Int	2022	Ilha M, Meira Martins LA, da Silveira Moraes K, Dias CK, Thomé MP, Petry F, Rohden F, Borojevic R, Trindade VMT, Klamt F, Barbé-Tuana F, Lenz G, Guma FCR (2022) Caveolin-1 influences mitochondrial plasticity and function in hepatic stellate cell activation. https://doi.org/10.1002/cbin.11876	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Liver
Quast 2022 Basic Res Cardiol	2022	Quast C, Kober F, Becker K, Zweck E, Hoffe J, Jacoby C, Flocke V, Gyamfi-Poku I, Keyser F, Piayda K, Erkens R, Niepmann S, Adam M, Baldus S, Zimmer S, Nickenig G, Grandoch M, Bönner F, Kelm M, Flögel U (2022) Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis. https://doi.org/10.1007/s00395-022-00936-5	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Heart
Zhou 2022 J Hum Genet	2022	Zhou X, Lou X, Zhou Y, Xie Y, Han X, Dong Q, Ying X, Laurentinah MR, Zhang L, Chen Z, Li D, Fang H, Lyu J, Yang Y, Wang Y (2022) Novel biallelic mutations in TMEM126B cause splicing defects and lead to Leigh-like syndrome with severe complex I deficiency. https://doi.org/10.1038/s10038-022-01102-4	LEAK ROUTINE ET		Intact cells	Human	Lymphocyte
Belal 2022 Biomedicines	2022	Belal S, Goudenège D, Bocca C, Dumont F, Chao De La Barca JM, Desquiret-Dumas V, Gueguen N, Geffroy G, Benyahia R, Kane S, Khiati S, Bris C, Aranyi T, Stockholm D, Inisan A, Renaud A, Barth M, Simard G, Reynier P, Letournel F, Lenaers G, Bonneau D, Chevrollier A, Procaccio V (2022) Glutamate-induced deregulation of krebs cycle in mitochondrial encephalopathy lactic acidosis syndrome stroke-like episodes (MELAS) syndrome is alleviated by ketone body exposure. https://doi.org/10.3390/biomedicines10071665	LEAK ROUTINE ET		Intact cells	Human	Neuroblastoma
Cano-Sanchez 2022 PLoS Negl Trop Dis	2022	Cano-Sanchez M, Ben-Hassen K, Louis OP, Dantin F, Gueye P, Roques F, Mehdaoui H, Resiere D, Neviere R (2022) Bothrops lanceolatus snake venom impairs mitochondrial respiration and induces DNA release in human heart preparation. https://doi.org/10.1371/journal.pntd.0010523	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Heart
Peugnet 2022 Antioxidants (Basel)	2022	Peugnet V, Chwastyniak M, Mulder P, Lancel S, Bultot L, Fourny N, Renguet E, Bugger H, Beseme O, Loyens A, Heyse W, Richard V, Amouyel P, Bertrand L, Pinet F, Dubois-Deruy E (2022) Mitochondrial-targeted therapies require mitophagy to prevent oxidative stress induced by SOD2 inactivation in hypertrophied cardiomyocytes. https://doi.org/10.3390/antiox11040723	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Torres-Quesada 2022 MitoFit	2022	Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Human Plasma-Like Media fine-tune mitochondrial function and alter drug sensitivity in cancer cell lines. https://doi.org/10.26124/mitofit:2022-0008 — 2022-08-13 published in https://doi.org/10.3390/cancers14163917	ROUTINE LEAK ET	ROX	Intact cells	Human	Other cell lines
Tilokani 2022 Sci Adv	2022	Tilokani L, Russell FM, Hamilton S, Virga DM, Segawa M, Paupe V, Gruszczyk AV, Protasoni M, Tabara LC, Johnson M, Anand H, Murphy MP, Hardie DG, Polleux F, Prudent J (2022) AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. https://doi.org/10.1126/sciadv.abo7956	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Napso 2022 Acta Physiol (Oxf)	2022	Napso T, Lean SC, Lu M, Mort EJ, Desforges M, Moghimi A, Bartels B, El-Bacha T, Fowden AL, Camm EJ, Sferruzzi-Perri AN (2022) Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice. https://doi.org/10.1111/apha.13795	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Genital
Rios-Morales 2022 Biochim Biophys Acta Mol Basis Dis	2022	Rios-Morales M, Vieira-Lara MA, Homan E, Langelaar-Makkinje M, Gerding A, Li Z, Huijkman N, Rensen PCN, Wolters JC, Reijngoud DJ, Bakker BM (2022) Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes. https://doi.org/10.1016/j.bbadis.2022.166476	LEAK OXPHOS	F N	Permeabilized cells	Mouse	Skeletal muscle
Bresciani 2022 J Hepatol	2022	Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, Schoonjans K (2022) The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. https://doi.org/10.1016/j.jhep.2022.05.040	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Liver
De Jong 2022 Nutrients	2022	De Jong NP, Rudolph MC, Jackman MR, Sharp RR, Jones K, Houck J, Pan Z, Reusch JEB, MacLean PS, Bessesen DH, Bergouignan A (2022) Short-term adaptations in skeletal muscle mitochondrial oxidative capacity and metabolic pathways to breaking up sedentary behaviors in overweight or obese adults. https://doi.org/10.3390/nu14030454	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Long 2022 Cell Commun Signal	2022	Long C, Guo R, Han R, Li K, Wan Y, Xu J, Gong X, Zhao Y, Yao X, Liu J (2022) Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells. https://doi.org/10.1186/s12964-022-00916-1	LEAK ROUTINE ET	ROX	Intact cells	Human	Macrophage-derived
Spagnuolo 2022 Mol Neurobiol	2022	Spagnuolo MS, Mazzoli A, Nazzaro M, Troise AD, Gatto C, Tonini C, Colardo M, Segatto M, Scaloni A, Pallottini V, Iossa S, Cigliano L (2022) Long-lasting Impact of sugar intake on neurotrophins and neurotransmitters from adolescence to young adulthood in rat frontal cortex. https://doi.org/10.1007/s12035-022-03115-8	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Lu 2022 J Cosmet Dermatol	2022	Lu Q, Zou LF, Gao YZ, Ye T, Li MJ, Zhang YK, Liang B, Sun W, Xing DM (2022) Liquiritigenin reverses skin aging by inhibiting UV-induced mitochondrial uncoupling and excessive energy consumption. https://doi.org/10.1111/jocd.15506	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Mandic 2022 J Comp Physiol B	2022	Mandic M, Frazier AJ, Naslund AW, Todgham AE (2022) A comparative and ontogenetic examination of mitochondrial function in antarctic notothenioid species. https://doi.org/10.1007/s00360-022-01461-6	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Heart
Hansen 2022 Magn Reson Med	2022	Hansen K, Hansen ESS, Jespersen NRV, Bøtker HE, Pedersen M, Wang T, Laustsen C (2022) Hyperpolarized ¹³C MRI reveals large changes in pyruvate metabolism during digestion in snakes. https://doi.org/10.1002/mrm.29239	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Reptiles	Liver
Lemminger 2022 Antioxidants (Basel)	2022	Lemminger AK, Fiorenza M, Eibye K, Bangsbo J, Hostrup M (2022) High-intensity exercise training alters the effect of N-acetylcysteine on exercise-related muscle ionic shifts in men. https://doi.org/10.3390/antiox12010053	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Nath 2022 Cell Rep	2022	Nath AS, Parsons BD, Makdissi S, Chilvers RL, Mu Y, Weaver CM, Euodia I, Fitze KA, Long J, Scur M, Mackenzie DP, Makrigiannis AP, Pichaud N, Boudreau LH, Simmonds AJ, Webber CA, Derfalvi B, Hammon Y, Rachubinski RA, Di Cara F (2022) Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses . Cell Rep 38:110433.	LEAK ROUTINE OXPHOS ET	N Gp CIV ROX	Permeabilized cells Intact cells
Vizuete 2022 J Neuroinflammation	2022	Vizuete AFK, Fróes F, Seady M, Zanotto C, Bobermin LD, Roginski AC, Wajner M, Quincozes-Santos A, Gonçalves CA (2022) Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. https://doi.org/10.1186/s12974-022-02612-w	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Pereyra 2022 Mol Metab	2022	Pereyra AS, Lin CT, Sanchez DM, Laskin J, Spangenburg EE, Neufer PD, Fisher-Wellman K, Ellis JM (2022) Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation. https://doi.org/10.1016/j.molmet.2022.101456	LEAK	F N S	Isolated mitochondria	Mouse	Skeletal muscle
Goudie 2022 Sci Rep	2022	Goudie L, Mancini NL, Shutt TE, Holloway GP, Mu C, Wang A, McKay DM, Shearer J (2022) Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells. https://doi.org/10.1038/s41598-022-11123-w	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Chinas Merlin 2022 Metabolites	2022	Chinas Merlin A, Gonzalez K, Mockler S, Perez Y, Jia UA, Chicco AJ, Ullevig SL, Chung E (2022) Switching to a standard chow diet at weaning improves the effects of maternal and postnatal high-fat and high-sucrose diet on cardiometabolic health in adult male mouse offspring. https://doi.org/10.3390/metabo12060563	LEAK OXPHOS	F N NS	Isolated mitochondria	Mouse	Heart
Markovic 2022 Biomedicines	2022	Marković A, Tauchmannová K, Šimáková M, Mlejnek P, Kaplanová V, Pecina P, Pecinová A, Papoušek F, Liška F, Šilhavý J, Mikešová J, Neckář J, Houštěk J, Pravenec M, Mráček T (2022) Genetic complementation of ATP synthase deficiency due to dysfunction of TMEM70 assembly factor in rat. https://doi.org/10.3390/biomedicines10020276	LEAK OXPHOS ET	F N S NS	Homogenate	Rat	Heart Liver
Lehto 2022 Neurochem Res	2022	Lehto A, Koch K, Barnstorf-Brandes J, Viel C, Fuchs M, Klein J (2022) ß-Hydroxybutyrate improves mitochondrial function after transient ischemia in the mouse. https://doi.org/10.1007/s11064-022-03637-6	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Hong 2022 Cell Stem Cell	2022	Hong X, Isern J, Campanario S, Perdiguero E, Ramírez-Pardo I, Segalés J, Hernansanz-Agustín P, Curtabbi A, Deryagin O, Pollán A, González-Reyes JA, Villalba JM, Sandri M, Serrano AL, Enríquez JA, Muñoz-Cánoves P (2022) Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. https://doi.org/10.1016/j.stem.2022.07.009	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Desjardins 2022 Proc Natl Acad Sci U S A	2022	Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR (2022) The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids. https://doi.org/10.1073/pnas.2119824119	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Liver
Komlodi 2022 BEC	2022	Komlódi T, Tretter L (2022) The protonmotive force – not merely membrane potential. Bioenerg Commun 2022.16. https://doi.org/10.26124/bec:2022-0016	LEAK OXPHOS		Isolated mitochondria
Xu 2022 Sci Adv	2022	Xu H, Ahn B, Van Remmen H (2022) Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation. https://doi.org/10.1126/sciadv.add7377	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Munoz-Pujol 2022 Brain Pathol	2022	Muñoz-Pujol G, Ortigoza-Escobar JD, Paredes-Fuentes AJ, Jou C, Ugarteburu O, Gort L, Yubero D, García-Cazorla A, O'Callaghan M, Campistol J, Muchart J, Yépez VA, Gusic M, Gagneur J, Prokisch H, Artuch R, Ribes A, Urreizti R, Tort F (2022) Leigh syndrome is the main clinical characteristic of PTCD3 deficiency. https://doi.org/10.1111/bpa.13134	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Karavyraki 2022 MitoFit	2022	Karavyraki M, Gnaiger E, Porter RK (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. https://doi.org/10.26124/mitofit:2022-0022 — 2022-11-11 published in Bioenerg Commun 2022.11.	LEAK ROUTINE ET	S ROX	Permeabilized cells	Human
Fernandez-Vizarra 2022 Cell Metab	2022	Fernández-Vizarra E, López-Calcerrada S, Sierra-Magro A, Pérez-Pérez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, Martín MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C (2022) Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. https://doi.org/10.1016/j.cmet.2022.09.005	LEAK ET	N S Gp NS ROX	Permeabilized cells Intact cells	Human	HEK
Lopes 2022 Int J Mol Sci	2022	Lopes JA, Collino F, Rodrigues-Ferreira C, Sampaio LDS, Costa-Sarmento G, Wendt CHC, Almeida FP, Miranda KR, Kasai-Brunswick TH, Lindoso RS, Vieyra A (2022) Early effects of extracellular vesicles secreted by adipose tissue mesenchymal cells in renal ischemia followed by reperfusion: mechanisms rely on a decrease in mitochondrial anion superoxide production. https://doi.org/10.3390/ijms23062906	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Human	Kidney
Brunetta 2022 Redox Biol	2022	Brunetta HS, Petrick HL, Momken I, Handy RM, Pignanelli C, Nunes EA, Piquereau J, Mericskay M, Holloway GP (2022) Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1. https://doi.org/10.1016/j.redox.2022.102307	LEAK OXPHOS	F N NS	Permeabilized tissue	Mouse	Skeletal muscle
Pedersen 2022 Nat Commun	2022	Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. https://doi.org/10.1038/s41467-022-30629-5	LEAK OXPHOS ET	F N S CIV NS	Permeabilized tissue	Human	Liver Fat
Englund 2022 Mol Metab	2022	Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE, Zeidler JD, Warner GM, McNinch C, White TA, Chini EN, Baker DJ, van Deursen JM, LeBrasseur NK (2022) p21 induces a senescence program and skeletal muscle dysfunction. https://doi.org/10.1016/j.molmet.2022.101652	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Barath 2022 Int J Mol Sci	2022	Baráth B, Jász DK, Horváth T, Baráth B, Maróti G, Strifler G, Varga G, Sándor L, Perényi D, Tallósy S, Donka T, Jávor P, Boros M, Hartmann P (2022) Mitochondrial side effects of surgical prophylactic antibiotics Ceftriaxone and Rifaximin lead to bowel mucosal damage. Int J Mol Sci 23:5064. https://doi.org/10.3390/ijms23095064	LEAK OXPHOS	S	Homogenate Isolated mitochondria	Rat	Liver
O'Hanlon 2022 Neurobiol Dis	2022	O'Hanlon ME, Tweedy C, Scialo F, Bass R, Sanz A, Smulders-Srinivasan TK (2022) Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. https://doi.org/10.1016/j.nbd.2022.105803	LEAK OXPHOS	N Gp CIV ROX	Homogenate	Drosophila
Zhang 2022 Ecotoxicol Environ Saf	2022	Zhang Y, Yuan F, Li P, Gu J, Han J, Ni Z, Liu F (2022) Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function. https://doi.org/10.1016/j.ecoenv.2022.113788	LEAK ROUTINE ET	ROX	Intact cells	Human	HeLa
Siewiera 2022 Int J Mol Sci	2022	Siewiera K, Labieniec-Watala M, Kassassir H, Wolska N, Polak D, Watala C (2022) Potential role of mitochondria as modulators of blood platelet activation and reactivity in diabetes and effect of metformin on blood platelet bioenergetics and platelet activation. https://doi.org/10.3390/ijms23073666	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Platelet
Ahn 2022 Aging Cell	2022	Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H (2022) Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging Cell 21:e13569.	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Cho 2022 BMC Med	2022	Cho J, Johnson BD, Watt KD, Niven AS, Yeo D, Kim CH (2022) Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD. https://doi.org/10.1186/s12916-022-02629-1	LEAK OXPHOS	N NS	Homogenate	Mouse	Lung;gill
Olesen 2022 Metabol Open	2022	Olesen K, Moruzzi N, Bulatovic I, Folmes C, Jeon R, Felldin U, Terzic A, Simonson OE, Le Blanc K, Österholm C, Berggren PO, Schiffer T, Rodin S, Tilevik A, Grinnemo KH (2022) Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells. https://doi.org/10.1016/j.metop.2022.100167	LEAK OXPHOS	N S NS ROX	Permeabilized cells	Human	Other cell lines
Thapa 2022 Physiol Rep	2022	Thapa D, Bugga P, Mushala BAS, Manning JR, Stoner MW, McMahon B, Zeng X, Cantrell PS, Yates N, Xie B, Edmunds LR, Jurczak MJ, Scott I (2022) GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. https://doi.org/10.14814/phy2.15415	LEAK OXPHOS ET	N ROX		Mouse	Heart
Pochakom 2022 Brain Sci	2022	Pochakom A, Mu C, Rho JM, Tompkins TA, Mayengbam S, Shearer J (2022) Selective probiotic treatment positively modulates the microbiota-gut-brain axis in the BTBR mouse model of autism. https://doi.org/10.3390/brainsci12060781	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Nervous system
Zhang 2022 Mol Med Rep	2022	Zhang J, Sun B, Yang J, Chen Z, Li Z, Zhang N, Li H, Shen L (2022) Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. https://doi.org/10.3892/mmr.2022.12607	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Nervous system
Laehteenmaeki 2022 Physiol Rep	2022	Lähteenmäki EI, Koski M, Koskela I, Lehtonen E, Kankaanpää A, Kainulainen H, Walker S, Lehti M (2022) Resistance exercise with different workloads have distinct effects on cellular respiration of peripheral blood mononuclear cells. https://doi.org/10.14814/phy2.15394	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Leibold 2022 PLoS One	2022	Leibold S, Bagivalu Lakshminarasimha A, Gremse F, Hammerschmidt M, Michel M (2022) Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. https://doi.org/10.1371/journal.pone.0267933	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Zebrafish
Liu 2022 Adv Sci (Weinh)	2022	Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J (2022) Geometric constraints regulate energy metabolism and cellular contractility in vascular smooth muscle cells by coordinating mitochondrial DNA methylation. https://doi.org/10.1002/advs.202203995	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Other cell lines
Della Noce 2022 J Biol Chem	2022	Della Noce B, Martins da Silva R, de Carvalho Uhl MV, Konnai S, Ohashi K, Calixto C, Arcanjo A, de Abreu LA, de Carvalho SS, da Silva Vaz I Jr, Logullo C (2022) Redox imbalance induces remodeling of glucose metabolism in Rhipicephalus microplus embryonic cell line. https://doi.org/10.1016/j.jbc.2022.101599	LEAK ROUTINE ET	ROX	Intact cells	Chelicerates	Other cell lines
Fischer 2022 Metabolites	2022	Fischer C, Valente de Souza L, Komlódi T, Garcia-Souza LF, Volani C, Tymoszuk P, Demetz E, Seifert M, Auer K, Hilbe R, Brigo N, Petzer V, Asshoff M, Gnaiger E, Weiss G (2022) Mitochondrial respiration in response to iron deficiency anemia. Comparison of peripheral blood mononuclear cells and liver. https://doi.org/10.3390/metabo12030270	LEAK ROUTINE OXPHOS ET	N S NS Other combinations ROX	Permeabilized cells Homogenate	Rat	Liver Blood cells
Babylon 2022 Int J Mol Sci	2022	Babylon L, Schmitt F, Franke Y, Hubert T, Eckert GP (2022) Effects of combining biofactors on bioenergetic parameters, Aβ levels and survival in Alzheimer model organisms. https://doi.org/10.3390/ijms23158670	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Lee 2022 Hum Mol Genet	2022	Lee RG, Balasubramaniam S, Stentenbach M, Kralj T, McCubbin T, Padman B, Smith J, Riley LG, Priyadarshi A, Peng L, Nuske MR, Webster R, Peacock K, Roberts P, Stark Z, Lemire G, Ito YA; Care4Rare Canada Consortium, Boycott KM, Geraghty MT, van Klinken JB, Ferdinandusse S, Zhou Y, Walsh R, Marcellin E, Thorburn DR, Rosciolli T, Fletcher J, Rackham O, Vaz FM, Reid GE, Filipovska A (2022) Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. https://doi.org/10.1093/hmg/ddac040	LEAK OXPHOS	N CIV ROX	Permeabilized cells	Human	Fibroblast
Spielmann 2022 Mamm Genome	2022	Spielmann N, Schenkl C, Komlódi T, da Silva-Buttkus P, Heyne E, Rohde J, Amarie OV, Rathkolb B, Gnaiger E, Doenst T, Fuchs H, Gailus-Durner V, de Angelis MH, Szibor M (2022) Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction. Mamm Genome 10.1007/s00335-022-09973-w	LEAK OXPHOS ET	N S NS ROX	Intact organism Isolated mitochondria	Mouse	Heart
Chinas 2022 Metabolites	2022	Chiñas Merlin A, Gonzalez K, Mockler S, Perez Y, Jia UA, Chicco AJ, Ullevig SL, Chung E (2022) Switching to a standard chow diet at weaning improves the effects of maternal and postnatal high-fat and high-sucrose diet on cardiometabolic health in adult male mouse offspring. https://doi.org/10.3390/metabo12060563	LEAK OXPHOS	F N NS	Isolated mitochondria	Mouse	Heart
De Paula Nascimento-Castro 2022 Biomedicines	2022	de Paula Nascimento-Castro C, Winkelmann-Duarte EC, Mancini G, Welter PG, Plácido E, Farina M, Gil-Mohapel J, Rodrigues ALS, de Bem AF, Brocardo PS (2022) Temporal characterization of behavioral and hippocampal dysfunction in the YAC128 mouse model of Huntington's disease. https://doi.org/10.3390/biomedicines10061433	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Heher 2022 Redox Biol	2022	Heher P, Ganassi M, Weidinger A, Engquist EN, Pruller J, Nguyen TH, Tassin A, Declèves AE, Mamchaoui K, Banerji CRS, Grillari J, Kozlov AV, Zammit PS (2022) Interplay between mitochondrial reactive oxygen species, oxidative stress and hypoxic adaptation in facioscapulohumeral muscular dystrophy: Metabolic stress as potential therapeutic target. https://doi.org/10.1016/j.redox.2022.102251	LEAK OXPHOS	N S	Permeabilized tissue	Human	Skeletal muscle
Leggio 2022 Adv Healthc Mater	2022	Leggio L, L'Episcopo F, Magrì A, Ulloa-Navas MJ, Paternò G, Vivarelli S, Bastos CAP, Tirolo C, Testa N, Caniglia S, Risiglione P, Pappalardo F, Serra A, García-Tárraga P, Faria N, Powell JJ, Peruzzotti-Jametti L, Pluchino S, García-Verdugo JM, Messina A, Marchetti B, Iraci N (2022) Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease. https://doi.org/10.1002/adhm.202201203	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Garcia-Roche 2022 J Dairy Sci	2022	García-Roche M, Talmón D, Cañibe G, Astessiano AL, Mendoza A, Quijano C, Cassina A, Carriquiry M (2022) Differential hepatic mitochondrial function and gluconeogenic gene expression in 2 Holstein strains in a pasture-based system. https://doi.org/10.3168/jds.2021-21358	LEAK OXPHOS ET	N S NS ROX	Intact cells	Bovines	Liver
Salyers 2022 JVS Vasc Sci	2022	Salyers ZR, Mariani V, Balestrieri N, Kumar RA, Vugman NA, Thome T, Villani KR, Berceli SA, Scali ST, Vasilakos G, Ryan TE (2022) S100A8 and S100A9 are elevated in chronically threatened ischemic limb muscle and induce ischemic mitochondrial pathology in mice. https://doi.org/10.1016/j.jvssci.2022.03.003	LEAK	F N	Permeabilized tissue Isolated mitochondria	Human Mouse	Skeletal muscle
Jedlicka 2022 Physiol Res	2022	Jedlička J, Grundmanová M, Švíglerová J, Tůma Z, Nalos L, Rajdl D, Štengl M, Kuncová J (2022) Mitochondrial dysfunction in kidney cortex and medulla of subtotally nephrectomized rats. https://doi.org/10.33549/physiolres.935000	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Rat	Kidney
Zhang 2022 Int J Mol Sci	2022	Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial complex II reactive oxygen species generation in human prostate cancer. https://doi.org/10.3390/ijms232012168	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Genital
Loughland 2022 J Exp Biol	2022	Loughland I, Lau GY, Jolly J, Seebacher F (2022) Rates of warming impact oxidative stress in zebrafish (Danio rerio).	LEAK OXPHOS ET	N NS	Isolated mitochondria	Zebrafish	Skeletal muscle
Juhaszova 2022 Function (Oxf)	2022	Juhaszova M, Kobrinsky E, Zorov DB, Nuss HB, Yaniv Y, Fishbein KW, de Cabo R, Montoliu L, Gabelli SB, Aon MA, Cortassa S, Sollott SJ (2022) ATP synthase K⁺- and H⁺-fluxes drive ATP synthesis and enable mitochondrial K⁺-"uniporter" function: II. Ion and ATP synthase flux regulation. Function (Oxf) 3(2):zqac001. doi: 10.1093/function/zqac001	LEAK OXPHOS
Quemeneur 2022 Sci Rep	2022	Quéméneur JB, Danion M, Cabon J, Collet S, Zambonino-Infante JL, Salin K (2022) The relationships between growth rate and mitochondrial metabolism varies over time. https://doi.org/10.1038/s41598-022-20428-9	LEAK OXPHOS	N CIV NS ROX	Homogenate	Fishes	Skeletal muscle
Harris 2022 Autophagy	2022	Harris MP, Zhang QJ, Cochran CT, Ponce J, Alexander S, Kronemberger A, Fuqua JD, Zhang Y, Fattal R, Harper T, Murry ML, Grueter CE, Abel ED, Lira VA (2022) Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function. https://doi.org/10.1080/15548627.2021.2022289	LEAK OXPHOS	F N	Permeabilized tissue	Mouse	Heart
Jelenik 2022 Pharmacol Res	2022	Jelenik T, Kodde A, Pesta D, Phielix E, Oosting A, Rohbeck E, Dewidar B, Mastrototaro L, Trenkamp S, Keijer J, van der Beek EM, Roden M (2022) Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming. https://doi.org/10.1016/j.phrs.2022.106193	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Gonzalez-Franquesa 2022 Redox Biol	2022	Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Nervous system Liver Fat
Sarabhai 2022 Diabetologia	2022	Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, Katsuyama H, Guthoff R, Wolkersdorfer M, Herder C, Meuth SG, Dreyer S, Roden M (2022) Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. https://doi.org/10.1007/s00125-022-05797-0	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle Fat
Copperi 2022 Commun Biol	2022	Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T (2022) EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. https://doi.org/10.1038/s42003-022-03201-6	LEAK OXPHOS ET	N	Intact cells	Mouse	Fat
Komlodi 2022 MitoFit	2022	Komlódi T, Tretter L (2022) The protonmotive force – not merely membrane potential. https://doi.org/10.26124/mitofit:2022-0012 — 2022-11-29 published in Bioenerg Commun 2022.16.	LEAK OXPHOS		Isolated mitochondria
Delfinis 2022 JCI Insight	2022	Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG (2022) Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress. https://doi.org/10.1172/jci.insight.155147	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Gomez 2022 Nutrients	2022	Gómez Rodríguez A, Talamonti E, Naudi A, Kalinovich AV, Pauter AM, Barja G, Bengtsson T, Jacobsson A, Pamplona R, Shabalina IG (2022) Elovl2-ablation leads to mitochondrial membrane fatty acid remodeling and reduced efficiency in mouse liver mitochondria. https://doi.org/10.3390/nu14030559	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Liver
Tomar 2022 Biochim Biophys Acta Bioenerg	2022	Tomar N, Zhang X, Kandel SM, Sadri S, Yang C, Liang M, Audi SH, Cowley AW Jr, Dash RK (2022) Substrate-dependent differential regulation of mitochondrial bioenergetics in the heart and kidney cortex and outer medulla. https://doi.org/10.1016/j.bbabio.2021.148518	LEAK OXPHOS ET	F N S	Isolated mitochondria	Rat	Heart Kidney
Adant 2022 Mol Metab	2022	Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	Fibroblast
Fedorov 2022 Naunyn Schmiedebergs Arch Pharmacol	2022	Fedorov A, Lehto A, Klein J (2022) Inhibition of mitochondrial respiration by general anesthetic drugs. https://doi.org/10.1007/s00210-022-02338-9	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Sumbalova 2022 Front Mol Biosci	2022	Sumbalová Z, Kucharská J, Rausová Z, Palacka P, Kovalčíková E, Takácsová T, Mojto V, Navas P, Lopéz-Lluch G, Gvozdjáková A (2022) Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy. https://doi.org/10.3389/fmolb.2022.1016352	LEAK ROUTINE OXPHOS ET	N NS	Permeabilized cells Intact cells	Human	Platelet
Trewin 2022 BMC Biol	2022	Trewin AJ, Silver J, Dillon HT, Della Gatta PA, Parker L, Hiam DS, Lee YP, Richardson M, Wadley GD, Lamon S (2022) Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle. https://doi.org/10.1186/s12915-022-01366-4	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Cossin-Sevrin 2022 J Exp Biol	2022	Cossin-Sevrin N, Hsu BY, Marciau C, Viblanc VA, Ruuskanen S, Stier A (2022) Effect of prenatal glucocorticoids and thyroid hormones on developmental plasticity of mitochondrial aerobic metabolism, growth and survival: an experimental test in wild great tits. https://doi.org/10.1242/jeb.243414	LEAK OXPHOS	N NS	Intact cells	Birds	Blood cells
Li 2022 Mol Med	2022	Li X, Zhou X, Liu X, Li X, Jiang X, Shi B, Wang S (2022) Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. https://doi.org/10.1186/s10020-022-00533-1	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Blood cells
Yin 2022 J Exp Med	2022	Yin Y, Xu D, Mao Y, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z (2022) FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. https://doi.org/10.1084/jem.20212491	LEAK OXPHOS	F N S ROX	Permeabilized cells	Mouse	Fat
Tepp 2022 Biochem Biophys Rep	2022	Tepp K, Aid-Vanakova J, Puurand M, Timohhina N, Reinsalu L, Tein K, Plaas M, Shevchuk I, Terasmaa A, Kaambre T (2022) Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochem Biophys Rep 30:101250.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Rat	Skeletal muscle
Dieter 2022 Int J Mol Sci	2022	Dieter F, Esselun C, Eckert GP (2022) Redox active α-lipoic acid differentially improves mitochondrial dysfunction in a cellular model of Alzheimer and its control cells. https://doi.org/10.3390/ijms23169186	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Hadanny 2022 Sports Med Open	2022	Hadanny A, Hachmo Y, Rozali D, Catalogna M, Yaakobi E, Sova M, Gattegno H, Abu Hamed R, Lang E, Polak N, Friedman M, Finci S, Zemel Y, Bechor Y, Gal N, Efrati S (2022) Effects of hyperbaric oxygen therapy on mitochondrial respiration and physical performance in middle-aged athletes: a blinded, randomized controlled trial.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Serna 2022 BEC	2022	Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca²⁺ efflux in isolated mitochondria and permeabilized cells. https://doi.org/10.26124/bec:2022-0007	LEAK OXPHOS	S ROX	Permeabilized cells Isolated mitochondria	Human Mouse	Liver Other cell lines
Vanweert 2022 Nat Commun	2022	Vanweert F, Neinast M, Tapia EE, van de Weijer T, Hoeks J, Schrauwen-Hinderling VB, Blair MC, Bornstein MR, Hesselink MKC, Schrauwen P, Arany Z, Phielix E (2022) A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes. https://doi.org/10.1038/s41467-022-31249-9	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Chojnacka 2022 Mol Biol Cell	2022	Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacinska A (2022) Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria. https://doi.org/10.1091/mbc.e21-03-0143	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Intact cells	Human	HEK
Torres-Quesada 2022 Cancers (Basel)	2022	Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Physiological cell culture media tune mitochondrial bioenergetics and drug sensitivity in cancer cell models. https://doi.org/10.3390/cancers14163917	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Broome 2022 Redox Biol	2022	Broome SC, Pham T, Braakhuis AJ, Narang R, Wang HW, Hickey AJR, Mitchell CJ, Merry TL (2022) MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. https://doi.org/10.1016/j.redox.2022.102341	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
McKenna 2022 J Appl Physiol (1985)	2022	McKenna CF, Salvador AF, Keeble AR, Khan NA, De Lisio M, Konopka AR, Paluska SA, Burd NA (2022) Muscle strength after resistance training correlates to mediators of muscle mass and mitochondrial respiration in middle-aged adults. https://doi.org/10.1152/japplphysiol.00186.2022	LEAK OXPHOS ET	NS	Permeabilized tissue	Human	Skeletal muscle
Erdem 2022 Nat Commun	2022	Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, Weinhäuser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ (2022) Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. https://doi.org/10.1038/s41467-022-29639-0	LEAK OXPHOS ET	N	Permeabilized cells	Human	Other cell lines
Jedlicka 2022a Physiol Res	2022	Jedlička J, Tůma Z, Razak K, Kunc R, Kala A, Proskauer Pena S, Lerchner T, Ježek K, Kuncová J (2022) Impact of aging on mitochondrial respiration in various organs. https://doi.org/10.33549/physiolres.934995	LEAK ROUTINE OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue Homogenate Intact cells	Rat	Heart Skeletal muscle Nervous system Liver Kidney Platelet
Pallag 2022 MitoFit Proline	2022	Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation leading to high electron flow through reduction of ubiquinone supports ATP production by F₁F_O-ATPase in mitochondria with inhibited Complex I. https://doi.org/10.26124/mitofit:2022-0001.v3 — 2022-05-04 published in https://doi.org/10.3390/ijms23095111	LEAK OXPHOS	N S NS Other combinations ROX	Isolated mitochondria	Mouse	Heart Kidney Liver Nervous system
Meszaros 2022 EBioMedicine	2022	Meszaros AT, Hofmann J, Buch ML, Cardini B, Dunzendorfer-Matt T, Nardin F, Blumer MJ, Fodor M, Hermann M, Zelger B, Otarashvili G, Schartner M, Weissenbacher A, Oberhuber R, Resch T, Troppmair J, Öfner D, Zoller H, Tilg H, Gnaiger E, Hautz T, Schneeberger S (2022) Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome. https://doi.org/10.1016/j.ebiom.2022.104311	OXPHOS ET LEAK	F N S NS ROX	Homogenate	Human	Liver
Bikman 2022 Eur J Clin Nutr	2022	Bikman BT, Shimy KJ, Apovian CM, Yu S, Saito ER, Walton CM, Ebbeling CB, Ludwig DS (2022) A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration. https://doi.org/10.1038/s41430-022-01097-3	LEAK OXPHOS ET	N NS	Permeabilized cells	Human	Fat
Yamauchi 2022 Sci Rep	2022	Yamauchi Y, Nakamura A, Yokota T, Takahashi K, Kawata S, Tsuchida K, Omori K, Nomoto H, Kameda H, Cho KY, Anzai T, Tanaka S, Terauchi Y, Miyoshi H, Atsumi T (2022) Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function. Sci Rep 12: 9740.	LEAK OXPHOS			Mouse	Islet cell;pancreas;thymus
Wang 2022 Redox Biol	2022	Wang P, Cui Y, Liu Y, Li Z, Bai H, Zhao Y, Chang YZ (2022) Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion. https://doi.org/10.1016/j.redox.2022.102475	LEAK OXPHOS ET	N ROX	Homogenate	Mouse	Nervous system
Damgaard 2022 iScience	2022	Damgaard MV, Nielsen TS, Basse AL, Chubanava S, Trost K, Moritz T, Dellinger RW, Larsen S, Treebak JT (2022) Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD⁺ without impacting respiratory capacity or insulin sensitivity. https://doi.org/10.1016/j.isci.2022.103863	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Salmon 2022 Geroscience	2022	Salmón P, Millet C, Selman C, Monaghan P, Dawson NJ (2022) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. https://doi.org/10.1007/s11357-022-00624-1	LEAK OXPHOS	N CIV NS ROX	Homogenate	Birds	Skeletal muscle Liver
Graham 2022 Physiol Rep	2022	Graham ZA, DeBerry JJ, Cardozo CP, Bamman MM (2022) SS-31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice. https://doi.org/10.14814/phy2.15266	LEAK OXPHOS ET	N ROX	Permeabilized tissue	Mouse	Skeletal muscle
Tang 2022 Sci China Life Sci	2022	Tang G, Ma C, Li L, Zhang S, Li F, Wu J, Yin Y, Zhu Q, Liang Y, Wang R, Huang H, Zhao TJ, Yang H, Li P, Chen FJ (2022) PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure. https://doi.org/10.1007/s11427-022-2157-y	LEAK ET	N	Isolated mitochondria	Mouse	Fat
Niemann 2022 Biology (Basel)	2022	Niemann B, Pan R, Issa H, Simm A, Schulz R, Rohrbach S (2022) AMPK activation is indispensable for the protective effects of caloric restriction on left ventricular function in postinfarct myocardium. https://doi.org/10.3390/biology11030448	LEAK OXPHOS	N S	Permeabilized tissue	Mouse Rat	Heart
Bellissimo 2022 MitoFit	2022	Bellissimo CA, Sondergaard S, Hughes MC, Ramos SV, Larsen S, Perry CGR (2022) The influence of adenylate cycling on mitochondrial calcium-induced permeability transition pore in permeabilized skeletal muscle fibres. https://doi.org/10.26124/mitofit:2022-0026 — 2023-02-20 published in Bioenerg Commun 2023.1.	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Gutierrez 2022 Cell Rep Med	2022	Gutierrez AD, Gao Z, Hamidi V, Zhu L, Saint Andre KB, Riggs K, Ruscheinsky M, Wang H, Yu Y, Miller C 3rd, Vasquez H, Taegtmeyer H, Kolonin MG (2022) Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes. https://doi.org/10.1016/j.xcrm.2022.100813	LEAK	S ROX		Mouse	Fat
Rome 2022 Mol Metab	2022	Rome FI, Hughey CC (2022) Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction. https://doi.org/10.1016/j.molmet.2022.101452	LEAK OXPHOS ET	N CIV ROX	Isolated mitochondria	Mouse	Liver
Pileggi 2022 EBioMedicine	2022	Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SAL, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME (2022) Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. https://doi.org/10.1016/j.ebiom.2022.104192	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Dawson 2022 FASEB J	2022	Dawson NJ, Scott GR (2022) Adaptive increases in respiratory capacity and O₂ affinity of subsarcolemmal mitochondria from skeletal muscle of high-altitude deer mice. https://doi.org/10.1096/fj.202200219r	LEAK OXPHOS	F N CIV NS	Isolated mitochondria	Mouse	Skeletal muscle
Wu 2022 Antioxidants (Basel)	2022	Wu YL, Chang JC, Chao YC, Chan H, Hsieh M, Liu CS (2022) In vitro efficacy and molecular mechanism of curcumin analog in pathological regulation of spinocerebellar ataxia type 3. https://doi.org/10.3390/antiox11071389	LEAK OXPHOS ET	N S NS ROX	Intact cells	Human	Neuroblastoma
Tremmel 2022 Sci Rep	2022	Tremmel DM, Sackett SD, Feeney AK, Mitchell SA, Schaid MD, Polyak E, Chlebeck PJ, Gupta S, Kimple ME, Fernandez LA, Odorico JS (2022) A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment. https://doi.org/10.1038/s41598-022-11085-z	LEAK ROUTINE ET	ROX	Intact cells	Human	Islet cell;pancreas;thymus
Colin 2021 J Cell Mol Med	2021	Colin M, Dechene L, Ceusters J, Niesten A, Demazy C, Lagneaux L, Zouaoui Boudjeltia K, Franck T, Van Antwerpen P, Renard P, Mathieu V, Serteyn D (2021) Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell-based therapy development. J Cell Mol Med 25:4877-81.	LEAK OXPHOS ET	N S NS	Intact cells	Horse	Stem cells
Zanou 2021 Nat Commun	2021	Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca²⁺ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Lei 2021 Ecotoxicol Environ Saf	2021	Lei C, Liao J, Li Q, Shi J, Zhang H, Guo J, Han Q, Hu L, Li Y, Pan J, Tang Z (2021) Copper induces mitochondria-mediated apoptosis via AMPK-mTOR pathway in hypothalamus of pigs. Ecotoxicol Environ Saf 220:112395.	LEAK OXPHOS ET	N S ROX		Pig	Nervous system
Valera-Alberni 2021 Cell Rep	2021	Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, Núñez Galindo A, Sanchez-Garcia JL, Valsesia A, Cercillieux A, Söllner F, Ladurner AG, Yanes O, Cantó C (2021) Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Rep 36:109565.	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Mouse	Liver Fat
Giordano 2021 Gene Ther	2021	Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, Rudolph C, Plank C, Jacobs HT, Szibor M (2021) Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. https://doi.org/10.1038/s41434-021-00235-z	LEAK ROUTINE OXPHOS	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Fibroblast
Babylon 2021 Antioxidants (Basel)	2021	Babylon L, Grewal R, Stahr PL, Eckert RW, Keck CM, Eckert GP (2021) Hesperetin nanocrystals improve mitochondrial function in a cell model of early Alzheimer disease. Antioxidants (Basel) 10:1003.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Gomez-Valades 2021 Cell Metab	2021	Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M (2021) Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca²⁺ homeostasis with adipose tissue lipolysis . Cell Metab 33:1820-35.e9.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Willis 2021 Sci Rep	2021	Willis JR, Hickey AJR, Devaux JBL (2021) Thermally tolerant intertidal triplefin fish (Tripterygiidae) sustain ATP dynamics better than subtidal species under acute heat stress. Sci Rep 11:11074.	LEAK OXPHOS ET ROUTINE	N ROX NS	Homogenate	Fishes	Nervous system
Avin 2021 Sci Rep	2021	Avin KG, Hughes MC, Chen NX, Srinivasan S, O'Neill KD, Evan AP, Bacallao RL, Schulte ML, Moorthi RN, Gisch DL, Perry CGR, Moe SM, O'Connell TM (2021) Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease. Sci Rep 11:9788.	LEAK OXPHOS	N NS	Permeabilized tissue	Rat	Skeletal muscle
Antico 2021 Sci Adv	2021	Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.	LEAK OXPHOS ET	F N S Gp NS ROX	Intact cells	Mouse	Nervous system
Dos Santos Escaliante 2021 Int J Biol Macromol	2021	Dos Santos Escaliante LA, Busato B, de Oliveira Petkowicz CL, Suter Correia Cadena SM, Rodrigues Noleto G (2021) Cytotoxic effect of xyloglucan and oxovanadium (IV/V) xyloglucan complex in HepG2 cells. Int J Biol Macromol 185:40-48.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Liver
Elliehausen 2021 Exp Gerontol	2021	Elliehausen CJ, Minton DM, Nichol AD, Konopka AR (2021) Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin. https://doi.org/10.1016/j.exger.2021.111579	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Guinea pig	Skeletal muscle
Christiansen 2021 Sci Rep	2021	Christiansen LB, Dohlmann TL, Ludvigsen TP, Parfieniuk E, Ciborowski M, Szczerbinski L, Kretowski A, Desler C, Tiano L, Orlando P, Martinussen T, Olsen LH, Larsen S (2021) Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected. Sci Rep 11:2167.	LEAK OXPHOS ET	F N S CIV NS	Permeabilized tissue	Pig	Heart Skeletal muscle Liver
Figueira 2021 Arch Biochem Biophys	2021	Figueira TR, Francisco A, Ronchi JA, Dos Santos GRRM, Santos WD, Treberg JR, Castilho RF (2021) NADPH supply and the contribution of NAD(P)⁺ transhydrogenase (NNT) to H₂O₂ balance in skeletal muscle mitochondria. Arch Biochem Biophys 707:108934.	LEAK OXPHOS ET	N F	Isolated mitochondria	Mouse	Skeletal muscle
Cannon 2021 Respir Physiol Neurobiol	2021	Cannon DT, Nogueira L, Gutierrez-Gonzalez AK, Gilmore NK, Bigby TD, Breen EC (2021) Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respir Physiol Neurobiol 295:103783.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Brito 2021 BMC Cancer	2021	Brito A, Merle C, Lagarde P, Faustin B, Devin A, Lartigue L, Chibon F (2021) Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion. BMC Cancer 21:863.	LEAK ET	N	Intact cells	Human	Fibroblast
McKenna 2021 Redox Biol	2021	McKenna HT, O'Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP, Mythen MG, Feelisch M, Murray AJ, Martin DS (2021) Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biol 41:101907.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Gratl 2021 J Transl Med	2021	Gratl A, Pesta D, Gruber L, Speichinger F, Raude B, Omran S, Greiner A, Frese JP (2021) The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study. https://doi.org/10.1186/s12967-021-02908-0J	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Mendham 2021 Diabetologia	2021	Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59.	LEAK OXPHOS ET	F N S NS ROX	Intact cells	Human	Skeletal muscle
Souza 2021 PLoS Pathog	2021	Souza ROO, Damasceno FS, Marsiccobetre S, Biran M, Murata G, Curi R, Bringaud F, Silber AM (2021) Fatty acid oxidation participates in resistance to nutrient-depleted environments in the insect stages of Trypanosoma cruzi. PLoS Pathog 17:1009495.	LEAK ET		Intact cells		Other cell lines
Klepinina 2021 PLoS One	2021	Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Axelrod 2021 EMBO Mol Med	2021	Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.	ROUTINE OXPHOS ET LEAK	F N S NS ROX DQ	Intact cells Permeabilized tissue	Mouse	Skeletal muscle
Oemer 2021 J Lipid Res	2021	Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. https://doi.org/10.1016/j.jlr.2021.100111	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells	Human	HeLa
Flouda 2021 Free Radic Biol Med	2021	Flouda K, Mercer J, Davies MJ, Hawkins CL (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radic Biol Med 166:165-77.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Daura 2021 Neurobiol Dis	2021	Daura E, Tegelberg S, Yoshihara M, Jackson C, Simonetti F, Aksentjeff K, Ezer S, Hakala P, Katayama S, Kere J, Lehesjoki AE, Joensuu T (2021) Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis. Neurobiol Dis 156:105418.	LEAK OXPHOS ET	N CIV NS	Permeabilized cells	Mouse	Stem cells Nervous system
Cardinale 2021 J Appl Physiol (1985)	2021	Cardinale DA, Gejl KD, Petersen KG, Nielsen J, Ørtenblad N, Larsen FJ (2021) Short-term intensified training temporarily impairs mitochondrial respiratory capacity in elite endurance athletes. J Appl Physiol (1985) 131:388-400.	LEAK OXPHOS	F N CIV NS	Permeabilized tissue	Human	Skeletal muscle
Fang 2021 Cell Rep	2021	Fang H, Ye X, Xie J, Li Y, Li H, Bao X, Yang Y, Lin Z, Jia M, Han Q, Zhu J, Li X, Zhao Q, Yang Y, Lyu J (2021) A membrane arm of mitochondrial complex I sufficient to promote respirasome formation. Cell Rep 35:108963.	LEAK ROUTINE OXPHOS ET	N S	Permeabilized cells Intact cells
Chowdhury 2021 Cancers (Basel)	2021	Chowdhury SR, Peltier C, Hou S, Singh A, Johnston JB, Gibson SB, Marshall A, Banerji V (2021) Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells. Cancers (Basel) 13:E354.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte
Liu 2021 FASEB J	2021	Liu Z, Chaillou T, Santos Alves E, Mader T, Jude B, Ferreira DMS, Hynynen H, Cheng AJ, Jonsson WO, Pironti G, Andersson DC, Kenne E, Ruas JL, Tavi P, Lanner JT (2021) Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. FASEB J 35:e22010.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Connell 2021 J Nutr	2021	Connell NJ, Grevendonk L, Fealy CE, Moonen-Kornips E, Bruls YMH, Schrauwen-Hinderling VB, de Vogel J, Hageman R, Geurts J, Zapata-Perez R, Houtkooper RH, Havekes B, Hoeks J, Schrauwen P (2021) NAD⁺-precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide does not affect mitochondrial function or skeletal muscle function in physically compromised older adults. J Nutr 151:2917-31	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Villanueva 2021 Transplant Direct	2021	Villanueva JE, Chew HC, Gao L, Doyle A, Scheuer SE, Hicks M, Jabbour A, Dhital KK, Macdonald PS (2021) The effect of increasing donor age on myocardial ischemic tolerance in a rodent model of donation after circulatory death. Transplant Direct 7:699.	LEAK OXPHOS ET	F N NS ROX S	Permeabilized tissue	Rat	Heart
Assis-de-Lemos 2021 Biosci Rep	2021	Assis-de-Lemos G, Monteiro J, Oliveira-Valença VM, Melo GA, Reis RAM, Rehen SK, Silveira MS, Galina A (2021) Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells. https://doi.org/10.1042/bsr20211191	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Bischof 2021 Sci Transl Med	2021	Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J (2021) Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Sci Transl Med 13:eabi7964.	LEAK OXPHOS ET	S
Thoral 2021 Biol Lett	2021	Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759.	LEAK OXPHOS	N CIV NS ROX	Homogenate	Fishes	Skeletal muscle
Cheng 2021 Comp Biochem Physiol B Biochem Mol Biol	2021	Cheng H, Munro D, Huynh K, Pamenter ME (2021) Naked mole-rat skeletal muscle mitochondria exhibit minimal functional plasticity in acute or chronic hypoxia. Comp Biochem Physiol B Biochem Mol Biol 255:110596.	OXPHOS ET LEAK	F N S CIV NS ROX	Isolated mitochondria	Other mammals	Skeletal muscle
Bastos Sant'Anna Silva 2021 Cancers (Basel)	2021	Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. https://doi.org/10.3390/cancers13071727	LEAK ROUTINE OXPHOS	S ROX	Permeabilized cells Intact cells	Human	Genital
Holody 2021 Mitochondrion	2021	Holody C, Anfray A, Mast H, Lessard M, Han WH, Carpenter R, Bourque S, Sauvé Y, Lemieux H (2021) Differences in relative capacities of oxidative phosphorylation pathways may explain sex- and tissue-specific susceptibility to vision defects due to mitochondrial dysfunction. Mitochondrion 56:102-10.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Nervous system
Ljubojevic-Holzer 2021 Cardiovasc Res	2021	Ljubojevic-Holzer S, Kraler S, Djalinac N, Abdellatif M, Voglhuber J, Schipke J, Schmidt M, Kling KM, Franke GT, Herbst V, Zirlik A, von Lewinski D, Scherr D, Rainer PP, Kohlhaas M, Nickel A, Muehlfeld C, Maack C, Sedej S (2021) Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca²⁺ cycling. https://doi.org/10.1093/cvr/cvab112	LEAK OXPHOS ET	F N	Isolated mitochondria	Mouse	Heart
Santana-Roman 2021 Insects	2021	Santana-Román ME, Maycotte P, Uribe-Carvajal S, Uribe-Alvarez C, Alvarado-Medina N, Khan M, Siddiqui A, Pando-Robles V (2021) Monitoring mitochondrial function in Aedes albopictus C6/36 cell line during dengue virus infection. Insects 12:934.	LEAK OXPHOS ET	S	Permeabilized cells
Terwilliger 2021 Vasc Med	2021	Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58.	OXPHOS LEAK	N S CIV ROX NS	Permeabilized tissue	Human	Skeletal muscle
James 2021 Nat Commun	2021	James OJ, Vandereyken M, Marchingo JM, Singh F, Bray SE, Wilson J, Love AG, Swamy M (2021) IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun 12:4290.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Lymphocyte
Seefeldt 2021 Sci Rep	2021	Seefeldt JM, Lassen TR, Vognstoft Hjortbak M, Jespersen NR, Kvist F, Hansen J, Boetker HE (2021) Cardioprotective effects of empagliflozin after ischemia and reperfusion in rats. Sci Rep 11:9544.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Rat	Heart
Vernerova 2021 Biomedicines	2021	Vernerova A, Garcia-Souza LF, Soucek O, Kostal M, Rehacek V, Krcmova LK, Gnaiger E, Sobotka O (2021) Mitochondrial respiration of platelets: comparison of isolation methods. https://doi.org/10.3390/biomedicines9121859	LEAK ROUTINE ET	ROX	Intact cells	Human	Platelet
Correia 2021 Hum Mutat	2021	Correia SP, Moedas MF, Naess K, Bruhn H, Maffezzini C, Calvo-Garrido J, Lesko N, Wibom R, Schober FA, Jemt A, Stranneheim H, Freyer C, Wedell A, Wredenberg A (2021) Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7. Hum Mutat 42:378-84.	LEAK OXPHOS	N S NS	Permeabilized cells	Human	Fibroblast
Brodnanova 2021 Eur J Pharmacol	2021	Brodnanova M, Hatokova Z, Evinova A, Cibulka M, Racay P (2021) Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. Eur J Pharmacol 902:174073.	LEAK ROUTINE ET	N S ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Drake 2021 Proc Natl Acad Sci U S A	2021	Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z (2021) Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. Proc Natl Acad Sci U S A 118:e2025932118.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Basse 2021 Mol Metab	2021	Basse AL, Agerholm M, Farup J, Dalbram E, Nielsen J, Oertenblad N, Altıntas A, Ehrlich AM, Krag T, Bruzzone S, Dall M, de Guia RM, Jensen JB, Moeller AB, Karlsen A, Kjaer M, Barres R, Vissing J, Larsen S, Jessen N, Treebak JT (2021) Nampt controls skeletal muscle development by maintaining Ca²⁺ homeostasis and mitochondrial integrity. Mol Metab 53:101271.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Apostolopoulou 2021 Sci Adv	2021	Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straßburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Müssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Pesta 2021 Front Endocrinol (Lausanne)	2021	Pesta D, Jelenik T, Zaharia OP, Bobrov P, Görgens S, Bódis K, Karusheva Y, Krako Jakovljevic N, Lalic NM, Markgraf DF, Burkart V, Müssig K, Knebel B, Kotzka J, Eckel J, Strassburger K, Szendroedi J, Roden M (2021) NDUFB6 polymorphism is associated with physical activity-mediated metabolic changes in type 2 diabetes. https://doi.org/10.3389/fendo.2021.693683	LEAK OXPHOS ET	F N	Permeabilized cells	Mouse	Skeletal muscle
Gupta 2021 Sci Rep	2021	Gupta MK, Sahu A, Sun Y, Mohan ML, Kumar A, Zalavadia A, Wang X, Martelli EE, Stenson K, Witherow CP, Drazba J, Dasarathy S, Naga Prasad SV (2021) Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling. Sci Rep 11:22018.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Heart
Avram 2021 Int J Mol Sci	2021	Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424.	ROUTINE ET LEAK	ROX	Intact cells	Human	Platelet
Newsom 2021 Med Sci Sports Exerc	2021	Newsom SA, Stierwalt HD, Ehrlicher SE, Robinson MM (2021) Substrate-specific respiration of isolated skeletal muscle mitochondria after 1 h of moderate cycling in sedentary adults. https://doi.org/10.1249/mss.0000000000002615	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Human	Skeletal muscle
Whitehead 2021 Nat Commun	2021	Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts LD (2021) Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis. Nat Commun 12:1905.	LEAK OXPHOS ET	F N S NS	Permeabilized cells	Human	Skeletal muscle
Bouche 2021 PLoS One	2021	Bouche L, Kamel R, Tamareille S, Garcia G, Villedieu C, Pillot B, Gueguen N, Chehaitly A, Chao de la Barca JM, Beaumont J, Baetz D, Ovize M, Sesaki H, Henrion D, Reynier P, Lenaers G, Prunier F, Mirebeau-Prunier D (2021) DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries. PLoS One 16:0248554.	LEAK OXPHOS ET	N S CIV NS ROX F	Permeabilized tissue	Mouse	Heart
Meng 2021 FEBS Open Bio	2021	Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio 11:921-31.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Kidney
Dubinin 2021 Free Radic Biol Med	2021	Dubinin MV, Semenova AA, Ilzorkina AI, Penkov NV, Nedopekina DA, Sharapov VA, Khoroshavina EI, Davletshin EV, Belosludtseva NV, Spivak AY, Belosludtsev KN (2021) Mitochondria-targeted prooxidant effects of betulinic acid conjugated with delocalized lipophilic cation F16. Free Radic Biol Med 168:55-69.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat	Liver
Trinity 2021 J Appl Physiol	2021	Trinity JD, Craig JC, Fermoyle CC, McKenzie AI, Lewis MT, Park SH, Rondina MT, Richardson RS (2021) Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study. J Appl Physiol (1985) 130:1961-70.	LEAK OXPHOS	N S NS	Permeabilized tissue	Human	Skeletal muscle
Moon 2021 J Lipid Res	2021	Moon SH, Dilthey BG, Liu X, Guan S, Sims HF, Gross RW (2021) High-Fat diet activates liver iPLA₂γ generating eicosanoids that mediate metabolic stress. J Lipid Res 62:100052.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Liver
Bandara 2021 Mitochondrion	2021	Bandara AB, Drake JC, James CC, Smyth JW, Brown DA (2021) Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics. Mitochondrion 58:160-68.	LEAK OXPHOS ET	N S	Permeabilized cells	Human	HEK
Sun 2021 J Genet Genomics	2021	Sun Y, Wei X, Fang F, Shen Y, Wei H, Li J, Ye X, Zhan Y, Ye X, Liu X, Yang W, Li Y, Geng X, Huang X, Ruan Y, Qin Z, Yi S, Lyu J, Fang H, Yu Y (2021) HPDL deficiency causes a neuromuscular disease by impairing the mitochondrial respiration. J Genet Genomics 48:727-36.	LEAK ROUTINE ET	N S NS	Permeabilized cells Intact cells	Human	HeLa Lymphocyte
Goldberg 2021 Biochem J	2021	Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2021) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.	LEAK OXPHOS ET	N S NS ROX F	Isolated mitochondria	Mouse	Heart Skeletal muscle Liver
Taylor 2021 Int J Mol Sci	2021	Taylor OJ, Thatcher MO, Carr ST, Gibbs JL, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, Reynolds PR, Bikman BT (2021) High-mobility group box 1 disrupts metabolic function with cigarette smoke exposure in a ceramide-dependent manner. Int J Mol Sci 18:1099.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells Permeabilized tissue	Mouse	Skeletal muscle
Liepinsh 2021 Free Radic Biol Med	2021	Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M (2021) Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free Radic Biol Med 177:370-80.	LEAK OXPHOS	F N S NS ROX	Permeabilized tissue	Mouse	Heart
Weiss 2021 Crit Care Explor	2021	Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG (2021) Decreased intestinal microbiome diversity in pediatric sepsis: a conceptual framework for intestinal dysbiosis to influence immunometabolic function. Crit Care Explor 3:0360.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte
Zhang 2021 Pharmaceutics	2021	Zhang H, Zhang A, Gupte AA, Hamilton DJ (2021) Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells. Pharmaceutics 13:706.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Sharma 2021 Cancer Cell Int	2021	Sharma P, Sharma V, Ahluwalia TS, Dogra N, Kumar S, Singh S (2021) Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4. Cancer Cell Int 21:629.	LEAK OXPHOS	N S	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Giovarelli 2021 Pharmacol Res	2021	Giovarelli M, Zecchini S, Catarinella G, Moscheni C, Sartori P, Barbieri C, Roux-Biejat P, Napoli A, Vantaggiato C, Cervia D, Perrotta C, Clementi E, Latella L, De Palma C (2021) Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy. Pharmacol Res 170:105751.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Palzur 2021 Int J Mol Sci	2021	Palzur E, Edelman D, Sakas R, Soustiel JF (2021) Etifoxine restores mitochondrial oxidative phosphorylation and improves cognitive recovery following traumatic brain injury. Int J Mol Sci 22:12881. doi: 10.3390/ijms222312881	LEAK OXPHOS	N S ROX	Isolated mitochondria	Rat	Nervous system
Furihata 2021 Commun Biol	2021	Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Lelcu 2021 Children (Basel)	2021	Lelcu T, Bînă AM, Dănilă MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: A pilot study in healthy children and children with acute lymphoblastic leukemia. https://doi.org/10.3390/children8121196	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Platelet
Vandenberg 2021 Neurochem Int	2021	Vandenberg GG, Dawson NJ, Head A, Scott GR, Scott AL (2021) Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model. Neurochem Int 146:105036.	LEAK OXPHOS	N CIV NS	Permeabilized cells	Mouse	Nervous system
Rossetti 2021 Sci Adv	2021	Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A (2021) A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv 7:eabi7514.	LEAK OXPHOS ET	F N S ROX	Isolated mitochondria	Mouse	Liver
Baldini 2021 Life Sci	2021	Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Fibroblast
Dorigatti 2021 Geroscience	2021	Dorigatti JD, Thyne KM, Ginsburg BC, Salmon AB (2021) Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice. Geroscience 43:1497-511.	LEAK OXPHOS ET	N S NS ROX F	Permeabilized tissue	Mouse	Skeletal muscle
Leduc-Gaudet 2021 bioRxiv	2021	Leduc-Gaudet JP, Miguez K, Marina Cefis M, Moamer A, Chaffer TJ, Faitg J, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G, Hussain SNA (2021) Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival. bioRxiv doi: https://doi.org/10.1101/2021.08.05.455081.	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Deline 2021 Biochim Biophys Acta Bioenerg	2021	Deline ML, Grashei M, van Heijster FHA, Schilling F, Straub J, Fromme T (2021) Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria. Biochim Biophys Acta Bioenerg 1862:148409.	OXPHOS LEAK	S	Isolated mitochondria	Mouse	Liver
Watt 2021 Nat Commun	2021	Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P (2021) Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun 12:2887.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Dall 2021 J Biol Chem	2021	Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barrès R, Larsen S, Poulsen SS, Mann M, Ørskov C, Treebak JT (2021) Hepatocyte-specific perturbation of NAD⁺ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. J Biol Chem 297:101388.	LEAK OXPHOS ET	N NS	Intact cells	Mouse	Liver
Riguet 2021 Nat Commun	2021	Riguet N, Mahul-Mellier AL, Maharjan N, Burtscher J, Croisier M, Knott G, Hastings J, Patin A, Reiterer V, Farhan H, Nasarov S, Lashuel HA (2021) Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nat Commun 12:6579.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	HEK
Cai 2021 Free Radic Biol Med	2021	Cai H, Bian X, Chen L, Zhang N, Li L, Tang W, Liu X, Li Z (2021) Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. Free Radic Biol Med 171:272-83.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Nervous system
Liang 2021 Biomed Pharmacother	2021	Liang L, Zhang G, Cheng C, Li H, Jin T, Su C, Xiao Y, Bradley J, Peberdy MA, Ornato JP, Mangino MJ, Tang W (2021) High-resolution respirometry for evaluation of mitochondrial function on brain and heart homogenates in a rat model of cardiac arrest and cardiopulmonary resuscitation. Biomed Pharmacother 142:111935.	LEAK OXPHOS ROUTINE	N S CIV ROX	Homogenate	Rat	Heart Nervous system
Goncalves 2021 Redox Biol	2021	Goncalves LS, Sales LP, Saito TR, Campos JC, Fernandes AL, Natali J, Jensen L, Arnold A, Ramalho L, Bechara LRG, Esteca MV, Correa I, Sant'Anna D, Ceroni A, Michelini LC, Gualano B, Teodoro W, Carvalho VH, Vargas BS, Medeiros MHG, Baptista IL, Irigoyen MC, Sale C, Ferreira JCB, Artioli GG (2021) Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: evidence from a novel CARNS1 knockout rat model. Redox Biol 44:102016.	LEAK OXPHOS ET	NS	Isolated mitochondria	Rat	Heart
Zunica 2021 Cancer Metab	2021	Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36.	LEAK OXPHOS ET	N S CIV NS ROX F DQ	Permeabilized cells Homogenate	Human Mouse	Endothelial;epithelial;mesothelial cell
Cardoso 2021 BEC MgG	2021	Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. https://doi.org/10.26124/bec:2021-0001	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Mouse	Heart
Zhang 2021 PLOS ONE	2021	Zhang X, Yuan T, Keijer J, de Boer VCJ (2021) OCRbayes: a Bayesian hierarchical modeling framework for Seahorse extracellular flux oxygen consumption rate data analysis. PLOS ONE 16:e0253926.	LEAK ROUTINE ET	ROX			Fibroblast
Ferreira 2021 Redox Biol	2021	Ferreira JJ, Cassina A, Irigoyen P, Ford M, Pietroroia S, Peramsetty N, Radi R, Santi CM, Sapiro R (2021) Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation. https://doi.org/10.1016/j.redox.2021.102176	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Genital
Knapp-Wilson 2021 bioRxiv	2021	Knapp-Wilson A, Pereira GC, Buzzard E, Richardson A, Corey RA, Neal C, Verkade P, Halestrap AP, Gold VAM, Kuwabara P, Collinson I (2021) Maintenance of complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health in C. elegans. bioRxiv doi: https://doi.org/10.1101/2021.01.06.425530.	LEAK OXPHOS	N S	Isolated mitochondria	Caenorhabditis elegans
Krako Jakovljevic 2021 Int J Mol Sci	2021	Krako Jakovljevic N, Pavlovic K, Jotic A, Lalic K, Stoiljkovic M, Lukic L, Milicic T, Macesic M, Stanarcic Gajovic J, Lalic NM (2021) Targeting mitochondria in diabetes. Int J Mol Sci 22:6642.	LEAK OXPHOS ET	F N S	Permeabilized tissue	Human	Skeletal muscle Liver Blood cells
Kruse 2021 Life (Basel)	2021	Kruse CJ, Stern D, Mouithys-Mickalad A, Niesten A, Art T, Lemieux H, Votion DM (2021) In vitro assays for the assessment of impaired mitochondrial bioenergetics in equine atypical myopathy. Life (Basel) 11:719.	LEAK OXPHOS ET	F N S NS ROX	Intact cells Permeabilized cells	Horse	Skeletal muscle
Amoedo 2021 J Clin Invest	2021	Amoedo ND, Sarlak S, Obre E, Esteves P, Bégueret H, Kieffer Y, Rousseau B, Dupis A, Izotte J, Bellance N, Dard L, Redonnet-Vernhet I, Punzi G, Rodrigues MF, Dumon E, Mafhouf W, Guyonnet-Dupérat V, Gales L, Palama T, Bellvert F, Dugot-Senan N, Claverol S, Baste JM, Lacombe D, Rezvani HR, Pierri CL, Mechta-Grigoriou F, Thumerel M, Rossignol R (2021) Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas. J Clin Invest 131:e133081.	LEAK ROUTINE	F CIV	Intact cells	Human	Lung;gill
Friederich 2021 Mol Genet Metab	2021	Friederich MW, Geddes GC, Wortmann SB, Punnoose A, Wartchow E, Knight KM, Prokisch H, Creadon-Swindell G, Mayr JA, Van Hove JLK (2021) Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect. Mol Genet Metab 133:362-71.	LEAK OXPHOS ET	N		Human	Fibroblast
Zuccarelli 2021 J Physiol	2021	Zuccarelli L, Baldassarre G, Magnesa B, Degano C, Comelli M, Gasparini M, Manferdelli G, Marzorati M, Mavelli I, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B (2021) Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. J Physiol 599:4813-29.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Wuest 2021 Int J Mol Sci	2021	Wüst RCI, Coolen BF, Held NM, Daal MRR, Alizadeh Tazehkandi V, Baks-Te Bulte L, Wiersma M, Kuster DWD, Brundel BJJM, van Weeghel M, Strijkers GJ, Houtkooper RH (2021) The antibiotic doxycycline impairs cardiac mitochondrial and contractile function. Int J Mol Sci 22:4100.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Heart
Scalzo 2021 J Physiol	2021	Scalzo RL, Schauer IE, Rafferty D, Knaub LA, Kvaratskhelia N, Johnson TK, Pott GB, Abushamat LA, Whipple MO, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG (2021) Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes. J Physiol 600:963-78.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Schroeder 2021 Cell Rep	2021	Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Mueller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Uecal M, Schaefer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Toelle RC, Sotonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Racz B, Kiechl S, Eisenberg T, Madeo F (2021) Dietary spermidine improves cognitive function. Cell Rep 35:108985.	LEAK OXPHOS ET	N NS ROX S	Homogenate	Mouse Drosophila	Nervous system
Scheffer 2021 Brain Commun	2021	Scheffer DDL, Freitas FC, Aguiar AS Jr, Ward C, Guglielmo LGA, Prediger RD, Cronin SJF, Walz R, Andrews NA, Latini A (2021) Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson's disease patients. Brain Commun 3:fcab116.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Skeletal muscle
Davis 2021 J Appl Physiol	2021	Davis MS, Barrett MR (2021) Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. J Appl Physiol. 130:1317-1325	LEAK OXPHOS	N S NS	Permeabilized cells	Dog	Skeletal muscle
Prieto-Carrasco 2021 Biology (Basel)	2021	Prieto-Carrasco R, Silva-Palacios A, Rojas-Morales P, Aparicio-Trejo OE, Medina-Reyes EI, Hernandez-Cruz EY, Sanchez-Garibay C, Salinas-Lara C, Pavon N, Roldan FJ, Zazueta C, Tapia E, Pedraza-Chaverri J (2021) Unilateral ureteral obstruction for 28 days in rats is not associated with changes in cardiac function or alterations in mitochondrial function. Biology (Basel) 10:671.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Rat	Heart
Sahl 2021 Adipocyte	2021	Sahl RE, Høy Helms EF, Schmücker M, Flensted-Jensen M, Ingersen A, Morville T, Dela F, Helge JW, Larsen S (2021) Reliability and variation in mitochondrial respiration in human adipose tissue. Adipocyte 10:605-11.	LEAK OXPHOS ET	N NS	Permeabilized cells	Human	Fat
Avram 2021 Life (Basel)	2021	Avram VF, Bina AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elmer E, Cretu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life (Basel) 11:288.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Tallosy 2021 Sci Rep	2021	Tallósy SP, Poles MZ, Rutai A, Fejes R, Juhász L, Burián K, Sóki J, Szabó A, Boros M, Kaszaki J (2021) The microbial composition of the initial insult can predict the prognosis of experimental sepsis. Sci Rep 11:22772.	LEAK OXPHOS	S ROX	Homogenate	Rat	Liver
Saura-Esteller 2021 Int J Mol Sci	2021	Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Cosialls AM, Gama-Pérez P, Bhosale G, Mendive-Tapia L, Lavilla R, Pons G, Garcia-Roves PM, Duchen MR, Iglesias-Serret D, Gil J (2021) Activation of the integrated stress response and ER stress protect from fluorizoline-induced apoptosis in HEK293T and U2OS cell lines. Int J Mol Sci 22:6117.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte HEK
Galli 2021 Front Physiol	2021	Galli GLJ, Ruhr IM, Crossley J, Crossley DA 2nd (2021) The long-term effects of developmental hypoxia on cardiac mitochondrial function in snapping turtles. Front Physiol 12:689684. doi: 10.3389/fphys.2021.689684	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Reptiles	Heart
Salin 2021 Mar Environ Res	2021	Salin K, Mathieu-Resuge M, Graziano N, Dubillot E, Le Grand F, Soudant P, Vagner M (2021) The relationship between membrane fatty acid content and mitochondrial efficiency differs within- and between- omega-3 dietary treatments. Mar Environ Res 163:105205.	LEAK OXPHOS	N NS	Isolated mitochondria	Fishes	Skeletal muscle
Acin-Perez 2021 Life (Basel)	2021	Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L (2021) Utilization of human samples for assessment of mitochondrial bioenergetics: gold standards, limitations, and future perspectives. Life (Basel) 11:949. doi: 10.3390/life11090949	LEAK ROUTINE OXPHOS ET		Intact organ Permeabilized cells Permeabilized tissue Intact cells	Human	Skeletal muscle Blood cells Fibroblast Platelet
Hansen 2021 Physiol Rep	2021	Hansen C, Olsen K, Pilegaard H, Bangsbo J, Gliemann L, Hellsten Y (2021) High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells. Physiol Rep 9:e14855.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Skeletal muscle Endothelial;epithelial;mesothelial cell
Bokhari 2021 Commun Biol	2021	Bokhari MH, Halleskog C, Åslund A, Boulet N, Casadesús Rendos E, de Jong JMA, Csikasz R, Amri EZ, Shabalina I, Bengtsson T (2021) Isothermal microcalorimetry measures UCP1-mediated thermogenesis in mature brite adipocytes. Commun Biol 4:1108.	LEAK ET			Mouse	Fat
Pereyra 2021 J Lipid Res	2021	Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM (2021) Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. J Lipid Res 62:100069.	LEAK OXPHOS	F N	Homogenate Isolated mitochondria	Mouse	Heart Skeletal muscle Liver
Kaspar 2021 Sci Adv	2021	Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv 7:0971.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Hoene 2021 Mol Metab	2021	Hoene M, Kappler L, Kollipara L, Hu C, Irmler M, Bleher D, Hoffmann C, Beckers J, Hrabě de Angelis M, Häring HU, Birkenfeld AL, Peter A, Sickmann A, Xu G, Lehmann R, Weigert C (2021) Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability. Mol Metab 54:101359.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Liver
Ko 2021 Biomolecules	2021	Ko HJ, Tsai CY, Chiou SJ, Lai YL, Wang CH, Cheng JT, Chuang TH, Huang CF, Kwan AL, Loh JK, Hong YR (2021) The phosphorylation status of Drp1-Ser637 by PKA in mitochondrial fission modulates mitophagy via PINK1/Parkin to exert multipolar spindles assembly during mitosis. Biomolecules 11:424.	LEAK ROUTINE ET	ROX	Intact cells	Human	HeLa
Hamm 2021 Mol Ther Methods Clin Dev	2021	Hamm SE, Fathalikhani DD, Bukovec KE, Addington AK, Zhang H, Perry JB, McMillan RP, Lawlor MW, Prom MJ, Vanden Avond MA, Kumar SN, Coleman KE, Dupont JB, Mack DL, Brown DA, Morris CA, Gonzalez JP, Grange RW (2023) Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice. https://doi.org/10.1016/j.omtm.2021.02.024	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
MacCannell 2021 Int J Obes (Lond)	2021	MacCannell ADV, Futers TS, Whitehead A, Moran A, Witte KK, Roberts LD (2021) Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. Int J Obes (Lond) 45:1773-81.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Fat
Fink 2021 Pharmacol Res Perspect	2021	Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI (2021) Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacol Res Perspect 9:e00701.	LEAK OXPHOS	NS	Isolated mitochondria	Rat	Liver
Morgan 2021 Resuscitation	2021	Morgan RW, Sutton RM, Himebauch AS, Roberts AL, Landis WP, Lin Y, Starr J, Ranganathan A, Delso N, Mavroudis CD, Volk L, Slovis J, Marquez AM, Nadkarni VM, Hefti M, Berg RA, Kilbaugh TJ (2021) A randomized and blinded trial of inhaled nitric oxide in a piglet model of pediatric cardiopulmonary resuscitation. Resuscitation 162:274-83 .	LEAK OXPHOS	N NS	Homogenate	Pig	Nervous system
Hoppel 2021 Front Physiol	2021	Hoppel F, Calabria E, Pesta DH, Kantner-Rumplmair W, Gnaiger E, Burtscher M (2021) Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. https://doi.org/10.3389/fphys.2021.632664	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Kakimoto 2021 Redox Biol	2021	Kakimoto PA, Serna JDC, de Miranda Ramos V, Zorzano A, Kowaltowski AJ (2021) Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling. Redox Biol 45:102026.	LEAK OXPHOS	N S NS	Permeabilized cells	Human	Liver
Conceicao 2021 Sci Rep	2021	Conceição CC, da Silva JN, Arcanjo A, Nogueira CL, de Abreu LA, de Oliveira PL, Gondim KC, Moraes B, de Carvalho SS, da Silva RM, da Silva Vaz I Jr, Moreira LA, Logullo C (2021) Aedes fluviatilis cell lines as new tools to study metabolic and immune interactions in mosquito-Wolbachia symbiosis. Sci Rep 11:19202.	LEAK ROUTINE ET	ROX	Intact cells	Molluscs
Viel 2021 Pharmaceuticals (Basel)	2021	Viel C, Brandtner AT, Weißhaar A, Lehto A, Fuchs M, Klein J (2021) Effects of magnesium orotate, benfotiamine and a combination of vitamins on mitochondrial and cholinergic function in the TgF344-AD rat model of Alzheimer's disease. https://doi.org/10.3390/ph14121218	LEAK OXPHOS ET	N S CIV ROX	Isolated mitochondria	Rat	Nervous system
Su 2021 Chin J Physiol	2021	Su Y, Wang Y, Xu P, Sun Y, Ping Z, Huang H, Cao X (2021) Study on the time-effectiveness of exercise preconditioning on heart protection in exhausted rats. Chin J Physiol 64:97-105.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Rat	Heart
Szczerbinski 2021 Cells	2021	Szczerbinski L, Taylor MA, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Goscik J, Gorska M, Larsen S, Kretowski A (2021) The response of mitochondrial respiration and quantity in skeletal muscle and adipose tissue to exercise in humans with prediabetes. Cells 10:3013.	LEAK OXPHOS ET	N S	Permeabilized tissue	Human	Skeletal muscle Fat
Dubinin 2021 Membranes (Basel)	2021	Dubinin MV, Semenova AA, Nedopekina DA, Davletshin EV, Spivak AY, Belosludtsev KN (2021) Effect of F16-betulin conjugate on mitochondrial membranes and its role in cell death initiation. Membranes (Basel) 11:352.	LEAK OXPHOS ET	N S	Isolated mitochondria	Rat	Liver
Schmidt 2021 Cancer Metab	2021	Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.	LEAK OXPHOS ET	N S Gp CIV ROX	Isolated mitochondria	Human	Liver
Honecker 2021 Int J Obes (Lond)	2021	Honecker J, Weidlich D, Heisz S, Lindgren CM, Karampinos DC, Claussnitzer M, Hauner H (2021) A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function. Int J Obes (Lond) [Ephub ahead of print].	LEAK ROUTINE OXPHOS ET		Intact cells	Human	Fat
Hoppel 2021 Cells	2021	Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. https://doi.org/10.3390/cells10082088	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Kripnerova 2021 J Clin Med	2021	Kripnerová M, Parmar HS, Šána J, Kopková A, Radová L, Sopper S, Biernacki K, Jedlička J, Kohoutová M, Kuncová J, Peychl J, Rudolf E, Červinka M, Houdek Z, Dvořák P, Houfková K, Pešta M, Tůma Z, Dolejšová M, Tichánek F, Babuška V, Leba M, Slabý O, Hatina J (2021) Complex interplay of genes underlies invasiveness in fibrosarcoma progression model. J Clin Med 10:2297.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fibroblast
Matsumoto 2021 Circ Heart Fail	2021	Matsumoto J, Takada S, Furihata T, Nambu H, Kakutani N, Maekawa S, Mizushima W, Nakano I, Fukushima A, Yokota T, Tanaka S, Handa H, Sabe H, Kinugawa S (2021) Brain-derived neurotrophic factor improves impaired fatty acid oxidation via the activation of adenosine monophosphate-activated protein kinase-ɑ - proliferator-activated receptor-r coactivator-1ɑ signaling in skeletal muscle of mice with heart failure. Circ Heart Fail 14: e005890.	LEAK OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Queiroz 2021 Mol Metab	2021	Queiroz AL, Lessard SJ, Ouchida AT, Araujo HN, Goncalves DA, Simoes Froes Guimaraes DSP, Teodoro BG, So K, Espreafico EM, Hirshman MF, Alberici LC, Kettelhut IDC, Goodyear LJ, Silveira LR (2021) The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition. Mol Metab 51:101226.	LEAK ET		Intact cells	Mouse	Skeletal muscle
Gvozdjakova 2021 PLoS One	2021	Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q₁₀ could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases. PLoS ONE 16:e0256135.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Zweck 2021 Diabetes Care	2021	Zweck E, Scheiber D, Jelenik T, Bönner F, Horn P, Pesta D, Schultheiss HP, Boeken U, Akhyari P, Lichtenberg A, Kelm M, Roden M, Westenfeld R, Szendroedi J (2021) Exposure to type 2 diabetes provokes mitochondrial impairment in apparently healthy human hearts. Diabetes Care 44:e82-e84.	LEAK OXPHOS ET	F N NS		Human	Heart
Davies 2021 FASEB J	2021	Davies KL, Smith DJ, El-Bacha T, Stewart ME, Easwaran A, Wooding PFP, Forhead AJ, Murray AJ, Fowden AL, Camm EJ (2021) Development of cerebral mitochondrial respiratory function is impaired by thyroid hormone deficiency before birth in a region-specific manner. FASEB J 35:21591.	LEAK OXPHOS	N S NS	Homogenate	Other mammals	Nervous system
Komlodi 2021 BEC Q	2021	Komlódi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. https://doi.org/10.26124/bec:2021-0003	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Heart Nervous system
Jasz 2021 J Cell Mol Med	2021	Jász DK, Szilágyi ÁL, Tuboly E, Baráth B, Márton AR, Varga P, Varga G, Érces D, Mohácsi Á, Szabó A, Bozó R, Gömöri K, Görbe A, Boros M, Hartmann P (2021) Reduction in hypoxia-reoxygenation-induced myocardial mitochondrial damage with exogenous methane. https://doi.org/10.1111/jcmm.16498	LEAK ROUTINE OXPHOS ET	S ROX	Permeabilized cells Isolated mitochondria	Rat	Heart
Cretin 2021 EMBO Mol Med	2021	Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu-Wai-Man P, Reynier P, Wai T (2021) High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med 13:13579.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fibroblast
Sanchez-de-Diego 2021 Redox Biol	2021	Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F (2021) NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression. Redox Biol 40:101845.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Other cell lines
Gnaiger 2021 MitoFit BCA	2021	Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. https://doi.org/10.26124/mitofit:2021-0008	LEAK OXPHOS ET	ROX	Intact cells	Human	Fibroblast
Kumar 2021 JCI Insight	2021	Kumar A, Welch N, Mishra S, Bellar A, Silva RN, Li L, Singh SS, Sharkoff M, Kerr A, Chelluboyina AK, Sekar J, Attaway AH, Hoppel C, Willard B, Davuluri G, Dasarathy S (2021) Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence. JCI Insight 6:e154089.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue Isolated mitochondria Intact cells	Mouse Rat	Skeletal muscle
Braga 2021 Sci Rep	2021	Braga RR, Crisol BM, Brícola RS, Sant'ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER (2021) Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR^mt in the hypothalamus of mice. Sci Rep 11:3813.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Nervous system
Jimenez-Uribe 2021 Free Radic Biol Med	2021	Jimenez-Uribe AP, Bellido B, Aparicio-Trejo OE, Tapia E, Sanchez-Lozada LG, Hernandez-Santos JA, Fernandez-Valverde F, Hernandez-Cruz EY, Orozco-Ibarra M, Pedraza-Chaverri J (2021) Temporal characterization of mitochondrial impairment in the unilateral ureteral obstruction model in rats. Free Radic Biol Med 172:358-71.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Rat	Kidney
Vidimce 2021 Front Pharmacol	2021	Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Rat	Skeletal muscle Liver
Chambers 2021 JCI Insight	2021	Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN (2021) Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight 6:134340.	LEAK OXPHOS ET	F N S	Permeabilized tissue	Mouse	Heart
Sarabhai 2021 Diabetologia	2021	Sarabhai T, Koliaki C, Mastrototaro L, Kahl S, Pesta D, Apostolopoulou M, Wolkersdorfer M, Bönner AC, Bobrov P, Markgraf DF, Herder C, Roden M (2021) Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia 65:301-14.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Human	Skeletal muscle
Lefranc 2021 Int J Mol Sci	2021	Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F (2021) Adipocyte-mineralocorticoid receptor alters mitochondrial quality control leading to mitochondrial dysfunction and senescence of visceral adipose tissue. Int J Mol Sci 22:2881.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Fat
Styles 2021 Cell Death Dis	2021	Styles FL, Al-Owais MM, Scragg JL, Chuntharpursat-Bon E, Hettiarachchi NT, Lippiat JD, Minard A, Bon RS, Porter K, Sukumar P, Peers C, Roberts LD (2021) Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. Cell Death Dis 12:372.	LEAK ROUTINE ET	CIV ROX	Intact cells	Human	HEK
Young 2021 J Biol Chem	2021	Young MP, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajnóczky G, Joseph SK (2021) Metabolic adaptation to the chronic loss of Ca²⁺ signaling induced by knockout of IP 3 receptors or the mitochondrial Ca²⁺ uniporter. J Biol Chem 298:101436.	LEAK ROUTINE ET	ROX	Intact cells	Human	HEK HeLa
Mazzoli 2021 Nutrients	2021	Mazzoli A, Gatto C, Crescenzo R, Cigliano L, Iossa S (2021) Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13:1370.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Theall 2021 Physiol Rep	2021	Theall B, Stampley J, Cho E, Granger J, Johannsen NM, Irving BA, Spielmann G (2021) Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults. Physiol Rep 9:e15147.	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Yardeni 2021 Proc Natl Acad Sci U S A	2021	Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Marrocco 2021 J Immunol	2021	Marrocco A, Frawley K, Pearce LL, Peterson J, O'Brien JP, Mullett SJ, Wendell SG, St Croix CM, Mischler SE, Ortiz LA (2021) Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immunol 207:1627-40.	LEAK OXPHOS ET	N ROX		Mouse	Macrophage-derived
Tonnesen 2021 Mol Cell Biochem	2021	Tonnesen PT, Hjortbak MV, Lassen TR, Seefeldt JM, Bøtker HE, Jespersen NR (2021) Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats. Mol Cell Biochem 476:2675-84.	LEAK OXPHOS	F N	Permeabilized tissue	Rat	Heart
Flensted-Jensen 2021 Free Radic Biol Med	2021	Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H₂O₂ emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes. Free Radic Biol Med 173:1-6.	LEAK OXPHOS	N NS	Permeabilized tissue	Human	Skeletal muscle
Branco Haas 2021 Thesis	2021	Branco Haas C (2021) Insulin signaling and microglia in the young and aged brain. PhD Thesis 135.	LEAK OXPHOS ET	N ROX	Intact cells
Garcia 2021 J Steroid Biochem Mol Biol	2021	Garcia AM, Bishop EL, Li D, Jeffery LE, Garten A, Thakker A, Certo M, Mauro C, Tennant DA, Dimeloe S, Evelo CT, Coort SL, Hewison M (2021) Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis. J Steroid Biochem Mol Biol 211:105891.	LEAK ET	ROX	Intact cells	Human	Nervous system
Tungtur 2021 Sci Rep	2021	Tungtur SK, Wilkins HM, Rogers RS, Badawi Y, Sage JM, Agbas A, Jawdat O, Barohn RJ, Swerdlow RH, Nishimune H (2021) Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord. Sci Rep 11:11051.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Nervous system
Akinbiyi 2021 Sci Rep	2021	Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106.	LEAK OXPHOS ET	F N S DQ CIV NS ROX	Permeabilized cells
Pharaoh 2021 JCSM Rapid Commun	2021	Pharaoh G, Brown J, Ranjit R, Ungvari Z, Van Remmen H (2021) Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation. https://doi.org/10.1002/rco2.29	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Jensen 2021 Free Radic Biol Med	2021	Jensen BS, Pardue S, Duffy B, Kevil CG, Staples JF, Fago A (2021) Suppression of mitochondrial respiration by hydrogen sulfide in hibernating 13-lined ground squirrels. Free Radic Biol Med 169:181-86.	LEAK	S	Isolated mitochondria	Other mammals	Liver
King 2021 J Biol Chem	2021	King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Nambu 2021 Cardiovasc Res	2021	Nambu H, Takada S, Maekawa S, Matsumoto J, Kakutani N, Furihata T, Shirakawa R, Katayama T, Nakajima T, Yamanashi K, Obata Y, Nakano I, Tsuda M, Saito A, Fukushima A, Yokota T, Nio-Kobayashi J, Yasui H, Higashikawa K, Kuge Y, Anzai T, Sabe H, Kinugawa S (2021) Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Cardiovasc Res 117:805-19.	LEAK OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle
Juhaszova 2021 Function (Oxf)	2021	Juhaszova M, Kobrinsky E, Zorov DB, Nuss HB, Yaniv Y, Fishbein KW, de Cabo R, Montoliu L, Gabelli SB, Aon MA, Cortassa S, Sollott SJ (2021) ATP synthase K⁺- and H⁺-fluxes drive ATP synthesis and enable mitochondrial K⁺-"uniporter" function: I. Characterization of ion fluxes. Function (Oxf) 3(2):zqab065. doi: 10.1093/function/zqab065	LEAK OXPHOS		Isolated mitochondria
Nedel 2021 Intensive Care Med Exp	2021	Nedel WL, Kopczynski A, Rodolphi MS, Strogulski NR, De Bastiani M, Montes THM, Abruzzi J Jr, Galina A, Horvath TL, Portela LV (2021) Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study. Intensive Care Med Exp 9:39.	LEAK OXPHOS	N NS ROX	Permeabilized cells	Human	Lymphocyte
Alves 2021 Eur J Nutr	2021	Alves BL, Araújo TDR, Guimarães DSPSF, Zoppi CC, Figueiredo MS, Carneiro EM (2021) Amino acid restriction alters survival mechanisms in pancreatic beta cells: possible role of the PI3K/Akt pathway. Eur J Nutr 60:3947-57.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Islet cell;pancreas;thymus
Peruzzotti-Jametti 2021 PLoS Biol	2021	Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166.	LEAK OXPHOS	N S Gp CIV ROX	Permeabilized cells	Mouse	Nervous system Stem cells
De Moura Alvorcem 2021 J Neurochem	2021	de Moura Alvorcem, L, Britto R, Cecatto C, Roginski AC, Rohden F, Scholl JN, Guma FCR, Figueiro F, Amaral AU, Zanatta G, Seminotti B, Wajner M, Leipnitz G. (2021) Ethylmalonic acid impairs bioenergetics by disturbing succinate and glutamate oxidation and induces mitochondrial permeability transition pore opening in rat cerebellum. J Neurochem 158(2): 262–81.	LEAK OXPHOS	N S	Homogenate Isolated mitochondria	Rat	Nervous system
Mazzoli 2021 Antioxidants (Basel)	2021	Mazzoli A, Spagnuolo MS, Nazzaro M, Gatto C, Iossa S, Cigliano L (2021) Fructose removal from the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus. Antioxidants (Basel) 10:487.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Dunn 2021 Arterioscler Thromb Vasc Biol	2021	Dunn LL, Kong SMY, Tumanov S, Chen W, Cantley J, Ayer A, Maghzal GJ, Midwinter RG, Chan KH, Ng MKC, Stocker R (2021) Hmox1 (heme oxygenase-1) protects against ischemia-mediated injury via stabilization of HIF-1α (hypoxia-inducible factor-1α). Arterioscler Thromb Vasc Biol 41:317-30.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Wall 2021 Dis Model Mech	2021	Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE (2021) CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech 14:dmm048603.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Drosophila	Skeletal muscle
Zdrazilova 2021 MitoFit ace-sce	2021	Zdrazilova L, Hansikova H, Gnaiger E (2021) Comparable respiratory activity in attached and suspended human fibroblasts. https://doi.org/10.26124/mitofit:2021-0007 — 2022-03-03 published in PLOS ONE 17:e0264496	LEAK ET ROUTINE	ROX	Intact cells	Human	Fibroblast
Liu 2021 Front Physiol	2021	Liu H, Tenzing N, van Patot MT, Qile M, Ge RL, Wuren T (2021) Enhanced placental mitochondrial respiration in Tibetan women at high altitude. Front Physiol 12:697022. doi: 10.3389/fphys.2021.697022	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Genital
Wigner 2021 Sci Rep	2021	Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Other cell lines
Burska 2021 Biochim Biophys Acta Mol Basis Dis	2021	Burska D, Stiburek L, Krizova J, Vanisova M, Martinek V, Sladkova J, Zamecnik J, Honzik T, Zeman J, Hansikova H, Tesarova M (2021) Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control. Biochim Biophys Acta Mol Basis Dis 1867:166147.	LEAK OXPHOS ET	CIV NS ROX N S	Permeabilized cells	Human	Fibroblast
Kladnicka 2021 Biomolecules	2021	Kladnicka I, Cedikova M, Jedlicka J, Kohoutova M, Muller L, Plavinova I, Kripnerova M, Bludovska M, Kuncova J, Mullerova D (2021) Chronic DDE exposure modifies mitochondrial respiration during differentiation of human adipose-derived mesenchymal stem cells into mature adipocytes. Biomolecules 11:1068.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fat
Davis 2021 Comparative Exercise Physiology	2021	Davis Michael, Barrett Montana, Popken Andrea (2021) Effect of hyperthermia and acidosis on equine skeletal muscle mitochondrial oxygen consumption. Comparative Exercise Physiology 17:171-179.	LEAK OXPHOS ET	N S NS	Permeabilized cells	Horse	Skeletal muscle
Xiao 2021 PLoS Genet	2021	Xiao L, Liu J, Sun Z, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li JZ, Chen S, Xie X, Gan Z (2021) AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1. PLoS Genet 17:e1009488.	LEAK OXPHOS	N S	Permeabilized tissue	Mouse	Skeletal muscle
Knapp-Wilson 2021 J Cell Sci	2021	Knapp-Wilson A, Pereira GC, Buzzard E, Ford HC, Richardson A, Corey RA, Neal C, Verkade P, Halestrap AP, Gold VAM, Kuwabara PE, Collinson I (2021) Maintenance of complex I and its supercomplexes by NDUF-11 is essential for mitochondrial structure, function and health. J Cell Sci 134:jcs258399. doi: 10.1242/jcs.258399	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Caenorhabditis elegans
Flockhart 2021 Cell Metab	2021	Flockhart M, Nilsson LC, Tais S, Ekblom B, Apro W, Larsen FJ (2021) Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell Metab 33:957-70.	LEAK OXPHOS ET	F N S NS	Isolated mitochondria	Human	Skeletal muscle
Rodrigues 2021 Sci Rep	2021	Rodrigues AQ, Picolo VL, Goulart JT, Silva IMG, Ribeiro RB, Aguiar BA, Ferreira YB, Oliveira DM, Lucci CM, de Bem AF, Paulini F (2021) Metabolic activity in cryopreserved and grafted ovarian tissue using high-resolution respirometry. Sci Rep 11:21517.	LEAK OXPHOS ET	S	Homogenate	Mouse	Genital
Palacka 2021 Int J Mol Sci	2021	Palacka P, Gvozdjáková A, Rausová Z, Kucharská J, Slopovský J, Obertová J, Furka D, Furka S, Singh KK, Sumbalová Z (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. https://doi.org/10.3390/ijms23010388	LEAK ROUTINE OXPHOS ET	F N S Gp NS ROX	Permeabilized cells Intact cells	Human	Platelet
Schumann 2021 Commun Biol	2021	Schumann T, Koenig J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL (2021) Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol 4:826.	LEAK ROUTINE OXPHOS ET	F N NS ROX	Intact cells	Mouse	Liver
Pamenter 2021 Biol Lett	2021	Pamenter ME, Gomez CR, Richards JG, Milsom WK (2021) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12:20150797.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Reptiles	Nervous system
Fischer 2021 Antioxidants	2021	Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe^-/- related hemochromatosis alter hepatic mitochondrial function. https://doi.org/10.3390/antiox10111818	LEAK OXPHOS ET	ROX N S Gp		Mouse	Liver
MiPNet21.17 BloodCellsIsolation	2020-10-22	O2k-Protocols: Isolation of blood cells for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Groennebaek 2020 Cells	2020	Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Hassan 2020 MitoFit Preprint Arch	2020	Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human
Gutierrez 2020 Sci Signal	2020	Gutiérrez T, Qi H, Yap MC, Tahbaz N, Milburn LA, Lucchinetti E, Lou PH, Zaugg M, LaPointe PG, Mercier P, Overduin M, Bischof H, Burgstaller S, Malli R, Ballanyi K, Shuai J, Simmen T (2020) The ER chaperone calnexin controls mitochondrial positioning and respiration . Sci Signal 13:eaax6660.	LEAK ROUTINE ET		Intact cells	Mouse	Fibroblast
Gumpp 2020 Proc Natl Acad Sci U S A	2020	Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-Fernández L, Welz T, Gündel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Ajime 2020 Nicotine Tob Res	2020	Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res 23:143-51.	LEAK ET	S	Permeabilized tissue	Mouse	Skeletal muscle
Gruenig 2020 Biochem Pharmacol	2020	Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860.	LEAK OXPHOS ET	N S DQ CIV ROX	Isolated mitochondria	Mouse	Liver
Allen 2020 Commun Biol	2020	Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389.	LEAK OXPHOS ET	N S CIV	Permeabilized tissue	Rat	Heart
Garcia 2020 Mol Hum Reprod	2020	Garcia BM, Machado TS, Carvalho KF, Nolasco P, Nociti RP, Del Collado M, Capo Bianco MJD, Grejo MP, Neto JDA, Sugiyama FHC, Tostes K, Pandey AK, Gonçalves LM, Perecin F, Meirelles FV, Ferraz JBS, Vanzela EC, Boschero AC, Guimarães FEG, Abdulkader F, Laurindo FRM, Kowaltowski AJ, Chiaratti MR (2020) Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. Mol Hum Reprod 26:938-52.	LEAK OXPHOS ET	S	Isolated mitochondria	Mouse	Liver
Shi 2020 Diabetes	2020	Shi JH, Lu JY, Chen HY, Wei CC, Xu X, Li H, Bai Q, Xia FZ, Lam SM, Zhang H, Shi YN, Cao D, Chen L, Shui G, Yang X, Lu Y, Chen YX, Zhang WJ (2020) Liver ChREBP protects against fructose-induced glycogenic hepatotoxicity by regulating L-type pyruvate kinase. Diabetes 120:29.	LEAK ROUTINE ET		Intact cells	Mouse	Liver
Burgin 2020 Int J Mol Sci	2020	Burgin HJ, Lopez Sanchez MIG, Smith CM, Trounce IA, McKenzie M (2020) Pioglitazone and deoxyribonucleoside combination treatment increases mitochondrial respiratory capacity in m.3243A>G MELAS cybrid cells. Int J Mol Sci 21:E2139.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Fecker 2020 Biomolecules	2020	Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 10:E818.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Guo 2020 Hum Gene Ther	2020	Guo Y, Zhang K, Gao X, Zhou Z, Liu Z, Yang K, Huang K, Yang Q, Long Q (2020) Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure-overload via improving mitochondrial function. Hum Gene Ther 31:1178-89.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Heart
Herpich 2020 Exp Gerontol	2020	Herpich C, Franz K, Klaus S, Müller-Werdan U, Ost M, Norman K (2020) Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells. Exp Gerontol 144:111177.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Grewal 2020 Exp Neurol	2020	Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Politis-Barber 2020 Am J Physiol Endocrinol Metab	2020	Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87.	LEAK OXPHOS	F N Gp NS	Permeabilized cells	Mouse	Fat
Russell 2020 Nutrients	2020	Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
Irion 2020 Stem Cells Int	2020	Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Heart
Song 2020 Obes Facts	2020	Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) Increased insulin sensitivity by high-altitude hypoxia in mice with high-fat diet-induced obesity is associated with activated AMPK signaling and subsequently enhanced mitochondrial biogenesis in skeletal muscles. Obes Facts 13:455-72.	LEAK OXPHOS	F N	Permeabilized tissue		Skeletal muscle
Cassereau 2020 Exp Neurol	2020	Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069.	LEAK OXPHOS ET	N S NS	Permeabilized cells	Human	Fibroblast
Jian 2020 Cell Metab	2020	Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908. https://doi.org/10.1016/j.cmet.2020.04.011	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Mouse	Liver
Cruz 2020 Cancers (Basel)	2020	Cruz B, Oliveira A, Viana LR, Lopes-Aguiar L, Canevarolo R, Colombera MC, Valentim RR, Garcia-Fóssa F, de Sousa LM, Castelucci BG, Consonni SR, Martins-de-Souza D, de Jesus MB, Russell ST, Gomes-Mardondes MCC (2020) Leucine-tich diet modulates the metabolomic and proteomic profile of skeletal muscle during cancer cachexia. Cancers (Basel) 12:E1880.	LEAK ROUTINE ET		Intact cells	Mouse	Skeletal muscle
Lensu 2020 Nutrients	2020	Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Kawamura 2021 Mol Ther Nucleic Acids	2020	Kawamura E, Maruyama M, Abe J, Sudo A, Takeda A, Takada S, Yokota T, Kinugawa S, Harashima H, Yamada Y (2021) Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-porter. Mol Ther Nucleic Acids 20:687-98.	LEAK OXPHOS		Permeabilized cells	Human	Fibroblast
Lara-Marqueza 2020 J Funct Foods	2020	Lara-Márquez M, Báez-Magaña M, Raymundo-Ramos C, Spagnuolo PA, Macías-Rodríguez L, Salgado-Garciglia R, Ochoa-Zarzosa A, López-Meza JE (2020) Lipid-rich extract from Mexican avocado (Persea americana var. drymifolia) induces apoptosis and modulates the inflammatory response in Caco-2 human colon cancer cells. J Funct Foods 64:103658.	LEAK ROUTINE ET		Intact cells	Human	Endothelial;epithelial;mesothelial cell
Tichanek 2020 Sci Rep	2020	Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Heinonen 2020 Sci Rep	2020	Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Pig	Heart
Piel 2020 FEBS J	2020	Piel MS, Masscheleyn S, Bouillaud F, Moncoq K, Miroux B (2020) Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant. FEBS J 288:3024-33.	LEAK OXPHOS ET		Permeabilized cells	Saccharomyces cerevisiae
Ehrlicher 2020 FASEB J	2020	Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18.	LEAK OXPHOS ET	F N S NS	Isolated mitochondria	Mouse	Skeletal muscle
Piel 2020 PLoS One	2020	Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Liver Platelet
Cecatto 2020 Toxicol In Vitro	2020	Cecatto C, Amaral AU, Roginski AC, Castilho RF, Wajner M (2020) Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. Toxicol In Vitro 62:104665.	LEAK OXPHOS ET	N S	Permeabilized tissue Isolated mitochondria	Rat	Skeletal muscle
Dolezelova 2020 PLoS Biol	2020	Doleželová E, Kunzová M, Dejung M, Levin M, Panicucci B, Regnault C, Janzen CJ, Barrett MP, Butter F, Zíková A (2020) Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei. PLoS Biol 18:e3000741.	LEAK ROUTINE	S Gp CIV	Permeabilized cells Intact cells	Protists
Assis-de-Lemos 2020 Curr Protoc Toxicol	2020	Assis-de-Lemos G, Ledur PF, Karmirian K, Rehen SK, Galina A (2020) A protocol to study mitochondrial function in human neural progenitors and iPSC-derived astrocytes. Curr Protoc Toxicol 85:e97.	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Plecita-Hlavata 2020 Antioxid Redox Signal	2020	Plecitá-Hlavatá L, Engstová H, Holendová B, Tauber J, Špaček T, Petrásková L, Křen V, Špačková J, Gotvaldová K, Ježek J, Dlasková A, Smolková K, Ježek P (2020) Mitochondrial superoxide production decreases on glucose-stimulated insulin secretion in pancreatic β cells due to decreasing mitochondrial matrix NADH/NAD⁺ ratio. Antioxid Redox Signal 33:789-815.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Islet cell;pancreas;thymus
D'Souza 2020 Nutrients	2020	D'Souza K, Mercer A, Mawhinney H, Pulinilkunnil T, Udenigwe CC, Kienesberger PC (2020) Whey peptides stimulate differentiation and lipid metabolism in adipocytes and ameliorate lipotoxicity-induced insulin resistance in muscle cells. Nutrients 12:E425.	LEAK ET	F N	Permeabilized cells	Mouse	Skeletal muscle Fat
Remie 2020 Am J Clin Nutr	2020	Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Human	Skeletal muscle
Oellermann 2020 Sci Rep	2020	Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202.	LEAK OXPHOS ET	N S NS	Homogenate	Crustaceans	Heart
Ferreira 2020 PLoS Genet	2020	Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Liver
Reutzel 2020 Oxid Med Cell Longev	2020	Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.	LEAK ET OXPHOS	N S CIV ROX	Isolated mitochondria	Mouse	Nervous system
Wefers 2020 Mol Metab	2020	Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P (2020) Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab 41:101050.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Kamarauskaite 2020 Biomed Res Int	2020	Kamarauskaite J, Baniene R, Trumbeckas D, Strazdauskas A, Trumbeckaite S (2020) Increased succinate accumulation induces ROS generation in in vivo ischemia/reperfusion-affected rat kidney mitochondria. Biomed Res Int 2020:8855585.	LEAK OXPHOS	N S		Rat	Kidney
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis	2020	Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Isolated mitochondria Intact cells	Rat	Liver Nervous system
Ayari 2020 Commun Biol	2020	Ayari Asma, Rosa-Calatrava Manuel, Lancel Steve, Barthelemy Johanna, Pizzorno Andres, Mayeuf-Louchart Alicia, Baron Morgane, Hot David, Deruyter Lucie, Soulard Daphnee, Julien Thomas, Faveeuw Christelle, Molendi-Coste Olivier, Dombrowicz David, Sedano Laura, Sencio Valentin, Le Goffic Ronan, Trottein Francois, Wolowczuk Isabelle (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fat
Marrocco 2020 Thesis	2020	Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108.	LEAK OXPHOS ET	S ROX	Intact cells	Mouse	Macrophage-derived
Anand 2020 Toxicol In Vitro	2020	Anand CR, Bhavya B, Jayakumar K, Harikrishnan VS, Gopala S (2020) Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia. Toxicol In Vitro 70:105048.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Luevano-Martinez 2020 FEBS Lett	2020	Luévano-Martínez LA, Girard RMBM, Alencar MB, Silber AM (2020) ATP regulates the activity of an alternative oxidase in Trypanosoma brucei. FEBS Lett [Epub ahead of print].	LEAK ROUTINE ET		Intact cells	Protists
Magnesa 2020 Thesis	2020	Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Cipullo 2020 Nucleic Acids Res	2020	Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res 49:354-70.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	HEK
Locatelli 2020 FASEB J	2020	Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria Intact cells	Human	Endothelial;epithelial;mesothelial cell
Hafstad 2020 Antioxidants (Basel)	2020	Hafstad AD, Hansen SS, Lund J, Santos CXC, Boardman NT, Shah AM, Aasum E (2020) NADPH oxidase 2 mediates myocardial oxygen wasting in obesity. Antioxidants (Basel) 9:E171.	LEAK OXPHOS	F N	Isolated mitochondria	Mouse	Heart
Andrade 2020 Nutr Metab Cardiovasc Dis	2020	Andrade D, Oliveira G, Menezes L, Nascimento AL, Carvalho S, Stumbo AC, Thole A, Garcia-Souza É, Moura A, Carvalho L, Cortez E (2020) Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis 30:151-61.	LEAK OXPHOS	F N NS	Permeabilized tissue	Mouse	Heart
Kuzniewska 2020 EMBO Rep	2020	Kuzniewska B, Cysewski D, Wasilewski M, Sakowska P, Milek J, Kulinski TM, Winiarski M, Kozielewicz P, Knapska E, Dadlez M, Chacinska A, Dziembowski A, Dziembowska M (2020) Mitochondrial protein biogenesis in the synapse is supported by local translation. EMBO Rep 21:e48882.	LEAK ET	N S	Permeabilized cells	Human Mouse	Nervous system HEK
Hingst 2020 Mol Metab	2020	Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Cruz 2020 Drug Alcohol Depend	2020	Cruz JV, Maba IK, Correia D, Kaziuk FD, Cadena SMSC, Zampronio AR (2020) Intermittent binge-like ethanol exposure during adolescence attenuates the febrile response by reducing brown adipose tissue thermogenesis in rats. Drug Alcohol Depend 209:107904.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Fat
Juarez-Flores 2020 Antioxidants (Basel)	2020	Juarez-Flores DL, Ezquerra M, Gonzalez-Casacuberta I, Ormazabal A, Moren C, Tolosa E, Fucho R, Guitart-Mampel M, Casado M, Valldeoriola F, de la Torre-Lara J, Munoz E, Tobias E, Compta Y, Garcia-Garcia FJ, Garcia-Ruiz C, Fernandez-Checa JC, Marti MJ, Grau JM, Cardellach F, Artuch R, Fernandez-Santiago R, Garrabou G (2020) Disrupted mitochondrial and metabolic plasticity underlie comorbidity between age-related and degenerative disorders as Parkinson disease and type 2 diabetes mellitus. Antioxidants (Basel) 9:1063.	LEAK ROUTINE ET	ROX	Permeabilized cells Intact cells	Human	Fibroblast
Macedo 2020 FASEB J	2020	Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J 34:9972-81.	LEAK OXPHOS	F N CIV ROX	Intact organism Isolated mitochondria	Caenorhabditis elegans
Avila-Rojas 2020 Food Chem Toxicol	2020	Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Kidney
Yadav 2020 Cell Death Dis	2020	Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Human	Heart Stem cells
Allen 2020 Thesis	2020	Allen FM (2020) Mitochondrial metabolism elucidated by rapid fractionation from tissue. PhD Thesis 298.	LEAK ET	S	Isolated mitochondria	Mouse Rat	Heart Liver
Seo 2020 J Clin Med	2020	Seo DY, Heo JW, No MH, Yoo SZ, Ko JR, Park DH, Kang JH, Kim CJ, Jung SJ, Han J, Kwak HB (2020) Exercise training protects against atorvastatin-induced skeletal muscle dysfunction and mitochondrial dysfunction in the skeletal muscle of rats. J Clin Med 9:E2292.	LEAK OXPHOS	N	Permeabilized tissue	Rat	Skeletal muscle
Risiglione 2020 Int J Mol Sci	2020	Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP⁺ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. https://doi.org/10.3390/ijms21217809	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Dawson 2020 J Exp Biol	2020	Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Fishes	Lung;gill
Ugarteburu 2020 J Clin Med	2020	Ugarteburu O, Sánchez-Vilés M, Ramos J, Barcos-Rodríguez T, Garrabou G, García-Villoria J, Ribes A, Tort F (2020) Physiopathological bases of the disease caused by HACE1 mutations: alterations in autophagy, mitophagy and oxidative stress response. J Clin Med 9:E913.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Pham 2020 Eur J Appl Physiol	2020	Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Visavadiya 2020 Mol Cell Biochem	2020	Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem 476:23-34.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Liver
Wen 2020 Biomedicines	2020	Wen JJ, Cummins CB, Williams TP, Radhakrishnan RS (2020) The genetic evidence of burn-induced cardiac mitochondrial metabolism dysfunction . Biomedicines 8:E566.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Rat	Heart
Cornelissen 2020 Hum Mol Genet	2020	Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Fibroblast
Boel 2020 J Exp Biol	2020	Boël M, Romestaing C, Duchamp C, Veyrunes F, Renaud S, Roussel D, Voituron Y (2020) Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. J Exp Biol 223:jeb215558.	LEAK ET	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Falcao-Tebas 2020 J Physiol	2020	Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Esselun 2020 Neuromolecular Med	2020	Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Dawid 2020 Biochim Biophys Acta Bioenerg	2020	Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.	LEAK ROUTINE OXPHOS ET	N S Gp NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human Mouse	Nervous system HEK
Lopez 2020 Function (Oxf)	2020	Lopez R, Marzban B, Gao X, Lauinger E, Van den Bergh F, Whitesall SE, Converso-Baran K, Burant CF, Michele DE, Beard DA (2020) Impaired myocardial energetics causes mechanical dysfunction in decompensated failing hearts. Function (Oxf) 1:zqaa018.	LEAK OXPHOS	F N	Isolated mitochondria	Rat	Heart
Stepanova 2020 Methods Cell Biol	2020	Stepanova A, Galkin A (2020) Measurement of mitochondrial H₂O₂ production under varying O₂ tensions. https://doi.org/10.1016/bs.mcb.2019.12.008	LEAK OXPHOS	S N Gp	Isolated mitochondria	Mouse	Nervous system
De Souza 2020 Heliyon	2020	De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver HeLa
Davidson 2020 Circ Res	2020	Davidson MT, Grimsrud P, Lai L, Draper J, Fisher-Wellman KH, Narowski TM, Koves TR, Kelly DP, Muoio DM (2020) Extreme acetylation of the cardiac mitochondrial proteome does not promote heart failure. Circ Res 127:1094-108.	LEAK	F N	Isolated mitochondria	Mouse	Heart
Dymkowska 2020 J Appl Toxicol	2020	Dymkowska D, Wrzosek A, Zabłocki K (2020) Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol 41:1076-88.	LEAK ET ROUTINE		Intact cells	Human	Endothelial;epithelial;mesothelial cell
Kahancova 2020 Sci Rep	2020	Kahancová A, Sklenář F, Ježek P, Dlasková A (2020) Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells. Sci Rep 10:1551.	LEAK ROUTINE ET		Intact cells	Rat	Islet cell;pancreas;thymus
Hayes 2020 Nutrients	2020	Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.	LEAK ROUTINE OXPHOS ET	N S Gp CIV ROX	Permeabilized cells Intact cells	Human	HeLa
Beninca 2020 J Med Genet	2020	Beninca C, Zanette V, Brischigliaro M, Johnson M, Reyes A, Valle DAD, Robinson AJ, Degiorgi A, Yeates A, Telles BA, Prudent J, Baruffini E, Santos ML, de Souza RL, Fernandez-Vizarra E, Whitworth A, Zeviani M (2020) Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features. J Med Genet 58:155-67.	LEAK ROUTINE ET		Intact cells	Human	Fibroblast
Larsen 2020 Cardiovasc Drugs Ther	2020	Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther 35:491-503.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Kupats 2020 Oxid Med Cell Longev	2020	Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598.	LEAK OXPHOS ET	N S NS	Homogenate Isolated mitochondria	Mouse	Nervous system
Ost 2020 EMBO Rep	2020	Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Jaber 2020 BM Exp Neurol	2020	Jaber SM, Yadava N, Polster BM (2020) Mapping mitochondrial respiratory chain deficiencies by respirometry: beyond the Mito Stress Test. BM Exp Neurol 328:113282.	LEAK ROUTINE ET	ROX	Intact cells		Nervous system
Sharma 2020 Integr Cancer Ther	2020	Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437.	LEAK OXPHOS	N S	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Rondot 2020 Thesis	2020	Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Hexapods	Skeletal muscle
Abid 2020 FASEB J	2020	Abid H, Ryan ZC, Delmotte P, Sieck GC, Lanza IR (2020) Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways. FASEB J 34:14458-72.	LEAK OXPHOS	N S NS	Intact cells	Mouse	Skeletal muscle
Krabbendam 2020 Cell Death Dis	2020	Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Nervous system
Protasoni 2020 EMBO J	2020	Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Jayakumari 2020 J Diabetes	2020	Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Human	Heart
Franco 2020 bioRxiv	2020	Franco JLM, Genoula M, Corral D, Duette G, Ferreyra M, Maio M, Dolotowicz MB, Aparicio-Trejo OE, Patiño-Martínez E, Fuentes F, Soldan V, Moraña EJ, Palmero D, Ostrowski M, Schierloh P, Sánchez-Torres C, Hernández-Pando R, Pedraza-Chaverri J, Rombouts Y, Layre E, Hudrisier D, Vérollet C, Neyrolles O, Sasiain MC, Lugo-Villarino G, Balboa L (2020) Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity. bioRxiv doi: https://doi.org/10.1101/2020.03.23.001818 .	LEAK ROUTINE	N S CIV ROX	Intact cells	Human	Macrophage-derived
Leguina-Ruzzi 2020 Biomolecules	2020	Leguina-Ruzzi A, Vodičková A, Holendová B, Pavluch V, Tauber J, Engstová H, Dlasková A, Ježek P (2020) Glucose-induced expression of DAPIT in pancreatic β-cells. Biomolecules 10:E1026.	LEAK ROUTINE ET		Intact cells	Rat	Islet cell;pancreas;thymus
Bose 2020 Aging Cell	2020	Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261.	LEAK OXPHOS	F N CIV NS ROX	Permeabilized tissue	Mouse	Heart
Tepp 2020 Biochim Biophys Acta Gen Subj	2020	Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Mouse	Heart Skeletal muscle
Alexopoulos 2020 Nat Commun	2020	Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun 11:2397.	LEAK	N	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Liver Fat
Lin 2020 Preprints	2020	Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567.	LEAK ROUTINE OXPHOS ET	F N S Gp NS ROX	Permeabilized cells Intact cells	Human	Platelet
Palavicini 2020 JCI Insight	2020	Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Nervous system
No 2020 Pflugers Arch	2020	No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93.	LEAK OXPHOS	N NS	Permeabilized tissue	Rat	Heart
MitoEAGLE blood cells 1	2020	Åsander Frostner Eleonor, Aburel Oana M, Avram Vlad F, Calabria Elisa, Castelo Rueda Maria Paulina, Chamkha Imen, Čižmárová Beata, Danila Maria-Daniela, Doerrier Carolina, Eckert Gunter P, Ehinger Johannes K, Elmer Eskil, Garcia-Souza Luiz F, Gnaiger Erich, Hoppel Florian, Karabatsiakis Alexander, Keppner Gloria, Kidere Dita, Krako Jakovljević Nina, Labieniec-Watala Magdalena, Lelcu Theia, Micankova Petra, Michalak Slawomir, Molina Anthony JA, Pavlovic Kasja, Pichler Irene, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina, Silaidos Carmina, Sjövall Fredrik, Sobotka Ondrej, Sumbalova Zuzana, Swiniuch Daria, Vernerova Andrea, Volani Chiara, Vujacic-Mirski Ksenija, Watala Cezary (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *Confirmed	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Keppner 2020 Thesis	2020	Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Messner 2020 Thesis	2020	Messner M (2020) Sorafenib resistance of hepatocellular carcinoma. PhD Thesis 130.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Gnaiger 2020 BEC MitoPathways	2020	Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5^th ed. https://doi.org/10.26124/bec:2020-0002	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells	Human Mouse	Heart Skeletal muscle Fibroblast
Wang 2020 J Mol Med (Berl)	2020	Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61.	LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Mohsin 2020 Arch Biochem Biophys	2020	Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299.	LEAK OXPHOS	N S	Permeabilized cells	Rat	Skeletal muscle
Briones-Herrera 2020 Free Radic Biol Med	2020	Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Rat	Kidney
Silva Ferraz 2020 Biochem Pharmacol	2020	Silva Ferraz L, Torres da Costa R, Alves da Costa C, Augusto João Ribeiro C, Costa Arruda D, Stuchi Maria-Engler S, Rodrigues T (2020) Targeting mitochondria in melanoma: interplay between MAPK signaling pathway and mitochondrial dynamics . Biochem Pharmacol 178:114104.	LEAK ROUTINE ET		Intact cells	Human	Endothelial;epithelial;mesothelial cell
Agil 2020 J Clin Med	2020	Agil A, Chayah M, Visiedo L, Navarro-Alarcon M, Rodríguez Ferrer JM, Tassi M, Reiter RJ, Fernández-Vázquez G (2020) Melatonin improves mitochondrial dynamics and function in the kidney of Zücker diabetic fatty rats. J Clin Med 9:E2916.	LEAK OXPHOS	N S	Isolated mitochondria	Rat	Kidney
MitoEAGLE muscle 1	2020	Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08	LEAK OXPHOS ET	N NS S ROX	Permeabilized tissue	Human	Skeletal muscle
Oliveira 2020 Anim Reprod	2020	Oliveira VS, Castro AJG, Domingues JT, Souza AZP, Scheffer DL, Latini A, Soares CHL, Van Der Kraak G, Silva FRMB (2020) A brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters sertoli cell secretion and mitochondrial activity. Anim Reprod 17:e20190116.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Genital
Nicolaisen 2020 FASEB J	2020	Nicolaisen TS, Klein AB, Dmytriyeva O, Lund J, Ingerslev LR, Fritzen AM, Carl CS, Lundsgaard AM, Frost M, Ma T, Schjerling P, Gerhart-Hines Z, Flamant F, Gauthier K, Larsen S, Richter EA, Kiens B, Clemmensen C (2020) Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure. FASEB J 34:15480-91.	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Purhonen 2020 Nat Commun	2020	Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Liver Kidney
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» Abstracts: LEAK

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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Irving 2022 Abstract Bioblast	2022	7.4. «5 min» Irving Brian A, Stampley J, Quiriarte H, Wigger Z, Stephens J, Soto P, Allerton TA (2022) Impact of nitric oxide promotors on mitochondrial bioenergetics in a murine model of Alzheimer's disease. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS ET	N Gp NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Gnaiger 2022 ESCI Bari	2022	Gnaiger E (2022) Bioenergetic cluster analysis – diagnostic evaluation of mitochondrial respiratory control in human fibroblasts. 56^th Annual Scientific Meeting of the European Society for Clinical Investigation.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Porter 2022 Abstract Bioblast	2022	6.3. «10+5» Karavyraki M, Gnaiger E, Porter Richard K (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint«	LEAK ROUTINE ET	S ROX	Permeabilized cells	Human
Axelrod 2022 Abstract Bioblast	2022	3.6. «5 min» Axelrod Christopher L, Heintz EC, Albaugh VL, Kirwan JP (2022) Segmental regulation of intestinal mitochondrial function. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS ET	N S CIV	Isolated mitochondria	Mouse	Endothelial;epithelial;mesothelial cell
Magri 2022 Abstract Bioblast	2022	8.5. «5 min» Magrì Andrea, Cubisino SAM, De Pinto V, Messina A (2022) Modulation of mitochondrial respiration in ALS cells by hexokinase-based peptides: a novel therapeutic approach to fight neurodegeneration. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Nervous system
Cecatto 2022 EBEC	2022	Cecatto C, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. EBEC 2022.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Liver
Cardoso 2022 Abstract Bioblast	2022	4.3. «10+5» Cardoso Luiza HD, Doerrier C, Donnelly C, Komlódi T, Gnaiger E (2022) Redox monitoring and respiration - a new horizon with the NextGen-O2k. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria	Mouse	Liver HEK
Schmitt 2022 EBEC	2022	Schmitt S, Gnaiger E (2022) Short-term effect of molecular hydrogen on mitochondrial respiration and hydrogen peroxide production in permeabilized HEK 293T cells. EBEC 2022.	LEAK OXPHOS	N	Permeabilized cells	Human	HEK
Komlodi 2022 Abstract Bioblast	2022	3.1. «10+5» Komlódi Timea, Tretter L (2022) The protonmotive force – not merely membrane potential. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint«	LEAK OXPHOS		Isolated mitochondria
Kolonics 2022 Abstract Bioblast	2022	P16. Kolonics Attila, Léner V, Kutasi B, Kutasi J (2022) Effects of Scenedesmus rubescens extract on Paraquat induced parkinsonism model in SH-SY5Y cells and mitochondrial dysfunction. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK	S	Isolated mitochondria	Mouse	Nervous system
Cardoso 2022a EBEC	2022	Cardoso LHD, Donnelly C, Komlódi T, Gnaiger E (2022) Characterizing electron transfer through the mitochondrial Q-junction from fatty acid oxidation and TCA cycle on HEK 293T cells: correlation with respiration. EBEC 2022.	LEAK OXPHOS ET	F N S NS	Permeabilized cells	Human	HEK
Schmitt 2022 Abstract Bioblast	2022	2.2. «10+5» Schmitt Sabine, Gnaiger E (2022) Using oxygen and hydrogen gas in studies of mitochondrial respiration and hydrogen peroxide production under hyperoxic, normoxic, and hypoxic conditions. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS	N	Permeabilized cells		HEK
Cecatto 2022 Abstract Bioblast	2022	5.1. «10+5» Cecatto Cristiane, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK		Isolated mitochondria	Mouse	Liver
Cardoso 2022 ESCI Bari	2022	Cardoso LHD, Donnelly C, Komlódi T, Gnaiger E (2022) Bioenergetic fingerprinting with coupling and pathway control of coenzyme Q redox state and respiration in permeabilized HEK 293T cells. 56^th Annual Scientific Meeting of the European Society for Clinical Investigation.	LEAK OXPHOS ET	N S NS	Permeabilized cells	Human	HEK
Doerrier 2020 PaduaMuscleDays Poster	2020	Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Lelcu 2019 MiP2019	2019	Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Human	Platelet
Evinova 2019 MiPschool Coimbra	2019	High resolution respirometry of neuroblastoma SK-N-SH and SH-SY 5Y cell lines.	LEAK ROUTINE ET	N	Intact cells	Human	Neuroblastoma
Hatokova 2019 MiPschool Coimbra	2019	Influence the passage number on a respiration of SH-SY 5Y cells.	LEAK ROUTINE ET		Intact cells	Human	Neuroblastoma
Lemieux 2019a MiP2019	2019	Partial prevention of oxidative stress damage to mitochondria with photobiomodulation.	LEAK OXPHOS ET	N S CIV NS		Other invertebrates
Dominguez-Amorocho 2019 MiP2019	2019	Role of Sirtuin 1/3 in CD4⁺ T cells activation and differentiation in obese and transplanted animals.	LEAK ET OXPHOS	ROX		Mouse	Lymphocyte
Goncalves Debora 2019 MiPschool Coimbra	2019	Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Drosophila
Van der Ende 2019 MiPschool Coimbra	2019	Mitochondrial respiration in muscle tissue of colon cancer patients.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Cardoso 2019 MiP2019	2019	Effects of glucose concentration in cell culture media on hepatocellular carcinoma HuH7 cells evaluated by high-resolution respirometry.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Kramer 2019 Abstract IOC141	2019	Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.	LEAK OXPHOS ET	N CIV NS ROX		Human	Skeletal muscle
Garcia-Roves 2019 MiPschool Coimbra	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Minuzzi 2019 MiPschool Coimbra	2019	A pilot study on mitochondrial function of mouse skin using high-resolution respirometry.	LEAK OXPHOS ET	F N S	Permeabilized tissue	Mouse	Endothelial;epithelial;mesothelial cell
Betiu 2019 MiP2019	2019	Cell-permeable succinate improves amiodarone-induced mitochondrial Complex I and II inhibition in human platelets.	LEAK ET	ROX	Permeabilized cells Intact cells	Human	Platelet
Timohhina 2019 MiP2019	2019	Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.	LEAK OXPHOS ET	ROX		Human	Endothelial;epithelial;mesothelial cell
Garcia 2019 MiPschool Coimbra	2019	Functional interactions between the Drosophila melanogaster mitochondrial glycerol-3-phosphate dehydrogenase and a xenotopically expressed alternative oxidase.	LEAK OXPHOS	N Gp		Drosophila
Sumbalova 2019a MiP2019	2019	Platelet mitochondrial function, coenzyme Q₁₀, and oxidative stress in patients with chronic kidney diseases.	LEAK OXPHOS	F N S Gp CIV NS ROX	Intact cells	Human	Platelet
Kandel 2019 Biophys J	2019	Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley Jr AW, Dash RK (2019) Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J.	LEAK OXPHOS	F N S	Isolated mitochondria	Rat	Heart Kidney
Chabi 2019 MiP2019	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Aid-Vanakova 2019 MiP2019	2019	Adaptation of muscle OXPHOS in developing glucose intolerance - Wfs1 mice model.	LEAK OXPHOS	N S		Mouse	Skeletal muscle Heart
Beleza 2019 MiPschool Coimbra	2019	Gestational exercise counteracts the deleterious consequences imposed by diabetes mellitus developed during pregnancy on 16 weeks old male offspring liver mitochondrial function.	LEAK OXPHOS	N S		Rat	Liver
Sumbalova 2019b MiP2019	2019	The decline of mitochondrial respiration in isolated platelets after short-term storage.	LEAK OXPHOS	F N S Gp CIV NS ROX	Intact cells	Human	Platelet
Doerrier 2019 MiP2019	2019	Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers.	LEAK ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT	2018	Cellular succinate transport and mitochondrial respiratory function in prostate cancer.	ROUTINE LEAK OXPHOS ET	S ROX	Permeabilized cells Intact cells	Human	HEK Genital
Garipi 2018 MiPschool Tromso E2	2018	Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production	LEAK ROUTINE OXPHOS ET	CIV NS ROX	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Other cell lines
McMaster 2018 Am J Obstet Gynecol	2018	Preeclampsia is associated with placental mitochondrial dysfunction.	LEAK ROUTINE OXPHOS ET	N	Isolated mitochondria	Human
Gnaiger 2018 EBEC2018	2018	The protonmotive force under pressure: an isomorphic analysis.	LEAK
Komlodi 2018 AussieMit	2018	Komlodi T, Hunger M, Moore AL, Gnaiger E (2018) Electron transfer at the Q-junction: new perspectives from combined measurement of mitochondrial O₂ flux, H₂O₂ flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU.	LEAK OXPHOS	S Gp	Isolated mitochondria	Mouse	Nervous system
Komlodi 2018 EBEC2018	2018	Electron supply to the Q-junction: assessment of mitochondrial respiration, H₂O₂ flux and the redox state of the Q-pool.	LEAK OXPHOS	S Gp	Isolated mitochondria	Mouse	Nervous system
Porter 2018 MiP2018b	2018	Skeletal muscle mitochondrial thermogenesis in hypermetabolic humans.	LEAK OXPHOS
Sobotka 2018 MiP2018	2018	Measurement of ROS production under hypoxia and unexpected methodological pitfalls of Amplex UltraRed assay.	LEAK OXPHOS		Isolated mitochondria	Mouse Saccharomyces cerevisiae	Heart Nervous system
Krajcova 2018 MiPschool Tromso E2	2018	High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.	LEAK OXPHOS ET	N NS ROX	Homogenate	Human	Heart
Schoepf 2018 33rd Annual EAU Congress Copenhagen	2018	Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.	LEAK OXPHOS ET	F N NS Other combinations ROX	Permeabilized cells Permeabilized tissue	Human	Genital
Acuna-Castroviejo 2018 MiP2018	2018	Mitochondria, melatonin, and neuroinflammation in Parkinson's disease. Acuna-Castroviejo_Presentation	LEAK OXPHOS	N		Mouse	Nervous system
Gnaiger 2018 AussieMit	2018	Komlodi Timea, Sobotka Ondrej, Doerrier Carolina, Gnaiger Erich (2018) Mitochondrial H₂O₂ production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU.	LEAK ROUTINE OXPHOS	NS	Isolated mitochondria Intact cells	Mouse Saccharomyces cerevisiae	Heart Nervous system
Doerrier 2018 EBEC2018	2018	Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system Blood cells HEK Platelet
Bovard 2018 IOC134	2018	Integrative determinants of oxygen uptake and biomolecular markers of exercise training.	LEAK			Human	Skeletal muscle
Kovalev 2018 EMBS	2018	Kovalev A, Sokolova I, Sukhotin A (2018) Allometry of mitochondrial respiration in mussels. EMBS.	LEAK OXPHOS ET	CIV	Isolated mitochondria	Molluscs	Liver Islet cell;pancreas;thymus
Garcia-Souza 2018 Life Sciences Meeting 2018 Innsbruck AT	2018	A respirometric cell viability test for peripheral-blood mononuclear cells and platelets.	LEAK ROUTINE ET	S	Intact cells	Human	Blood cells Platelet
Nemec 2018 MiP2018	2018	Aerobic/strength exercise intervention modulates skeletal muscle mitochondrial function in seniors.	LEAK	F N NS Other combinations	Permeabilized tissue	Human	Skeletal muscle
Gnaiger 2018 MiPschool Tromso A1	2018	Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.	LEAK ET OXPHOS	F N S Gp DQ CIV NS Other combinations
Han 2018 MiP2018	2018	Mitochondrial functional changes elicited by a single near-infrared (670nm) exposure. Han_Presentation	LEAK ROUTINE ET			Human	Kidney HEK
Krajcova 2018 ICO134	2018	Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Human	Skeletal muscle
Li 2018 IBEC	2018	Li C, Li N, Zhang Y (2018) UPRmt and mitophagy are selectively activated depending on muscle fiber types in insulin resistant rats. IBEC.	LEAK OXPHOS			Rat	Skeletal muscle
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT	2018	pH dependence of mitochondrial respiration and H₂O₂ production in oral cancer cells – a pilot study.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells	Human	HEK Kidney
Evinova 2018 MiP2018	2018	High-resolution respirometry of neuroblastoma SH-SY 5Y cell line.	LEAK ROUTINE ET		Intact cells	Human	Other cell lines Neuroblastoma
Harper 2018 MiPschool Tromso D1	2018	OXPHOS efficiency in skeletal and cardiac muscles: Proton leaks, ROS and glutathione redox.	LEAK				Heart Skeletal muscle
Meszaros 2018 EBEC2018	2018	Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Heart Nervous system Liver
Doerrier 2018 ESCI2018	2018	High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease	LEAK ROUTINE OXPHOS ET	F N S Gp ROX CIV	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria	Human Mouse	Heart Skeletal muscle Nervous system Blood cells HEK
Doerrier 2018 MiP2018a	2018	Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Kuka 2018 MiP2018	2018	The discovery of methyl-GBB - acylcarnitine lowering as an effective strategy to treat cardiometabolic diseases.	LEAK OXPHOS			Rat	Heart
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4	2018	Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.	LEAK ROUTINE OXPHOS ET	S ROX	Intact cells	Human	Genital
Avram 2018 MiP2018	2018	Cell-permeable succinate bypasses statin-induced mitochondrial complex I inhibition in human platelets. Avram_Presentation	LEAK ET	S	Permeabilized cells Intact cells	Human	Platelet
Ravasz 2018 Abstract The evolving concept of mitochondria	2018	Vast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Liver
Pchelin 2018 IOC130	2018	Activation of heterodimeric receptor to erythropoietin with its agonist CdEPO regulates brain mitochondrial bioenergetics after local acute ischemia/reperfusion in C57BL/6 mice.	LEAK	N	Isolated mitochondria	Mouse	Nervous system
Doerrier 2018 MiP2018c	2018	Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Meszaros 2018 Mt Med Hinxton	2018	High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments.	LEAK OXPHOS ET	N CIV NS	Isolated mitochondria	Mouse	Heart Nervous system Liver
Reboredo-Rodriguez 2017 MiPschool Obergurgl	2017	Protective effect of a polyphenol-rich strawberry extract on oxidative and endoplasmic reticulum stresses in HepG2 cell line.	LEAK ET	ROX		Human	Liver
Siewiera 2017 MiP2017	2017	Changes in blood platelet and brain mitochondrial respiration during short and long-lasting STZ-induced diabetes.	LEAK ET	N	Homogenate Intact cells	Rat	Nervous system Blood cells Platelet
O'Brien 2017 Abstract IOC122	2017	PPARα independent effects of nitrate supplementation on skeletal muscle mitochondrial function in hypoxia.	LEAK OXPHOS	F		Mouse	Skeletal muscle
Waldauf 2017 MITOEAGLE Obergurgl	2017	Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates.	LEAK OXPHOS ET	F N S CIV NS	Homogenate	Human	Skeletal muscle
Komlodi 2017 MiP2017	2017	H₂O₂ production under hypoxia in brain and heart mitochondria: does O₂ concentration matter?	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Heart Nervous system
Meszaros 2017 MiPschool Obergurgl	2017	(Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Liver Nervous system Kidney
Krylova 2017 MiPschool Obergurgl	2017	High-resolution respirometry in diagnostic of mitochondrial complex I deficiency.	LEAK ROUTINE ET	N S	Intact cells Permeabilized cells		Endothelial;epithelial;mesothelial cell Fibroblast
Doerrier 2017 MiP2017 WG2	2017	Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Komlodi 2017 Abstract MITOEAGLE Barcelona	2017	Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria.	OXPHOS LEAK ET	N S	Isolated mitochondria Homogenate	Guinea pig Mouse	Nervous system Kidney Heart Liver
Hoel 2017 MiPschool Obergurgl	2017	A study on mitochondrial stress responses due to OXPHOS inhibition.	LEAK	ROX		Human	Nervous system
Kovalcikova 2017 MiP2017	2017	Mitochondrial protein TMEM70: key role in the biogenesis of ATP synthase verified in a mouse knockout model.	LEAK OXPHOS			Mouse	Heart Liver
Keppner 2017 MiPschool Obergurgl	2017	Different respiratory states to determine LEAK and uncoupled respiration in the SUIT protocol: effect and consequences.	LEAK OXPHOS ET	N NS	Permeabilized cells		Blood cells
Gnaiger 2017 MiPschool A1	2017	Elemental steps towards understanding mitochondrial core energy metabolism: coupling control.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells Permeabilized cells Permeabilized tissue Isolated mitochondria
Meszaros 2017 MiP2017	2017	Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Nervous system Liver Kidney
Nogueras 2017 MiPschool Obergurgl	2017	Mitochondrial dysfunction in peripheral blood mononuclear cells from multiple sclerosis patients.	LEAK ROUTINE ET	ROX	Intact cells		Blood cells
Ukropec 2017 MITOEAGLE Obergurgl	2017	Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?	LEAK OXPHOS ET	F N S Gp NS	Permeabilized cells		Skeletal muscle
Doerrier 2017 MiP2017 C1	2017	Effects of warm ischemia on cardiac mitochondria to detect specific targets by high-resolution respirometry (HRR)	LEAK ET	F N S CIV NS	Isolated mitochondria	Mouse	Heart
Hartmann 2017 Abstract MITOEAGLE Barcelona	2017	Mitochondrial respiration of isolated peripheral blood mononuclear cells in an experimental porcine brain injury model.	LEAK ROUTINE ET		Intact cells	Human Pig	Blood cells
Gnaiger 2017 Abstract MitoEAGLE Barcelona	2017	Quality first: a paradigm shift in mt-respiratory control towards global connection.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human Mouse	Heart Genital
Gasparrini 2017 MiPschool Obergurgl	2017	Anti-inflammatory effects of strawberry and honey extracts in RAW 264.7 macrophages stressed with LPS.	LEAK	ROX		Mouse	Macrophage-derived
Markova 2017 MiP2017	2017	Porcine sepsis and associated myocardial depression.	LEAK OXPHOS	N S CIV NS ROX		Pig	Heart
Siewiera 2017 MiPschool Obergurgl	2017	Blood platelets as bioenergetic markers of brain damage in STZ-diabetes.	LEAK ROUTINE ET		Intact cells	Rat	Blood cells Platelet
Doerrier 2017 MiPschool C2	2017	Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system HEK
Calabria 2017 MiP2017	2017	Age and frailty related changes in PBMCs mitochondrial function and whole body physiology.	LEAK ET	S	Permeabilized cells	Human	Blood cells
Juhasz 2017 MiPschool Obergurgl	2017	Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.	LEAK OXPHOS	N S	Homogenate	Rat	Liver
Chabi 2017 MITOEAGLE Obergurgl	2017	Optimization of permeabilized fibers preparation for mitochondrial respiration measurements using Design of Experiments methodology.	LEAK	NS	Permeabilized tissue	Mouse	Skeletal muscle
Gnaiger 2017 MiP2017	2017	Gnaiger E (2017) Protonmotive force and chemiosmotic pressure: a generalization of non-ohmic flux control of the proton leak. MiP2017.	LEAK
Michalak 2017 Abstract MITOEAGLE Barcelona	2017	Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells	Human	Blood cells
Doerrier 2017 Abstract MitoEAGLE Barcelona	2017	SUIT reference protocol for comparative mitochondrial physiology.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system HEK
Giampieri 2017 MiPschool Obergurgl	2017	Strawberry extract protects human dermal fibroblasts against oxidative stress and improves mitochondrial functionality.	LEAK	ROX			Fibroblast
Michalak 2017 MiP2017	2017	The effect of anticoagulants on mitochondrial respiration in intact peripheral blood mononuclear cells.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Karavyraki 2017 MiPschool Obergurgl	2017	Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells.	LEAK	ROX	Intact cells	Human
Lin 2017 FASEB J	2017	Mitochondrial respiration is fiber-type specific in skeletal muscles.	LEAK ROUTINE	N NS	Permeabilized tissue	Rat	Skeletal muscle
Hellgren 2017 MiPschool Obergurgl	2017	Effect of prenatal hypoxia on adult mitochondrial respiration and ROS production.	LEAK ROUTINE ET	N	Homogenate	Mouse	Heart
Cizmarova 2017 MiP2017	2017	PBMC cryopreservation and evaluation for functional mitochondrial diagnosis.	LEAK ROUTINE ET		Intact cells	Human	Blood cells
Krajcova 2017 MITOEAGLE Obergurgl	2017	Developing a method of assessing mitochondrial functions in homogenates of human heart muscle.	LEAK OXPHOS ET	N NS	Homogenate	Human
Irving 2017 MiP2017	2017	Impact of acute exercise on PBMC respiratory function and methodological considerations.	LEAK ROUTINE OXPHOS ET	N NS ROX			Blood cells
Amick 2017 MiPschool Obergurgl	2017	Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates.	LEAK OXPHOS	F N	Isolated mitochondria	Other mammals	Nervous system
Afrin 2017 MiPschool Obergurgl	2017	Induction of mitochondrial dysfunction by Manuka honey as a strategy for prevention of colon cancer in vitro model: a rising role on reactive oxygen species, apoptosis, and cell metabolism.	LEAK	ROX
Rybacka-Mossakowska 2017 MiP2017	2017	Mitochondrial respiration in intact peripheral blood mononuclear cells in multiple sclerosis patients.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Komlodi 2017 MiPschool Obergurgl	2017	Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H₂O₂ production.	LEAK OXPHOS	N S Gp Other combinations ROX	Isolated mitochondria	Mouse	Nervous system
Nemec 2017 MiP2017	2017	Three-month exercise modulates skeletal muscle mitochondria function in patients with mild cognitive impairment.	LEAK	N NS	Permeabilized tissue	Human	Skeletal muscle
Chowdhury 2017 Blood	2017	Importance of mitochondrial metabolism as a selective therapeutic approach in chronic lymphocytic leukemia patients.	LEAK	ROX	Intact cells	Human	Lymphocyte
Distefano 2017 MiPschool Obergurgl	2017	Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.	LEAK OXPHOS ET	F NS	Permeabilized tissue	Human	Skeletal muscle
Bento 2017 MITOEAGLE Obergurgl	2017	Isolation of human urine-derived stem cells for mitochondrial function profile assessment.	LEAK ET	ROX	Intact cells	Human	Stem cells
Iyer 2017 MiP2017	2017	Bioenergetic profiling of patient derived human fibroblasts for mitochondrial diseases. Iyer_Presentation	LEAK ROUTINE			Human	Fibroblast
Markova 2017 MiPschool Obergurgl	2017	Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Heart
MitoFit Open Seminar 2017-07-14	2017	Innsbruck AT, 2017 Jul 14. MitoFit Open Seminar on immune cell bioenergetics. Investigating the role of mitochondria in healthy and psychopathological aging.	LEAK ROUTINE ET		Intact cells	Human	Blood cells
Han 2017 MiP2017	2017	Metabolic syndrome differentially impacts the retina and underlying retinal pigment epithelium cells.	LEAK OXPHOS	S CIV NS		Rat	Nervous system
Davies 2016 Abstract Proceedings of The Physiological Society	2016	Development of mitochondrial function in the cortex and cerebellum of the ovine fetus.	LEAK OXPHOS	N S NS	Homogenate	Bovines	Nervous system
Herminghaus 2016 Abstract MitoFit Science Camp 2016	2016	Sterile laparotomy time-dependently modulates hepatic but not colonic mitochondrial function similar to moderate abdominal sepsis.	LEAK OXPHOS	N NS		Rat	Liver Endothelial;epithelial;mesothelial cell
Sumbalova 2016b Abstract MitoFit Science Camp 2016	2016	Human blood cells: isolation and HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Bezuidenhout 2016b Abstract MitoFit Science Camp 2016	2016	Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Mouse	Skeletal muscle
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.	LEAK OXPHOS ET	F N S NS ROX		Mouse	Nervous system
Madlala 2016 Abstract MitoFit Science Camp 2016	2016	Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates.	LEAK OXPHOS ET	N	Permeabilized cells	Human	Liver
Sobotka 2016 Abstract IOC116	2016	Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11	LEAK OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Isolated mitochondria	Rat	Liver
Laner 2016 Abstract Mito Xmas Meeting Innsbruck	2016	OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Lamberti 2016 Abstract MitoFit Science Camp 2016	2016	Development of a reference sample for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX		Human	Kidney HEK
Krajcova 2016 Abstract MitoFit Science Camp 2016	2016	Mitochondrial pathogenesis of propofol infusion syndrome in an in vitro model of human skeletal muscle.	LEAK ET	F	Homogenate	Human	Skeletal muscle
Sparagna 2016 Abstract IOC109	2016	Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01.	LEAK OXPHOS	N S NS		Human	Heart
Cecatto 2016 Abstract IOC116	2016	Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca²⁺ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11	LEAK OXPHOS ET	F N CIV Other combinations	Permeabilized tissue Isolated mitochondria	Rat	Nervous system Liver
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck	2016	Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Mouse	Heart
Krumschnabel 2016a Abstract MitoFit Science Camp 2016	2016	O2k-Protocols: Mitochondrial preparations for HRR.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate Isolated mitochondria	Mouse	Heart
Calzia 2016 Abstract MitoFit Science Camp 2016	2016	Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains.	LEAK OXPHOS ET	NS		Fishes	Heart Skeletal muscle Nervous system Liver
Gnaiger 2016 Abstract UMDF2016	2016	Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.	LEAK OXPHOS ET	F N NS	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Mitochondrial function in primary prostate cancer.	LEAK OXPHOS ET	N S Other combinations	Permeabilized tissue	Human
Doerrier 2016 Abstract MitoFit Science Camp 2016	2016	Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria	Human Mouse	Heart Blood cells HEK Platelet
Volani 2016 Abstract MitoFit Science Camp 2016	2016	Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs.	LEAK OXPHOS ET	N S	Homogenate	Mouse Rat	Liver Blood cells Lymphocyte
Chicco 2016b Abstract MitoFit Science Camp 2016	2016	OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.	LEAK OXPHOS ET	F N	Permeabilized tissue	Human	Skeletal muscle
Volani 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo.	LEAK ROUTINE OXPHOS ET	N S	Homogenate	Mouse	Liver
Laner 2016 Abstract MitoFit Science Camp 2016	2016	OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Krumschnabel 2016b Abstract MitoFit Science Camp 2016	2016	O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.	LEAK OXPHOS ET	N S NS ROX		Human	Kidney HEK
Laner 2015 Abstract MiPschool Cape Town 2015	2015	The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.	LEAK ROUTINE OXPHOS ET	N S NS	Isolated mitochondria Intact cells	Mouse Saccharomyces cerevisiae	Heart
Sleiman 2015 Abstract MiP2015	2015	Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs.	LEAK OXPHOS ET	N S	Homogenate	Pig	Skeletal muscle
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	LEAK OXPHOS	F N	Permeabilized tissue	Mouse	Skeletal muscle
Blecha 2015 Abstract MiP2015	2015	Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.	LEAK ET	ROX
Laner 2015 Abstract MiP2015	2015	Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Dyrstad 2015 Abstract MiPschool London 2015	2015	Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells.	LEAK ROUTINE ET	N ROX		Human	Endothelial;epithelial;mesothelial cell Other cell lines
Ost 2015 Abstract IOC100	2015	Ost M (2015) “Mitokines” and the organismal role of mitochondrial function in energy homeostasis & metabolism. Mitochondr Physiol Network 20.01.	LEAK OXPHOS		Permeabilized tissue	Mouse	Skeletal muscle Fibroblast
Weidgang 2015 Abstract MiP2015	2015	Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39.	LEAK OXPHOS ET	N S	Homogenate	Mouse	Heart Skeletal muscle Liver Kidney
Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	LEAK OXPHOS ET	F	Permeabilized tissue	Human Rat	Skeletal muscle
Calzia 2015 Abstract MiP2015	2015	Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.	LEAK OXPHOS ET	N S ROX		Human	Skeletal muscle
Salin 2015 Abstract MiP2015	2015	Individual variation in whole-organism performance is related to mitochondrial properties at high temperatures.	LEAK			Fishes	Skeletal muscle Liver
Sheldon 2015 Abstract MiPschool Greenville 2015	2015	eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease.	LEAK OXPHOS ET	N NS		Mouse	Liver
Devaux 2015 Abstract MiP2015	2015	Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression.	LEAK OXPHOS ET	N S	Homogenate	Fishes	Nervous system
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II	2015	On coupling control of mitochondrial respiration. What is wrong with the RCR?	LEAK ROUTINE OXPHOS ET	N S ROX
Van Dyk 2015 Abstract MiPschool Cape Town 2015	2015	Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer.	LEAK ROUTINE ET	N ROX	Isolated mitochondria	Human	Other cell lines Fibroblast
Gnaiger 2015 Abstract MiP2015	2015	Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Intact cells	Human	HEK
Galina 2015 Abstract MiP2015	2015	High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles.	LEAK	N S ROX	Permeabilized tissue	Rat	Skeletal muscle
Doerrier 2015 Abstract MiPschool Greenville 2015	2015	"Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.	LEAK OXPHOS	S	Isolated mitochondria	Mouse	Heart
Doerrier 2015 Abstract MiP2015	2015	Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.	LEAK OXPHOS	S	Isolated mitochondria	Mouse	Heart
Maarman 2015 Abstract MiPschool Cape Town 2015	2015	Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure.	LEAK OXPHOS	N S NS	Isolated mitochondria	Rat	Heart
Smenes 2015 Abstract IOC100	2015	Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01.	LEAK ROUTINE ET	N S		Human	Skeletal muscle
Karabatsiakis 2015 Abstract MiP2015	2015	Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.	LEAK ROUTINE OXPHOS ET	ROX		Human	Blood cells
Funk 2015 Abstract MiPschool Greenville 2015	2015	Isolated mitochondria from liver and brain of long-lived growth hormone receptor gene disrupted mice demonstrate reduced respiration rates.	LEAK OXPHOS		Isolated mitochondria	Mouse	Nervous system Liver
Renshaw 2015 Abstract MiP2015	2015	Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress?	LEAK OXPHOS ET	N S	Homogenate	Fishes	Nervous system
Ojuka 2015 Abstract MiPschool Cape Town 2015	2015	Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation.	LEAK OXPHOS ET		Permeabilized cells Permeabilized tissue Isolated mitochondria
Gnaiger 2015 Abstract MiPschool Cape Town 2015	2015	The functional design of the electron transfer system (ETS) and mitochondrial respiratory control.	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria
Ali 2015 Abstract MiP2015	2015	Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor!	LEAK OXPHOS ET		Homogenate	Mouse	Heart Nervous system
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Rutkai 2015 Abstract MiPschool Greenville 2015	2015	Sex-differences in mitochondrial respiration is mediated by nitric oxide in rat cerebral arteries.	LEAK ROUTINE ET			Rat	Endothelial;epithelial;mesothelial cell
Sumbalova 2015 Abstract MiP2015	2015	High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Nervous system
Ali 2015 Abstract MiPschool Cape Town 2015	2015	Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics.	LEAK OXPHOS ET			Mouse	Heart Nervous system
El-Bacha 2014 Abstract MiP2014	2014	Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.	LEAK ROUTINE ET		Intact cells	Human	Liver
Laner 2014 Abstract MiP2014	2014	Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers.	LEAK ROUTINE OXPHOS ET	N NS	Permeabilized tissue	Dog	Skeletal muscle
Schoepf 2014 Abstract MiP2014	2014	OXPHOS analysis in small prostate biopsies.	LEAK OXPHOS ET	N S CIV NS	Permeabilized tissue	Human	Genital
Paes 2014 Abstract IOC 2014-04 Schroecken	2014	Paes MC, Saraiva FMS, Nogueira NP, Laranja GAT, Coelho MGP, Oliveira MF (2014) Heme increases mitochondrial membrane potential and ROS production in Trypanosoma cruzi epimastigotes. Mitochondr Physiol Network 19.02.	LEAK OXPHOS ET	S Other combinations	Permeabilized cells Oxidase;biochemical oxidation	Protists
Herminghaus 2014 Abstract MiP2014	2014	Severity of polymicrobial sepsis modulates mitochondrial function in rat liver.	LEAK OXPHOS	N S	Isolated mitochondria	Rat	Liver
Karabatsiakis 2014 Abstract IOC96	2014	Karabatsiakis A (2014) Consequences of depression on respiratory activity in peripheral blood mononuclear cells. Mitochondr Physiol Network 19.11.	LEAK ROUTINE ET		Intact cells	Human	Blood cells Lymphocyte
Sparks 2014 Abstract MiP2014	2014	NAMPT remodels substrate metabolism in skeletal muscle.	LEAK OXPHOS	N S	Permeabilized tissue	Mouse	Skeletal muscle
Mendonca 2014 Abstract IOC 2014-04 Schroecken	2014	Mendonca AP, Rodrigues MF, Amoedo ND, Oliveira MF (2014) Effects of iron on mitochondrial physiology of central nervous system cell lines. Mitochondr Physiol Network 19.02.	LEAK OXPHOS ET				Nervous system Other cell lines Neuroblastoma
Jezek 2014 Abstract MiP2014	2014	Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.	LEAK OXPHOS		Isolated mitochondria		Other cell lines
Volodina 2014 Abstract MiP2014	2014	Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Rat	Liver
Alberici 2014 Abstract MiP2014	2014	Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism.	LEAK ROUTINE ET		Intact cells	Rat	Skeletal muscle
Krumschnabel 2014 Abstract MiP2014	2014	Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.	LEAK OXPHOS ET	N S NS	Homogenate Isolated mitochondria	Mouse	Nervous system
Doerrier 2014 Abstract SECF	2014	Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Heart
Zorzano 2014 Abstract MiP2014	2014	Metabolic implications of mitofusin 2 dysfunction.	LEAK OXPHOS			Mouse	Skeletal muscle
Bristot 2014 Abstract MiP2014	2014	High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations.	LEAK OXPHOS		Intact cells	Human	Fibroblast
Lai 2014 Abstract1 MiP2014	2014	Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.	LEAK OXPHOS	N	Isolated mitochondria	Rat Dog	Heart Skeletal muscle Fibroblast
Porter 2014 Abstract IOC95	2014	Porter C (2014) The impact of resistance exercise training on skeletal muscle mitochondrial respiration in healthy young adults. Mitochondr Physiol Network 19.10	LEAK OXPHOS ET		Permeabilized tissue	Human	Skeletal muscle
Power 2014 Abstract MiP2014	2014	The hot heart: cardiac mitochondrial energetics during hyperthermia.	LEAK OXPHOS		Isolated mitochondria	Rat	Heart
Quistorff 2013 Abstract MiP2013	2013	Quistorff B (2013) With type 2 diabetes mitochondrial dysfunction develops earlier in liver than in skeletal muscle. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	F S Other combinations		Rat	Skeletal muscle Liver
Gnaiger 2013 Abstract Mito2013	2013	Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Human	Skeletal muscle
Amoedo 2013 Abstract MiP2013	2013	Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Enzyme Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Other cell lines
Korzeniewski 2013 Abstract MiP2013	2013	Korzeniewski B (2013) Regulation of oxidative phosphorylation during work transitions in different tissues results from its kinetic properties. Mitochondr Physiol Network 18.08.	LEAK OXPHOS				Heart Skeletal muscle
Krumschnabel 2013 Abstract MiP2013	2013	Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse Fishes	Heart Nervous system Liver
Gnaiger 2013 Abstract MiP2013	2013	Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Human	Skeletal muscle
Irving 2013 Abstract MiP2013	2013	Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N NS	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Liver Fat
Cavalcanti de Albuquerque 2013 Abstract MiP2013	2013	Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N S Gp NS ROX	Intact organism Permeabilized tissue	Rat	Skeletal muscle
Rodrigues 2013 Abstract MiP2013	2013	Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.	LEAK ROUTINE ET	ROX	Intact cells		Genital
Borutaite 2013 Abstract MiP2013	2013	Borutaite V, Jablonskiene G, Arandarcikaite O (2013) Mitochondrial response to heart and brain ischemia. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	N S	Isolated mitochondria	Pig Rat	Heart Nervous system
Kotwica 2013 Abstract MiP2013	2013	Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	F N S	Permeabilized tissue	Mouse	Heart Skeletal muscle
Pecina 2013 Abstract MiP2013	2013	Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S Gp NS Other combinations ROX	Permeabilized cells Homogenate	Human	Blood cells Lymphocyte
Hendricks 2013 Abstract MiP2013	2013	Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S NS	Intact cells Permeabilized cells Isolated mitochondria	Mouse	Nervous system
Garcia-Roves 2013 Abstract MiP2013	2013	Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S CIV NS	Permeabilized cells Permeabilized tissue Homogenate	Mouse	Skeletal muscle Nervous system Liver Islet cell;pancreas;thymus Fat
Galina 2013 Abstract MiP2013	2013	Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S	Permeabilized cells Isolated mitochondria Enzyme Intact cells	Rat	Skeletal muscle Nervous system Liver Other cell lines
Salin 2013 Abstract MiP2013	2013	Salin K, Luquet E, Rey B, Roussel D, Voituron Y (2013) Mitochondrial functioning, a proximate mechanism underlying the pace-of- life? Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	S CIV	Isolated mitochondria Enzyme Oxidase;biochemical oxidation	Other mammals Amphibians	Liver
Calzia 2013 Abstract MiP2013	2013	Calzia E, Wagner K, Wagner F, Groeger M, Matallo J, McCook O, Wachter U, Vogt J, Radermacher P (2013) Studying mitochondrial effects of sulfide. Does the species matter? Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET			Pig Mouse	Liver
Oliveira MF 2013 Abstract MiP2013	2013	Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV ROX	Intact organism Intact organ Permeabilized cells Permeabilized tissue Homogenate Intact cells	Human Drosophila Hexapods Other invertebrates	Skeletal muscle Neuroblastoma
Garcia-Souza 2013 Abstract IOC80	2013	Garcia-Souza LF (2013) Thrombin trigger mitochondrial functional remodeling in human platelets. Mitochondr Physiol Network 18.09.	LEAK ROUTINE ET		Intact cells	Human	Blood cells
Gomez Rodriguez 2013 Abstract IOC75	2013	Gomez Rodriguez A (2013) ß-adrenergic receptor signaling interruption with two β-blockers (atenolol or nebivolol) can modify different oxidative stress related parameters linked to longevity in mouse liver. Mitochondr Physiol Network 18.03.	LEAK		Isolated mitochondria	Mouse	Liver
Jezek 2013 Abstract MiP2013	2013	Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S ROX	Isolated mitochondria Intact cells	Mouse	Lung;gill Islet cell;pancreas;thymus
Kressig 2013 Abstract IOC79	2013	Kressig F (2013) et al. Mechanism of increased pulmonary vascular remodeling in UCP2 k/o mice. Mitochondr Physiol Network 18.07	LEAK		Permeabilized cells Isolated mitochondria	Mouse	Lung;gill Other cell lines
Slinde 2013 Abstract MiP2013	2013	Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N ROX	Permeabilized tissue Isolated mitochondria	Other mammals Fishes	Heart Liver Blood cells
Chicco 2013 Abstract MiP2013	2013	Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N Other combinations	Permeabilized tissue	Human Other mammals	Skeletal muscle
Palm 2013 Abstract MiP2013	2013	Palm F, Hansell P, Friederich-Persson M (2013) Role of mitochondrial function for the onset and progression of kidney disease. Mitochondr Physiol Network 18.08.	LEAK OXPHOS		Intact organ Intact cells Isolated mitochondria	Mouse Rat	Kidney
Laner 2013 ASMRM	2013	Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
DeLany 2013 TOS	2013	Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness.	LEAK OXPHOS		Permeabilized tissue	Human	Skeletal muscle
Hand 2013 Abstract MiP2013	2013	Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S	Intact organism Homogenate Isolated mitochondria Enzyme	Artemia Crustaceans
Skulachev 2013 Abstract MiP2013	2013	Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08.	LEAK ET		Intact organism Isolated mitochondria SMP Intact cells	Human Mouse Horse Dog Rabbit Fishes Other invertebrates Fungi Plants	Heart Skeletal muscle Nervous system Kidney Islet cell;pancreas;thymus Other cell lines HeLa Fibroblast Stem cells
Camacho-Pereira 2013 Abstract IOC75	2013	Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.	LEAK ROUTINE OXPHOS ET	N S NS	Intact cells Permeabilized cells Isolated mitochondria	Mouse	Liver HEK Macrophage-derived
Szibor 2013 Abstract MiP2013	2013	Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	ROX	Isolated mitochondria Oxidase;biochemical oxidation	Mouse	Heart Skeletal muscle Nervous system Liver Lung;gill
Dzialowski 2013 Abstract MiP2013	2013	Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N S NS	Intact organism Permeabilized tissue	Birds	Skeletal muscle
Pichaud 2013 Abstract MiP2013	2013	Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Drosophila Hexapods	Skeletal muscle
Gnaiger 2013 Abstract ASMRM	2013	Gnaiger E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul.	LEAK OXPHOS			Human
Shabalina 2013 Abstract IOC79	2013	Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Heart Skeletal muscle Liver
Schulte 2013 Abstract MiP2013	2013	Chung DJ, Schulte PM, Richards JG (2013) The effect of low-temperature acclimation on mitochondrial function in the common killifish (Fundulus heteroclitus), a top-down elasticity analysis. Mitochondr Physiol Network 18.08.	LEAK OXPHOS		Isolated mitochondria	Fishes	Liver
Scott 2013 Abstract MiP2013	2013	Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08.	LEAK OXPHOS		Isolated mitochondria Enzyme	Other mammals Birds	Skeletal muscle
Menze 2013 Abstract MiP2013	2013	Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS	N	Intact organism Intact cells Permeabilized cells Isolated mitochondria Enzyme	Drosophila Artemia Crustaceans Hexapods	Other cell lines CHO HEK Macrophage-derived
Hickey 2013 Abstract MiP2013	2013	Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S CIV NS	Permeabilized tissue	Other mammals Fishes	Heart
Volska 2013 Abstract MiP2013	2013	Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reoxygenation injury. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Nervous system
Horscroft 2012 Abstract IOC72	2012	Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13.	LEAK OXPHOS ET	N NS		Human	Skeletal muscle
Rodrigues 2012 Abstract IOC72	2012	Rodrigues MF, Amoedo ND, Rumjanek FD (2012) Studies of bioenergetics alterations in breast cancer lines induced by sodium butyrate. Mitochondr Physiol Network 17.13.	LEAK ROUTINE ET
Kamath 2012 Abstract IOC72	2012	Kamath VG, Lizenby ZJ, Adusumilli VRKR, Hsiung CH, McKee EE (2012) Measuring mitochondrial OXPHOS as a nucleoside reverse transcriptase inhibitor induced cardiac toxicity endpoint. Mitochondr Physiol Network 17.13.	LEAK OXPHOS ET		Isolated mitochondria	Rat
Doerrier 2012 Abstract Bioblast	2012	Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Heart
Hepple 2012 Abstract Bioblast	2012	Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12.	LEAK OXPHOS		Permeabilized tissue Isolated mitochondria		Skeletal muscle
Amoedo 2012 Abstract Bioblast	2012	Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.	LEAK ROUTINE OXPHOS ET	S	Intact cells	Mouse	Other cell lines
Harper 2012 Abstract Bioblast	2012	Harper ME, Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, Van IJcken W Frank Grosveld F, Dekemp RA, Boushel RC, Rudnicki MA (2012) Metabolic effects of microRNA-133 and its antagomir in mice. Mitochondr Physiol Network 17.12.	LEAK		Intact organism Permeabilized cells	Mouse	Skeletal muscle Fat
Horvath 2012 Abstract Bioblast	2012	Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
Albertini 2012 Abstract Bioblast	2012	Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12.	LEAK ROUTINE ET		Intact cells		Endothelial;epithelial;mesothelial cell HUVEC
Labieniec-Watala 2012 Abstract Bioblast	2012	Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12.	LEAK OXPHOS ET	N S NS	Homogenate Isolated mitochondria	Mouse Rat	Heart Liver Fibroblast
Dzialowski 2012 Abstract IOC72	2012	Dzialowski EM, Sirsat T, Goy S (2012) T3: Does it really make the alligator go “Tick, Tock”? Mitochondr Physiol Network 17.13.	LEAK OXPHOS	N S NS	Isolated mitochondria	Reptiles	Heart Skeletal muscle
Jacobs 2012 Abstract Bioblast	2012	Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12.	LEAK OXPHOS ET	F N S NS	Permeabilized cells	Human	Skeletal muscle
Towheed 2012 Abstract IOC72	2012	Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13.	LEAK ROUTINE OXPHOS ET	N S NS	Intact organism Permeabilized tissue	Drosophila Hexapods
Mark 2012 Abstract Bioblast	2012	Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12.	LEAK ROUTINE OXPHOS	N S CIV NS	Permeabilized tissue Isolated mitochondria	Fishes	Heart Liver
Sumbalova 2011 Abstract Mitochondrial Medicine	2011	Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.	LEAK OXPHOS ET	N S NS	Homogenate Isolated mitochondria	Mouse	Nervous system
Pesta 2011Abstract Mitochondrial Medicine-Training	2011	Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Gnaiger 2011 Abstract SMRM-Hyderabad	2011	Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arctic winter. Abstract SMRM-Hyderabad.	LEAK OXPHOS			Human
Pesta 2010 MiP Abstract	2010	Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via ³¹P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.	LEAK OXPHOS ET	F N S NS		Human
Borutaite MiP2010	2010	Borutaite V, Cizas P, Morkuniene R, Budvytyte R (2010) Effect of beta amyloid oligomers on neuronal viability and mitochondrial functions.	LEAK		Isolated mitochondria	Rat	Nervous system